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Article ; Online: Flow Microreactor Synthesis of Zeolitic Imidazolate Framework (ZIF)@ZIF Core-Shell Metal-Organic Framework Particles and Their Adsorption Properties.

Fujiwara, Atsushi / Watanabe, Satoshi / Miyahara, Minoru T

Langmuir : the ACS journal of surfaces and colloids

2021 Volume 37, Issue 13, Page(s) 3858–3867

Abstract: Metal-organic frameworks (MOFs) with core-shell structures enable to enhance intrinsic properties of constituent MOFs and impart additional functional activities. Although shell thickness is a key factor for regulating the properties of core-shell MOF ... ...

Abstract	Metal-organic frameworks (MOFs) with core-shell structures enable to enhance intrinsic properties of constituent MOFs and impart additional functional activities. Although shell thickness is a key factor for regulating the properties of core-shell MOF particles, controlling it has been challenging. The widely used batch reactor synthesis cannot produce core-shell particles with uniform shell thickness because of poor reactant mixing. A microreactor could ensure excellent mixing, and that would allow to control shell thickness. In this study, we synthesized zeolitic imidazolate framework-8 (ZIF-8)@ZIF-67 and ZIF-67@ZIF-8 core-shell particles using a microreactor and investigated the effects of the mixing performance on the shell thickness of the obtained particles. Our results demonstrated that rapid mixing was critical for the uniformity of the synthesized particles. The concentration of core particles is another key factor that can preferentially induce heterogeneous nucleation on the surface of the core particles without inducing self-nucleation in the bulk solution, particularly when the self-nucleation rate of the shell MOF is high. The N
Language	English
Publishing date	2021-02-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	2005937-1
ISSN	1520-5827 ; 0743-7463
ISSN (online)	1520-5827
ISSN	0743-7463
DOI	10.1021/acs.langmuir.0c03378
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Possible correlation between serum interleukin-8 levels and the activity of myositis in anti-NXP2 antibody-positive dermatomyositis.

Konishi, Risa / Ichimura, Yuki / Tanaka, Ryota / Miyahara, Hanako / Okune, Mari / Miyamoto, Masahide / Hara, Monami / Iwabuchi, Atsushi / Takada, Hidetoshi / Nakagishi, Yasuo / Mizuta, Mao / Kaneko, Shuya / Shimizu, Masaki / Morio, Tomohiro / Nishino, Ichizo / Nomura, Toshifumi / Okiyama, Naoko

Immunological medicine

2024 , Page(s) 1–6

Abstract: Anti-nuclear matrix protein 2 (NXP2) antibody-positive dermatomyositis (DM) is characterized by extensive and severe myositis. In this study, we evaluated which cytokines/chemokines involved with the activity of the myositis. We performed quantitative ... ...

Abstract	Anti-nuclear matrix protein 2 (NXP2) antibody-positive dermatomyositis (DM) is characterized by extensive and severe myositis. In this study, we evaluated which cytokines/chemokines involved with the activity of the myositis. We performed quantitative immunoassays using the MILLIPLEX
Language	English
Publishing date	2024-01-04
Publishing country	England
Document type	Journal Article
ISSN	2578-5826
ISSN (online)	2578-5826
DOI	10.1080/25785826.2023.2300553
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Article ; Online: Diagnostic Accuracy of Highest-Grade or Predominant Histological Differentiation of T1 Colorectal Cancer in Predicting Lymph Node Metastasis: A Systematic Review and Meta-Analysis.

Watanabe, Jun / Ichimasa, Katsuro / Kataoka, Yuki / Miyahara, Shoko / Miki, Atsushi / Yeoh, Khay Guan / Kawai, Shigeo / Martínez de Juan, Fernando / Machado, Isidro / Kotani, Kazuhiko / Sata, Naohiro

Clinical and translational gastroenterology

2024 Volume 15, Issue 3, Page(s) e00673

Abstract: Introduction: Treatment guidelines for colorectal cancer (CRC) suggest 2 classifications for histological differentiation-highest grade and predominant. However, the optimal predictor of lymph node metastasis (LNM) in T1 CRC remains unknown. This ... ...

Abstract	Introduction: Treatment guidelines for colorectal cancer (CRC) suggest 2 classifications for histological differentiation-highest grade and predominant. However, the optimal predictor of lymph node metastasis (LNM) in T1 CRC remains unknown. This systematic review aimed to evaluate the impact of the use of highest-grade or predominant differentiation on LNM determination in T1 CRC. Methods: The study protocol is registered in the International Prospective Register of Systematic Reviews (PROSPERO, registration number: CRD42023416971) and was published in OSF ( https://osf.io/TMAUN/ ) on April 13, 2023. We searched 5 electronic databases for studies assessing the diagnostic accuracy of highest-grade or predominant differentiation to determine LNM in T1 CRC. The outcomes were sensitivity and specificity. We simulated 100 cases with T1 CRC, with an LNM incidence of 11.2%, to calculate the differences in false positives and negatives between the highest-grade and predominant differentiations using a bootstrap method. Results: In 42 studies involving 41,290 patients, the differentiation classification had a pooled sensitivity of 0.18 (95% confidence interval [CI] 0.13-0.24) and 0.06 (95% CI 0.04-0.09) ( P < 0.0001) and specificity of 0.95 (95% CI 0.93-0.96) and 0.98 (95% CI 0.97-0.99) ( P < 0.0001) for the highest-grade and predominant differentiations, respectively. In the simulation, the differences in false positives and negatives between the highest-grade and predominant differentiations were 3.0% (range 1.6-4.4) and -1.3% (range -2.0 to -0.7), respectively. Discussion: Highest-grade differentiation may reduce the risk of misclassifying cases with LNM as negative, whereas predominant differentiation may prevent unnecessary surgeries. Further studies should examine differentiation classification using other predictive factors.
MeSH term(s)	Humans ; Lymphatic Metastasis/diagnosis ; Sensitivity and Specificity ; Colorectal Neoplasms/pathology
Language	English
Publishing date	2024-03-01
Publishing country	United States
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2581516-7
ISSN	2155-384X ; 2155-384X
ISSN (online)	2155-384X
ISSN	2155-384X
DOI	10.14309/ctg.0000000000000673
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Article: Development and Validation of a Japanese-Language Questionnaire to Screen for Tension-Type Headaches and Migraines.

Tanobe, Kaho / Machida, Minori / Motoya, Ryo / Takeoka, Atsushi / Danno, Daisuke / Miyahara, Junichi / Takeshima, Takao / Kumano, Hiroaki / Tayama, Jun

Cureus

2023 Volume 15, Issue 9, Page(s) e44633

Abstract: Introduction Migraine and tension-type headache (TTH) are chronic diseases associated with significant socioeconomic losses and social and psychological impact (current global prevalence: 10% and 38%, respectively). Thus, they require accurate ... ...

Abstract	Introduction Migraine and tension-type headache (TTH) are chronic diseases associated with significant socioeconomic losses and social and psychological impact (current global prevalence: 10% and 38%, respectively). Thus, they require accurate identification and classification. In clinical practice, validated screening tools able to quickly determine migraine and TTH with high sensitivity and specificity help provide an objective and multifaceted understanding of patients' headache symptoms. However, no tool has been developed or validated yet in Japan to ask multifaceted questions about headache-related symptoms in order to identify migraine and TTH and understand these symptoms. This study aimed to develop a questionnaire for screening TTH and migraine. Methods The study was conducted from March to June 2022 at a medical institution in Osaka, Japan. The questionnaire - comprising 24 questions that were generated based on the 3rd edition of the International Classification of Headache Disorders - was used to screen for migraine and TTH, aiming for a deeper understanding of related symptoms. The participants were patients aged ≥18 years with at least one of the following diagnoses: migraine, TTH. The participants were asked to respond in writing or online. The inclusion criteria were age ≥18 years; headache patients attending a hospital; and diagnoses of at least one of the following: migraine, TTH. The informativeness and discriminating ability of the screening items were evaluated using the item response theory. Items with a calculated discrimination ≥1.35 (high or very high) were retained for screening purposes. Basic questions required to screen for primary headaches were retained, despite their limited computational discrimination power. Ultimately, nine and eight screening items were finalized for migraine and TTH, respectively. The previous neurologists' clinical diagnosis of each patient was used as the gold standard reference for calculating sensitivity, specificity, and positive and negative predictive values regarding the screening items. Cohen's kappa coefficients with 95% CIs were also calculated to determine the agreement between the neurologists' clinical diagnosis and the questionnaire results. Results The study population comprised 69 patients aged 19-89 years who were assisted at a hospital division specializing in headache medicine and diagnosed by neurologists. Of these, 22 patients had migraine, 30 had TTH, and 17 had migraine/TTH. Comparing the neurologists' clinical diagnosis with our screening questionnaire results, the sensitivity and specificity were 72.7% and 86.7% for migraine and 50.0% and 86.4% for TTH, respectively. Conclusions Our brief screening tool was highly specific for diagnosing migraine and TTH in individuals with headache symptoms but lacked sufficient sensitivity, especially for TTH. The high specificity for migraine and TTH suggests that the screening tool we developed in this study can correctly identify those who do not have migraine and TTH. The sensitivity was also relatively high for migraine, suggesting that the tool can correctly identify migraine-positive individuals. However, the sensitivity for TTH was low. This tool could help clinicians in providing detailed course assessment of migraine symptoms and TTH symptoms; however, the issue of low sensitivity for TTH needs to be addressed.
Language	English
Publishing date	2023-09-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.44633
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Article ; Online: Double recurrence of double cancers: Rhabdomyosarcoma and secondary AML.

Kajita, Naoki / Saito, Yuya / Makimoto, Atsushi / Miyahara, Satoshi / Yuza, Yuki

Pediatrics international : official journal of the Japan Pediatric Society

2020 Volume 62, Issue 6, Page(s) 742–744

MeSH term(s)	Adolescent ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Cyclophosphamide/adverse effects ; Cyclophosphamide/therapeutic use ; Etoposide/adverse effects ; Etoposide/therapeutic use ; Fatal Outcome ; Humans ; Ifosfamide/therapeutic use ; Japan ; Leukemia, Myeloid, Acute/chemically induced ; Leukemia, Myeloid, Acute/drug therapy ; Male ; Neoplasm Recurrence, Local ; Neoplasms, Second Primary/chemically induced ; Neoplasms, Second Primary/drug therapy ; Rhabdomyosarcoma, Alveolar/drug therapy
Chemical Substances	Etoposide (6PLQ3CP4P3) ; Cyclophosphamide (8N3DW7272P) ; Ifosfamide (UM20QQM95Y)
Language	English
Publishing date	2020-06-04
Publishing country	Australia
Document type	Case Reports ; Journal Article
ZDB-ID	1470376-2
ISSN	1442-200X ; 1328-8067
ISSN (online)	1442-200X
ISSN	1328-8067
DOI	10.1111/ped.14172
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Article: Flow Microreactor Synthesis of Zeolitic Imidazolate Framework (ZIF)@ZIF Core–Shell Metal–Organic Framework Particles and Their Adsorption Properties

Fujiwara, Atsushi / Watanabe, Satoshi / Miyahara, Minoru T

Langmuir. 2021 Feb. 24, v. 37, no. 13

2021

Abstract: Metal–organic frameworks (MOFs) with core–shell structures enable to enhance intrinsic properties of constituent MOFs and impart additional functional activities. Although shell thickness is a key factor for regulating the properties of core–shell MOF ... ...

Abstract	Metal–organic frameworks (MOFs) with core–shell structures enable to enhance intrinsic properties of constituent MOFs and impart additional functional activities. Although shell thickness is a key factor for regulating the properties of core–shell MOF particles, controlling it has been challenging. The widely used batch reactor synthesis cannot produce core–shell particles with uniform shell thickness because of poor reactant mixing. A microreactor could ensure excellent mixing, and that would allow to control shell thickness. In this study, we synthesized zeolitic imidazolate framework-8 (ZIF-8)@ZIF-67 and ZIF-67@ZIF-8 core–shell particles using a microreactor and investigated the effects of the mixing performance on the shell thickness of the obtained particles. Our results demonstrated that rapid mixing was critical for the uniformity of the synthesized particles. The concentration of core particles is another key factor that can preferentially induce heterogeneous nucleation on the surface of the core particles without inducing self-nucleation in the bulk solution, particularly when the self-nucleation rate of the shell MOF is high. The N₂ adsorption isotherms of the synthesized particles revealed their unique adsorption properties, which were ascribed to the core–shell structures obtained at low shell formation rates. Our simple and versatile synthesis technique not only allowed the preparation of ZIF@ZIF particles with novel functionalities but also can be extended to synthesize core–shell MOF particles with different combinations of core particles and shells.
Keywords	adsorption ; batch systems ; coordination polymers
Language	English
Dates of publication	2021-0224
Size	p. 3858-3867.
Publishing place	American Chemical Society
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	2005937-1
ISSN	1520-5827 ; 0743-7463
ISSN (online)	1520-5827
ISSN	0743-7463
DOI	10.1021/acs.langmuir.0c03378
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Nutritional Assessment of Hospital Meals by Food-Recording Applications.

Iizuka, Katsumi / Ishihara, Takuma / Watanabe, Mayuka / Ito, Akemi / Sarai, Masayoshi / Miyahara, Ryoji / Suzuki, Atsushi / Saitoh, Eiichi / Sasaki, Hitomi

Nutrients

2022 Volume 14, Issue 18

Abstract: Mobile food records are currently used to determine the nutrition of healthy subjects. To determine the accuracy of such records, we evaluated the nutritional composition of a test meal (noodles and fruit juice) and a hospital meal (Japanese set meal) ... ...

Abstract	Mobile food records are currently used to determine the nutrition of healthy subjects. To determine the accuracy of such records, we evaluated the nutritional composition of a test meal (noodles and fruit juice) and a hospital meal (Japanese set meal) using two types of mobile food records. Eighteen healthy subjects (2 males and 16 females) were enrolled. Using these diets and validated nutrient-composition information, we evaluated the accuracy of the dietary assessments made by two dietary-record applications, Asken
MeSH term(s)	Carbohydrates ; Diet ; Energy Intake ; Female ; Hospitals ; Humans ; Male ; Meals ; Nutrition Assessment
Chemical Substances	Carbohydrates
Language	English
Publishing date	2022-09-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14183754
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Article: Microglial cannabinoid receptor type 1 mediates social memory deficits produced by adolescent THC exposure and 16p11.2 duplication.

Hasegawa, Yuto / Kim, Juhyun / Ursini, Gianluca / Jouroukhin, Yan / Zhu, Xiaolei / Miyahara, Yu / Xiong, Feiyi / Madireddy, Samskruthi / Obayashi, Mizuho / Lutz, Beat / Sawa, Akira / Brown, Solange P / Pletnikov, Mikhail V / Kamiya, Atsushi

bioRxiv : the preprint server for biology

2023

Abstract: Adolescent cannabis use increases the risk for cognitive impairments and psychiatric disorders. Cannabinoid receptor type 1 (Cnr1) is expressed not only in neurons and astrocytes, but also in microglia, which shape synaptic connections during adolescence. ...

Abstract	Adolescent cannabis use increases the risk for cognitive impairments and psychiatric disorders. Cannabinoid receptor type 1 (Cnr1) is expressed not only in neurons and astrocytes, but also in microglia, which shape synaptic connections during adolescence. Nonetheless, until now, the role of microglia in mediating the adverse cognitive effects of delta-9-tetrahydrocannabinol (THC), the principal psychoactive constituent of cannabis, has been unexplored. Here, we report that adolescent THC exposure produces microglial apoptosis in the medial prefrontal cortex (mPFC), which was exacerbated in the mouse model of 16p11.2 duplication, a representative copy number variation (CNV) risk factor for psychiatric disorders. These effects are mediated by microglial Cnr1, leading to reduction in the excitability of mPFC pyramidal-tract neurons and deficits in social memory in adulthood. Our findings highlight the importance of microglial Cnr1 to produce the adverse effect of cannabis exposure in genetically vulnerable individuals.
Language	English
Publishing date	2023-07-26
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.07.24.550212
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Article ; Online: The Evaluation of Lipoma Arborescens with Intermittent Knee Joint Effusion Based on an Analysis of Serum Cytokine Levels and an Immunohistological Examination.

Umetsu, Ayaka / Eguchi, Katsumi / Koga, Tomohiro / Araki, Takeshi / Takatani, Ayuko / Aramaki, Toshiyuki / Terada, Kaoru / Iwamoto, Naoki / Miyahara, Kenji / Yonemitsu, Nobuhisa / Nakamura, Hideki / Kawakami, Atsushi / Ueki, Yukitaka

Internal medicine (Tokyo, Japan)

2023 Volume 63, Issue 9, Page(s) 1305–1309

Abstract: We herein report a 27-year-old woman who presented with recurrent knee pain. Laboratory findings revealed minimal inflammation. Arthrography revealed structures resembling adipose tissues. Magnetic resonance imaging showed a high signal intensity of ... ...

Abstract	We herein report a 27-year-old woman who presented with recurrent knee pain. Laboratory findings revealed minimal inflammation. Arthrography revealed structures resembling adipose tissues. Magnetic resonance imaging showed a high signal intensity of these structures, leading to the diagnosis of lipoma arborescens (LA). Synovectomy was performed. Pathology revealed adipocyte proliferation and B-cell clusters but no T-cell infiltration. A serum cytokine analysis revealed low levels of interleukin-6 and tumor necrosis factor-α compared with patients with rheumatoid arthritis. The pathogenesis of LA remains unclear, but immunostaining and serum cytokine levels may provide valuable data for future investigations.
MeSH term(s)	Humans ; Female ; Adult ; Lipoma/blood ; Lipoma/diagnosis ; Lipoma/pathology ; Lipoma/diagnostic imaging ; Knee Joint/pathology ; Knee Joint/diagnostic imaging ; Magnetic Resonance Imaging ; Synovectomy ; Cytokines/blood ; Interleukin-6/blood ; Immunohistochemistry
Chemical Substances	Cytokines ; Interleukin-6
Language	English
Publishing date	2023-09-29
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	32371-8
ISSN	1349-7235 ; 0021-5120 ; 0918-2918
ISSN (online)	1349-7235
ISSN	0021-5120 ; 0918-2918
DOI	10.2169/internalmedicine.2393-23
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Article ; Online: Case of anti-nuclear matrix protein 2 antibody-positive juvenile dermatomyositis preceded by linear cutaneous lupus erythematosus on the face.

Miyahara, Hanako / Okiyama, Naoko / Okune, Mari / Konishi, Risa / Miyamoto, Masahide / Hara, Monami / Iwabuchi, Atsushi / Takada, Hidetoshi / Nishino, Ichizo / Nomura, Toshifumi

The Journal of dermatology

2021 Volume 49, Issue 1, Page(s) e18–e19

MeSH term(s)	Dermatomyositis/complications ; Dermatomyositis/diagnosis ; Face ; Humans ; Lupus Erythematosus, Cutaneous/diagnosis ; Lupus Erythematosus, Systemic ; Skin
Language	English
Publishing date	2021-10-08
Publishing country	England
Document type	Case Reports ; Letter
ZDB-ID	800103-0
ISSN	1346-8138 ; 0385-2407
ISSN (online)	1346-8138
ISSN	0385-2407
DOI	10.1111/1346-8138.16192
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