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  1. Article: A novel study for automatic two-class COVID-19 diagnosis (between COVID-19 and Healthy, Pneumonia) on X-ray images using texture analysis and 2-D/3-D convolutional neural networks.

    Yaşar, Huseyin / Ceylan, Murat

    Multimedia systems

    2022  , Page(s) 1–19

    Abstract: The pandemic caused by the COVID-19 virus affects the world widely and heavily. When examining the CT, X-ray, and ultrasound images, radiologists must first determine whether there are signs of COVID-19 in the images. That is, COVID-19/Healthy detection ... ...

    Abstract The pandemic caused by the COVID-19 virus affects the world widely and heavily. When examining the CT, X-ray, and ultrasound images, radiologists must first determine whether there are signs of COVID-19 in the images. That is, COVID-19/Healthy detection is made. The second determination is the separation of pneumonia caused by the COVID-19 virus and pneumonia caused by a bacteria or virus other than COVID-19. This distinction is key in determining the treatment and isolation procedure to be applied to the patient. In this study, which aims to diagnose COVID-19 early using X-ray images, automatic two-class classification was carried out in four different titles: COVID-19/Healthy, COVID-19 Pneumonia/Bacterial Pneumonia, COVID-19 Pneumonia/Viral Pneumonia, and COVID-19 Pneumonia/Other Pneumonia. For this study, 3405 COVID-19, 2780 Bacterial Pneumonia, 1493 Viral Pneumonia, and 1989 Healthy images obtained by combining eight different data sets with open access were used. In the study, besides using the original X-ray images alone, classification results were obtained by accessing the images obtained using Local Binary Pattern (LBP) and Local Entropy (LE). The classification procedures were repeated for the images that were combined with the original images, LBP, and LE images in various combinations. 2-D CNN (Two-Dimensional Convolutional Neural Networks) and 3-D CNN (Three-Dimensional Convolutional Neural Networks) architectures were used as classifiers within the scope of the study. Mobilenetv2, Resnet101, and Googlenet architectures were used in the study as a 2-D CNN. A 24-layer 3-D CNN architecture has also been designed and used. Our study is the first to analyze the effect of diversification of input data type on classification results of 2-D/3-D CNN architectures. The results obtained within the scope of the study indicate that diversifying X-ray images with tissue analysis methods in the diagnosis of COVID-19 and including CNN input provides significant improvements in the results. Also, it is understood that the 3-D CNN architecture can be an important alternative to achieve a high classification result.
    Language English
    Publishing date 2022-01-29
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1463005-9
    ISSN 1432-1882 ; 0942-4962
    ISSN (online) 1432-1882
    ISSN 0942-4962
    DOI 10.1007/s00530-022-00892-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Deep Learning-Based Approaches to Improve Classification Parameters for Diagnosing COVID-19 from CT Images.

    Yasar, Huseyin / Ceylan, Murat

    Cognitive computation

    2021  , Page(s) 1–28

    Abstract: Patients infected with the COVID-19 virus develop severe pneumonia, which generally leads to death. Radiological evidence has demonstrated that the disease causes interstitial involvement in the lungs and lung opacities, as well as bilateral ground-glass ...

    Abstract Patients infected with the COVID-19 virus develop severe pneumonia, which generally leads to death. Radiological evidence has demonstrated that the disease causes interstitial involvement in the lungs and lung opacities, as well as bilateral ground-glass opacities and patchy opacities. In this study, new pipeline suggestions are presented, and their performance is tested to decrease the number of false-negative (FN), false-positive (FP), and total misclassified images (FN + FP) in the diagnosis of COVID-19 (COVID-19/non-COVID-19 and COVID-19 pneumonia/other pneumonia) from CT lung images. A total of 4320 CT lung images, of which 2554 were related to COVID-19 and 1766 to non-COVID-19, were used for the test procedures in COVID-19 and non-COVID-19 classifications. Similarly, a total of 3801 CT lung images, of which 2554 were related to COVID-19 pneumonia and 1247 to other pneumonia, were used for the test procedures in COVID-19 pneumonia and other pneumonia classifications. A 24-layer convolutional neural network (CNN) architecture was used for the classification processes. Within the scope of this study, the results of two experiments were obtained by using CT lung images with and without local binary pattern (LBP) application, and sub-band images were obtained by applying dual-tree complex wavelet transform (DT-CWT) to these images. Next, new classification results were calculated from these two results by using the five pipeline approaches presented in this study. For COVID-19 and non-COVID-19 classification, the highest sensitivity, specificity, accuracy, F-1, and AUC values obtained without using pipeline approaches were 0.9676, 0.9181, 0.9456, 0.9545, and 0.9890, respectively; using pipeline approaches, the values were 0.9832, 0.9622, 0.9577, 0.9642, and 0.9923, respectively. For COVID-19 pneumonia/other pneumonia classification, the highest sensitivity, specificity, accuracy, F-1, and AUC values obtained without using pipeline approaches were 0.9615, 0.7270, 0.8846, 0.9180, and 0.9370, respectively; using pipeline approaches, the values were 0.9915, 0.8140, 0.9071, 0.9327, and 0.9615, respectively. The results of this study show that classification success can be increased by reducing the time to obtain per-image results through using the proposed pipeline approaches.
    Language English
    Publishing date 2021-07-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2486574-6
    ISSN 1866-9964 ; 1866-9956
    ISSN (online) 1866-9964
    ISSN 1866-9956
    DOI 10.1007/s12559-021-09915-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The use of calprotectin and other inflammatory parameters in the investigation of pseudoexfoliation syndrome concomitant glaucoma and systemic diseases.

    Yasar, Erdogan / Erdal, Huseyin / Tuncer, Sibel Cigdem / Yagcı, Betul Akbulut

    Indian journal of ophthalmology

    2023  Volume 72, Issue Suppl 3, Page(s) S393–S397

    Abstract: Purpose: The present study aimed to investigate the value of calprotectin and other inflammatory parameters in patients with glaucoma and systemic diseases accompanying pseudoexfoliation syndrome (PEX-S).: Methods: This prospective study included 45 ... ...

    Abstract Purpose: The present study aimed to investigate the value of calprotectin and other inflammatory parameters in patients with glaucoma and systemic diseases accompanying pseudoexfoliation syndrome (PEX-S).
    Methods: This prospective study included 45 PEX-S patients and 45 non-PEX control patients. Patients were investigated for the presence of glaucoma, cardiovascular disease (CVD), ischemic brain disease (IBD), Alzheimer's disease, and neurosensory hearing loss (NSHL). After excluding diseases that may affect inflammatory parameters, a detailed biomicroscopic examination, and blood tests were performed for the patients.
    Results: Glaucoma, CVD, NVK, Alzheimer's disease, and NSHL were high in the PEX-S group ( P = 0.01, P = 0.01, P = 0.04, P = 0.04, and P = 0.03, respectively). Calprotectin, ferritin, neutrophil-to-platelet ratio, and lymphocyte-to-platelet ratio were found to be high in the PEX-S group ( P < 0.01, P = 0.04, P < 0.01, and P < 0.01, respectively). On evaluating the relationship between PEX-S and glaucoma and systemic diseases, it was found that elevated calprotectin increased the risk of glaucoma by 4.36 times and elevated neutrophil-to-lymphocyte ratio (NLR) increased the risk of CVD by 3.23 times in PEX-S patients ( P = 0.02 and P = 0.03, respectively).
    Conclusion: This study demonstrated the value of calprotectin elevation in detecting concomitant glaucoma in PEX-S patients and, in addition, the value of NLR elevation in detecting concomitant CVD.
    Language English
    Publishing date 2023-12-15
    Publishing country India
    Document type Journal Article
    ZDB-ID 187392-1
    ISSN 1998-3689 ; 0301-4738
    ISSN (online) 1998-3689
    ISSN 0301-4738
    DOI 10.4103/IJO.IJO_914_23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: A novel comparative study for detection of Covid-19 on CT lung images using texture analysis, machine learning, and deep learning methods.

    Yasar, Huseyin / Ceylan, Murat

    Multimedia tools and applications

    2020  Volume 80, Issue 4, Page(s) 5423–5447

    Abstract: The Covid-19 virus outbreak that emerged in China at the end of 2019 caused a huge and devastating effect worldwide. In patients with severe symptoms of the disease, pneumonia develops due to Covid-19 virus. This causes intense involvement and damage in ... ...

    Abstract The Covid-19 virus outbreak that emerged in China at the end of 2019 caused a huge and devastating effect worldwide. In patients with severe symptoms of the disease, pneumonia develops due to Covid-19 virus. This causes intense involvement and damage in lungs. Although the emergence of the disease occurred a short time ago, many literature studies have been carried out in which these effects of the disease on the lungs were revealed by the help of lung CT imaging. In this study, 1.396 lung CT images in total (386 Covid-19 and 1.010 Non-Covid-19) were subjected to automatic classification. In this study, Convolutional Neural Network (CNN), one of the deep learning methods, was used which suggested automatic classification of CT images of lungs for early diagnosis of Covid-19 disease. In addition, k-Nearest Neighbors (k-NN) and Support Vector Machine (SVM) was used to compare the classification successes of deep learning with machine learning. Within the scope of the study, a 23-layer CNN architecture was designed and used as a classifier. Also, training and testing processes were performed for Alexnet and Mobilenetv2 CNN architectures as well. The classification results were also calculated for the case of increasing the number of images used in training for the first 23-layer CNN architecture by 5, 10, and 20 times using data augmentation methods. To reveal the effect of the change in the number of images in the training and test clusters on the results, two different training and testing processes, 2-fold and 10-fold cross-validation, were performed and the results of the study were calculated. As a result, thanks to these detailed calculations performed within the scope of the study, a comprehensive comparison of the success of the texture analysis method, machine learning, and deep learning methods in Covid-19 classification from CT images was made. The highest mean sensitivity, specificity, accuracy, F-1 score, and AUC values obtained as a result of the study were 0,9197, 0,9891, 0,9473, 0,9058, 0,9888; respectively for 2-fold cross-validation, and they were 0,9404, 0,9901, 0,9599, 0,9284, 0,9903; respectively for 10-fold cross-validation.
    Keywords covid19
    Language English
    Publishing date 2020-10-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1479928-5
    ISSN 1573-7721 ; 1380-7501
    ISSN (online) 1573-7721
    ISSN 1380-7501
    DOI 10.1007/s11042-020-09894-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A new deep learning pipeline to detect Covid-19 on chest X-ray images using local binary pattern, dual tree complex wavelet transform and convolutional neural networks.

    Yasar, Huseyin / Ceylan, Murat

    Applied intelligence (Dordrecht, Netherlands)

    2020  Volume 51, Issue 5, Page(s) 2740–2763

    Abstract: In this study, which aims at early diagnosis of Covid-19 disease using X-ray images, the deep-learning approach, a state-of-the-art artificial intelligence method, was used, and automatic classification of images was performed using convolutional neural ... ...

    Abstract In this study, which aims at early diagnosis of Covid-19 disease using X-ray images, the deep-learning approach, a state-of-the-art artificial intelligence method, was used, and automatic classification of images was performed using convolutional neural networks (CNN). In the first training-test data set used in the study, there were 230 X-ray images, of which 150 were Covid-19 and 80 were non-Covid-19, while in the second training-test data set there were 476 X-ray images, of which 150 were Covid-19 and 326 were non-Covid-19. Thus, classification results have been provided for two data sets, containing predominantly Covid-19 images and predominantly non-Covid-19 images, respectively. In the study, a 23-layer CNN architecture and a 54-layer CNN architecture were developed. Within the scope of the study, the results were obtained using chest X-ray images directly in the training-test procedures and the sub-band images obtained by applying dual tree complex wavelet transform (DT-CWT) to the above-mentioned images. The same experiments were repeated using images obtained by applying local binary pattern (LBP) to the chest X-ray images. Within the scope of the study, four new result generation pipeline algorithms having been put forward additionally, it was ensured that the experimental results were combined and the success of the study was improved. In the experiments carried out in this study, the training sessions were carried out using the k-fold cross validation method. Here the k value was chosen as 23 for the first and second training-test data sets. Considering the average highest results of the experiments performed within the scope of the study, the values of sensitivity, specificity, accuracy, F-1 score, and area under the receiver operating characteristic curve (AUC) for the first training-test data set were 0,9947, 0,9800, 0,9843, 0,9881 and 0,9990 respectively; while for the second training-test data set, they were 0,9920, 0,9939, 0,9891, 0,9828 and 0,9991; respectively. Within the scope of the study, finally, all the images were combined and the training and testing processes were repeated for a total of 556 X-ray images comprising 150 Covid-19 images and 406 non-Covid-19 images, by applying 2-fold cross. In this context, the average highest values of sensitivity, specificity, accuracy, F-1 score, and AUC for this last training-test data set were found to be 0,9760, 1,0000, 0,9906, 0,9823 and 0,9997; respectively.
    Language English
    Publishing date 2020-11-04
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1479519-X
    ISSN 1573-7497 ; 0924-669X
    ISSN (online) 1573-7497
    ISSN 0924-669X
    DOI 10.1007/s10489-020-02019-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Is serum vitamin D level a risk factor for idiopathic male fertility?

    Mustafa Ozan Horsanalı / Huseyin Eren / Alper Caglayan / Yasar Issi

    Journal of Men's Health, Vol 18, Iss 4, p

    2022  Volume 86

    Abstract: Background: Idiopathic male infertility is a health problem that is increasingly common worldwide. Aetiology of idiopathic male infertility is still controversial. In this cross-sectional retrospective study, we aimed to investigate the relationship ... ...

    Abstract Background: Idiopathic male infertility is a health problem that is increasingly common worldwide. Aetiology of idiopathic male infertility is still controversial. In this cross-sectional retrospective study, we aimed to investigate the relationship between serum vitamin D level and sperm quality in patients with idiopathic male infertility. Methods: Between June 2018 and June 2020, 297 patients including 147 men with idiopathic infertility (as a study group) and 150 fertile men (as a control group) were retrospectively enrolled into the study. Blood samples were collected, and these samples included serum sex steroids, serum vitamin D levels, glucose tests, lipid profiles, liver function tests and kidney function tests. At least two sperm analyses, scrotal doppler ultrasonography and karyotype analysis were performed on each of the patients. Demographic, laboratory and radiological features were also recorded. The Mann Whitney-U test was used to compare groups and quantitative independent data. The Chi-square test was used for qualitative independent data. Spearman’s correlation analysis was applied for correlation. Significant results were investigated and analysed further using the logistic regression test. Results: The mean age of the patients was 31.98 ± 6.97 years. The mean serum vitamin D level of the patients was 23.16 ± 10.40 ng/dL and the mean infertility duration of patients with idiopathic infertility was 29.88 ± 28.86 months. We observed statistical significance in terms of serum vitamin D levels, impaired total sperm motility, progressive sperm motility and sperm morphology in idiopathic infertile men when compared to fertile men. There were no statistically significant between idiopathic infertile men and fertile men in terms of serum testosterone levels. Conclusions: We observed a positive correlation between serum vitamin D levels and impaired sperm parameters, specifically in terms of sperm morphology, total sperm motility and progressive sperm motility. Vitamin D supplementation may be a ...
    Keywords infertility ; vitamin d ; testosterone ; semen ; spermiogram ; Medicine (General) ; R5-920
    Subject code 630
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher MRE Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: Evaluation of the Mechanical Properties and Drilling of Glass Bead/Fiber-Reinforced Polyamide 66 (PA66)-Based Hybrid Polymer Composites.

    Demirsöz, Recep / Yaşar, Nafiz / Korkmaz, Mehmet Erdi / Günay, Mustafa / Giasin, Khaled / Pimenov, Danil Yurievich / Aamir, Muhammad / Unal, Huseyin

    Materials (Basel, Switzerland)

    2022  Volume 15, Issue 8

    Abstract: In this study, mechanical testing of glass bead (GB), glass fiber (GF), and hybrid (GB/GF) composites was carried out. Following that, drilling tests were undertaken on glass bead/fiber-reinforced hybrid Polyamide 66 (PA66) polymer composites. The ... ...

    Abstract In this study, mechanical testing of glass bead (GB), glass fiber (GF), and hybrid (GB/GF) composites was carried out. Following that, drilling tests were undertaken on glass bead/fiber-reinforced hybrid Polyamide 66 (PA66) polymer composites. The purpose of this study is to determine the mechanical properties of the cutting elements and the effect of cutting parameters (spindle speed and feed rate) and reinforcement ratios on thrust force and surface roughness (Ra). The contribution of the cutting parameters to the investigated outcomes was determined using statistical analysis. Optical microscopy and scanning electron microscopy (SEM) was used to inspect the hole quality and damage mechanisms. The results revealed that the feed rate was the most contributing factor to thrust force (96.94%) and surface roughness (63.59%). Furthermore, in comparison to other hybrid composites, the lowest R
    Language English
    Publishing date 2022-04-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma15082765
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Can treatment with teicoplanin improve the prognosis of COVID-19 patients?

    Yasar, Zehra / Yemisen, Mucahit / Yasar, Huseyin / Ertaş, Aysun / Meric, Kaan / Sahin, Soner

    International journal of clinical practice

    2021  Volume 75, Issue 11, Page(s) e14752

    Abstract: Aim: In patients with COVID-19, no validated efficient treatment has been reported. Herein, we examine the effect of treatment with teicoplanin in hospitalised patients with COVID-19.: Methods: This retrospective study included 115 hospitalised ... ...

    Abstract Aim: In patients with COVID-19, no validated efficient treatment has been reported. Herein, we examine the effect of treatment with teicoplanin in hospitalised patients with COVID-19.
    Methods: This retrospective study included 115 hospitalised patients in one medical centre. Fifty-four patients with laboratory-confirmed COVID-19 who received teicoplanin plus standard care were included in the Teicoplanin arm of this study, whereas 61 patients who were treated with standard care (SC) according to the Turkish Health Organization guidelines were included in the control arm. Patients' baseline characteristics, clinical presentation, treatment and outcomes were compared between the two groups.
    Results: In this non-randomised control study, all baseline characteristics were comparable between the two arms and there were no significant differences in the presenting symptoms, comorbidities and clinical outcomes between the two groups. However, the mortality rate was significantly lower in the teicoplanin group than in the control group (1.9% vs 14.8%; P < .05). In addition, no adverse reactions were found in the teicoplanin arm.
    Conclusions: Teicoplanin administration is associated significantly with lower mortality in hospitalised patients with COVID-19 in our study. Further clinical investigations is required to verify the role of teicoplanin in COVID-19 patients.
    MeSH term(s) COVID-19 ; Humans ; Prognosis ; Retrospective Studies ; SARS-CoV-2 ; Teicoplanin/therapeutic use ; Treatment Outcome
    Chemical Substances Teicoplanin (61036-62-2)
    Language English
    Publishing date 2021-09-18
    Publishing country England
    Document type Clinical Trial ; Journal Article
    ZDB-ID 1386246-7
    ISSN 1742-1241 ; 1368-5031
    ISSN (online) 1742-1241
    ISSN 1368-5031
    DOI 10.1111/ijcp.14752
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Individual Differences in Plate Wasting Behavior: The Roles of Dispositional Greed, Impulsivity, Food Satisfaction, and Ecolabeling.

    Üngüren, Engin / Tekin, Ömer Akgün / Avsallı, Hüseyin / Kaçmaz, Yaşar Yiğit

    Behavioral sciences (Basel, Switzerland)

    2023  Volume 13, Issue 8

    Abstract: This study examines the effects of dispositional greed, impulsivity, food satisfaction, and ecolabeling on consumers' plate waste in all-inclusive hotels. Using a moderated mediation research model, a cross-sectional survey was conducted among 1253 ... ...

    Abstract This study examines the effects of dispositional greed, impulsivity, food satisfaction, and ecolabeling on consumers' plate waste in all-inclusive hotels. Using a moderated mediation research model, a cross-sectional survey was conducted among 1253 tourists of different nationalities, all staying in five-star hotels in Alanya, Türkiye. The results show that both dispositional greed and impulsivity positively predict and significantly contribute to plate waste. Conversely, food satisfaction was found to be an influential variable that moderates the effects of greed and impulsivity on plate waste, highlighting its critical role in waste reduction strategies. Ecolabels, despite their intended purpose, were not found to have a significant impact on consumer attitudes toward plate waste. Future research is encouraged to explore strategies to counteract dispositional greed and impulsivity, given their significant impact on plate waste behavior. At the same time, refining methods to promote food satisfaction and the effective use of ecolabels may contribute significantly to reducing plate waste in all-inclusive resorts. This research contributes to our understanding of the psychological factors that influence consumer behavior in buffet settings and provides guidance to hospitality industry practitioners seeking to reduce waste.
    Language English
    Publishing date 2023-07-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2651997-5
    ISSN 2076-328X
    ISSN 2076-328X
    DOI 10.3390/bs13080626
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: A novel comparative study for detection of Covid-19 on CT lung images using texture analysis, machine learning, and deep learning methods

    Yasar, Huseyin / Ceylan, Murat

    Multimed Tools Appl

    Abstract: The Covid-19 virus outbreak that emerged in China at the end of 2019 caused a huge and devastating effect worldwide. In patients with severe symptoms of the disease, pneumonia develops due to Covid-19 virus. This causes intense involvement and damage in ... ...

    Abstract The Covid-19 virus outbreak that emerged in China at the end of 2019 caused a huge and devastating effect worldwide. In patients with severe symptoms of the disease, pneumonia develops due to Covid-19 virus. This causes intense involvement and damage in lungs. Although the emergence of the disease occurred a short time ago, many literature studies have been carried out in which these effects of the disease on the lungs were revealed by the help of lung CT imaging. In this study, 1.396 lung CT images in total (386 Covid-19 and 1.010 Non-Covid-19) were subjected to automatic classification. In this study, Convolutional Neural Network (CNN), one of the deep learning methods, was used which suggested automatic classification of CT images of lungs for early diagnosis of Covid-19 disease. In addition, k-Nearest Neighbors (k-NN) and Support Vector Machine (SVM) was used to compare the classification successes of deep learning with machine learning. Within the scope of the study, a 23-layer CNN architecture was designed and used as a classifier. Also, training and testing processes were performed for Alexnet and Mobilenetv2 CNN architectures as well. The classification results were also calculated for the case of increasing the number of images used in training for the first 23-layer CNN architecture by 5, 10, and 20 times using data augmentation methods. To reveal the effect of the change in the number of images in the training and test clusters on the results, two different training and testing processes, 2-fold and 10-fold cross-validation, were performed and the results of the study were calculated. As a result, thanks to these detailed calculations performed within the scope of the study, a comprehensive comparison of the success of the texture analysis method, machine learning, and deep learning methods in Covid-19 classification from CT images was made. The highest mean sensitivity, specificity, accuracy, F-1 score, and AUC values obtained as a result of the study were 0,9197, 0,9891, 0,9473, 0,9058, 0,9888; respectively for 2-fold cross-validation, and they were 0,9404, 0,9901, 0,9599, 0,9284, 0,9903; respectively for 10-fold cross-validation.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #846755
    Database COVID19

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