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  1. Article ; Online: A new passive immune strategy based on IgY antibodies as a key element to control neonatal calf diarrhea in dairy farms

    Celina Guadalupe Vega / Marina Bok / Maren Ebinger / Lucía Alejandra Rocha / Alejandra Antonella Rivolta / Valeria González Thomas / Pilar Muntadas / Ricardo D’Aloia / Verónica Pinto / Viviana Parreño / Andrés Wigdorovitz

    BMC Veterinary Research, Vol 16, Iss 1, Pp 1-

    2020  Volume 9

    Abstract: ... in Argentina, 2017), (Vega C, et al., Vet Immunol Immunopathol, 142:156–69, 2011), (Vega C, et al., Res Vet Sci ...

    Abstract Abstract Background Neonatal diarrhea remains one of the main causes of morbi-mortality in dairy calves under artificial rearing. It is often caused by infectious agents of viral, bacterial, or parasitic origin. Cows vaccination and colostrum intake by calves during the first 6 h of life are critical strategies to prevent severe diarrhea but these are still insufficient. Here we report the field evaluation of a product based on IgY antibodies against group A rotavirus (RVA), coronavirus (CoV), enterotoxigenic Escherichia coli, and Salmonella sp. This product, named IgY DNT, has been designed as a complementary passive immunization strategy to prevent neonatal calf diarrhea. The quality of the product depends on the titers of specific IgY antibodies to each antigen evaluated by ELISA. In the case of the viral antigens, ELISA antibody (Ab) titers are correlated with protection against infection in calves experimentally challenged with RVA and CoV (Bok M, et al., Passive immunity to control bovine coronavirus diarrhea in a dairy herd in Argentina, 2017), (Vega C, et al., Vet Immunol Immunopathol, 142:156–69, 2011), (Vega C, et al., Res Vet Sci, 103:1–10, 2015). To evaluate the efficiency in dairy farms, thirty newborn Holstein calves were randomly assigned to IgY DNT or control groups and treatment initiated after colostrum intake and gut closure. Calves in the IgY DNT group received 20 g of the oral passive treatment in 2 L of milk twice a day during the first 2 weeks of life. Animals were followed until 3 weeks of age and diarrhea due to natural exposure to infectious agents was recorded during all the experimental time. Results Results demonstrate that the oral administration of IgY DNT during the first 2 weeks of life to newborn calves caused a delay in diarrhea onset and significantly reduced its severity and duration compared with untreated calves. Animals treated with IgY DNT showed a trend towards a delay in RVA infection with significantly shorter duration and virus shedding compared to control calves. ...
    Keywords Infectious neonatal calf diarrhea ; IgY antibody ; Rotavirus ; Passive treatment ; Veterinary medicine ; SF600-1100
    Subject code 630
    Language English
    Publishing date 2020-07-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: A new passive immune strategy based on IgY antibodies as a key element to control neonatal calf diarrhea in dairy farms.

    Vega, Celina Guadalupe / Bok, Marina / Ebinger, Maren / Rocha, Lucía Alejandra / Rivolta, Alejandra Antonella / González Thomas, Valeria / Muntadas, Pilar / D'Aloia, Ricardo / Pinto, Verónica / Parreño, Viviana / Wigdorovitz, Andrés

    BMC veterinary research

    2020  Volume 16, Issue 1, Page(s) 264

    Abstract: ... in Argentina, 2017), (Vega C, et al., Vet Immunol Immunopathol, 142:156-69, 2011), (Vega C, et al., Res Vet Sci ...

    Abstract Background: Neonatal diarrhea remains one of the main causes of morbi-mortality in dairy calves under artificial rearing. It is often caused by infectious agents of viral, bacterial, or parasitic origin. Cows vaccination and colostrum intake by calves during the first 6 h of life are critical strategies to prevent severe diarrhea but these are still insufficient. Here we report the field evaluation of a product based on IgY antibodies against group A rotavirus (RVA), coronavirus (CoV), enterotoxigenic Escherichia coli, and Salmonella sp. This product, named IgY DNT, has been designed as a complementary passive immunization strategy to prevent neonatal calf diarrhea. The quality of the product depends on the titers of specific IgY antibodies to each antigen evaluated by ELISA. In the case of the viral antigens, ELISA antibody (Ab) titers are correlated with protection against infection in calves experimentally challenged with RVA and CoV (Bok M, et al., Passive immunity to control bovine coronavirus diarrhea in a dairy herd in Argentina, 2017), (Vega C, et al., Vet Immunol Immunopathol, 142:156-69, 2011), (Vega C, et al., Res Vet Sci, 103:1-10, 2015). To evaluate the efficiency in dairy farms, thirty newborn Holstein calves were randomly assigned to IgY DNT or control groups and treatment initiated after colostrum intake and gut closure. Calves in the IgY DNT group received 20 g of the oral passive treatment in 2 L of milk twice a day during the first 2 weeks of life. Animals were followed until 3 weeks of age and diarrhea due to natural exposure to infectious agents was recorded during all the experimental time.
    Results: Results demonstrate that the oral administration of IgY DNT during the first 2 weeks of life to newborn calves caused a delay in diarrhea onset and significantly reduced its severity and duration compared with untreated calves. Animals treated with IgY DNT showed a trend towards a delay in RVA infection with significantly shorter duration and virus shedding compared to control calves.
    Conclusions: This indicates that IgY DNT is an effective product to complement current preventive strategies against neonatal calf diarrhea in dairy farms. Furthermore, to our knowledge, this is the only biological product available for the prevention of virus-associated neonatal calf diarrhea.
    MeSH term(s) Animals ; Animals, Newborn ; Antibodies, Bacterial/therapeutic use ; Antibodies, Protozoan ; Antibodies, Viral/therapeutic use ; Cattle ; Cattle Diseases/microbiology ; Cattle Diseases/therapy ; Cattle Diseases/virology ; Cryptosporidiosis/prevention & control ; Dairying ; Diarrhea/microbiology ; Diarrhea/therapy ; Diarrhea/veterinary ; Diarrhea/virology ; Immunization, Passive/methods ; Immunization, Passive/veterinary ; Immunoglobulins/therapeutic use ; Immunotherapy
    Chemical Substances Antibodies, Bacterial ; Antibodies, Protozoan ; Antibodies, Viral ; IgY ; Immunoglobulins
    Keywords covid19
    Language English
    Publishing date 2020-07-29
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial, Veterinary
    ISSN 1746-6148
    ISSN (online) 1746-6148
    DOI 10.1186/s12917-020-02476-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: A new passive immune strategy based on IgY antibodies as a key element to control neonatal calf diarrhea in dairy farms

    Vega, Celina Guadalupe / Bok, Marina / Ebinger, Maren / Rocha, Lucía Alejandra / Rivolta, Alejandra Antonella / González Thomas, Valeria / Muntadas, Pilar / D’Aloia, Ricardo / Pinto, Verónica / Parreño, Viviana / Wigdorovitz, Andrés

    BMC veterinary research. 2020 Dec., v. 16, no. 1

    2020  

    Abstract: ... in Argentina, 2017), (Vega C, et al., Vet Immunol Immunopathol, 142:156–69, 2011), (Vega C, et al., Res Vet Sci ...

    Abstract BACKGROUND: Neonatal diarrhea remains one of the main causes of morbi-mortality in dairy calves under artificial rearing. It is often caused by infectious agents of viral, bacterial, or parasitic origin. Cows vaccination and colostrum intake by calves during the first 6 h of life are critical strategies to prevent severe diarrhea but these are still insufficient. Here we report the field evaluation of a product based on IgY antibodies against group A rotavirus (RVA), coronavirus (CoV), enterotoxigenic Escherichia coli, and Salmonella sp. This product, named IgY DNT, has been designed as a complementary passive immunization strategy to prevent neonatal calf diarrhea. The quality of the product depends on the titers of specific IgY antibodies to each antigen evaluated by ELISA. In the case of the viral antigens, ELISA antibody (Ab) titers are correlated with protection against infection in calves experimentally challenged with RVA and CoV (Bok M, et al., Passive immunity to control bovine coronavirus diarrhea in a dairy herd in Argentina, 2017), (Vega C, et al., Vet Immunol Immunopathol, 142:156–69, 2011), (Vega C, et al., Res Vet Sci, 103:1–10, 2015). To evaluate the efficiency in dairy farms, thirty newborn Holstein calves were randomly assigned to IgY DNT or control groups and treatment initiated after colostrum intake and gut closure. Calves in the IgY DNT group received 20 g of the oral passive treatment in 2 L of milk twice a day during the first 2 weeks of life. Animals were followed until 3 weeks of age and diarrhea due to natural exposure to infectious agents was recorded during all the experimental time. RESULTS: Results demonstrate that the oral administration of IgY DNT during the first 2 weeks of life to newborn calves caused a delay in diarrhea onset and significantly reduced its severity and duration compared with untreated calves. Animals treated with IgY DNT showed a trend towards a delay in RVA infection with significantly shorter duration and virus shedding compared to control calves. CONCLUSIONS: This indicates that IgY DNT is an effective product to complement current preventive strategies against neonatal calf diarrhea in dairy farms. Furthermore, to our knowledge, this is the only biological product available for the prevention of virus-associated neonatal calf diarrhea.
    Keywords Bovine coronavirus ; Holstein ; Rotavirus A ; Salmonella ; age ; antibodies ; artificial rearing ; colostrum ; complement ; cows ; dairy calves ; dairy farming ; dairy herds ; diarrhea ; digestive system ; duration ; enterotoxigenic Escherichia coli ; infection ; knowledge ; milk ; neonates ; oral administration ; passive immunity ; pathogens ; vaccination ; veterinary medicine ; viral antigens ; viral shedding ; Argentina
    Language English
    Dates of publication 2020-12
    Size p. 264.
    Publishing place BioMed Central
    Document type Article
    Note NAL-light
    ISSN 1746-6148
    DOI 10.1186/s12917-020-02476-3
    Database NAL-Catalogue (AGRICOLA)

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    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article: A new passive immune strategy based on IgY antibodies as a key element to control neonatal calf diarrhea in dairy farms

    Vega, Celina Guadalupe / Bok, Marina / Ebinger, Maren / Rocha, Lucía Alejandra / Rivolta, Alejandra Antonella / González Thomas, Valeria / Muntadas, Pilar / D039, / Aloia, Ricardo / Pinto, Verónica / Parreño, Viviana / Wigdorovitz, Andrés

    BMC Vet Res

    Abstract: ... in Argentina, 2017), (Vega C, et al., Vet Immunol Immunopathol, 142:156-69, 2011), (Vega C, et al., Res Vet Sci ...

    Abstract BACKGROUND: Neonatal diarrhea remains one of the main causes of morbi-mortality in dairy calves under artificial rearing. It is often caused by infectious agents of viral, bacterial, or parasitic origin. Cows vaccination and colostrum intake by calves during the first 6 h of life are critical strategies to prevent severe diarrhea but these are still insufficient. Here we report the field evaluation of a product based on IgY antibodies against group A rotavirus (RVA), coronavirus (CoV), enterotoxigenic Escherichia coli, and Salmonella sp. This product, named IgY DNT, has been designed as a complementary passive immunization strategy to prevent neonatal calf diarrhea. The quality of the product depends on the titers of specific IgY antibodies to each antigen evaluated by ELISA. In the case of the viral antigens, ELISA antibody (Ab) titers are correlated with protection against infection in calves experimentally challenged with RVA and CoV (Bok M, et al., Passive immunity to control bovine coronavirus diarrhea in a dairy herd in Argentina, 2017), (Vega C, et al., Vet Immunol Immunopathol, 142:156-69, 2011), (Vega C, et al., Res Vet Sci, 103:1-10, 2015). To evaluate the efficiency in dairy farms, thirty newborn Holstein calves were randomly assigned to IgY DNT or control groups and treatment initiated after colostrum intake and gut closure. Calves in the IgY DNT group received 20 g of the oral passive treatment in 2 L of milk twice a day during the first 2 weeks of life. Animals were followed until 3 weeks of age and diarrhea due to natural exposure to infectious agents was recorded during all the experimental time. RESULTS: Results demonstrate that the oral administration of IgY DNT during the first 2 weeks of life to newborn calves caused a delay in diarrhea onset and significantly reduced its severity and duration compared with untreated calves. Animals treated with IgY DNT showed a trend towards a delay in RVA infection with significantly shorter duration and virus shedding compared to control calves. CONCLUSIONS: This indicates that IgY DNT is an effective product to complement current preventive strategies against neonatal calf diarrhea in dairy farms. Furthermore, to our knowledge, this is the only biological product available for the prevention of virus-associated neonatal calf diarrhea.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #684697
    Database COVID19

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