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  1. Book: Estrogens and memory

    Frick, Karyn M.

    basic research and clinical implications

    (Oxford series in behavioral neuroendocrinology)

    2020  

    Author's details edited by Karyn M. Frick
    Series title Oxford series in behavioral neuroendocrinology
    Keywords Estrogen ; Physiological effect ; Cognition disorders ; Endocrine aspects ; Memory disorders ; Endocrine aspects ; Estrogen ; Therapeutic use.
    Language English
    Size XIV, 501 Seiten, Illustrationen, Diagramme
    Publisher Oxford University Press
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT020451548
    ISBN 978-0-19-064590-8 ; 9780190645922 ; 9780190669102 ; 9780190645915 ; 0-19-064590-3 ; 019064592X ; 0190669101 ; 0190645911
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2020 A 659 available for loan (reading room) Lesesaal EG

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  2. Article ; Online: New perspectives on sex differences in learning and memory.

    Fleischer, Aaron W / Frick, Karyn M

    Trends in endocrinology and metabolism: TEM

    2023  Volume 34, Issue 9, Page(s) 526–538

    Abstract: Females have historically been disregarded in memory research, including the thousands of studies examining roles for the hippocampus, medial prefrontal cortex, and amygdala in learning and memory. Even when included, females are often judged based on ... ...

    Abstract Females have historically been disregarded in memory research, including the thousands of studies examining roles for the hippocampus, medial prefrontal cortex, and amygdala in learning and memory. Even when included, females are often judged based on male-centric behavioral and neurobiological standards, generating and perpetuating scientific stereotypes that females exhibit worse memories compared with males in domains such as spatial navigation and fear. Recent research challenges these dogmas by identifying sex-specific strategies in common memory tasks. Here, we discuss rodent data illustrating sex differences in spatial and fear memory, as well as the neural mechanisms underlying memory formation. The influence of sex steroid hormones in both sexes is discussed, as is the importance to basic and translational neuroscience of studying sex differences.
    MeSH term(s) Male ; Female ; Animals ; Sex Characteristics ; Learning ; Gonadal Steroid Hormones ; Hippocampus
    Chemical Substances Gonadal Steroid Hormones
    Language English
    Publishing date 2023-07-25
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1042384-9
    ISSN 1879-3061 ; 1043-2760
    ISSN (online) 1879-3061
    ISSN 1043-2760
    DOI 10.1016/j.tem.2023.06.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2999: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: A Putative Role for Ubiquitin-Proteasome Signaling in Estrogenic Memory Regulation.

    Beamish, Sarah B / Frick, Karyn M

    Frontiers in behavioral neuroscience

    2022  Volume 15, Page(s) 807215

    Abstract: Sex steroid hormones such as 17β-estradiol ( ... ...

    Abstract Sex steroid hormones such as 17β-estradiol (E
    Language English
    Publishing date 2022-01-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452960-6
    ISSN 1662-5153
    ISSN 1662-5153
    DOI 10.3389/fnbeh.2021.807215
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Connecting the Dots: Potential Interactions Between Sex Hormones and the Circadian System During Memory Consolidation.

    Boyd, Hannah M / Frick, Karyn M / Kwapis, Janine L

    Journal of biological rhythms

    2023  Volume 38, Issue 6, Page(s) 537–555

    Abstract: Both the circadian clock and sex hormone signaling can strongly influence brain function, yet little is known about how these 2 powerful modulatory systems might interact during complex neural processes like memory consolidation. Individually, the ... ...

    Abstract Both the circadian clock and sex hormone signaling can strongly influence brain function, yet little is known about how these 2 powerful modulatory systems might interact during complex neural processes like memory consolidation. Individually, the molecular components and action of each of these systems have been fairly well-characterized, but there is a fundamental lack of information about how these systems cooperate. In the circadian system, clock genes function as timekeeping molecules that convey time-of-day information on a well-stereotyped cycle that is governed by the suprachiasmatic nucleus. Keeping time is particularly important to synchronize various physiological processes across the brain and body, including those that regulate memory consolidation. Similarly, sex hormones are powerful modulators of memory, with androgens, estrogens, and progestins, all influencing memory consolidation within memory-relevant brain regions like the hippocampus. Despite clear evidence that each system can influence memory individually, exactly how the circadian and hormonal systems might interact to impact memory consolidation remains unclear. Research investigating either sex hormone action or circadian gene function within memory-relevant brain regions has unveiled several notable places in which the two systems could interact to control memory. Here, we bring attention to known interactions between the circadian clock and sex hormone signaling. We then review sex hormone-mediated control of memory consolidation, highlighting potential nodes through which the circadian system might interact during memory formation. We suggest that the bidirectional relationship between these two systems is essential for proper control of memory formation based on an animal's hormonal and circadian state.
    MeSH term(s) Animals ; Circadian Rhythm/physiology ; Memory Consolidation ; Circadian Clocks/genetics ; Suprachiasmatic Nucleus/physiology ; Gonadal Steroid Hormones
    Chemical Substances Gonadal Steroid Hormones
    Language English
    Publishing date 2023-07-19
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 896387-3
    ISSN 1552-4531 ; 0748-7304
    ISSN (online) 1552-4531
    ISSN 0748-7304
    DOI 10.1177/07487304231184761
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2872: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: G protein-coupled estrogen receptor (GPER) in the dorsal hippocampus regulates memory consolidation in gonadectomized male mice, likely via different signaling mechanisms than in female mice.

    Machado, Gustavo D B / Schnitzler, Alexis L / Fleischer, Aaron W / Beamish, Sarah B / Frick, Karyn M

    Hormones and behavior

    2024  Volume 161, Page(s) 105516

    Abstract: Studies in ovariectomized (OVX) female rodents suggest that G protein-coupled estrogen receptor (GPER) is a key regulator of memory, yet little is known about its importance to memory in males or the cellular mechanisms underlying its mnemonic effects in ...

    Abstract Studies in ovariectomized (OVX) female rodents suggest that G protein-coupled estrogen receptor (GPER) is a key regulator of memory, yet little is known about its importance to memory in males or the cellular mechanisms underlying its mnemonic effects in either sex. In OVX mice, bilateral infusion of the GPER agonist G-1 into the dorsal hippocampus (DH) enhances object recognition and spatial memory consolidation in a manner dependent on rapid activation of c-Jun N-terminal kinase (JNK) signaling, cofilin phosphorylation, and actin polymerization in the DH. However, the effects of GPER on memory consolidation and DH cell signaling in males are unknown. Thus, the present study first assessed effects of DH infusion of G-1 or the GPER antagonist G-15 on object recognition and spatial memory consolidation in gonadectomized (GDX) male mice. As in OVX mice, immediate post-training bilateral DH infusion of G-1 enhanced, whereas G-15 impaired, memory consolidation in the object recognition and object placement tasks. However, G-1 did not increase levels of phosphorylated JNK (p46, p54) or cofilin in the DH 5, 15, or 30 min after infusion, nor did it affect phosphorylation of ERK (p42, p44), PI3K, or Akt. Levels of phospho-cAMP-responsive element binding protein (CREB) were elevated in the DH 30 min following G-1 infusion, indicating that GPER in males activates a yet unknown signaling mechanism that triggers CREB-mediated gene transcription. Our findings show for the first time that GPER in the DH regulates memory consolidation in males and suggests sex differences in underlying signaling mechanisms.
    Language English
    Publishing date 2024-02-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 214409-8
    ISSN 1095-6867 ; 0018-506X
    ISSN (online) 1095-6867
    ISSN 0018-506X
    DOI 10.1016/j.yhbeh.2024.105516
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 693: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  6. Article ; Online: Activation of androgen receptors protects intact male mice from memory impairments caused by aromatase inhibition.

    Koss, Wendy A / Frick, Karyn M

    Hormones and behavior

    2019  Volume 111, Page(s) 96–104

    Abstract: Although 17β-estradiol ( ... ...

    Abstract Although 17β-estradiol (E
    MeSH term(s) Androgens/pharmacology ; Animals ; Aromatase Inhibitors/adverse effects ; Aromatase Inhibitors/pharmacology ; Castration ; Estradiol/pharmacology ; Hippocampus/drug effects ; Male ; Memory/drug effects ; Memory Consolidation/drug effects ; Memory Disorders/prevention & control ; Mice ; Mice, Inbred C57BL ; Receptors, Androgen/metabolism ; Recognition, Psychology/drug effects ; Signal Transduction/drug effects
    Chemical Substances Androgens ; Aromatase Inhibitors ; Receptors, Androgen ; Estradiol (4TI98Z838E)
    Language English
    Publishing date 2019-01-17
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 214409-8
    ISSN 1095-6867 ; 0018-506X
    ISSN (online) 1095-6867
    ISSN 0018-506X
    DOI 10.1016/j.yhbeh.2019.01.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 693: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Extracellular matrix metalloproteinase-9 (MMP-9) is required in female mice for 17β-estradiol enhancement of hippocampal memory consolidation.

    Gross, Kellie S / Lincoln, Carnita M / Anderson, McKenna M / Geiger, Grace E / Frick, Karyn M

    Psychoneuroendocrinology

    2022  Volume 141, Page(s) 105773

    Abstract: Hippocampal plasticity and memory are modulated by the potent estrogen 17β-estradiol ( ... ...

    Abstract Hippocampal plasticity and memory are modulated by the potent estrogen 17β-estradiol (E
    MeSH term(s) Animals ; Estradiol/metabolism ; Estradiol/pharmacology ; Female ; Hippocampus/metabolism ; Matrix Metalloproteinase 9/metabolism ; Memory Consolidation ; Mice ; Mice, Inbred C57BL
    Chemical Substances Estradiol (4TI98Z838E) ; Matrix Metalloproteinase 9 (EC 3.4.24.35)
    Language English
    Publishing date 2022-04-21
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 197636-9
    ISSN 1873-3360 ; 0306-4530
    ISSN (online) 1873-3360
    ISSN 0306-4530
    DOI 10.1016/j.psyneuen.2022.105773
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1235: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  8. Article ; Online: Mechanisms underlying the rapid effects of estradiol and progesterone on hippocampal memory consolidation in female rodents.

    Frick, Karyn M / Kim, Jaekyoon

    Hormones and behavior

    2018  Volume 104, Page(s) 100–110

    Abstract: Contribution to Special Issue on Fast effects of steroids. Although rapid effects of 17β‑estradiol ( ... ...

    Abstract Contribution to Special Issue on Fast effects of steroids. Although rapid effects of 17β‑estradiol (E
    MeSH term(s) Animals ; Estradiol/pharmacology ; Female ; Hippocampus/drug effects ; Hippocampus/physiology ; Memory Consolidation/drug effects ; Progesterone/pharmacology ; Recognition, Psychology/drug effects ; Rodentia ; Signal Transduction/drug effects
    Chemical Substances Progesterone (4G7DS2Q64Y) ; Estradiol (4TI98Z838E)
    Language English
    Publishing date 2018-05-09
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 214409-8
    ISSN 1095-6867 ; 0018-506X
    ISSN (online) 1095-6867
    ISSN 0018-506X
    DOI 10.1016/j.yhbeh.2018.04.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Distinct effects of estrogen receptor antagonism on object recognition and spatial memory consolidation in ovariectomized mice.

    Kim, Jaekyoon / Frick, Karyn M

    Psychoneuroendocrinology

    2017  Volume 85, Page(s) 110–114

    Abstract: Exogenous treatment with the potent estrogen 17β-estradiol ( ... ...

    Abstract Exogenous treatment with the potent estrogen 17β-estradiol (E
    Language English
    Publishing date 2017-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 197636-9
    ISSN 1873-3360 ; 0306-4530
    ISSN (online) 1873-3360
    ISSN 0306-4530
    DOI 10.1016/j.psyneuen.2017.08.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Molecular mechanisms underlying the memory-enhancing effects of estradiol.

    Frick, Karyn M

    Hormones and behavior

    2015  Volume 74, Page(s) 4–18

    Abstract: This article is part of a Special Issue "Estradiol and cognition". Since the publication of the 1998 special issue of Hormones and Behavior on estrogens and cognition, substantial progress has been made towards understanding the molecular mechanisms ... ...

    Abstract This article is part of a Special Issue "Estradiol and cognition". Since the publication of the 1998 special issue of Hormones and Behavior on estrogens and cognition, substantial progress has been made towards understanding the molecular mechanisms through which 17β-estradiol (E2) regulates hippocampal plasticity and memory. Recent research has demonstrated that rapid effects of E2 on hippocampal cell signaling, epigenetic processes, and local protein synthesis are necessary for E2 to facilitate the consolidation of object recognition and spatial memories in ovariectomized female rodents. These effects appear to be mediated by non-classical actions of the intracellular estrogen receptors ERα and ERβ, and possibly by membrane-bound ERs such as the G-protein-coupled estrogen receptor (GPER). New findings also suggest a key role of hippocampally-synthesized E2 in regulating hippocampal memory formation. The present review discusses these findings in detail and suggests avenues for future study.
    MeSH term(s) Animals ; Epigenesis, Genetic/drug effects ; Estradiol/pharmacology ; Estrogen Receptor alpha/genetics ; Estrogen Receptor alpha/metabolism ; Estrogen Receptor beta/genetics ; Estrogen Receptor beta/metabolism ; Female ; Hippocampus/drug effects ; Hippocampus/metabolism ; Humans ; Memory/drug effects ; Performance-Enhancing Substances/pharmacology ; Signal Transduction/drug effects ; Signal Transduction/genetics
    Chemical Substances Estrogen Receptor alpha ; Estrogen Receptor beta ; Performance-Enhancing Substances ; Estradiol (4TI98Z838E)
    Language English
    Publishing date 2015-05-08
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 214409-8
    ISSN 1095-6867 ; 0018-506X
    ISSN (online) 1095-6867
    ISSN 0018-506X
    DOI 10.1016/j.yhbeh.2015.05.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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