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Article ; Online: Carrier capability of halloysite nanotubes for the intracellular delivery of antisense PNA targeting mRNA of neuroglobin gene.

Falanga, Andrea P / Massaro, Marina / Borbone, Nicola / Notarbartolo, Monica / Piccialli, Gennaro / Liotta, Leonarda F / Sanchez-Espejo, Rita / Viseras Iborra, Cesar / Raymo, Françisco M / Oliviero, Giorgia / Riela, Serena

Journal of colloid and interface science

2024 Volume 663, Page(s) 9–20

Abstract: Peptide nucleic acid (PNA) is a DNA mimic that shows good stability against nucleases and proteases, forming strongly recognized complementary strands of DNA and RNA. However, due to its feeble ability to cross the cellular membrane, PNA activity and its ...

Abstract	Peptide nucleic acid (PNA) is a DNA mimic that shows good stability against nucleases and proteases, forming strongly recognized complementary strands of DNA and RNA. However, due to its feeble ability to cross the cellular membrane, PNA activity and its targeting gene action is limited. Halloysite nanotubes (HNTs) are a natural and low-cost aluminosilicate clay. Because of their peculiar ability to cross cellular membrane, HNTs represent a valuable candidate for delivering genetic materials into cells. Herein, two differently charged 12-mer PNAs capable of recognizing as molecular target a 12-mer DNA molecule mimicking a purine-rich tract of neuroglobin were synthetized and loaded onto HNTs by electrostatic attraction interactions. After characterization, the kinetic release was also assessed in media mimicking physiological conditions. Resonance light scattering measurements assessed their ability to bind complementary single-stranded DNA. Furthermore, their intracellular delivery was assessed by confocal laser scanning microscopy on living MCF-7 cells incubated with fluorescence isothiocyanate (FITC)-PNA and HNTs labeled with a probe. The nanomaterials were found to cross cellular membrane and cell nuclei efficiently. Finally, it is worth mentioning that the HNTs/PNA can reduce the level of neuroglobin gene expression, as shown by reverse transcription-quantitative polymerase chain reaction and western blotting analysis.
MeSH term(s)	Clay ; Neuroglobin ; RNA, Messenger/genetics ; DNA ; Nanotubes/chemistry
Chemical Substances	Clay (T1FAD4SS2M) ; Neuroglobin ; RNA, Messenger ; DNA (9007-49-2)
Language	English
Publishing date	2024-02-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	241597-5
ISSN	1095-7103 ; 0021-9797
ISSN (online)	1095-7103
ISSN	0021-9797
DOI	10.1016/j.jcis.2024.02.136
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Article ; Online: Genomic characterisation of the population structure and antibiotic resistance of

Piña-Iturbe, Alejandro / Díaz-Gavidia, Constanza / Álvarez, Francisca P / Barron-Montenegro, Rocio / Álvarez-Espejo, Diana M / García, Patricia / Solís, Doina / Constenla-Albornoz, Rodrigo / Toro, Magaly / Olivares-Pacheco, Jorge / Reyes-Jara, Angélica / Meng, Jianghong / Bell, Rebecca L / Moreno-Switt, Andrea I

Lancet regional health. Americas

2024 Volume 32, Page(s) 100711

Abstract: Background: Multidrug-resistant (MDR) : Methods: We sequenced 396 : Findings: The genomic and phylogenetic analyses showed that : Interpretation: Our findings show a widespread dissemination of MDR : Funding: Partially supported by the Food ... ...

Abstract	Background: Multidrug-resistant (MDR) Methods: We sequenced 396 Findings: The genomic and phylogenetic analyses showed that Interpretation: Our findings show a widespread dissemination of MDR Funding: Partially supported by the Food and Drug Administration (FDA) of the U.S. Department of Health and Human Services as part of an award, FDU001818, with 30% percent funded by FDA/HHS; and by Agencia de Investigación y Desarrollo de Chile (ANID) through FONDECYT de Postdoctorado Folio 3230796 and Folio 3210317, FONDECYT Regular Folio 1231082, and ANID-Millennium Science Initiative Program-ICN2021_044.
Language	English
Publishing date	2024-03-11
Publishing country	England
Document type	Journal Article
ISSN	2667-193X
ISSN (online)	2667-193X
DOI	10.1016/j.lana.2024.100711
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Article ; Online: Describing IgA Myeloma: An Immunophenotypic and Molecular Approach.

Akgun, Yamac / Baykara, Yigit / Hacking, Sean M / Langlie, Jake / Huberman, Melissa Ann / Espejo, Andrea P / Chapman, Jennifer / Poveda, Julio

Rhode Island medical journal (2013)

2022 Volume 105, Issue 6, Page(s) 41–45

Abstract: Plasma cell myeloma (PCM) is defined as a clonal disease of terminally differentiated plasma cells that secrete immunoglobulin. The biologic underpinnings of IgA-type multiple myeloma's (IgAMM) aggressive nature, including its increased morbidity and ... ...

Abstract	Plasma cell myeloma (PCM) is defined as a clonal disease of terminally differentiated plasma cells that secrete immunoglobulin. The biologic underpinnings of IgA-type multiple myeloma's (IgAMM) aggressive nature, including its increased morbidity and mortality, have not been elucidated. We describe the clinical, phenotypic, and cytogenetic characteristics of IgA-MM. Flow-cytometry analysis was performed to phenotype clonal plasma cell populations, and interface with fluorescent in situ hybridization (iFISH) to exploit cytogenetics to determine risk stratification; 68.1% of cases were of intermediate or high risk. On flow cytometry, samples from our IgA-PCM cohort revealed less frequent CD56 expression when compared to samples with other PCM subtypes. Our study demonstrated lower frequency of CD56 expression (52.8%). We hypothesize that loss of CD56 may play a significant role in the aggressive behavior of IgA-PCM due to the loss of cell-to-cell adhesion resulting in a higher propensity for extramedullary presentation.
MeSH term(s)	Humans ; Immunoglobulin A/genetics ; Immunoglobulin A/metabolism ; Immunophenotyping ; In Situ Hybridization, Fluorescence/methods ; Multiple Myeloma/diagnosis ; Multiple Myeloma/genetics ; Plasma Cells
Chemical Substances	Immunoglobulin A
Language	English
Publishing date	2022-08-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	419430-5
ISSN	2327-2228 ; 0363-7913
ISSN (online)	2327-2228
ISSN	0363-7913
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Article ; Online: Consequences of sea level rise for high metal(loid) loads in the Ría of Huelva estuary sediments.

Kerl, Carolin F / Basallote, M Dolores / Käberich, Merle / Oldani, Erica / Cerón Espejo, Nathalia P / Colina Blanco, Andrea E / Cánovas, Carlos Ruiz / Nieto, José Miguel / Planer-Friedrich, Britta

The Science of the total environment

2023 Volume 873, Page(s) 162354

Abstract: Ría of Huelva, located in southwestern Spain, is a highly metal(loid)-contaminated estuary system where sediments are exceeding action limits in an increasing order for Cd, Zn, Pb, Cu, and As. With a predicted sea level rise over the next 50 years, the ... ...

Abstract	Ría of Huelva, located in southwestern Spain, is a highly metal(loid)-contaminated estuary system where sediments are exceeding action limits in an increasing order for Cd, Zn, Pb, Cu, and As. With a predicted sea level rise over the next 50 years, the estuary will be subject to flooding with brackish water or seawater. To evaluate the risk of metal(loid) mobilization under future climate scenarios, different locations along the estuary were sampled at different depths. Samples were flooded with river water, brackish water, and seawater under different short- and long-term laboratory setups. Potential metal(loid) mobilization showed that water quality standards for As, Pb, Zn, Ni, Cu, and Cd could be exceeded upon seawater flooding. However, metal(loid) mobilization was not predictable solely based on sediment loads. The driving factors for cation and anion mobility were identified to be mainly pH under low salinity and competitive desorption under high salinity conditions. Further drivers such as wave movement or labile C input in C-limited systems were found to enhance metal(loid) mobilization. Long-term flooding of intact sediment cores revealed that sea level rise will have different effects on the estuary system depending on duration of flooding. Short-term flooding in the near future will first affect alkaline sediments and enhance currently low cation mobilization, while anion mobilization due to reductive Fe dissolution will remain high. Once acidic sediments further inland are flooded with seawater, highest contaminant mobilization can be expected as high salinity will further enhance already high cation mobilization under acidic pH. Long-term flooding with seawater will neutralize the sediment pH and limit cation mobilization compared to acidic pH. However, the contaminant load stored in the estuary is so high that, extrapolating data obtained, mobilization could last for >1000 years, e.g. for As, Pb, and Al.
Language	English
Publishing date	2023-02-22
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2023.162354
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Article ; Online: Treatment of Disseminated Intravenous Leiomyomatosis With ALK Targeting Crizotinib: A Successful Case Report.

Barreto-Coelho, Priscila / Rosenberg, Andrew / Subhawong, Ty / Costa, Philippos / Espejo-Freire, Andrea P / Bialick, Steven / Jonczak, Emily / Trent, Jonathan C / D'Amato, Gina Z

JCO precision oncology

2022 Volume 6, Page(s) e2100336

MeSH term(s)	Anaplastic Lymphoma Kinase/genetics ; Carcinoma, Non-Small-Cell Lung ; Crizotinib/therapeutic use ; Humans ; Leiomyomatosis/drug therapy ; Lung Neoplasms
Chemical Substances	Crizotinib (53AH36668S) ; Anaplastic Lymphoma Kinase (EC 2.7.10.1)
Language	English
Publishing date	2022-02-02
Publishing country	United States
Document type	Case Reports ; Journal Article
ISSN	2473-4284
ISSN (online)	2473-4284
DOI	10.1200/PO.21.00336
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Article ; Online: Using photovoice to generate policy recommendations to improve the alcohol urban environment: A participatory action research project.

Sandín Vázquez, María / Pastor, Andrea / Molina de la Fuente, Irene / Conde Espejo, Paloma / Sureda Llul, Francisca

Health & place

2023 Volume 84, Page(s) 103131

Abstract: The place where we live, work and play may influence our alcohol drinking behaviours. This study aimed to present local policy recommendations on urban determinants for alcohol consumption prevention in a low-income and a high-income area of Madrid ( ... ...

Abstract	The place where we live, work and play may influence our alcohol drinking behaviours. This study aimed to present local policy recommendations on urban determinants for alcohol consumption prevention in a low-income and a high-income area of Madrid (Spain) using a participatory action research method, with photovoice and nominal group techniques. Participants (n = 26) engaged in a photovoice project initiated a process of critical reflection by discussing and analysing their alcohol environment based on photographs they took themselves. At the end of six week group discussion sessions, participants identified 33 themes related to their alcohol environment. They later met to translate the final categories into urban policy recommendations using a logical framework approach. Then, with a nominal group, they prioritized these recommendations based on time, impact, feasibility, and cost. Finally, participants produced a total of 61 policy recommendations for the improvement of the alcohol environment, highlighting the need for researcher-community collaborations when designing public health interventions.
MeSH term(s)	Humans ; Health Services Research ; Public Health ; Poverty ; Policy ; Spain ; Photography ; Community-Based Participatory Research
Language	English
Publishing date	2023-10-15
Publishing country	England
Document type	Journal Article
ZDB-ID	1262540-1
ISSN	1873-2054 ; 1353-8292
ISSN (online)	1873-2054
ISSN	1353-8292
DOI	10.1016/j.healthplace.2023.103131
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Article ; Online: Consequences of sea level rise for high metal(loid) loads in the Ría of Huelva estuary sediments

Kerl, Carolin F. / Basallote, M. Dolores / Käberich, Merle / Oldani, Erica / Cerón Espejo, Nathalia P. / Colina Blanco, Andrea E. / Cánovas, Carlos Ruiz / Nieto, José Miguel / Planer-Friedrich, Britta

Science of the Total Environment. 2023 May, v. 873 p.162354-

2023

Abstract	Ría of Huelva, located in southwestern Spain, is a highly metal(loid)-contaminated estuary system where sediments are exceeding action limits in an increasing order for Cd, Zn, Pb, Cu, and As. With a predicted sea level rise over the next 50 years, the estuary will be subject to flooding with brackish water or seawater. To evaluate the risk of metal(loid) mobilization under future climate scenarios, different locations along the estuary were sampled at different depths. Samples were flooded with river water, brackish water, and seawater under different short- and long-term laboratory setups. Potential metal(loid) mobilization showed that water quality standards for As, Pb, Zn, Ni, Cu, and Cd could be exceeded upon seawater flooding. However, metal(loid) mobilization was not predictable solely based on sediment loads. The driving factors for cation and anion mobility were identified to be mainly pH under low salinity and competitive desorption under high salinity conditions. Further drivers such as wave movement or labile C input in C-limited systems were found to enhance metal(loid) mobilization. Long-term flooding of intact sediment cores revealed that sea level rise will have different effects on the estuary system depending on duration of flooding. Short-term flooding in the near future will first affect alkaline sediments and enhance currently low cation mobilization, while anion mobilization due to reductive Fe dissolution will remain high. Once acidic sediments further inland are flooded with seawater, highest contaminant mobilization can be expected as high salinity will further enhance already high cation mobilization under acidic pH. Long-term flooding with seawater will neutralize the sediment pH and limit cation mobilization compared to acidic pH. However, the contaminant load stored in the estuary is so high that, extrapolating data obtained, mobilization could last for >1000 years, e.g. for As, Pb, and Al.
Keywords	brackish water ; cations ; climate ; desorption ; environment ; estuaries ; pH ; risk assessment ; river water ; salinity ; sea level ; seawater ; sediments ; water quality ; Spain ; Mining-impacted estuary ; Río Tinto ; Río Odiel ; Climate change ; Contaminants ; Metal(loid) mobilization
Language	English
Dates of publication	2023-05
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2023.162354
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Article ; Online: Review of Current Advances in Serologic Testing for COVID-19.

Espejo, Andrea P / Akgun, Yamac / Al Mana, Abdulaziz F / Tjendra, Youley / Millan, Nicolas C / Gomez-Fernandez, Carmen / Cray, Carolyn

American journal of clinical pathology

2020 Volume 154, Issue 3, Page(s) 293–304

Abstract: Objectives: To examine and summarize the current literature on serologic methods for the detection of antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).: Methods: A literature review was performed using searches in databases ... ...

Abstract	Objectives: To examine and summarize the current literature on serologic methods for the detection of antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Methods: A literature review was performed using searches in databases including PubMed, medRxiv, and bioRxiv. Thirty-two peer-reviewed papers and 23 preprints were examined. Results: The studies included lateral flow immunoassay, enzyme-linked immunosorbent assay, chemiluminescence immunoassay, and neutralizing antibody assays. The use of all major SARS-CoV-2 antigens was demonstrated to have diagnostic value. Assays measuring total antibody reactivity had the highest sensitivity. In addition, all the methods provided opportunities to characterize the humoral immune response by isotype. The combined use of IgM and IgG detection resulted in a higher sensitivity than that observed when detecting either isotype alone. Although IgA was rarely studied, it was also demonstrated to be a sensitive marker of infection, and levels correlated with disease severity and neutralizing activity. Conclusions: The use of serologic testing, in conjunction with reverse transcription polymerase chain reaction testing, was demonstrated to significantly increase the sensitivity of detection of patients infected with SARS-CoV-2. There was conflicting evidence regarding whether antibody titers correlated with clinical severity. However, preliminary investigations indicated some immunoassays may be a surrogate for the prediction of neutralizing antibody titers and the selection of recovered patients for convalescent serum donation.
MeSH term(s)	Antibody Formation ; Betacoronavirus ; COVID-19 ; COVID-19 Testing ; Clinical Laboratory Techniques ; Coronavirus ; Coronavirus Infections/diagnosis ; Humans ; Immunoglobulin G ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
Chemical Substances	Immunoglobulin G
Keywords	covid19
Language	English
Publishing date	2020-06-09
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	2944-0
ISSN	1943-7722 ; 0002-9173
ISSN (online)	1943-7722
ISSN	0002-9173
DOI	10.1093/ajcp/aqaa112
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Article ; Online: In vivo antitumor activity by dual stromal and tumor-targeted oncolytic measles viruses.

Jing, Yuqi / Chavez, Valery / Khatwani, Natasha / Ban, Yuguang / Espejo, Andrea P / Chen, Xi / Merchan, Jaime R

Cancer gene therapy

2020 Volume 27, Issue 12, Page(s) 910–922

Abstract: The tumor stroma acts as a barrier that limits the efficacy of systemically administered oncolytic viruses (OV). We previously demonstrated that stromal-selective, retargeted oncolytic measles viruses (MVs) delay in vivo tumor progression. To further ... ...

Abstract	The tumor stroma acts as a barrier that limits the efficacy of systemically administered oncolytic viruses (OV). We previously demonstrated that stromal-selective, retargeted oncolytic measles viruses (MVs) delay in vivo tumor progression. To further characterize the contribution of stromal targeting to MV's overall in vivo efficacy in an experimental cancer model, a dual targeted oncolytic measles virus (MV-CD46-muPA) able to simultaneously infect murine stromal (via murine uPAR) and human cancer (via CD46) cells was developed. MV-CD46-muPA infected, replicated, and induced cytotoxicity in both murine and human cancer cells. Viral infection was successfully transferred from stromal to tumor cells in vitro, leading to tumor cell oncolysis. Systemic administration of MV-CD46-muPA led to improved antitumor effects in colon (HT-29) cancer xenografts compared to vehicle or CD46 only targeted MVs. These effects were associated with improved tumor viral deposition, increased apoptosis, and decreases in murine stromal endothelial cells and fibroblasts. MV-CD46-muPA modulated cell cycle, survival, proliferation, and metabolic pathways, as determined by functional proteomic analysis of treated tumors. The above findings further validate the concept that dual stromal and tumor cell viral targeting enhances the therapeutic effects of systemically administered OVs and support further preclinical and clinical development of stromal directed virotherapies.
MeSH term(s)	Animals ; Cell Line, Tumor ; Disease Models, Animal ; Female ; Humans ; In Vitro Techniques/methods ; Measles virus/genetics ; Mice ; Oncogenic Viruses/genetics ; Oncolytic Viruses/genetics
Language	English
Publishing date	2020-03-31
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1212513-1
ISSN	1476-5500 ; 0929-1903
ISSN (online)	1476-5500
ISSN	0929-1903
DOI	10.1038/s41417-020-0171-1
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Article ; Online: Predicting Disease Severity and Outcome in COVID-19 Patients: A Review of Multiple Biomarkers.

Tjendra, Youley / Al Mana, Abdulaziz F / Espejo, Andrea P / Akgun, Yamac / Millan, Nicolas C / Gomez-Fernandez, Carmen / Cray, Carolyn

Archives of pathology & laboratory medicine

2020 Volume 144, Issue 12, Page(s) 1465–1474

Abstract: Context.—: An abundance of clinical reports focused on specific laboratory parameters have been reported on coronavirus disease 19 (COVID-19), but a systematic analysis synthesizing these findings has not been performed.: Objective.—: To review and ... ...

Abstract	Context.—: An abundance of clinical reports focused on specific laboratory parameters have been reported on coronavirus disease 19 (COVID-19), but a systematic analysis synthesizing these findings has not been performed. Objective.—: To review and summarize the current available literature on the predictive role of various biomarkers in COVID-19 patients. Data sources.—: A literature search was performed using databases including PubMed, medRxiv, and bioRxiv. A total of 72 papers were reviewed, including 54 peer-reviewed papers and 18 non-peer-reviewed preprints. Conclusions.—: Although the markers are considered nonspecific, acute-phase reactants, including C-reactive protein (CRP), ferritin, serum amyloid A (SAA), and procalcitonin, were reported as sensitive markers of acute COVID-19 disease. Significantly elevated white blood cell count; marked lymphopenia; decreased CD3, CD4, or CD8 T-lymphocyte counts; high neutrophil count; thrombocytopenia; and markedly elevated inflammatory biomarkers were associated with severe disease and the risk of developing sepsis with rapid progression. Trends observed by serial laboratory measurements during hospitalization, including progressive decrease of lymphocyte count, thrombocytopenia, elevated CRP, procalcitonin, increased liver enzymes, decreased renal function, and coagulation derangements, were more common in critically ill patient groups and associated with a high incidence of clinical complications. Elevated interleukin 6 level and markedly increased SAA were most often reported in severely and critically ill patients. Indicators of systemic inflammation, such as neutrophil to lymphocyte ratio, systemic immune-inflammation index, or COVID-19 Severity Score, may be used to predict disease severity, outcome, and mortality. Interpretation of the data reported in the studies reviewed here is limited because of the study design (mostly retrospective), limited sample size, and a lack of defined clinical criteria.
MeSH term(s)	Biomarkers/blood ; COVID-19/blood ; COVID-19/diagnosis ; COVID-19/mortality ; COVID-19/therapy ; COVID-19 Testing/methods ; Global Health ; Hospitalization ; Humans ; Prognosis ; Severity of Illness Index
Chemical Substances	Biomarkers
Keywords	covid19
Language	English
Publishing date	2020-08-18
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	194119-7
ISSN	1543-2165 ; 0363-0153 ; 0096-8528 ; 0003-9985
ISSN (online)	1543-2165
ISSN	0363-0153 ; 0096-8528 ; 0003-9985
DOI	10.5858/arpa.2020-0471-SA
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