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Article ; Online: Application of terahertz Time-Domain spectroscopy and chemometrics-based whale optimization algorithm in PDE5 inhibitor detection.

Zhang, Aolin / Qin, Ge / Wang, Jifen / Li, Na / Wu, Shihao

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

2024 Volume 310, Page(s) 123894

Abstract: Combating the illicit use of PDE5 inhibitor drugs is a focal point in forensic science research. In order to achieve rapid identification of such drugs, this study applies terahertz time-domain spectroscopy combined with chemometrics to establish a fast ... ...

Abstract	Combating the illicit use of PDE5 inhibitor drugs is a focal point in forensic science research. In order to achieve rapid identification of such drugs, this study applies terahertz time-domain spectroscopy combined with chemometrics to establish a fast and accurate detection method for PDE5 inhibitors. The optimal detection method is determined by comparing the spectral performance of three optical parameters, namely absorption coefficient, refractive index, and dielectric constant. Linear discriminant models based on different spectral parameters, whale optimization algorithm optimized extreme learning machine models, and whale optimization algorithm optimized random forest models are established. The effectiveness and performance of principal component analysis and competitive adaptive reweighted sampling algorithm for spectral feature data selection are also investigated. The PDE5 inhibitor identification model based on the competitive adaptive reweighted sampling - whale optimization algorithm - random forest (CARS-WOA-RF) model achieves an accuracy of 98.61%, and the identification model for two concentrations of Sildenafil achieves 100% accuracy. The results demonstrate that terahertz time-domain spectroscopy combined with chemometrics can effectively detect various common types of PDE5 inhibitor drugs and different concentrations.
MeSH term(s)	Animals ; Phosphodiesterase 5 Inhibitors ; Whales ; Chemometrics ; Support Vector Machine ; Algorithms ; Terahertz Spectroscopy
Chemical Substances	Phosphodiesterase 5 Inhibitors
Language	English
Publishing date	2024-01-19
Publishing country	England
Document type	Journal Article
ZDB-ID	210413-1
ISSN	1873-3557 ; 0370-8322 ; 0584-8539 ; 1386-1425
ISSN (online)	1873-3557
ISSN	0370-8322 ; 0584-8539 ; 1386-1425
DOI	10.1016/j.saa.2024.123894
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Article ; Online: Association between very advanced maternal age women with gestational diabetes mellitus and the risks of adverse infant outcomes: a cohort study from the NVSS 2014-2019.

Lu, Lin / He, Lidan / Hu, Jifen / Li, Jianhua

BMC pregnancy and childbirth

2023 Volume 23, Issue 1, Page(s) 158

Abstract: Background: To evaluate the association between gestational diabetes mellitus (GDM) and infant outcomes in women of very advanced maternal age (vAMA) (≥45 years).: Methods: This cohort study utilized data from the National Vital Statistics System ( ... ...

Abstract	Background: To evaluate the association between gestational diabetes mellitus (GDM) and infant outcomes in women of very advanced maternal age (vAMA) (≥45 years). Methods: This cohort study utilized data from the National Vital Statistics System (NVSS) database (2014-2019) in the United States. Preterm birth was the primary outcome, which was subdivided into extremely preterm, very preterm, and moderate or late preterm. The secondary outcomes were neonatal intensive care unit (NICU) admission, low birthweight and small for gestational age. Univariate and multivariate logistic regression analyses were used to explore the association between GDM and infant outcomes among vAMA women. Subgroup analyses were performed based on race and use of infertility treatment. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated. Results: A total of 52,544 vAMA pregnant women were included. All analysis made comparisons between women with vAMA and GDM and women with vAMA and no GDM. Women with GDM had a significantly higher risk of preterm birth than those without GDM (OR = 1.26, 95%CI = 1.18-1.36, P < 0.001). Compared with women without GDM, those with GDM had a significantly increased risk of moderate or late preterm birth (OR = 1.27, 95%CI = 1.18-1.37, P < 0.001); no significant association of GDM with extremely preterm birth and very preterm birth was observed. Women with GDM had a significantly greater risk of NICU admission than those without (OR = 1.33, 95%CI = 1.23-1.43, P < 0.001). GDM was associated with a significantly lower risk of low birthweight (OR = 0.91, 95%CI = 0.84-0.98, P = 0.010), and no significant association was found between GDM and small for gestational age (OR = 0.95, 95%CI = 0.87-1.03, P = 0.200) in vAMA women. Conclusion: vAMA women with GDM had an increased risk of preterm birth, especially moderate or late preterm birth. NICU admission and low birthweight were also associated with GDM among vAMA women.
MeSH term(s)	Pregnancy ; Female ; Infant, Newborn ; Infant ; Humans ; Middle Aged ; Diabetes, Gestational/therapy ; Maternal Age ; Premature Birth ; Cohort Studies ; Birth Weight ; Fetal Growth Retardation ; Pregnancy Outcome
Language	English
Publishing date	2023-03-10
Publishing country	England
Document type	Journal Article
ZDB-ID	2059869-5
ISSN	1471-2393 ; 1471-2393
ISSN (online)	1471-2393
ISSN	1471-2393
DOI	10.1186/s12884-023-05449-0
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Article: Alterations in cell adhesion proteins and cardiomyopathy.

Li, Jifen

World journal of cardiology

2014 Volume 6, Issue 5, Page(s) 304–313

Abstract: Cell adhesive junction is specialized intercellular structure composed of cell adhesion proteins. They are essential to connect adjacent heart muscle cell and make heart contraction effectively and properly. Clinical and genetic studies have revealed ... ...

Abstract	Cell adhesive junction is specialized intercellular structure composed of cell adhesion proteins. They are essential to connect adjacent heart muscle cell and make heart contraction effectively and properly. Clinical and genetic studies have revealed close relationship between cell adhesive proteins and the occurrence of various cardiomyopathies. Here we will review recent development on the disease phenotype, potential cellular and molecular mechanism related to cell adhesion molecules, with particular disease pathogenesis learned from genetic manipulated murine models.
Language	English
Publishing date	2014-04-10
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2573665-6
ISSN	1949-8462
ISSN	1949-8462
DOI	10.4330/wjc.v6.i5.304
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Article ; Online: The successes and future prospects of the linear antisense RNA amplification methodology.

Li, Jifen / Eberwine, James

Nature protocols

2018 Volume 13, Issue 5, Page(s) 811–818

Abstract: It has been over a quarter of a century since the introduction of the linear RNA amplification methodology known as antisense RNA (aRNA) amplification. Whereas most molecular biology techniques are rapidly replaced owing to the fast-moving nature of ... ...

Abstract	It has been over a quarter of a century since the introduction of the linear RNA amplification methodology known as antisense RNA (aRNA) amplification. Whereas most molecular biology techniques are rapidly replaced owing to the fast-moving nature of development in the field, the aRNA procedure has become a base that can be built upon through varied uses of the technology. The technique was originally developed to assess RNA populations from small amounts of starting material, including single cells, but over time its use has evolved to include the detection of various cellular entities such as proteins, RNA-binding-protein-associated cargoes, and genomic DNA. In this Perspective we detail the linear aRNA amplification procedure and its use in assessing various components of a cell's chemical phenotype. This procedure is particularly useful in efforts to multiplex the simultaneous detection of various cellular processes. These efforts are necessary to identify the quantitative chemical phenotype of cells that underlies cellular function.
MeSH term(s)	DNA, Complementary/analysis ; Gene Expression Profiling ; Nucleic Acid Amplification Techniques ; RNA, Antisense/metabolism
Chemical Substances	DNA, Complementary ; RNA, Antisense
Keywords	covid19
Language	English
Publishing date	2018-03-29
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2244966-8
ISSN	1750-2799 ; 1754-2189
ISSN (online)	1750-2799
ISSN	1754-2189
DOI	10.1038/nprot.2018.011
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Article: Intracellular uptake of nanocrystals: Probing with aggregation-induced emission of fluorescence and kinetic modeling.

Zhang, Jifen / Corpstein, Clairissa D / Li, Tonglei

Acta pharmaceutica Sinica. B

2020 Volume 11, Issue 4, Page(s) 1021–1029

Abstract: Nanocrystal formulations have been explored to deliver poorly water-soluble drug molecules. Despite various studies of nanocrystal formulation and delivery, much more understanding needs to be gained into absorption mechanisms and kinetics of drug ... ...

Abstract	Nanocrystal formulations have been explored to deliver poorly water-soluble drug molecules. Despite various studies of nanocrystal formulation and delivery, much more understanding needs to be gained into absorption mechanisms and kinetics of drug nanocrystals at various levels, ranging from cells to tissues and to the whole body. In this study, nanocrystals of tetrakis (4-hydroxyphenyl) ethylene (THPE) with an aggregation-induced emission (AIE) property was used as a model to explore intracellular absorption mechanism and dissolution kinetics of nanocrystals. Cellular uptake studies were conducted with KB cells and characterized by confocal microscopy, flow cytometry, and quantitative analyses. The results suggested that THPE nanocrystals could be taken up by KB cells directly, as well as in the form of dissolved molecules. The cellular uptake was found to be concentration- and time-dependent. In addition, the intracellular THPE also could be exocytosed from cells in forms of dissolved molecules and nanocrystals. Kinetic modeling was conducted to further understand the cellular mechanism of THPE nanocrystals based on first-order ordinary differential equations (ODEs). By fitting the kinetic model against experimental measurements, it was found that the initial nanocrystal concentration had a great influence on the dynamic process of dissolution, cellular uptake, and exocytosis of THPE nanocrystals. As the nanocrystal concentration increased in the culture media, dissolution of endocytosed nanocrystals became enhanced, subsequently driving the efflux of THPE molecules from cells.
Language	English
Publishing date	2020-10-14
Publishing country	Netherlands
Document type	Journal Article
ISSN	2211-3835
ISSN	2211-3835
DOI	10.1016/j.apsb.2020.09.017
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Article ; Online: Research trends in readiness for hospital discharge between 2002 and 2021: A bibliometric analysis.

Zhang, Rong / Wang, Dongmei / Zhu, Ling / He, Yongdong / Cheng, Ling / Ma, Jifen / Zhang, Ting / Zhang, Jun / Li, Longti

Nursing open

2023 Volume 10, Issue 12, Page(s) 7676–7693

Abstract: Aim: This study aimed to undertake a bibliometric analysis to provide comprehensive information in demonstrating the current status and outline the overall trends in the area of readiness for hospital discharge (RHD).: Design: A bibliometric and ... ...

Abstract	Aim: This study aimed to undertake a bibliometric analysis to provide comprehensive information in demonstrating the current status and outline the overall trends in the area of readiness for hospital discharge (RHD). Design: A bibliometric and visual analysis of RHD literature was undertaken. Methods: Articles were retrieved from the Web of Science network from 2002 to 2021. VOSviewer was used to identify the co-authorship network of countries/institutions, co-authorship and co-citation analysis of authors, and co-citation analysis of references and citation analysis of documents. CiteSpace was used to identify the keyword co-occurrence network and perform cluster analysis, detecting the keywords with citation bursts and speculated frontiers in this research field. Results: A total of 512 articles were included in the final analysis. Key findings are: (1) There has been a continuous but somewhat fluctuating rise in the number of publications. (2) 56.05% of publications come from the USA with Marquette University making the highest contribution. (3) Most publications (17, 3.32%) in RHD research were from the Journal of Clinical Nursing, and Anaesthesia and Analgesia had the highest number of citations (584 citations). (4) Weiss ME (25, 4.88%) was the most productive author whose articles have been the most highly cited (646 citations). (5) Cited references from Weiss ME (2007) also made the largest contribution to co-citations, and the most cited reference was from Jack BW (2009) (1022 citations). (6) The 20 most frequent keywords and keywords with the strongest citation bursts were retrieved. There were seven research hotspots, and three emerging research frontiers were explored. Conclusions: The bibliometric analysis of material published in the last 20 years indicates that there have been statistically significant gains in comprehensive information on RHD, including the knowledge mapping of the countries, institutions, authors, references and keywords. The hotspots and frontiers, which have been explored can give guidance to researchers as to new angles and directions to take. Implications for nursing management: The effects of the implementation of ERAS on RHD-related risk for adverse post-discharge outcomes in surgical patients will be of increasing concern for healthcare professionals. It is important for patients and their relatives to be confident that on discharge they are sufficiently ready for hospital discharge to enable them to safely and smoothly make the transition to home. Improving the level of RHD in discharged patients can help nurse managers and researchers measure the effectiveness of discharge planning services.
MeSH term(s)	Humans ; Aftercare ; Bibliometrics ; Hospitals ; Patient Discharge
Language	English
Publishing date	2023-09-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	2809556-X
ISSN	2054-1058 ; 2054-1058
ISSN (online)	2054-1058
ISSN	2054-1058
DOI	10.1002/nop2.2009
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Article: Characterization of Salivary Secreted Proteins That Induce Cell Death From

Dong, Yumei / Huang, Xingge / Yang, Yuxia / Li, Jifen / Zhang, Meiqian / Shen, Hui / Ren, Yanrong / Li, Xinyu / Tian, Jiale / Shen, Danyu / Dou, Daolong / Xia, Ai

Frontiers in plant science

2022 Volume 13, Page(s) 912603

Abstract: Riptortus ... ...

Abstract	Riptortus pedestris
Language	English
Publishing date	2022-07-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2613694-6
ISSN	1664-462X
ISSN	1664-462X
DOI	10.3389/fpls.2022.912603
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Article: Expression and clinical significance of LXRα and SREBP-1c in placentas of preeclampsia.

Jianhua, Li / Xueqin, Miao / Jifen, Hu

Open medicine (Warsaw, Poland)

2016 Volume 11, Issue 1, Page(s) 292–296

Abstract: Objective: To evaluate the expression and correlations of liver X receptor alpha (LXRa) and its target gene sterol regulatory element-binding protein-1c (SREBP-1c) in placentas of preeclampsia (PE) and their significance in PE.: Methods: Pregnancies ... ...

Abstract	Objective: To evaluate the expression and correlations of liver X receptor alpha (LXRa) and its target gene sterol regulatory element-binding protein-1c (SREBP-1c) in placentas of preeclampsia (PE) and their significance in PE. Methods: Pregnancies were divided into two groups, 60 cases (29 cases of mild and 31 cases of severe) of PE group and 56 cases of normal group. The level of mRNA and protein of LXRa and SREBP-1c were analyzed by reverse transcription-polymerase chain reaction (RTPCR) and immunohistochemistry (IHC) in the placentas. Results: RT-PCR and IHC results showed that the mRNA and protein expression of both LXRa and SREBP-1c increased gradually with the extent of PE among normal pregnancy, mild PE and severe PE groups, and the differences were of statistically significance (P<0.01 or P<0.05). There were positive correlations between the expression of LXRa mRNA and SREBP-1c mRNA, also between LXRa mRNA and LXRa protein (r=0.521, P<0.01; r=0.422, P<0.01). The expression of SREBP-1c mRNA positively correlated with its protein level (r=0.598, P<0.01). There were positive correlations between the expression of LXRa protein and SREBP-1c protein (r=0.612, P<0.01). Conclusion: The expression of LXRa is elevated significantly in placentas of PE patients, and might contribute for promoting the transcription and translation of its target gene SREBP1-c, which is related to the occurrence and development of PE.
Language	English
Publishing date	2016-08-13
Publishing country	Poland
Document type	Journal Article ; Review
ZDB-ID	2829380-0
ISSN	2391-5463
ISSN	2391-5463
DOI	10.1515/med-2016-0057
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Article: Alkaline-earth metal substitution stabilizes the anionic redox of Li-rich oxides

Li, Haoxin / Zhao, Xiaolin / Li, Yining / Gan, Yang / Qiu, Wujie / Wang, Jifen / Liu, Jianjun

Journal of materials chemistry A. 2021 Apr. 28, v. 9, no. 16

2021

Abstract: Anionic oxygen redox chemistry in Li-excess transition metal oxides has emerged as a new paradigm ... in Li₂MnO₃ through a light metal (Mg, Ca and Al) substitution of Li. Our first-principle thermodynamic ... calculations show that Mg²⁺ substitution in Li₂MnO₃ prefers locating at the Li⁺ site, which induces ...

Abstract	Anionic oxygen redox chemistry in Li-excess transition metal oxides has emerged as a new paradigm to increase the energy density of rechargeable batteries. However, the anionic redox of oxygen mostly forms the O–O bond, leading to partly irreversible discharge. To address this issue, we demonstrate a new strategy to achieve dual functions of activating cation activity and enhancing oxygen anion redox activity in Li₂MnO₃ through a light metal (Mg, Ca and Al) substitution of Li. Our first-principle thermodynamic calculations show that Mg²⁺ substitution in Li₂MnO₃ prefers locating at the Li⁺ site, which induces the formation of reductive Mn-ions with electrochemical activity. The substituted local structure of (Li–O–Mg)/2(Li–O–Mn) becomes more electrochemically stable than the specific Li–O–Li local structure in Li₂MnO₃, which effectively retards O–O combination. Therefore, the reversible capacity (245 mA h g⁻¹) of the optimal substituent compound Li₁.₅Mg₀.₅MnO₃ is significantly improved compared with that (115 mA h g⁻¹) of Li₂MnO₃. More importantly, this substitution strategy can be effectively extended to other Li-rich electrodes such as Li₃VO₄ and Li₃NbO₄ with Mg-substitution activating cationic redox. The study opens a new avenue in improving the reversible capacity of Li-rich cathode materials through low-cost element substitution.
Keywords	cathodes ; cations ; electrochemistry ; energy density ; oxygen ; thermodynamics
Language	English
Dates of publication	2021-0428
Size	p. 10364-10373.
Publishing place	The Royal Society of Chemistry
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	2702232-8
ISSN	2050-7496 ; 2050-7488
ISSN (online)	2050-7496
ISSN	2050-7488
DOI	10.1039/d1ta00282a
Database	NAL-Catalogue (AGRICOLA)

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Article: [Simultaneous determination of 36 hypotensive drugs in fingerprints by ultra performance liquid chromatography-triple quadrupole composite linear ion trap mass spectrometry].

DU, Qiuyao / Zhang, Yunfeng / Wang, Jifen / Zhao, Peng / Wu, Xiaojun / Dong, Linpei / Li, Jiayi / Liu, Bingjie

Se pu = Chinese journal of chromatography

2022 Volume 40, Issue 2, Page(s) 182–189

Abstract: Fingerprints contain important information such as the ingredients ingested by the donor. By analyzing the characteristic components in fingerprints, the donor can be characterized, which would provide insights for investigation of a given case. This ... ...

Abstract	Fingerprints contain important information such as the ingredients ingested by the donor. By analyzing the characteristic components in fingerprints, the donor can be characterized, which would provide insights for investigation of a given case. This approach can also be used in the qualitative monitoring of drug intake. Therefore, the examination of hypotensive drugs in fingerprints has significant value in practical application. This study established a method based on ultra performance liquid chromatography-triple quadrupole composite linear ion trap mass spectrometry (UPLC-Q-TRAP/MS) for the simultaneous determination of 36 hypotensive drugs in fingerprints. The pre-treatment method was based on protein precipitation. A 3×3 cm filter paper was cut into pieces and placed in a 2 mL plastic centrifuge tube after fingerprint collection. Then, 0.50 mL methanol was added, followed by vortex mixing for 1 min and ultrasonic oscillation for 3 min. The filter paper was centrifuged at 12000 r/min for 5 min, and the supernatant was withdrawn for sample analysis. An ACQUITY UPLC
MeSH term(s)	Chromatography, High Pressure Liquid ; Chromatography, Liquid ; Gas Chromatography-Mass Spectrometry ; Humans ; Pharmaceutical Preparations ; Tandem Mass Spectrometry
Chemical Substances	Pharmaceutical Preparations
Language	Chinese
Publishing date	2022-01-25
Publishing country	China
Document type	Journal Article
ISSN	1000-8713
ISSN	1000-8713
DOI	10.3724/SP.J.1123.2021.05012
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