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  1. Article ; Online: Reply to Ben-Dor and Barkai: A low Zn isotope ratio is not equal to a low Zn content.

    Jaouen, Klervia / Tütken, Thomas / Bourgon, Nicolas / Lüdecke, Tina / Smith, Geoff M / Salazar-García, Domingo C / Hublin, Jean-Jacques / Villalba-Mouco, Vanessa / Méjean, Pauline

    Proceedings of the National Academy of Sciences of the United States of America

    2023  Volume 120, Issue 6, Page(s) e2218491120

    Language English
    Publishing date 2023-01-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2218491120
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
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  2. Article ; Online: High-Pressure Synthesis of Dirac Materials: Layered van der Waals Bonded BeN_{4} Polymorph.

    Bykov, Maxim / Fedotenko, Timofey / Chariton, Stella / Laniel, Dominique / Glazyrin, Konstantin / Hanfland, Michael / Smith, Jesse S / Prakapenka, Vitali B / Mahmood, Mohammad F / Goncharov, Alexander F / Ponomareva, Alena V / Tasnádi, Ferenc / Abrikosov, Alexei I / Bin Masood, Talha / Hotz, Ingrid / Rudenko, Alexander N / Katsnelson, Mikhail I / Dubrovinskaia, Natalia / Dubrovinsky, Leonid /
    Abrikosov, Igor A

    Physical review letters

    2021  Volume 126, Issue 17, Page(s) 175501

    Abstract: ... material BeN_{4}. A triclinic phase of beryllium tetranitride tr-BeN_{4} was synthesized from elements ... BeN_{4} layers interconnected via weak van der Waals bonds and consisting of polyacetylene-like ... calculations for a single BeN_{4} layer show that its electronic lattice is described by a slightly distorted ...

    Abstract High-pressure chemistry is known to inspire the creation of unexpected new classes of compounds with exceptional properties. Here, we employ the laser-heated diamond anvil cell technique for synthesis of a Dirac material BeN_{4}. A triclinic phase of beryllium tetranitride tr-BeN_{4} was synthesized from elements at ∼85  GPa. Upon decompression to ambient conditions, it transforms into a compound with atomic-thick BeN_{4} layers interconnected via weak van der Waals bonds and consisting of polyacetylene-like nitrogen chains with conjugated π systems and Be atoms in square-planar coordination. Theoretical calculations for a single BeN_{4} layer show that its electronic lattice is described by a slightly distorted honeycomb structure reminiscent of the graphene lattice and the presence of Dirac points in the electronic band structure at the Fermi level. The BeN_{4} layer, i.e., beryllonitrene, represents a qualitatively new class of 2D materials that can be built of a metal atom and polymeric nitrogen chains and host anisotropic Dirac fermions.
    Language English
    Publishing date 2021-05-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.126.175501
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    In stock of ZB MED Bonn / Germany

    Z 4' 58/153: Show issues

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  4. Article ; Online: Review of Neil Selwyn, Felicitas Macgilchrist, and Ben Williamson (2020). Digital Education after COVID-19. TECHLASH, 1

    Smith, Mark

    Postdigital Science and Education ; ISSN 2524-485X 2524-4868

    2020  

    Keywords covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    DOI 10.1007/s42438-020-00184-7
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Effects of the aldehyde dehydrogenase inhibitor disulfiram on the plasma pharmacokinetics, metabolism, and toxicity of benzaldehyde dimethane sulfonate (NSC281612, DMS612, BEN) in mice.

    Parise, Robert A / Beumer, Jan H / Clausen, Dana M / Rigatti, Lora H / Ziegler, Judy A / Gasparetto, Maura / Smith, Clayton A / Eiseman, Julie L

    Cancer chemotherapy and pharmacology

    2013  Volume 72, Issue 6, Page(s) 1195–1204

    Abstract: Purpose: Benzaldehyde dimethane sulfonate (DMS612, NSC281612, BEN) is an alkylator with activity ... against renal cell carcinoma, currently in phase I trials. In blood, BEN is rapidly metabolized ... that BEN is metabolized to BA by aldehyde dehydrogenase (ALDH) and aimed to increase BEN exposure in blood ...

    Abstract Purpose: Benzaldehyde dimethane sulfonate (DMS612, NSC281612, BEN) is an alkylator with activity against renal cell carcinoma, currently in phase I trials. In blood, BEN is rapidly metabolized into its highly reactive carboxylic acid (BA), presumably the predominant alkylating species. We hypothesized that BEN is metabolized to BA by aldehyde dehydrogenase (ALDH) and aimed to increase BEN exposure in blood and tissues by inhibiting ALDH with disulfiram, thereby shifting BA production from blood to tissues.
    Methods: Female CD2F1 mice were dosed with 20 mg/kg BEN iv alone or 24 h after 300 mg/kg disulfiram ip. BEN, BA, and metabolites were quantitated in plasma and urine, and toxicities were assessed.
    Results: BEN had a plasma t½ <5 min and produced at least 12 products. The metabolite half-lives were <136 min. Disulfiram increased BEN plasma exposure 368-fold (AUC0-inf from 0.11 to 40.5 mg/L min), while plasma levels of BA remained similar. Urinary BEN excretion increased (1.0-1.5 % of dose), while BA excretion was unchanged. Hematocrit, white blood cell counts, and percentage lymphocytes decreased after BEN administration. Coadministration of disulfiram appeared to enhance these effects. Profound liver pathology was observed in mice treated with disulfiram and BEN.
    Conclusions: BEN plasma concentrations increased after administration of disulfiram, suggesting that ALDH mediates the rapid metabolism of BEN in vivo, which may explain the increased toxicity seen with BEN after administration of disulfiram. Our results suggest that the coadministration of BEN with drugs that inhibit ALDH to patients that are ALDH deficient may cause liver damage.
    MeSH term(s) Aldehyde Dehydrogenase/antagonists & inhibitors ; Animals ; Antineoplastic Agents/pharmacokinetics ; Antineoplastic Agents/toxicity ; Area Under Curve ; Benzaldehydes/pharmacokinetics ; Benzaldehydes/toxicity ; Chemical and Drug Induced Liver Injury/etiology ; Chemical and Drug Induced Liver Injury/pathology ; Disulfiram/pharmacology ; Drug Interactions ; Enzyme Inhibitors/pharmacology ; Female ; Half-Life ; Mice
    Chemical Substances Antineoplastic Agents ; Benzaldehydes ; Enzyme Inhibitors ; NSC281612 ; Aldehyde Dehydrogenase (EC 1.2.1.3) ; Disulfiram (TR3MLJ1UAI)
    Language English
    Publishing date 2013-09-24
    Publishing country Germany
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural
    ZDB-ID 6820-2
    ISSN 1432-0843 ; 0344-5704 ; 0943-9404
    ISSN (online) 1432-0843
    ISSN 0344-5704 ; 0943-9404
    DOI 10.1007/s00280-013-2296-5
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1420: Show issues Location:
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  6. Article: The ben gene of bacteriophage lambda. Mapping, identification and control of synthesis.

    Sumner-Smith, M / Benchimol, S / Murialdo, H / Becker, A

    Journal of molecular biology

    1982  Volume 160, Issue 1, Page(s) 1–22

    MeSH term(s) Bacteriophage lambda/genetics ; Chromosome Mapping ; Electrophoresis, Agar Gel ; Endonucleases/biosynthesis ; Endonucleases/genetics ; Gene Expression Regulation ; Genes, Viral ; Mutation ; Phenotype ; Protein Biosynthesis ; Transcription, Genetic ; Viral Proteins/genetics
    Chemical Substances Viral Proteins ; Endonucleases (EC 3.1.-)
    Language English
    Publishing date 1982-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 80229-3
    ISSN 1089-8638 ; 0022-2836
    ISSN (online) 1089-8638
    ISSN 0022-2836
    DOI 10.1016/0022-2836(82)90128-0
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    Zs.A 867: Show issues Location:
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  7. Article ; Online: Tolerance-conferring defensive symbionts and the evolution of parasite virulence.

    Smith, Cameron A / Ashby, Ben

    Evolution letters

    2023  Volume 7, Issue 4, Page(s) 262–272

    Abstract: Defensive symbionts in the host microbiome can confer protection from infection or reduce the harms of being infected by a parasite. Defensive symbionts are therefore promising agents of biocontrol that could be used to control or ameliorate the impact ... ...

    Abstract Defensive symbionts in the host microbiome can confer protection from infection or reduce the harms of being infected by a parasite. Defensive symbionts are therefore promising agents of biocontrol that could be used to control or ameliorate the impact of infectious diseases. Previous theory has shown how symbionts can evolve along the parasitism-mutualism continuum to confer greater or lesser protection to their hosts and in turn how hosts may coevolve with their symbionts to potentially form a mutualistic relationship. However, the consequences of introducing a defensive symbiont for parasite evolution and how the symbiont may coevolve with the parasite have received relatively little theoretical attention. Here, we investigate the ecological and evolutionary implications of introducing a tolerance-conferring defensive symbiont into an established host-parasite system. We show that while the defensive symbiont may initially have a positive impact on the host population, parasite and symbiont evolution tend to have a net negative effect on the host population in the long term. This is because the introduction of the defensive symbiont always selects for an increase in parasite virulence and may cause diversification into high- and low-virulence strains. Even if the symbiont experiences selection for greater host protection, this simply increases selection for virulence in the parasite, resulting in a net negative effect on the host population. Our results therefore suggest that tolerance-conferring defensive symbionts may be poor biocontrol agents for population-level infectious disease control.
    Language English
    Publishing date 2023-05-05
    Publishing country England
    Document type Journal Article
    ISSN 2056-3744
    ISSN (online) 2056-3744
    DOI 10.1093/evlett/qrad015
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  8. Article: Nota bene. Awakening aurora.

    Smith, O

    Science (New York, N.Y.)

    2000  Volume 288, Issue 5463, Page(s) 69

    MeSH term(s) Animals ; Aurora Kinases ; Cell Cycle Proteins ; Genes, mos ; MAP Kinase Signaling System ; Meiosis ; Oocytes/cytology ; Oocytes/metabolism ; Phosphorylation ; Phosphoserine/metabolism ; Poly A/metabolism ; Progesterone/metabolism ; Protein Biosynthesis ; Protein Kinases/metabolism ; Protein-Serine-Threonine Kinases ; Proto-Oncogene Proteins c-mos/genetics ; Proto-Oncogene Proteins c-mos/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; RNA-Binding Proteins/metabolism ; Receptors, Progesterone/metabolism ; Transcription Factors/metabolism ; Xenopus ; Xenopus Proteins ; mRNA Cleavage and Polyadenylation Factors
    Chemical Substances Cell Cycle Proteins ; Cpeb1 protein, Xenopus ; RNA, Messenger ; RNA-Binding Proteins ; Receptors, Progesterone ; Transcription Factors ; Xenopus Proteins ; mRNA Cleavage and Polyadenylation Factors ; Phosphoserine (17885-08-4) ; Poly A (24937-83-5) ; Progesterone (4G7DS2Q64Y) ; Protein Kinases (EC 2.7.-) ; AURKA protein, Xenopus (EC 2.7.11.1) ; Aurora Kinases (EC 2.7.11.1) ; Protein-Serine-Threonine Kinases (EC 2.7.11.1) ; Proto-Oncogene Proteins c-mos (EC 2.7.11.1)
    Language English
    Publishing date 2000-04-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.288.5463.69
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    Zs.A 27: Show issues Location:
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    Zs.MG 77: Show issues

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  9. Article ; Online: Evolutionary characteristics of the mitochondrial NADH dehydrogenase subunit 6 gene in some populations of four sympatric Mustela species (Mustelidae, Mammalia) from central Europe.

    Tissaoui, Ghada / Suchentrunk, Franz / Awadi, Asma / Smith, Steve / Weber, Antje / Ben Slimen, Hichem

    Molecular biology reports

    2024  Volume 51, Issue 1, Page(s) 575

    Abstract: Background: Selection on or reticulate evolution of mtDNA is documented in various mammalian taxa and could lead to misleading phylogenetic conclusions if not recognized. We sequenced the MT-ND6 gene of four sympatric Mustelid species of the genus ... ...

    Abstract Background: Selection on or reticulate evolution of mtDNA is documented in various mammalian taxa and could lead to misleading phylogenetic conclusions if not recognized. We sequenced the MT-ND6 gene of four sympatric Mustelid species of the genus Mustela from some central European populations. We hypothesised positive selection on MT-ND6, given its functional importance and the different body sizes and life histories of the species, even though climatic differences may be unimportant for adaptation in sympatry.
    Methods and results: MT-ND6 genes were sequenced in 187 sympatric specimens of weasels, Mustela nivalis, stoats, M. erminea, polecats, M. putorius, and steppe polecats, M. eversmannii, from eastern Austria and of fourteen allopatric polecats from eastern-central Germany. Median joining networks, neighbour joining and maximum likelihood analyses as well as Bayesian inference grouped all species according to earlier published phylogenetic models. However, polecats and steppe polecats, two very closely related species, shared the same two haplotypes. We found only negative selection within the Mustela sequences, including 131 downloaded ones covering thirteen species. Positive selection was observed on three MT-ND6 codons of other mustelid genera retrieved from GenBank.
    Conclusions: Negative selection for MT-ND6 within the genus Mustela suggests absence of both environmental and species-specific effects of cellular energy metabolism despite large species-specific differences in body size. The presently found shared polymorphism in European polecats and steppe polecats may result from ancestral polymorphism before speciation and historical or recent introgressive hybridization; it may indicate mtDNA capture of steppe polecats by M. putorius in Europe.
    MeSH term(s) Animals ; Bayes Theorem ; DNA, Mitochondrial/genetics ; Europe ; Evolution, Molecular ; Genetics, Population ; Haplotypes/genetics ; Mustelidae/genetics ; NADH Dehydrogenase/genetics ; Phylogeny ; Selection, Genetic ; Sympatry/genetics
    Chemical Substances DNA, Mitochondrial ; NADH Dehydrogenase (EC 1.6.99.3) ; MT-ND6 protein, human (EC 1.6.99.3)
    Language English
    Publishing date 2024-04-25
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 186544-4
    ISSN 1573-4978 ; 0301-4851
    ISSN (online) 1573-4978
    ISSN 0301-4851
    DOI 10.1007/s11033-024-09505-6
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1140: Show issues Location:
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  10. Article ; Online: Comparison of experiences of military foundation doctors in defence and civilian general practice.

    Bapty, James / Smith, Ben / Noakes, A / Dyke, G / Holland, T

    BMJ military health

    2023  

    Language English
    Publishing date 2023-09-25
    Publishing country England
    Document type Letter
    ZDB-ID 3011686-7
    ISSN 2633-3775 ; 2633-3767
    ISSN (online) 2633-3775
    ISSN 2633-3767
    DOI 10.1136/military-2023-002488
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    Un I Zs.541: Show issues Location:
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