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  1. Article ; Online: Historical perspective: An INTERVIEW WITH JEAN-PIERRE CHANGEUX by Ernesto Carafoli.

    Changeux, Jean-Pierre / Carafoli, Ernesto

    Biochemical and biophysical research communications

    2015  Volume 467, Issue 4, Page(s) 612–616

    MeSH term(s) Biology ; Paris
    Language English
    Publishing date 2015-11-27
    Publishing country United States
    Document type Interview
    ZDB-ID 205723-2
    ISSN 1090-2104 ; 0006-291X ; 0006-291X
    ISSN (online) 1090-2104 ; 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2015.10.046
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Jean-Pierre Changeux: allostery as neuro-enlightenment.

    Changeux, Jean-Pierre

    Molecular interventions

    2009  Volume 9, Issue 2, Page(s) 61–67

    MeSH term(s) Allosteric Site ; Animals ; Bioethics ; Enzymes/chemistry ; Enzymes/metabolism ; Esthetics ; Humans ; Models, Molecular ; Neurosciences ; Protein Conformation
    Chemical Substances Enzymes
    Language English
    Publishing date 2009-04
    Publishing country United States
    Document type Interview
    ZDB-ID 2108819-6
    ISSN 1543-2548 ; 1534-0384
    ISSN (online) 1543-2548
    ISSN 1534-0384
    DOI 10.1124/mi.9.2.2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Travailler avec François Gros à l’Institut Pasteur : l’allostérie, le récepteur nicotinique et la biologie du futur.

    Changeux, Jean-Pierre

    Comptes rendus biologies

    2024  Volume 346, Issue S2, Page(s) 9–13

    Abstract: Working with François Gros was a privileged moment in my scientific life, enabling me to appreciate a scientific personality whose generosity knew no bounds and whose vision of science was far ahead of its time. ...

    Title translation Working with François Gros at the Institut Pasteur: allostery, the nicotinic receptor and the biology of the future.
    Abstract Working with François Gros was a privileged moment in my scientific life, enabling me to appreciate a scientific personality whose generosity knew no bounds and whose vision of science was far ahead of its time.
    MeSH term(s) Receptors, Nicotinic ; Molecular Biology
    Chemical Substances Receptors, Nicotinic
    Language French
    Publishing date 2024-03-29
    Publishing country France
    Document type Historical Article
    ZDB-ID 2072863-3
    ISSN 1768-3238 ; 1631-0691
    ISSN (online) 1768-3238
    ISSN 1631-0691
    DOI 10.5802/crbiol.143
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  4. Article ; Online: Louis Pasteur, molecular dissymmetry, therapeutic chemistry and neuropharmacology.

    Changeux, Jean-Pierre

    Comptes rendus biologies

    2022  Volume 345, Issue 3, Page(s) 7–20

    Abstract: Louis Pasteur is celebrated as the founding father of microbiology. But he was a chemist by training and discovered molecular dissymmetry experimentally. All his life, his constant preoccupation will be to apply the method and strategies of the ... ...

    Abstract Louis Pasteur is celebrated as the founding father of microbiology. But he was a chemist by training and discovered molecular dissymmetry experimentally. All his life, his constant preoccupation will be to apply the method and strategies of the fundamental sciences to living processes, "from the molecule to the brain". His fundamental aim will be, beyond the biology of microbes, the chemistry of life, a disposition which signs the originality of his work. More unexpectedly, Pasteur was at the origin of therapeutic chemistry-which his successors, and especially Daniel Bovet, brilliantly illustrated at the Pasteur Institute and which they would pursue with the pharmacology of the nervous system or "neuropharmacology".
    MeSH term(s) Male ; Humans ; Academies and Institutes ; Brain
    Language English
    Publishing date 2022-11-10
    Publishing country France
    Document type Journal Article
    ZDB-ID 2072863-3
    ISSN 1768-3238 ; 1631-0691
    ISSN (online) 1768-3238
    ISSN 1631-0691
    DOI 10.5802/crbiol.81
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  5. Article ; Online: The Nicotinic Acetylcholine Receptor and its Pentameric Homologs: Toward an Allosteric Mechanism of Signal Transduction at the Atomic Level.

    Cecchini, Marco / Corringer, Pierre-Jean / Changeux, Jean-Pierre

    Annual review of biochemistry

    2024  

    Abstract: The nicotinic acetylcholine receptor has served, since its biochemical identification in the 1970s, as a model of an allosteric ligand-gated ion channel mediating signal transition at the synapse. In recent years, the application of X-ray crystallography ...

    Abstract The nicotinic acetylcholine receptor has served, since its biochemical identification in the 1970s, as a model of an allosteric ligand-gated ion channel mediating signal transition at the synapse. In recent years, the application of X-ray crystallography and high-resolution cryo-electron microscopy, together with molecular dynamic simulations of nicotinic receptors and homologs, have opened a new era in the understanding of channel gating by the neurotransmitter. They reveal, at atomic resolution, the diversity and flexibility of the multiple ligand-binding sites, including recently discovered allosteric modulatory sites distinct from the neurotransmitter orthosteric site, and the conformational dynamics of the activation process as a molecular switch linking these multiple sites. The model emerging from these studies paves the way for a new pharmacology based, first, upon the occurrence of an original mode of indirect allosteric modulation, distinct from a steric competition for a single and rigid binding site, and second, the design of drugs that specifically interact with privileged conformations of the receptor such as agonists, antagonists, and desensitizers. Research on nicotinic receptors is still at the forefront of understanding the mode of action of drugs on the nervous system. Expected final online publication date for the
    Language English
    Publishing date 2024-02-12
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 207924-0
    ISSN 1545-4509 ; 0066-4154
    ISSN (online) 1545-4509
    ISSN 0066-4154
    DOI 10.1146/annurev-biochem-030122-033116
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  6. Article ; Online: About the compatibility between the perturbational complexity index and the global neuronal workspace theory of consciousness.

    Farisco, Michele / Changeux, Jean-Pierre

    Neuroscience of consciousness

    2023  Volume 2023, Issue 1, Page(s) niad016

    Abstract: This paper investigates the compatibility between the theoretical framework of the global neuronal workspace theory (GNWT) of conscious processing and the perturbational complexity index (PCI). Even if it has been introduced within the framework of a ... ...

    Abstract This paper investigates the compatibility between the theoretical framework of the global neuronal workspace theory (GNWT) of conscious processing and the perturbational complexity index (PCI). Even if it has been introduced within the framework of a concurrent theory (i.e. Integrated Information Theory), PCI appears, in principle, compatible with the main tenet of GNWT, which is a conscious process that depends on a long-range connection between different cortical regions, more specifically on the amplification, global propagation, and integration of brain signals. Notwithstanding this basic compatibility, a number of limited compatibilities and apparent differences emerge. This paper starts from the description of brain complexity, a notion that is crucial for PCI, to then summary of the main features of PCI and the main tenets of GNWT. Against this background, the text explores the compatibility between PCI and GNWT. It concludes that GNWT and PCI are fundamentally compatible, even though there are some partial disagreements and some points to further examine.
    Language English
    Publishing date 2023-06-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2815642-0
    ISSN 2057-2107 ; 2057-2107
    ISSN (online) 2057-2107
    ISSN 2057-2107
    DOI 10.1093/nc/niad016
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  7. Article ; Online: Louis Pasteur, molecular dissymmetry, therapeutic chemistry and neuropharmacology

    Changeux, Jean-Pierre

    Comptes Rendus Biologies, Vol 345, Iss 3, Pp 7-

    2022  Volume 20

    Abstract: Louis Pasteur is celebrated as the founding father of microbiology. But he was a chemist by training and discovered molecular dissymmetry experimentally. All his life, his constant preoccupation will be to apply the method and strategies of the ... ...

    Abstract Louis Pasteur is celebrated as the founding father of microbiology. But he was a chemist by training and discovered molecular dissymmetry experimentally. All his life, his constant preoccupation will be to apply the method and strategies of the fundamental sciences to living processes, “from the molecule to the brain”. His fundamental aim will be, beyond the biology of microbes, the chemistry of life, a disposition which signs the originality of his work. More unexpectedly, Pasteur was at the origin of therapeutic chemistry—which his successors, and especially Daniel Bovet, brilliantly illustrated at the Pasteur Institute and which they would pursue with the pharmacology of the nervous system or “neuropharmacology”.
    Keywords Louis Pasteur ; Molecular dissymmetry ; Medical chemistry ; Microbiology ; Neuropharmacology ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2022-10-01T00:00:00Z
    Publisher Académie des sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Discovery of the First Neurotransmitter Receptor: The Acetylcholine Nicotinic Receptor.

    Changeux, Jean-Pierre

    Biomolecules

    2020  Volume 10, Issue 4

    Abstract: The concept of pharmacological receptor was proposed at the turn of the 20th century but it took almost 70 years before the first receptor for a neurotransmitter was isolated and identified as a protein. This review retraces the history of the ... ...

    Abstract The concept of pharmacological receptor was proposed at the turn of the 20th century but it took almost 70 years before the first receptor for a neurotransmitter was isolated and identified as a protein. This review retraces the history of the difficulties and successes in the identification of the nicotinic acetylcholine receptor, the first neurotransmitter receptor to be identified.
    MeSH term(s) Animals ; Drug Discovery ; Humans ; Receptors, Nicotinic/chemistry ; Receptors, Nicotinic/metabolism
    Chemical Substances Receptors, Nicotinic
    Language English
    Publishing date 2020-04-03
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom10040547
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  9. Article ; Online: Golden Anniversary of the Nicotinic Receptor.

    Changeux, Jean-Pierre

    Neuron

    2020  Volume 107, Issue 1, Page(s) 14–16

    Abstract: The high-resolution structure of the nicotinic acetylcholine receptor from Torpedo electric tissue in association with the snake toxin α-bungarotoxin (Rahman et al., 2020) is presented 50 years after its identification as the first neurotransmitter ... ...

    Abstract The high-resolution structure of the nicotinic acetylcholine receptor from Torpedo electric tissue in association with the snake toxin α-bungarotoxin (Rahman et al., 2020) is presented 50 years after its identification as the first neurotransmitter receptor and ligand-gated ion channel.
    MeSH term(s) Animals ; Anniversaries and Special Events ; Bungarotoxins ; Receptors, Nicotinic ; Snake Venoms ; Torpedo
    Chemical Substances Bungarotoxins ; Receptors, Nicotinic ; Snake Venoms
    Keywords covid19
    Language English
    Publishing date 2020-07-08
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 808167-0
    ISSN 1097-4199 ; 0896-6273
    ISSN (online) 1097-4199
    ISSN 0896-6273
    DOI 10.1016/j.neuron.2020.05.026
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  10. Article ; Online: Paleoanthropology of cognition: an overview on Hominins brain evolution.

    Hublin, Jean-Jacques / Changeux, Jean-Pierre

    Comptes rendus biologies

    2022  Volume 345, Issue 2, Page(s) 57–75

    Abstract: Recent advances in neurobiology, paleontology, and paleogenetics allow us to associate changes in brain size and organization with three main "moments" of increased behavioral complexity and, more speculatively, language development. First, Australopiths ...

    Abstract Recent advances in neurobiology, paleontology, and paleogenetics allow us to associate changes in brain size and organization with three main "moments" of increased behavioral complexity and, more speculatively, language development. First, Australopiths display a significant increase in brain size relative to the great apes and an incipient extension of postnatal brain development. However, their cortical organization remains essentially similar to that of apes. Second, over the last 2 My, with two notable exceptions, brain size increases dramatically, partly in relation to changes in body size. Differential enlargements and reorganizations of cortical areas lay the foundation for the "language-ready" brain and cumulative culture of later Homo species. Third, in Homo sapiens, brain size remains fairly stable over the last 300,000 years but an important cerebral reorganization takes place. It affects the frontal and temporal lobes, the parietal areas and the cerebellum and resulted in a more globular shape of the brain. These changes are associated, among others, with an increased development of long-distance-horizontal-connections. A few regulatory genetic events took place in the course of this hominization process with, in particular, enhanced neuronal proliferation and global brain connectivity.
    MeSH term(s) Humans ; Animals ; Hominidae ; Biological Evolution ; Brain ; Cognition/physiology ; Neurons ; Fossils
    Language English
    Publishing date 2022-12-08
    Publishing country France
    Document type Journal Article
    ZDB-ID 2072863-3
    ISSN 1768-3238 ; 1631-0691
    ISSN (online) 1768-3238
    ISSN 1631-0691
    DOI 10.5802/crbiol.92
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