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Article ; Online: Prognostic Factors Affecting Survival of Patients With Single Primary Breast Cancer vs Patients With Multiple Primary Cancers in Lifetime, One of Which is Breast Cancer.

Sanli, Ahmet Necati / Tekcan Sanli, Deniz Esin / Altundag, M Kadri / Aydogan, Fatih

2024 , Page(s) 31348241248695

Abstract: Purpose: The aim of this study was to investigate the demographic and molecular characteristics, overall survival (OS), cancer-specific survival (CSS), and prognostic factors affecting the survival of patients with single primary breast cancer (SPBC) ... ...

Abstract	Purpose: The aim of this study was to investigate the demographic and molecular characteristics, overall survival (OS), cancer-specific survival (CSS), and prognostic factors affecting the survival of patients with single primary breast cancer (SPBC) and patients with multiple primary cancers in their life time in which one of them is breast cancer (MPC). Methods: Using data from SEER 17 Research Plus, patients with breast cancer diagnosed between 2010 and 2019 were included in this study. Race, marital status, laterality, tumor size, molecular subtype, grade, stage, radiotherapy-chemotherapy treatment, and surgery data were analyzed in the data obtained after excluding patients with missing values. Kaplan-Meier survival analysis was used for survival analysis, and Cox regression analysis was used to evaluate the prognostic factors. Results: 573175 patients were included in the study. The mean age of MPC patients was significantly higher than SPBC patients (65.99 ± 12.68, 60.33 ± 13.47, Conclusion: Although patients with SPBC have worse prognostic tumor characteristics, OS and CSS rates are better than patients with MPC.
Language	English
Publishing date	2024-04-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	202465-2
ISSN	1555-9823 ; 0003-1348
ISSN (online)	1555-9823
ISSN	0003-1348
DOI	10.1177/00031348241248695
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Article ; Online: A case of ectopic fibroadenoma mimicking left axillary lymphadenopathy

Deniz Esin Tekcan Sanli

Journal of Clinical and Investigative Surgery, Vol 7, Iss 1, Pp 113-

2022 Volume 116

Abstract: Fibroadenomas are the most common benign tumors of the breast. Since they originate from the fibroglandular breast tissue, they cannot be localized anywhere outside the breast. However, they can be localized in accessory or ectopic breast tissue and ... ...

Abstract	Fibroadenomas are the most common benign tumors of the breast. Since they originate from the fibroglandular breast tissue, they cannot be localized anywhere outside the breast. However, they can be localized in accessory or ectopic breast tissue and cause confusion in terms of clinical differential diagnosis. Small ectopic fibroadenomas placed in normal breast tissue are generally asymptomatic and nonpalpable. In contrast, lesions located in the axillary region are usually palpable, due to their superficial location and skin that is thinner at this level. This case report presents the clinical and imaging findings of a patient with a preliminary diagnosis of lymphadenopathy, with a superficial axillary location of the lesion and who underwent biopsy. In our case, no obvious accessory breast tissue was detected by physical examination or ultrasound of the left armpit. Even though there was axillary accessory breast tissue, it was not at a level that could be detected by ultrasound.
Keywords	fibroadenoma ; ectopic fibroadenoma ; axillary fibroadenoma ; lymphadenopathy ; Medicine ; R
Subject code	616
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	Digital ProScholar Media
Document type	Article ; Online
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Article ; Online: Should the Breast Cancer Staging System be Revised?

Sanli, Ahmet Necati / Tekcan Sanli, Deniz Esin / Aydogan, Fatih / Altundag, M Kadri

The American surgeon

2023 Volume 90, Issue 5, Page(s) 1066–1073

Abstract: Objective: The purpose of this study was to determine whether breast cancer patients at stage T2N0 with tumor size ≥4 cm and <4 cm.: Method: Patients with T2N0 stage breast cancer diagnosed between 2010 and 2019 were analyzed in 2 groups as <4 cm ( ... ...

Abstract	Objective: The purpose of this study was to determine whether breast cancer patients at stage T2N0 with tumor size ≥4 cm and <4 cm. Method: Patients with T2N0 stage breast cancer diagnosed between 2010 and 2019 were analyzed in 2 groups as <4 cm (T2a) and ≥4 cm (T2b) in the study using the SEER 17 Research Plus database. The patients' clinicopathological characteristics and oncological outcomes were included. Group comparisons of prognostic factors, overall survival (OS), and cancer-specific survival (CSS) were made. Results: In this study, which involved 70971 patients, the T2a group had higher 5-year OS rate (87.2 ± .2 vs 80.8 ± .5%) and 5-year CSS rate (93.7 ± .1% vs 89.4 ± .4%) than the T2b group ( Conclusion: Overall survival and BCSS rates in stage T2b breast cancer patients are significantly lower than in T2a patients. Tumor size ≥4 cm in breast cancer is a negative predictor of prognosis.
MeSH term(s)	Humans ; Female ; Breast Neoplasms ; Neoplasm Staging ; Prognosis ; Survival Rate ; Databases, Factual
Language	English
Publishing date	2023-12-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	202465-2
ISSN	1555-9823 ; 0003-1348
ISSN (online)	1555-9823
ISSN	0003-1348
DOI	10.1177/00031348231223074
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Article ; Online: Normative reference values of major thoracic arterial vasculature in Turkiye.

Tekcan Sanli, Deniz Esin / Sanli, Ahmet Necati / Yildirim, Onur / Erginoz, Ergin / Yildirim, Duzgun

Northern clinics of Istanbul

2023 Volume 10, Issue 2, Page(s) 263–270

Abstract: Objective: The aim of this study was to determine normative reference values for major thoracic arterial vasculature in Turkiye and to evaluate differences according to age and gender.: Methods: Low-dose unenhanced chest computerized tomography ... ...

Abstract	Objective: The aim of this study was to determine normative reference values for major thoracic arterial vasculature in Turkiye and to evaluate differences according to age and gender. Methods: Low-dose unenhanced chest computerized tomography images acquired with pre-diagnosis of COVID-19 between March and June 2020 were evaluated retrospectively. Patients with known chronic lung parenchymal disease, pleural effusion, pneumothorax, chronic diseases such as diabetes, hypertension, obesity, and chronic heart diseases (coronary artery disease, atherosclerosis, congestive heart failure, valve replacement, and arrhythmia) were excluded from the study. The ascending aorta diameter (AAD), descending aorta diameter (DAD), aortic arch diameter (ARCAD), main pulmonary artery diameter (MPAD), right pulmonary artery diameter (RPAD), and the left pulmonary artery diameter (LPAD) were measured in the same sections by standardized methods. The variability of parameters according to age (<40 years; ≥40 years) and gender (male to female) was evaluated by statistical methods. The Student's t test was used to compare the normal distribution according to the given quantitative age and gender, while the data that did not fit the normal distribution were compared with the Mann-Whitney U test. The conformity of the data to the normal distribution was tested with the Kolmogorov-Smirnov, Shapiro-Wilk test, and graphical examinations. Results: Totally 777 cases between the ages of 18-96 (43.80±15.98) were included in the study. Among these, 52.8% (n=410) were male and 47.2% (n=367) were female. Mean diameters were 28.52±5.13 mm (12-48 mm in range) for AAD, 30.83±5.25 mm (12-52 mm in range) for ARCAD, DAD 21.27±3.57 mm (11-38 mm in range) for DAD; 23.27±4.03 mm (14-40 mm in range) for MPAD, 17.27±3.19 mm (10-30 mm in range) for RPAD, and 17.62±3.06 mm (10-37 mm in range) for LPAD. Statistically significantly higher values were obtained in all diameters for cases over 40 years of age. Similarly, higher values were obtained in all diameters for males compared to females. Conclusion: The diameters of all thoracic main vascular structures are larger in men than in women and increase with age.
Language	English
Publishing date	2023-04-17
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	3031921-3
ISSN	2536-4553 ; 2148-4902
ISSN (online)	2536-4553
ISSN	2148-4902
DOI	10.14744/nci.2021.03206
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Article ; Online: Secretory Carcinoma of Breast: A Population-Based Study.

Sanli, Ahmet Necati / Tekcan Sanli, Deniz Esin / Altundag, M Kadri / Aydogan, Fatih

The American surgeon

2023 Volume 90, Issue 2, Page(s) 252–260

Abstract: Aim: In this study, it was aimed to evaluate the characteristic features and survival of secretory carcinoma of the breast (SCB), which is one of the rare malignant tumors of the breast.: Methods: Data of patients with histopathological diagnosis of ... ...

Abstract	Aim: In this study, it was aimed to evaluate the characteristic features and survival of secretory carcinoma of the breast (SCB), which is one of the rare malignant tumors of the breast. Methods: Data of patients with histopathological diagnosis of SCB between 2010 and 2019 were extracted from the SEER database. These patients were evaluated in terms of age, race, molecular subtype, grade, estrogen receptor (ER), progesterone receptor (PR), HER2 receptor, TNM stage, surgical status, chemotherapy and radiotherapy treatment. Overall survival (OS) and breast cancer-specific survival (BCSS) of the whole population and subgroups [in terms of surgery procedure (mastectomy/breast-conserving surgery), and hormone receptor status (positive/negative)] were analyzed. Results: 70 patients were included in the study. The mean age was 57 years (range 2-82). 32.9% of the patients were diagnosed under the age of 50. 97.1% of the patients were female; 2.9% were male. The vast majority of patients were white race (81.4%). Although the rates of localization were higher in the upper outer quadrant (31.4%), centrally located tumors (18.5%) were also quite common. The most frequently detected molecular subtype was hormone positive/HER2 negative. All patients were non-metastatic, 81.4% of patients did not have lymph node metastases, and most of the patients were stage IA. Median follow-up was 37 months (range 0-118 months). Considering all patients, OS was 76.3%, 5-year OS was 91.8%, and BCSS was 88%, 5-year BCSS was 97.8%. There was no statistically significant difference in OS and BCSS according to subgroups ( Conclusion: SCB, a rare histopathologic type, has high OS and BCSS rates.
MeSH term(s)	Humans ; Female ; Male ; Child, Preschool ; Child ; Adolescent ; Young Adult ; Adult ; Middle Aged ; Aged ; Aged, 80 and over ; Breast Neoplasms/pathology ; Mastectomy ; Carcinoma/surgery ; Hormones ; SEER Program
Chemical Substances	Hormones
Language	English
Publishing date	2023-08-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	202465-2
ISSN	1555-9823 ; 0003-1348
ISSN (online)	1555-9823
ISSN	0003-1348
DOI	10.1177/00031348231199174
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Article ; Online: Is There a Survival Difference Between Male and Female Breast Cancer Subtypes According to the Prognostic Staging System? A Population-Based Cohort Study.

Sanli, Ahmet Necati / Tekcan Sanli, Deniz Esin / Altundag, M Kadri / Aydogan, Fatih

The American surgeon

2023 Volume 90, Issue 4, Page(s) 788–799

Abstract: Background: In retrospective studies investigating the difference in survival by gender, there are conflicting results. It was aimed to compare overall survival (OS) and breast cancer-specific survival (BCSS) in male and female breast cancer subtypes ... ...

Abstract	Background: In retrospective studies investigating the difference in survival by gender, there are conflicting results. It was aimed to compare overall survival (OS) and breast cancer-specific survival (BCSS) in male and female breast cancer subtypes according to the prognostic staging system. Methods: Overall survival rates and BCSS rates of patients diagnosed with breast cancer between 2010 and 2019 compared by gender for all cohorts, stages, and molecular subtypes using the SEER Database. The stage has been rearranged according to the eighth edition of the AJCC. Results: 364 039 patients were included in the study. .7% (n = 2503) of all breast cancers were male breast cancer. Overall survival (male: 5-year OS 73.9%, female = 5-year OS 86%) and BCSS rates (male: 5-year BCSS 78.9%, female = 5-year BCSS 94.7%) were significantly higher in females than in males for all cohorts. OS (male: 5-year OS 66.2% vs female: 5-year OS 88.3%), and BCSS (male: 5-year BCSS 88.4% vs female: 5-year 93.6%) rates were higher in hormone receptor (HR)-positive/Her2-negative female patients. Overall survival rate is higher in females in stage I (male: 5-year OS 81.5%, female: 5-year OS 92.8%), and BCSS rate is higher in stage I (male: 5-year BCSS 94.8%, female: 5-year BCSS 97.5%). Males have 2 times (HR = 2.023) higher overall mortality risk than females, but the risk of dying from breast cancer is only 1.6 times (HR = 1.596) higher. Conclusions: Breast cancer-specific mortality is significantly higher in male breast cancers, especially in the early stage, and HR-positive subtype than females.
MeSH term(s)	Female ; Humans ; Male ; Breast Neoplasms, Male ; Prognosis ; Cohort Studies ; Retrospective Studies ; Breast
Language	English
Publishing date	2023-11-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	202465-2
ISSN	1555-9823 ; 0003-1348
ISSN (online)	1555-9823
ISSN	0003-1348
DOI	10.1177/00031348231212588
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Article ; Online: Olfactory Cleft Width and Volumes in Patients with COVID-19 Anosmia.

Tekcan Sanli, Deniz Esin / Sanli, Ahmet Necati / Kandemirli, Sedat Giray / Altundag, Aytug / Yıldırım, Duzgun

ORL; journal for oto-rhino-laryngology and its related specialties

2022 Volume 84, Issue 4, Page(s) 269–270

MeSH term(s)	Anosmia/etiology ; COVID-19 ; Humans ; SARS-CoV-2 ; Smell
Language	English
Publishing date	2022-03-30
Publishing country	Switzerland
Document type	Letter ; Comment
ZDB-ID	121482-2
ISSN	1423-0275 ; 0301-1569
ISSN (online)	1423-0275
ISSN	0301-1569
DOI	10.1159/000523785
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Article ; Online: Evaluation of the Effect of Age, Menopausal Status, and Parity on Breast Parenchyma Stiffness by Multiparametric Shear Wave Elastography.

Sanli, Deniz Esin Tekcan / Yildirim, Duzgun

Academic radiology

2021 Volume 29 Suppl 1, Page(s) S62–S68

Abstract: Rationale and objectives: To evaluate the relationship between quantitative breast parenchyma stiffness by using multiparametric shear wave elastography (mpSWE) and the potential risk factors of breast cancer.: Material and methods: The Vmean, Vmax, ... ...

Abstract	Rationale and objectives: To evaluate the relationship between quantitative breast parenchyma stiffness by using multiparametric shear wave elastography (mpSWE) and the potential risk factors of breast cancer. Material and methods: The Vmean, Vmax, Vmin, Vsd values were measured with mpSWE from each breast and each quadrant in all cases under and over the age of 40. Statistical analysis was performed to evaluate the relationship between breast stiffness and age, side, quadrant, menopausal status, mammographic breast density, and obstetric history. Results: The study cohort included 964 breasts of 482 patients, where 342 patients were ≥40 years of age; and 140 cases were <40 years of age with a mean age of 45.07 ± 10.96. No significant difference in breast stiffness was detected between right and left breasts (p > 0.05); however, upper quadrants were found to be stiffer than the lower quadrants (p < 0.05). The effect of age on all values was found to be significant (p < 0.05), and stiffness increased with age. All mpSWE values of post-menopausal cases were significantly higher (p < 0.05) than premenopausal cases. Nulliparous cases had higher values than cases with prior parity (p < 0.05). Cases with Type C and D breast density had higher stiffness values than those with Type A and Type B breast density. Conclusion: Breast parenchyma shows increased stiffness in in post-menopausal, nulliparous and older patients and patients with dense breast density. Similar to the mammographic increased breast density, elastographically increased breast parenchymal stiffness may be used as a possible risk factor for breast cancer or as a predictor of breast cancer.
MeSH term(s)	Adult ; Breast Density ; Breast Neoplasms/diagnostic imaging ; Elasticity Imaging Techniques ; Female ; Humans ; Mammography ; Menopause ; Middle Aged ; Parity ; Pregnancy
Language	English
Publishing date	2021-10-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	1355509-1
ISSN	1878-4046 ; 1076-6332
ISSN (online)	1878-4046
ISSN	1076-6332
DOI	10.1016/j.acra.2021.09.021
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Article ; Online: A case of primary bilateral breast lymphoma presenting with a painless mass in the left breast

Deniz Esin Tekcan Sanli / Duzgun Yildirim

Journal of Clinical and Investigative Surgery, Vol 6, Iss 1, Pp 64-

2021 Volume 67

Abstract: Breast cancer is the most common cancer in women. Patients usually present with a rapidly progressed painless mass in the breast. The first pathological entity to be considered is breast cancer in case of newly developed painless mass, so that ... ...

Abstract	Breast cancer is the most common cancer in women. Patients usually present with a rapidly progressed painless mass in the breast. The first pathological entity to be considered is breast cancer in case of newly developed painless mass, so that radiological and pathological evaluations must be performed. However, some systemic disorders; benign conditions like rheumatological diseases, and also systemic malignancies such as lymphoma, can mimic breast cancer by involving the breast. It is necessary to distinguish between such diseases through a correct diagnosis, because they have very different treatments and prognoses. We present a case diagnosed as bilateral primary breast lymphoma with a palpable mass in a single breast, its clinical and radiological characteristics. This case report suggests that systemic diseases should be considered in the differential diagnosis of breast diseases and breast masses, especially when there is bilaterally involvement, as discussed in this article.
Keywords	primary breast lymphoma ; bilaterally breast lymphoma ; advanced stage ; breast implant-associated lymphoma ; intramammarian lymph node ; Medicine ; R
Subject code	610 ; 616
Language	English
Publishing date	2021-05-01T00:00:00Z
Publisher	Digital ProScholar Media
Document type	Article ; Online
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Article ; Online: Comparison of Olfactory Cleft Width and Volumes in Patients with COVID-19 Anosmia and COVID-19 Cases Without Anosmia.

Tekcan Sanli, Deniz Esin / Altundag, Aytug / Yıldırım, Duzgun / Kandemirli, Sedat Giray / Sanli, Ahmet Necati

ORL; journal for oto-rhino-laryngology and its related specialties

2021 Volume 84, Issue 1, Page(s) 1–9

Abstract: Introduction: The aim of this study was to assess the relationship between olfactory cleft width/volume and COVID-19-related anosmia.: Methods: This study consisted of PCR-proven COVID-19 patients. Cases with COVID-19-related anosmia constituted ... ...

Abstract	Introduction: The aim of this study was to assess the relationship between olfactory cleft width/volume and COVID-19-related anosmia. Methods: This study consisted of PCR-proven COVID-19 patients. Cases with COVID-19-related anosmia constituted Group 1 and cases without any olfactory dysfunction (OD) throughout COVID-19 infection or after recovery constituted Group 2. A total of 50 patients were included in the study, comprising 24 cases in Group 1 and 26 cases in Group 2. Group 1 patients underwent a 4-item-odor identification test during active symptoms and a Sniffin' Sticks test after reconversion of PCR results to negative. All patients in Group 2 also underwent the Sniffin' Stick test to document normosmia. All cases had paranasal sinus CT performed. Olfactory cleft widths and olfactory volumes were measured. The differences in width and volume between groups and the correlation with odor test scores (threshold-discrimination-identification [TDI]) were calculated. In addition, regression analyzes analysis was performed for cleft widths, volumes, and TDI scores according to age. Results: Olfactory cleft widths and olfactory volumes were significantly higher in Group 1 than those in Group 2 (p = 0.001; p < 0.01). There was a significant negative correlation between total TDI scores and olfactory cleft widths and total olfactory volumes (r = -0.665; r = -0.731, respectively). Patients younger than 40 years of age had significantly higher right olfactory cleft width, left olfactory cleft width, and olfactory cleft volume than those in patients older than 40 years of age (p = 0.004, p = 0.005, p = 0.003; p < 0,01, respectively). However, patients younger than 40 years of age had a significantly lower total TDI score and in all other values individually (t-d-i) than those in patients older than 40 years of age (p = 0.004; p < 0.01). Conclusion: Patients with COVID-19-related OD had larger olfactory cleft width and volumes than those without OD in this study. Total TDI score was found to be inversely correlated with cleft width and volume.
MeSH term(s)	Adult ; Anosmia ; COVID-19 ; Humans ; Olfaction Disorders ; SARS-CoV-2 ; Smell
Language	English
Publishing date	2021-09-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	121482-2
ISSN	1423-0275 ; 0301-1569
ISSN (online)	1423-0275
ISSN	0301-1569
DOI	10.1159/000518672
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