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Article ; Online: Nucleoside diphosphate kinases 1 and 2 regulate a protective liver response to a high-fat diet.

Iuso, Domenico / Garcia-Saez, Isabel / Couté, Yohann / Yamaryo-Botté, Yoshiki / Boeri Erba, Elisabetta / Adrait, Annie / Zeaiter, Nour / Tokarska-Schlattner, Malgorzata / Jilkova, Zuzana Macek / Boussouar, Fayçal / Barral, Sophie / Signor, Luca / Couturier, Karine / Hajmirza, Azadeh / Chuffart, Florent / Bourova-Flin, Ekaterina / Vitte, Anne-Laure / Bargier, Lisa / Puthier, Denis /

Decaens, Thomas / Rousseaux, Sophie / Botté, Cyrille / Schlattner, Uwe / Petosa, Carlo / Khochbin, Saadi

Science advances

2023 Volume 9, Issue 36, Page(s) eadh0140

Abstract: The synthesis of fatty acids from acetyl-coenzyme A (AcCoA) is deregulated in diverse pathologies, including cancer. Here, we report that fatty acid accumulation is negatively regulated by nucleoside diphosphate kinases 1 and 2 (NME1/2), housekeeping ... ...

Abstract	The synthesis of fatty acids from acetyl-coenzyme A (AcCoA) is deregulated in diverse pathologies, including cancer. Here, we report that fatty acid accumulation is negatively regulated by nucleoside diphosphate kinases 1 and 2 (NME1/2), housekeeping enzymes involved in nucleotide homeostasis that were recently found to bind CoA. We show that NME1 additionally binds AcCoA and that ligand recognition involves a unique binding mode dependent on the CoA/AcCoA 3' phosphate. We report that
MeSH term(s)	Animals ; Mice ; Nucleoside-Diphosphate Kinase/genetics ; Diet, High-Fat/adverse effects ; Epigenesis, Genetic ; Histones ; Liver ; Fatty Acids ; Mice, Knockout
Chemical Substances	Nucleoside-Diphosphate Kinase (EC 2.7.4.6) ; Histones ; Fatty Acids
Language	English
Publishing date	2023-09-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2810933-8
ISSN	2375-2548 ; 2375-2548
ISSN (online)	2375-2548
ISSN	2375-2548
DOI	10.1126/sciadv.adh0140
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Article ; Online: ATAD2 controls chromatin-bound HIRA turnover.

Wang, Tao / Perazza, Daniel / Boussouar, Fayçal / Cattaneo, Matteo / Bougdour, Alexandre / Chuffart, Florent / Barral, Sophie / Vargas, Alexandra / Liakopoulou, Ariadni / Puthier, Denis / Bargier, Lisa / Morozumi, Yuichi / Jamshidikia, Mahya / Garcia-Saez, Isabel / Petosa, Carlo / Rousseaux, Sophie / Verdel, André / Khochbin, Saadi

Life science alliance

2021 Volume 4, Issue 12

Abstract: Taking advantage of the evolutionary conserved nature of ATAD2, we report here a series of parallel functional studies in human, mouse, ... ...

Abstract	Taking advantage of the evolutionary conserved nature of ATAD2, we report here a series of parallel functional studies in human, mouse, and
MeSH term(s)	ATPases Associated with Diverse Cellular Activities/genetics ; ATPases Associated with Diverse Cellular Activities/metabolism ; Animals ; Cell Cycle Proteins/metabolism ; Cell Proliferation/genetics ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Gene Deletion ; Gene Knockout Techniques ; Genotype ; HeLa Cells ; Hep G2 Cells ; Histone Chaperones/metabolism ; Humans ; Mice ; Microorganisms, Genetically-Modified ; Mouse Embryonic Stem Cells/metabolism ; Nucleosomes/metabolism ; Schizosaccharomyces/genetics ; Schizosaccharomyces/metabolism ; Schizosaccharomyces pombe Proteins/genetics ; Schizosaccharomyces pombe Proteins/metabolism ; Signal Transduction/genetics ; Transcription Factors/metabolism ; Transfection
Chemical Substances	Cell Cycle Proteins ; DNA-Binding Proteins ; HIRA protein, human ; Hira protein, mouse ; Histone Chaperones ; Nucleosomes ; Schizosaccharomyces pombe Proteins ; Transcription Factors ; ATAD2 protein, human (EC 3.6.1.3) ; ATAD2 protein, mouse (EC 3.6.1.3) ; ATPases Associated with Diverse Cellular Activities (EC 3.6.4.-)
Language	English
Publishing date	2021-09-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2575-1077
ISSN (online)	2575-1077
DOI	10.26508/lsa.202101151
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Article: Malignant genome reprogramming by ATAD2.

Boussouar, Fayçal / Jamshidikia, Mahya / Morozumi, Yuichi / Rousseaux, Sophie / Khochbin, Saadi

Biochimica et biophysica acta

2013 Volume 1829, Issue 10, Page(s) 1010–1014

Abstract: Background: Unscheduled expression of critical cellular regulators could be central to malignant genome reprogramming and tumor establishment. One such factor appears to be ATAD2, a remarkably conserved protein normally predominantly expressed in germ ... ...

Abstract	Background: Unscheduled expression of critical cellular regulators could be central to malignant genome reprogramming and tumor establishment. One such factor appears to be ATAD2, a remarkably conserved protein normally predominantly expressed in germ cells but almost systematically over-expressed in a variety of unrelated cancers. The presence of a bromodomain adjacent to an AAA type ATPase domain, points to ATAD2 as a factor preliminarily acting on chromatin structure and function. Accordingly, ATAD2 has been shown to cooperate with a series of transcription factors and chromatin modifiers to regulate specific set of genes. Scope of review: Here we discuss our knowledge on ATAD2 to evaluate its role as a cancer driver and its value as a new anti-cancer target. Major conclusions: Upon its activation, ATAD2 through its interaction with defined transcription factors, initiates a loop of transcriptional stimulation of target genes, including ATAD2 itself, leading to enhanced cell proliferation and resistance to apoptosis in an ATAD2-dependent manner. Approaches aiming at neutralizing ATAD2 activity in cancer, including the use of small molecule inhibitors of its two "druggable" domains, AAA ATPase and bromodomain, could become part of a promising anti-cancer strategy.
MeSH term(s)	ATPases Associated with Diverse Cellular Activities ; Adenosine Triphosphatases/genetics ; DNA-Binding Proteins/genetics ; Epigenesis, Genetic/genetics ; Genome, Human ; Humans ; Neoplasms/genetics
Chemical Substances	DNA-Binding Proteins ; Adenosine Triphosphatases (EC 3.6.1.-) ; ATAD2 protein, human (EC 3.6.1.3) ; ATPases Associated with Diverse Cellular Activities (EC 3.6.4.-)
Language	English
Publishing date	2013-10
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	60-7
ISSN	1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
ISSN (online)	1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
ISSN	0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
DOI	10.1016/j.bbagrm.2013.06.003
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Article: Lactate and energy metabolism in male germ cells.

Boussouar, Fayçal / Benahmed, Mohamed

Trends in endocrinology and metabolism: TEM

2004 Volume 15, Issue 7, Page(s) 345–350

Abstract: Various alterations in germ cell proliferation/differentiation, survival and energy metabolism are potentially involved in hypospermatogenesis leading to male infertility. Several reviews have been devoted to the different processes whose alteration ... ...

Abstract	Various alterations in germ cell proliferation/differentiation, survival and energy metabolism are potentially involved in hypospermatogenesis leading to male infertility. Several reviews have been devoted to the different processes whose alteration might underlie hypospermatogenesis, except for energy metabolism in the testis. Energy metabolism in the testis exhibits some specificity in that lactate is the central energy metabolite used by germ cells. This metabolite is produced by somatic Sertoli cells, transported and used by germ cells in the context of an active cooperation under the control of the endocrine system and local cytokines. In this review, we present and discuss relevant published data on energy metabolism in male germ cells with a specific emphasis on lactate.
MeSH term(s)	Animals ; Carrier Proteins/metabolism ; Energy Metabolism/physiology ; Glycolysis ; Humans ; Lactic Acid/metabolism ; Male ; Sertoli Cells/metabolism ; Spermatogenesis/physiology ; Spermatozoa/enzymology ; Spermatozoa/metabolism
Chemical Substances	Carrier Proteins ; Lactic Acid (33X04XA5AT)
Language	English
Publishing date	2004-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1042384-9
ISSN	1879-3061 ; 1043-2760
ISSN (online)	1879-3061
ISSN	1043-2760
DOI	10.1016/j.tem.2004.07.003
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Zs.A 2999: Show issues

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Article: Malignant genome reprogramming by ATAD2

Boussouar, Fayçal / Jamshidikia, Mahya / Morozumi, Yuichi / Rousseaux, Sophie / Khochbin, Saadi

BBA - Gene Regulatory Mechanisms. 2013 Oct., v. 1829, no. 10

2013

Abstract: BACKGROUND: Unscheduled expression of critical cellular regulators could be central to malignant genome reprogramming and tumor establishment. One such factor appears to be ATAD2, a remarkably conserved protein normally predominantly expressed in germ ... ...

Abstract	BACKGROUND: Unscheduled expression of critical cellular regulators could be central to malignant genome reprogramming and tumor establishment. One such factor appears to be ATAD2, a remarkably conserved protein normally predominantly expressed in germ cells but almost systematically over-expressed in a variety of unrelated cancers. The presence of a bromodomain adjacent to an AAA type ATPase domain, points to ATAD2 as a factor preliminarily acting on chromatin structure and function. Accordingly, ATAD2 has been shown to cooperate with a series of transcription factors and chromatin modifiers to regulate specific set of genes. SCOPE OF REVIEW: Here we discuss our knowledge on ATAD2 to evaluate its role as a cancer driver and its value as a new anti-cancer target. MAJOR CONCLUSIONS: Upon its activation, ATAD2 through its interaction with defined transcription factors, initiates a loop of transcriptional stimulation of target genes, including ATAD2 itself, leading to enhanced cell proliferation and resistance to apoptosis in an ATAD2-dependent manner. Approaches aiming at neutralizing ATAD2 activity in cancer, including the use of small molecule inhibitors of its two “druggable” domains, AAA ATPase and bromodomain, could become part of a promising anti-cancer strategy.
Keywords	adenosinetriphosphatase ; apoptosis ; cell proliferation ; chromatin ; genes ; germ cells ; neoplasms ; neutralization ; transcription (genetics) ; transcription factors
Language	English
Dates of publication	2013-10
Size	p. 1010-1014.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	2406725-8
ISSN	1876-4320 ; 1874-9399
ISSN (online)	1876-4320
ISSN	1874-9399
DOI	10.1016/j.bbagrm.2013.06.003
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Article ; Online: A new insight into male genome reprogramming by histone variants and histone code.

Boussouar, Fayçal / Rousseaux, Sophie / Khochbin, Saadi

Cell cycle (Georgetown, Tex.)

2008 Volume 7, Issue 22, Page(s) 3499–3502

Abstract: The very nature of the packed male genome, essentially containing non-histone proteins, suggests that most of the epigenetic marks which have been defined in somatic cells are not valid in mature male gametes and that new specific rules prevail for the ... ...

Abstract	The very nature of the packed male genome, essentially containing non-histone proteins, suggests that most of the epigenetic marks which have been defined in somatic cells are not valid in mature male gametes and that new specific rules prevail for the transmission of epigenetic information in male germ cells. Recent investigations are now uncovering a male-specific genome reprogramming mechanism, which likely cooperates with and extends beyond DNA methylation, specifying different regions of the genome and which could encode a new type of epigenetic information transmitted to the egg. Here we highlight the general traits of this unconventional male-specific epigenetic code, which largely relies on the use of histone variants and specific histone modifications.
MeSH term(s)	Animals ; Epigenesis, Genetic ; Genome/genetics ; Histone Code/physiology ; Histones/genetics ; Humans ; Male ; Spermatogenesis/genetics
Chemical Substances	Histones
Language	English
Publishing date	2008-11-12
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2146183-1
ISSN	1551-4005 ; 1538-4101 ; 1554-8627
ISSN (online)	1551-4005
ISSN	1538-4101 ; 1554-8627
DOI	10.4161/cc.7.22.6975
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Zs.A 5881: Show issues

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Article ; Online: Lessons from yeast on emerging roles of the ATAD2 protein family in gene regulation and genome organization.

Cattaneo, Matteo / Morozumi, Yuichi / Perazza, Daniel / Boussouar, Fayçal / Jamshidikia, Mahya / Rousseaux, Sophie / Verdel, André / Khochbin, Saadi

Molecules and cells

2014 Volume 37, Issue 12, Page(s) 851–856

Abstract: ATAD2, a remarkably conserved, yet poorly characterized factor is found upregulated and associated with poor prognosis in a variety of independent cancers in human. Studies conducted on the yeast Saccharomyces cerevisiae ATAD2 homologue, Yta7, are now ... ...

Abstract	ATAD2, a remarkably conserved, yet poorly characterized factor is found upregulated and associated with poor prognosis in a variety of independent cancers in human. Studies conducted on the yeast Saccharomyces cerevisiae ATAD2 homologue, Yta7, are now indicating that the members of this family may primarily be regulators of chromatin dynamics and that their action on gene expression could only be one facet of their general activity. In this review, we present an overview of the literature on Yta7 and discuss the possibility of translating these findings into other organisms to further define the involvement of ATAD2 and other members of its family in regulating chromatin structure and function both in normal and pathological situations.
MeSH term(s)	ATPases Associated with Diverse Cellular Activities ; Adenosine Triphosphatases/metabolism ; Chromatin/metabolism ; Chromosomal Proteins, Non-Histone/metabolism ; DNA-Binding Proteins/metabolism ; Gene Expression Regulation ; Genome, Fungal ; Genome, Human ; Histone Chaperones/metabolism ; Humans ; Phylogeny ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/metabolism ; Transcriptional Activation
Chemical Substances	Chromatin ; Chromosomal Proteins, Non-Histone ; DNA-Binding Proteins ; Histone Chaperones ; Saccharomyces cerevisiae Proteins ; YTA7 protein, S cerevisiae ; Adenosine Triphosphatases (EC 3.6.1.-) ; ATAD2 protein, human (EC 3.6.1.3) ; ATPases Associated with Diverse Cellular Activities (EC 3.6.4.-)
Language	English
Publishing date	2014-11-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1148964-9
ISSN	0219-1032 ; 1016-8478
ISSN (online)	0219-1032
ISSN	1016-8478
DOI	10.14348/molcells.2014.0258
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Zs.A 4713: Show issues

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Article ; Online: From meiosis to postmeiotic events: the secrets of histone disappearance.

Gaucher, Jonathan / Reynoird, Nicolas / Montellier, Emilie / Boussouar, Fayçal / Rousseaux, Sophie / Khochbin, Saadi

The FEBS journal

2010 Volume 277, Issue 3, Page(s) 599–604

Abstract: One of the most obscure phenomena in modern biology is the near genome-wide displacement of histones that occurs during the postmeiotic phases of spermatogenesis in many species. Here we review the literature to show that, during spermatogenic ... ...

Abstract	One of the most obscure phenomena in modern biology is the near genome-wide displacement of histones that occurs during the postmeiotic phases of spermatogenesis in many species. Here we review the literature to show that, during spermatogenic differentiation, three major molecular mechanisms come together to 'prepare' the nucleosomes for facilitated disassembly and histone removal.
MeSH term(s)	Acetylation ; Animals ; Chromatin/metabolism ; Chromosomal Proteins, Non-Histone/physiology ; Histone Deacetylases/genetics ; Histones/metabolism ; Humans ; Male ; Meiosis/physiology ; Mice ; Nucleosomes/drug effects ; Nucleosomes/metabolism ; Protamines/metabolism ; Spermatids/metabolism ; Spermatogenesis/genetics
Chemical Substances	Chromatin ; Chromosomal Proteins, Non-Histone ; Histones ; Nucleosomes ; Protamines ; spermatid transition proteins ; Histone Deacetylases (EC 3.5.1.98)
Language	English
Publishing date	2010-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2173655-8
ISSN	1742-4658 ; 1742-464X
ISSN (online)	1742-4658
ISSN	1742-464X
DOI	10.1111/j.1742-4658.2009.07504.x
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Zs.A 260: Show issues

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Article ; Online: Histone acetyltransferase CBP is vital to demarcate conventional and innate CD8+ T-cell development.

Fukuyama, Tomofusa / Kasper, Lawryn H / Boussouar, Fayçal / Jeevan, Trushar / van Deursen, Jan / Brindle, Paul K

Molecular and cellular biology

2009 Volume 29, Issue 14, Page(s) 3894–3904

Abstract: Defining the chromatin modifications and transcriptional mechanisms that direct the development of different T-cell lineages is a major challenge in immunology. The transcriptional coactivators CREB binding protein (CBP) and the closely related p300, ... ...

Abstract	Defining the chromatin modifications and transcriptional mechanisms that direct the development of different T-cell lineages is a major challenge in immunology. The transcriptional coactivators CREB binding protein (CBP) and the closely related p300, which comprise the KAT3 family of histone/protein lysine acetyltransferases, interact with over 50 T-lymphocyte-essential transcriptional regulators. We show here that CBP, but not p300, modulates the thymic development of conventional adaptive T cells versus those having unconventional innate functions. Conditional inactivation of CBP in the thymus yielded CD8 single-positive (SP) thymocytes with an effector-, memory-, or innate-like T-cell phenotype. In this regard, CD8 SP thymocytes in CBP mutant mice were phenotypically similar to those reported for Itk and Rlk protein tyrosine kinase mutants, including the increased expression of the T-cell master regulatory transcription factor eomesodermin (Eomes) and the interleukin-2 and -15 receptor beta chain (CD122) and an enhanced ability to rapidly produce gamma interferon. CBP was required for the expression of the Itk-dependent genes Egr2, Egr3, and Il2, suggesting that CBP helps mediate Itk-responsive transcription. CBP therefore defines a nuclear component of the signaling pathways that demarcate the development of innate and adaptive naïve CD8(+) T cells in the thymus.
MeSH term(s)	Animals ; Base Sequence ; CD4-Positive T-Lymphocytes/cytology ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/metabolism ; CD8-Positive T-Lymphocytes/cytology ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/metabolism ; CREB-Binding Protein/genetics ; CREB-Binding Protein/metabolism ; Cell Differentiation ; DNA Primers/genetics ; Female ; Gene Expression ; Histone Acetyltransferases/genetics ; Histone Acetyltransferases/metabolism ; Immunity, Innate ; Immunologic Memory ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Mutant Strains ; Mice, Transgenic ; Protein-Tyrosine Kinases/genetics ; Protein-Tyrosine Kinases/metabolism ; Signal Transduction ; T-Box Domain Proteins/genetics ; T-Box Domain Proteins/metabolism
Chemical Substances	DNA Primers ; Eomes protein, mouse ; T-Box Domain Proteins ; CREB-Binding Protein (EC 2.3.1.48) ; Crebbp protein, mouse (EC 2.3.1.48) ; Histone Acetyltransferases (EC 2.3.1.48) ; Protein-Tyrosine Kinases (EC 2.7.10.1) ; emt protein-tyrosine kinase (EC 2.7.10.2)
Language	English
Publishing date	2009-05-11
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	779397-2
ISSN	1098-5549 ; 0270-7306
ISSN (online)	1098-5549
ISSN	0270-7306
DOI	10.1128/MCB.01598-08
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Zs.A 1666: Show issues

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Article ; Online: Molecular models for post-meiotic male genome reprogramming.

Rousseaux, Sophie / Boussouar, Fayçal / Gaucher, Jonathan / Reynoird, Nicolas / Montellier, Emilie / Curtet, Sandrine / Vitte, Anne-Laure / Khochbin, Saadi

Systems biology in reproductive medicine

2011 Volume 57, Issue 1-2, Page(s) 50–53

Abstract: The molecular basis of post-meiotic male genome reorganization and compaction constitutes one of the last black boxes in modern biology. Although the successive transitions in DNA packaging have been well described, the molecular factors driving these ... ...

Abstract	The molecular basis of post-meiotic male genome reorganization and compaction constitutes one of the last black boxes in modern biology. Although the successive transitions in DNA packaging have been well described, the molecular factors driving these near genome-wide reorganizations remain obscure. We have used a combination of different approaches aiming at the discovery of critical factors capable of directing the post-meiotic male genome reprogramming, which is now shedding new light on the nature of the fundamental mechanisms controlling post-meiotic histone replacement and genome compaction. Here we present a summary of these findings. The identification of the first factor capable of reading a precise combination of histone acetylation marks, BRDT, allowed highlighting a critical role for the genome-wide histone hyperacetylation that occurs before generalized histone replacement. In this context, the recent identification of a group of new histone variants capable of forming novel DNA packaging structures on specific regions during late spermatogenesis, when hyperacetylated histones are massively replaced in spermatids, also revealed the occurrence of a post-meiotic region-specific genome reprogramming. Additionally, the functional characterization of other molecular actors and chaperones in action in post-meiotic cells now allows one to describe the first general traits of the mechanisms underlying the structural transitions taking place during the post-meiotic reorganization and epigenetic reprogramming of the male genome.
MeSH term(s)	Acetylation ; Animals ; Genome/physiology ; Histones/metabolism ; Humans ; Male ; Meiosis/physiology ; Models, Biological ; Nuclear Proteins/physiology
Chemical Substances	BRDT protein, human ; Histones ; Nuclear Proteins
Language	English
Publishing date	2011-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2417234-0
ISSN	1939-6376 ; 1939-6368
ISSN (online)	1939-6376
ISSN	1939-6368
DOI	10.3109/19396368.2010.498076
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