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  1. Article ; Online: A novel concept of human antiviral protection: It's all about RNA (Review).

    Aripova, Tamara / Muratkhodjaev, Javdat

    Biomedical reports

    2022  Volume 16, Issue 4, Page(s) 29

    Abstract: The comparative analysis of the antiviral protective mechanisms, including protozoa and RNA interference in multicellular organisms, has revealed their similarity and provided a basic understanding of adaptive immunity. The present article summarizes the ...

    Abstract The comparative analysis of the antiviral protective mechanisms, including protozoa and RNA interference in multicellular organisms, has revealed their similarity and provided a basic understanding of adaptive immunity. The present article summarizes the latest studies on RNA-guided gene regulation in human antiviral protection, and its importance. Additionally, the role of both neutralizing antibodies and the interferon system in viral invasion is considered. The interferon system is an additional mechanism for suppressing viral infections in humans, which shifts cells into an 'alarm' mode to attempt to prevent further contagion. The primary task of the human central immune system is to maintain integrity and to protect against foreign organisms. In this review, a novel concept is proposed: Antiviral protection in all organisms can be achieved through an intracellular RNA-guided mechanism. A simple and effective defence against viruses is incorporation of a part of a virus's DNA (spacer) into the hosts chromosomes. Following reinfection, RNA transcripts of this spacer are created to direct nuclease enzymes to destroy the viral genome. This is an example of real-time adaptive immunity potentially possessed by every cell with a full complement of chromosomes, and an indicator that antiviral immunity is not only mediated by the presence of neutralizing antibodies and memory B- and T-cells, but also by the presence of specific spacers in the DNA of individuals who have recovered from a viral infection.
    Language English
    Publishing date 2022-02-18
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2763624-0
    ISSN 2049-9442 ; 2049-9434
    ISSN (online) 2049-9442
    ISSN 2049-9434
    DOI 10.3892/br.2022.1512
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Tomato-made edible COVID-19 vaccine TOMAVAC induces neutralizing IgGs in the blood sera of mice and humans.

    Buriev, Zabardast T / Shermatov, Shukhrat E / Usmanov, Dilshod E / Mirzakhmedov, Mukhammadjon K / Ubaydullaeva, Khurshida A / Kamburova, Venera S / Rakhmanov, Bakhtiyor K / Ayubov, Mirzakamol S / Abdullaev, Adkham N / Eshmurzaev, Jakhongir B / Mamajonov, Behzod O / Tulanov, Akmal A / Ismailova, Adolat A / Petrova, Tatyana A / Rozumbetov, Ramazan J / Aripova, Tamara U / Muminov, Muzaffar I / Ermatova, Khusnora Y / Dalimova, Dilbar A /
    Turdikulova, Shahlo U / Abdukarimov, Abdusattor / Abdurakhmonov, Ibrokhim Y

    Frontiers in nutrition

    2024  Volume 10, Page(s) 1275307

    Abstract: Plant-based edible vaccines that provide two-layered protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outweigh the currently used parenteral types of vaccines, which predominantly cause a systemic immune response. Here, we ... ...

    Abstract Plant-based edible vaccines that provide two-layered protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outweigh the currently used parenteral types of vaccines, which predominantly cause a systemic immune response. Here, we engineered and selected a transgenic tomato genotype (TOMAVAC) that stably synthesized an antigenic S1 protein of SARS-CoV-2. Two-course spaced force-feeding of mice with ≈5.4 μg/ml TOMAVAC increased up to 16-fold the synthesis of RBD-specific NAbs in blood serum and the significant induction of S-IgA in intestinal lavage fluid. In a surrogate virus neutralization test, TOMAVAC-induced NAbs had 15-25% viral neutralizing activity. The results suggested early evidence of the immunogenicity and protectivity of TOMAVAC against the coronavirus disease 2019 (COVID-19) infection. Furthermore, we observed a positive trend of statistically significant 1.2-fold (average of +42.28 BAU/ml) weekly increase in NAbs in the volunteers' serum relative to the initial day. No severe side effects were observed, preliminarily supporting the safety of TOMAVAC. With the completion of future large-scale studies, higher-generation TOMAVAC should be a cost-effective, ecologically friendly, and widely applicable novel-generation COVID-19 vaccine, providing two-layered protection against SARS-CoV-2.
    Language English
    Publishing date 2024-01-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2776676-7
    ISSN 2296-861X
    ISSN 2296-861X
    DOI 10.3389/fnut.2023.1275307
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women.

    Steinthorsdottir, Valgerdur / McGinnis, Ralph / Williams, Nicholas O / Stefansdottir, Lilja / Thorleifsson, Gudmar / Shooter, Scott / Fadista, João / Sigurdsson, Jon K / Auro, Kirsi M / Berezina, Galina / Borges, Maria-Carolina / Bumpstead, Suzannah / Bybjerg-Grauholm, Jonas / Colgiu, Irina / Dolby, Vivien A / Dudbridge, Frank / Engel, Stephanie M / Franklin, Christopher S / Frigge, Michael L /
    Frisbaek, Yr / Geirsson, Reynir T / Geller, Frank / Gretarsdottir, Solveig / Gudbjartsson, Daniel F / Harmon, Quaker / Hougaard, David Michael / Hegay, Tatyana / Helgadottir, Anna / Hjartardottir, Sigrun / Jääskeläinen, Tiina / Johannsdottir, Hrefna / Jonsdottir, Ingileif / Juliusdottir, Thorhildur / Kalsheker, Noor / Kasimov, Abdumadjit / Kemp, John P / Kivinen, Katja / Klungsøyr, Kari / Lee, Wai K / Melbye, Mads / Miedzybrodska, Zosia / Moffett, Ashley / Najmutdinova, Dilbar / Nishanova, Firuza / Olafsdottir, Thorunn / Perola, Markus / Pipkin, Fiona Broughton / Poston, Lucilla / Prescott, Gordon / Saevarsdottir, Saedis / Salimbayeva, Damilya / Scaife, Paula Juliet / Skotte, Line / Staines-Urias, Eleonora / Stefansson, Olafur A / Sørensen, Karina Meden / Thomsen, Liv Cecilie Vestrheim / Tragante, Vinicius / Trogstad, Lill / Simpson, Nigel A B / Aripova, Tamara / Casas, Juan P / Dominiczak, Anna F / Walker, James J / Thorsteinsdottir, Unnur / Iversen, Ann-Charlotte / Feenstra, Bjarke / Lawlor, Deborah A / Boyd, Heather Allison / Magnus, Per / Laivuori, Hannele / Zakhidova, Nodira / Svyatova, Gulnara / Stefansson, Kari / Morgan, Linda

    Nature communications

    2020  Volume 11, Issue 1, Page(s) 5976

    Abstract: Preeclampsia is a serious complication of pregnancy, affecting both maternal and fetal health. In genome-wide association meta-analysis of European and Central Asian mothers, we identify sequence variants that associate with preeclampsia in the maternal ... ...

    Abstract Preeclampsia is a serious complication of pregnancy, affecting both maternal and fetal health. In genome-wide association meta-analysis of European and Central Asian mothers, we identify sequence variants that associate with preeclampsia in the maternal genome at ZNF831/20q13 and FTO/16q12. These are previously established variants for blood pressure (BP) and the FTO variant has also been associated with body mass index (BMI). Further analysis of BP variants establishes that variants at MECOM/3q26, FGF5/4q21 and SH2B3/12q24 also associate with preeclampsia through the maternal genome. We further show that a polygenic risk score for hypertension associates with preeclampsia. However, comparison with gestational hypertension indicates that additional factors modify the risk of preeclampsia.
    MeSH term(s) Adaptor Proteins, Signal Transducing/genetics ; Adult ; Aged ; Alpha-Ketoglutarate-Dependent Dioxygenase FTO/genetics ; Asia, Central/epidemiology ; Blood Pressure/genetics ; Case-Control Studies ; Datasets as Topic ; Europe/epidemiology ; Female ; Fibroblast Growth Factor 5/genetics ; Genetic Loci/genetics ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Humans ; Hypertension, Pregnancy-Induced/epidemiology ; Hypertension, Pregnancy-Induced/genetics ; MDS1 and EVI1 Complex Locus Protein/genetics ; Middle Aged ; Multifactorial Inheritance ; Pre-Eclampsia/epidemiology ; Pre-Eclampsia/genetics ; Pregnancy ; Prospective Studies
    Chemical Substances Adaptor Proteins, Signal Transducing ; FGF5 protein, human ; MDS1 and EVI1 Complex Locus Protein ; MECOM protein, human ; SH2B3 protein, human ; Fibroblast Growth Factor 5 (129653-64-1) ; Alpha-Ketoglutarate-Dependent Dioxygenase FTO (EC 1.14.11.33) ; FTO protein, human (EC 1.14.11.33)
    Language English
    Publishing date 2020-11-25
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-020-19733-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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