LIVIVO - Search results -

Search results

Result 1 - 10 of total 109

Search options

Article ; Online: A comparison of synthetic control approaches for the evaluation of policy interventions using observational data: Evaluating the impact of redesigning urgent and emergency care in Northumberland.

Clarke, Geraldine M / Steventon, Adam / O'Neill, Stephen

2023 Volume 58, Issue 2, Page(s) 445–457

Abstract: Objective: To compare the original synthetic control (OSC) method with alternative approaches (Generalized [GSC], Micro [MSC], and Bayesian [BSC] synthetic control methods) and re-evaluate the impact of a significant restructuring of urgent and ... ...

Abstract	Objective: To compare the original synthetic control (OSC) method with alternative approaches (Generalized [GSC], Micro [MSC], and Bayesian [BSC] synthetic control methods) and re-evaluate the impact of a significant restructuring of urgent and emergency care in Northeast England, which included the opening of the UK's first purpose-built specialist emergency care hospital. Data sources: Simulations and data from Secondary Uses Service data, a single comprehensive repository for patient-level health care data in England. Study design: Hospital use of individuals exposed and unexposed to the restructuring is compared. We estimate the impact using OSC, MSC, BSC, and GSC applied at the general practice level. We contrast the estimation methods' performance in a Monte Carlo simulation study. Data collection/extraction methods: Hospital activity data from Secondary Uses Service for patients aged over 18 years registered at a general practice in England from April 2011 to March 2019. Principal findings: None of the methods dominated all simulation scenarios. GSC was generally preferred. In contrast to an earlier evaluation that used OSC, GSC reported a smaller impact of the opening of the hospital on Accident and Emergency (A&E) department (also known as emergency department or casualty) visits and no evidence for any impact on the proportion of A&E patients seen within 4 h. Conclusions: The simulation study highlights cases where the considered methods may lead to biased estimates in health policy evaluations. GSC was found to be the most reliable method of those considered. Considering more disaggregated data over a longer time span and applying GSC indicates that the specialist emergency care hospitals in Northumbria had less impact on A&E visits and waiting times than suggested by the original evaluation which applied OSC to more aggregated data.
MeSH term(s)	Humans ; Adult ; Middle Aged ; Bayes Theorem ; Emergency Medical Services ; Emergency Service, Hospital ; Hospitals ; Health Policy
Language	English
Publishing date	2023-01-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	410435-3
ISSN	1475-6773 ; 0017-9124
ISSN (online)	1475-6773
ISSN	0017-9124
DOI	10.1111/1475-6773.14126
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 582: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Non-invasive continuous cardiac output monitoring in infants with hypoxic ischaemic encephalopathy.

Garvey, Aisling A / O'Neill, Roisin / Livingstone, Vicki / Pavel, Andreea M / Finn, Daragh / Boylan, Geraldine B / Murray, Deirdre M / Dempsey, Eugene M

Journal of perinatology : official journal of the California Perinatal Association

2022 Volume 42, Issue 12, Page(s) 1622–1629

Abstract: Objective: To describe early, continuous, non-invasive measures of cardiac output (CO) and evolution over time in infants with hypoxic-ischaemic encephalopathy (HIE).: Study design: Prospective observational study of 44 infants with HIE (23 mild, 17 ... ...

Abstract	Objective: To describe early, continuous, non-invasive measures of cardiac output (CO) and evolution over time in infants with hypoxic-ischaemic encephalopathy (HIE). Study design: Prospective observational study of 44 infants with HIE (23 mild, 17 moderate, 4 severe) and 17 term controls. Infants with HIE had non-invasive CO monitoring (NICOM) continuously in the neonatal unit. Term controls had NICOM recorded at 6 and 24 h. A mixed-modelling approach was used to assess change in CO over time by group. Results: Infants with moderate HIE have significantly lower CO than the mild group at all timepoints (10.7 mls/kg/min lower, 95% CI:1.0,20.4, p = 0.03) which increases over time, driven by a gradual increase in stroke volume (SV). CO increased further during rewarming predominantly due to an increase in HR. Conclusion: TH has a significant impact on HR but SV appears largely unaffected. NICOM may provide a non-invasive, continuous, low-cost alternative to monitoring CO in infants with HIE however further research is warranted.
MeSH term(s)	Infant, Newborn ; Humans ; Hypoxia-Ischemia, Brain/diagnosis ; Hypoxia-Ischemia, Brain/therapy ; Cardiac Output ; Monitoring, Physiologic ; Prospective Studies ; Stroke Volume ; Hypothermia, Induced
Language	English
Publishing date	2022-09-02
Publishing country	United States
Document type	Observational Study ; Journal Article
ZDB-ID	645021-0
ISSN	1476-5543 ; 0743-8346
ISSN (online)	1476-5543
ISSN	0743-8346
DOI	10.1038/s41372-022-01495-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 2412: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Forcing a growth factor response - tissue-stiffness modulation of integrin signaling and crosstalk with growth factor receptors.

Sarker, Farhana A / Prior, Victoria G / Bax, Samuel / O'Neill, Geraldine M

Journal of cell science

2020 Volume 133, Issue 23

Abstract: Research throughout the 90s established that integrin crosstalk with growth factor receptors stimulates robust growth factor signaling. These insights were derived chiefly from comparing adherent versus suspension cell cultures. Considering the new ... ...

Abstract	Research throughout the 90s established that integrin crosstalk with growth factor receptors stimulates robust growth factor signaling. These insights were derived chiefly from comparing adherent versus suspension cell cultures. Considering the new understanding that mechanosensory inputs tune adhesion signaling, it is now timely to revisit this crosstalk in different mechanical environments. Here, we present a brief historical perspective on integrin signaling against the backdrop of the mechanically diverse extracellular microenvironment, then review the evidence supporting the mechanical regulation of integrin crosstalk with growth factor signaling. We discuss early studies revealing distinct signaling consequences for integrin occupancy (binding to matrix) and aggregation (binding to immobile ligand). We consider how the mechanical environments encountered
MeSH term(s)	Integrins ; Intercellular Signaling Peptides and Proteins ; Signal Transduction
Chemical Substances	Integrins ; Intercellular Signaling Peptides and Proteins
Language	English
Publishing date	2020-12-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2993-2
ISSN	1477-9137 ; 0021-9533
ISSN (online)	1477-9137
ISSN	0021-9533
DOI	10.1242/jcs.242461
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1200: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 14: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: From Pediatric to Adult Brain Cancer: Exploring Histone H3 Mutations in Australian Brain Cancer Patients.

Biomedicines

2023 Volume 11, Issue 11

Abstract: Genetic histone variants have been implicated in cancer development and progression. Mutations affecting the histone 3 (H3) family, H3.1 (encoded ... ...

Abstract	Genetic histone variants have been implicated in cancer development and progression. Mutations affecting the histone 3 (H3) family, H3.1 (encoded by
Language	English
Publishing date	2023-10-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines11112907
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Fiber alignment in 3D collagen networks as a biophysical marker for cell contractility.

Böhringer, David / Bauer, Andreas / Moravec, Ivana / Bischof, Lars / Kah, Delf / Mark, Christoph / Grundy, Thomas J / Görlach, Ekkehard / O'Neill, Geraldine M / Budday, Silvia / Strissel, Pamela L / Strick, Reiner / Malandrino, Andrea / Gerum, Richard / Mak, Michael / Rausch, Martin / Fabry, Ben

Matrix biology : journal of the International Society for Matrix Biology

2023 Volume 124, Page(s) 39–48

Abstract: Cells cultured in 3D fibrous biopolymer matrices exert traction forces on their environment that induce deformations and remodeling of the fiber network. By measuring these deformations, the traction forces can be reconstructed if the mechanical ... ...

Abstract	Cells cultured in 3D fibrous biopolymer matrices exert traction forces on their environment that induce deformations and remodeling of the fiber network. By measuring these deformations, the traction forces can be reconstructed if the mechanical properties of the matrix and the force-free matrix configuration are known. These requirements limit the applicability of traction force reconstruction in practice. In this study, we test whether force-induced matrix remodeling can instead be used as a proxy for cellular traction forces. We measure the traction forces of hepatic stellate cells and different glioblastoma cell lines and quantify matrix remodeling by measuring the fiber orientation and fiber density around these cells. In agreement with simulated fiber networks, we demonstrate that changes in local fiber orientation and density are directly related to cell forces. By resolving Rho-kinase (ROCK) inhibitor-induced changes of traction forces, fiber alignment, and fiber density in hepatic stellate cells, we show that the method is suitable for drug screening assays. We conclude that differences in local fiber orientation and density, which are easily measurable, can be used as a qualitative proxy for changes in traction forces. The method is available as an open-source Python package with a graphical user interface.
MeSH term(s)	Extracellular Matrix/metabolism ; Cell Line ; Collagen/metabolism
Chemical Substances	Collagen (9007-34-5)
Language	English
Publishing date	2023-11-14
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1183793-7
ISSN	1569-1802 ; 0945-053X
ISSN (online)	1569-1802
ISSN	0945-053X
DOI	10.1016/j.matbio.2023.11.004
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1694: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Scared stiff: Stabilizing the actin cytoskeleton to stop invading cancer cells in their tracks.

O'Neill, Geraldine M

Bioarchitecture

2011 Volume 1, Issue 1, Page(s) 29–31

Abstract: In recent years the concept of plasticity between invasion modes used by individual cancer cells has been gaining increasing interest in the field. Individually invading tumour cells can be divided into those that use a mesenchymal invasion mode, those ... ...

Abstract	In recent years the concept of plasticity between invasion modes used by individual cancer cells has been gaining increasing interest in the field. Individually invading tumour cells can be divided into those that use a mesenchymal invasion mode, those that use "amoeboid" invasion and those that can switch between the two modes. The morphological distinctions between these different modes of invasion suggest that the actin cytoskeleton is likely to be a major contributor to the plasticity of cancer cell invasion mechanisms. We have recently investigated this idea by manipulating expression of Tm5NM1, one isoform of the tropomyosin family of actin-associating proteins. In a novel finding, we discovered that stabilizing the actin cytoskeleton via elevated expression of Tm5NM1 specifically inhibits mesenchymal-type cancer cell invasion, without causing transition to "amoeboid" motility-thus stopping the invading cancer cells in their tracks. The present perspective discusses our recent data in the context of current understanding of invasion plasticity and considers how stabilizing actin filaments may inhibit the mesenchymal invasion mode.
Language	English
Publishing date	2011-08-08
Publishing country	United States
Document type	Journal Article
ISSN	1949-100X
ISSN (online)	1949-100X
DOI	10.4161/bioa.1.1.14665
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Small molecule targeting of the actin associating protein tropomyosin Tpm3.1 increases neuroblastoma cell response to inhibition of Rac-mediated multicellular invasion.

Mitchell, Camilla B / Stehn, Justine R / O'Neill, Geraldine M

Cytoskeleton (Hoboken, N.J.)

2018 Volume 75, Issue 7, Page(s) 307–317

Abstract: The migration and invasion of cells through tissues in the body is facilitated by a dynamic actin cytoskeleton. The actin-associating protein, tropomyosin Tpm3.1 has emerged to play important roles in cell migration and invasion. To date, investigations ... ...

Abstract	The migration and invasion of cells through tissues in the body is facilitated by a dynamic actin cytoskeleton. The actin-associating protein, tropomyosin Tpm3.1 has emerged to play important roles in cell migration and invasion. To date, investigations have focused on single cell migration and invasion where Tpm3.1 expression is inversely associated with Rac GTPase-mediated cell invasion. While single cell and collective cell invasion have many features in common, collective invasion is additionally impacted by cell-cell adhesion, and the role of Tpm3.1 in collective invasion has not been established. In the present study we have modelled multicellular invasion using neuroblastoma spheroids embedded in 3D collagen and analysed the function of Tpm3.1 using recently established compounds that target the Tpm3.1 C-terminus. The major findings from our study reveal that combined Rac inhibition and Tpm3.1 targeting result in greater inhibition of multicellular invasion than either treatment alone. Together, the data suggest that Tpm3.1 disruption sensitises neuroblastoma cells to inhibition of Rac-mediated multicellular invasion.
MeSH term(s)	Actins/metabolism ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/pharmacology ; Antineoplastic Combined Chemotherapy Protocols/pharmacology ; Cell Line, Tumor ; Drug Synergism ; Enzyme Inhibitors/administration & dosage ; Enzyme Inhibitors/pharmacology ; Humans ; N-Myc Proto-Oncogene Protein/genetics ; Neoplasm Invasiveness ; Neuroblastoma/drug therapy ; Neuroblastoma/genetics ; Neuroblastoma/metabolism ; Neuroblastoma/pathology ; Tropomyosin/antagonists & inhibitors ; Tropomyosin/metabolism ; rac GTP-Binding Proteins/antagonists & inhibitors ; rac GTP-Binding Proteins/metabolism
Chemical Substances	Actins ; Antineoplastic Agents ; Enzyme Inhibitors ; MYCN protein, human ; N-Myc Proto-Oncogene Protein ; TPM3 protein, human ; Tropomyosin ; rac GTP-Binding Proteins (EC 3.6.5.2)
Language	English
Publishing date	2018-08-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2534372-5
ISSN	1949-3592 ; 1949-3584
ISSN (online)	1949-3592
ISSN	1949-3584
DOI	10.1002/cm.21452
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1840: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: Improving marinade absorption and shelf life of vacuum packed marinated pork chops through the application of high pressure processing as a hurdle

O’Neill, Ciara M / Cruz-Romero, Malco C / Duffy, Geraldine / Kerry, Joseph P

Food packaging and shelf life. 2019 Sept., v. 21

2019

Abstract: The objective of this study was to determine the efficacy of HPP to accelerate marinade (piri-piri) absorption in pork chops and to study the effects on the physicochemical, sensory and microbiological characteristics during storage. HPP (300 MPa, 400 ... ...

Abstract	The objective of this study was to determine the efficacy of HPP to accelerate marinade (piri-piri) absorption in pork chops and to study the effects on the physicochemical, sensory and microbiological characteristics during storage. HPP (300 MPa, 400 MPa or 500 MPa) and organic acids InbacTM (0.3%) were used as hurdles to extend the shelf life. The results showed that HPP ≥ 400 MPa increased (P < 0.05) the marinade absorption which enhanced the flavour acceptability of the marinated pork chops. The piri-piri marinade masked the discolouration caused by HPP and increased (P < 0.05) the tenderness of the pork chops over storage. From the microbiological point of view, HPP at 300, 400 or 500 MPa and InbacTM (0.3%) extended (P < 0.05) the shelf life by 16, 22 and 29 days, respectively. The results highlighted the potential of combined effects of HPP and antimicrobial InbacTM to accelerate marinade absorption and extend the shelf life of marinated pork chops.
Keywords	absorption ; chops ; discoloration ; flavor ; food packaging ; high pressure treatment ; marinating ; organic acids and salts ; pork ; shelf life ; vacuum packaging
Language	English
Dates of publication	2019-09
Publishing place	Elsevier Ltd
Document type	Article
ISSN	2214-2894
DOI	10.1016/j.fpsl.2019.100350
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: The application of response surface methodology for development of sensory acceptable, low-salt, shelf-stable frankfurters using high-pressure processing and a mix of organic acids

O’Neill, Ciara M / Cruz-Romero, Malco C / Duffy, Geraldine / Kerry, Joe P

European food research & technology. 2019 June, v. 245, no. 6

2019

Abstract: Response surface methodology was used to develop sensory acceptable, low-salt, shelf-stable frankfurters. A Box–Behnken experimental design assessed the effects of three independent factors: salt replacer (ArtisaltTM) (0–100%), high-pressure processing ( ... ...

Abstract	Response surface methodology was used to develop sensory acceptable, low-salt, shelf-stable frankfurters. A Box–Behnken experimental design assessed the effects of three independent factors: salt replacer (ArtisaltTM) (0–100%), high-pressure processing (HPP) (0.1–600 MPa) and a mix of organic acids (InbacTM) (0.2–0.4%). Measured responses included: hardness, flavour, saltiness and overall sensory acceptability (OSA) of the frankfurters. The primary factor affecting (P < 0.05) all the responses was the salt replacer. The optimum parameters to maximise salt reduction and produce frankfurters with OSA similar to commercial-type products were ArtisaltTM (48%), HPP (580 MPa), and InbacTM (0.3%) which contained a total salt content of 1.3%, compared to control samples which contained 2.5% total salt. The hurdles applied (HPP and InbacTM) extended product shelf life by 27 days compared to control samples. The results found in this study indicated that the optimum combination of HPP and a mix of organic acids InbacTM compensated for the significant salt reduction and extended the shelf life of low-salt frankfurters by 51% compared to control samples which contained significantly (P < 0.05) higher salt content and the preservative effects of salt. Overall, these results indicate the potential use of the hurdle approach for improving the shelf life and safety of low-salt processed meat products.
Keywords	experimental design ; hardness ; high pressure treatment ; hot dogs ; organic acids and salts ; processed meat ; response surface methodology ; salt content ; salt substitutes ; saltiness ; shelf life
Language	English
Dates of publication	2019-06
Size	p. 1277-1291.
Publishing place	Springer Berlin Heidelberg
Document type	Article
ZDB-ID	1359456-4
ISSN	1431-4630 ; 1438-2377
ISSN	1431-4630 ; 1438-2377
DOI	10.1007/s00217-019-03243-x
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

Z 792: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article: Comparative study on the acceptability and consumer appeal of commercial products and research-optimised low-salt frankfurters and cooked ham manufactured using high-pressure processing and organic acids

O’Neill, Ciara M / Cruz-Romero, Malco C / Duffy, Geraldine / Kerry, Joe P

European food research & technology. 2019 Apr., v. 245, no. 4

2019

Abstract: The objective of this study was to assess the acceptability and consumer (n = 100) appeal of research-optimised low-salt (ROLS) frankfurters or cooked ham manufactured using high-pressure processing (HPP) and organic acids as hurdles and compared to ... ...

Abstract	The objective of this study was to assess the acceptability and consumer (n = 100) appeal of research-optimised low-salt (ROLS) frankfurters or cooked ham manufactured using high-pressure processing (HPP) and organic acids as hurdles and compared to research control and gold standard commercially available products. For frankfurters, consumers preferred the firmness and saltiness of the ROLS and research control frankfurters while the flavour and juiciness of commercial frankfurters was preferred. In terms of overall sensory acceptability (OSA), the ROLS frankfurter was liked just as much as the commercial brand frankfurter. For cooked ham, the appearance and firmness of ROLS and research control cooked ham was preferred while the juiciness of the commercial cooked ham was preferred. Consumers did not find significant differences in flavour, saltiness or OSA and the ROLS cooked ham was liked just as much as the commercial brand cooked ham. Overall, these results indicate that the ROLS processed meat products were just as acceptable or better than the gold standard commercially available products confirming the potential of the use of response surface methodology to optimise salt replacer ArtisaltTM, HPP and organic acids to manufacture consumer-accepted low-salt processed meat products with enhanced safety and shelf life.
Keywords	cooked foods ; firmness ; food research ; ham ; high pressure treatment ; hot dogs ; juiciness ; manufacturing ; organic acids and salts ; processed meat ; response surface methodology ; salt substitutes ; saltiness ; shelf life
Language	English
Dates of publication	2019-04
Size	p. 793-804.
Publishing place	Springer Berlin Heidelberg
Document type	Article
ZDB-ID	1359456-4
ISSN	1431-4630 ; 1438-2377
ISSN	1431-4630 ; 1438-2377
DOI	10.1007/s00217-018-3213-2
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

Z 792: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED