LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 2314

Search options

  1. Article ; Online: Assessment of the Selenoprotein M (SELM) over-expression on human hepatocellular carcinoma tissues by immunohistochemistry.

    Guerriero, E / Accardo, M / Capone, F / Colonna, G / Castello, G / Costantini, S

    European journal of histochemistry : EJH

    2014  Volume 58, Issue 4, Page(s) 2433

    Abstract: ... its biological function through selenoproteins. In particular, Selenoprotein M (SELM) is located ...

    Abstract Selenium is an essential trace mineral of fundamental importance to human healthy and exerts its biological function through selenoproteins. In particular, Selenoprotein M (SELM) is located in the endoplasmic reticulum and contains the common redox motif of cysteine-X-X-selenocysteine type. It attracts great attention due to its high expression in brain and its potential roles as antioxidant, neuroprotective, and cytosolic calcium regulator. Recently, our group found SELM over-expression  in human hepatocellular carcinoma (HCC) cell lines. In this report some paraffin-embedded tissues from liver biopsy of patients with hepatitis C virus (HCV)-related cirrhosis and HCC were immunohistochemically stained and SELM expression scoring was evaluated. Our results evidence for the first time an increase of SELM expression in HCC liver tissues, and its gradual expression raise associated with an increased malignancy grade. Therefore, we propose to use i) SELM as putative marker for HCC as well as ii) simple immunohistochemistry technique to distinguish between the different grades of malignancy.
    MeSH term(s) Aged ; Aged, 80 and over ; Carcinoma, Hepatocellular/metabolism ; Carcinoma, Hepatocellular/pathology ; Female ; Gene Expression Regulation, Neoplastic ; Hepatitis C/metabolism ; Hepatitis C/pathology ; Humans ; Immunohistochemistry ; Liver Cirrhosis/metabolism ; Liver Cirrhosis/pathology ; Liver Neoplasms/metabolism ; Liver Neoplasms/pathology ; Male ; Middle Aged ; Neoplasm Proteins/biosynthesis ; Selenoproteins/biosynthesis
    Chemical Substances Neoplasm Proteins ; SELM protein, human ; Selenoproteins
    Language English
    Publishing date 2014-12-01
    Publishing country Italy
    Document type Clinical Trial ; Journal Article
    ZDB-ID 1109511-8
    ISSN 2038-8306 ; 0391-7258 ; 1121-4201 ; 1121-760X
    ISSN (online) 2038-8306
    ISSN 0391-7258 ; 1121-4201 ; 1121-760X
    DOI 10.4081/ejh.2014.2433
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 739: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article: Structure-function relationship and evolutionary history of the human selenoprotein M (SelM) found over-expressed in hepatocellular carcinoma.

    Guariniello, Stefano / Colonna, Giovanni / Raucci, Raffaele / Costantini, Maria / Di Bernardo, Gianni / Bergantino, Francesca / Castello, Giuseppe / Costantini, Susan

    Biochimica et biophysica acta

    2014  Volume 1844, Issue 2, Page(s) 447–456

    Abstract: ... immune-system protection and viral suppression. In particular, selenoprotein M (SelM) may function ...

    Abstract In humans we know 25 selenoproteins that play important roles in redox regulation, detoxification, immune-system protection and viral suppression. In particular, selenoprotein M (SelM) may function as thiol disulfide oxidoreductase that participates in the formation of disulfide bonds, and can be implicated in calcium responses. However, it presents a redox motif (CXXU), where U is a selenocysteine, and may also function as redox regulator because its decreased or increased expression regulated by dietary selenium alters redox homeostasis. No data are reported in literature about its involvement in cancer but only in neurodegenerative diseases. In this paper we evaluated the SelM expression in two hepatoma cell lines, HepG2 and Huh7, compared to normal hepatocytes. The results suggested its involvement in hepatocellular carcinoma (HCC) as well as its possible use to follow the progression of this cancer as putative marker. The aim of this study has been to analyze the structure-function relationships of SelM. Hence, firstly we studied the evolutionary history of this protein by phylogenetic analysis and GC content of genes from various species. So, we modeled the three-dimensional structure of the human SelM evaluating its energetic stability by molecular dynamics simulations. Moreover, we modeled some of its mutants to obtain structural information helpful for structure-based drug design.
    MeSH term(s) Amino Acid Sequence ; Carcinoma, Hepatocellular/enzymology ; Evolution, Molecular ; Hep G2 Cells ; Humans ; Liver Neoplasms/enzymology ; Models, Molecular ; Molecular Dynamics Simulation ; Molecular Sequence Data ; Phylogeny ; Selenoproteins/chemistry ; Selenoproteins/genetics ; Sequence Homology, Amino Acid ; Structure-Activity Relationship ; Tumor Cells, Cultured
    Chemical Substances SELM protein, human ; Selenoproteins
    Language English
    Publishing date 2014-02
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 60-7
    ISSN 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    ISSN (online) 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
    ISSN 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    DOI 10.1016/j.bbapap.2013.12.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.247: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Assessment of the Selenoprotein M (SELM) over-expression on human hepatocellular carcinoma tissues by immunohistochemistry

    E. Guerriero / M. Accardo / F. Capone / G. Colonna / G. Castello / S. Costantini

    European Journal of Histochemistry, Vol 58, Iss

    2014  Volume 4

    Abstract: ... its biological function through selenoproteins. In particular, Selenoprotein M (SELM) is located ...

    Abstract Selenium is an essential trace mineral of fundamental importance to human healthy and exerts its biological function through selenoproteins. In particular, Selenoprotein M (SELM) is located in the endoplasmic reticulum and contains the common redox motif of cysteine-X-X-selenocysteine type. It attracts great attention due to its high expression in brain and its potential roles as antioxidant, neuroprotective, and cytosolic calcium regulator. Recently, our group found SELM over-expression in human hepatocellular carcinoma (HCC) cell lines. In this report some paraffin-embedded tissues from liver biopsy of patients with hepatitis C virus (HCV)-related cirrhosis and HCC were immunohistochemically stained and SELM expression scoring was evaluated. Our results evidence for the first time an increase of SELM expression in HCC liver tissues, and its gradual expression raise associated with an increased malignancy grade. Therefore, we propose to use i) SELM as putative marker for HCC as well as ii) simple immunohistochemistry technique to distinguish between the different grades of malignancy.
    Keywords Hepatocellular carcinoma ; SELM ; immunohistochemistry ; Biology (General) ; QH301-705.5
    Subject code 616
    Language English
    Publishing date 2014-10-01T00:00:00Z
    Publisher PAGEPress Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article ; Online: The biology of TREM receptors.

    Colonna, Marco

    Nature reviews. Immunology

    2023  Volume 23, Issue 9, Page(s) 580–594

    Abstract: Triggering receptors expressed on myeloid cells (TREMs) encompass a family of cell-surface receptors chiefly expressed by granulocytes, monocytes and tissue macrophages. These receptors have been implicated in inflammation, neurodegenerative diseases, ... ...

    Abstract Triggering receptors expressed on myeloid cells (TREMs) encompass a family of cell-surface receptors chiefly expressed by granulocytes, monocytes and tissue macrophages. These receptors have been implicated in inflammation, neurodegenerative diseases, bone remodelling, metabolic syndrome, atherosclerosis and cancer. Here, I review the structure, ligands, signalling modes and functions of TREMs in humans and mice and discuss the challenges that remain in understanding TREM biology.
    MeSH term(s) Humans ; Animals ; Mice ; Triggering Receptor Expressed on Myeloid Cells-1 ; Receptors, Immunologic/metabolism ; Membrane Glycoproteins/metabolism ; Myeloid Cells/metabolism ; Biology
    Chemical Substances Triggering Receptor Expressed on Myeloid Cells-1 ; Receptors, Immunologic ; Membrane Glycoproteins
    Language English
    Publishing date 2023-02-07
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 2062776-2
    ISSN 1474-1741 ; 1474-1733
    ISSN (online) 1474-1741
    ISSN 1474-1733
    DOI 10.1038/s41577-023-00837-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5565: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 34: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article: Overview: Themes in Innate Lymphoid Cell Biology.

    Colonna, Marco

    Advances in experimental medicine and biology

    2022  Volume 1365, Page(s) 1–6

    Abstract: Since their initial identification more than 10 years ago, innate lymphoid cells (ILCs) have emerged as denizens of an immune realm parallel to that of T cells. Here I highlight basic similarities shared by all and underscore features related to ... ...

    Abstract Since their initial identification more than 10 years ago, innate lymphoid cells (ILCs) have emerged as denizens of an immune realm parallel to that of T cells. Here I highlight basic similarities shared by all and underscore features related to development, tissue residency and regulation that distinguish ILCs from T cells. I further discuss the potential of ILCs as promising targets for therapeutic intervention in human diseases.
    MeSH term(s) Biology ; Cytokines ; Humans ; Immunity, Innate ; Lymphocytes ; T-Lymphocytes
    Chemical Substances Cytokines
    Language English
    Publishing date 2022-05-14
    Publishing country United States
    Document type Journal Article
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-981-16-8387-9_1
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Book ; Online: The Second Life of Natural Killer (NK) Cells

    Colonna, Marco / Sun, Joseph C. / Romagnani, Chiara

    2018  

    Abstract: Natural Killer (NK) cells are innate lymphocytes, now recognized as members of a larger family of "Innate lymphoid cells" (ILCs). Both murine and human NK cells are well characterized effector cells with cytotoxic as well as cytokine production ability ... ...

    Abstract Natural Killer (NK) cells are innate lymphocytes, now recognized as members of a larger family of "Innate lymphoid cells" (ILCs). Both murine and human NK cells are well characterized effector cells with cytotoxic as well as cytokine production ability which mainly react in response to microbial and cell stress stimuli, thus playing a central role in the defense against pathogen infection, in tumor surveillance and in regulating immune homeostasis. Despite these established concepts, our understanding of the complexity of NK cells, also in view of their developmental and functional relationship with other ILC subsets, is only recently emerging. This Research Topic highlights the recent advances in NK cell (and ILC) research in human and mouse from basic research to clinical applications
    Keywords Medicine (General) ; Immunologic diseases. Allergy
    Size 1 electronic resource (118 p.)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020101860
    ISBN 9782889455461 ; 2889455467
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Article: Structure–function relationship and evolutionary history of the human selenoprotein M (SelM) found over-expressed in hepatocellular carcinoma

    Guariniello, Stefano / Francesca Bergantino / Gianni Di Bernardo / Giovanni Colonna / Giuseppe Castello / Maria Costantini / Raffaele Raucci / Susan Costantini

    BBA - Proteins and Proteomics. 2014 Feb., v. 1844

    2014  

    Abstract: ... immune-system protection and viral suppression. In particular, selenoprotein M (SelM) may function ...

    Abstract In humans we know 25 selenoproteins that play important roles in redox regulation, detoxification, immune-system protection and viral suppression. In particular, selenoprotein M (SelM) may function as thiol disulfide oxidoreductase that participates in the formation of disulfide bonds, and can be implicated in calcium responses. However, it presents a redox motif (CXXU), where U is a selenocysteine, and may also function as redox regulator because its decreased or increased expression regulated by dietary selenium alters redox homeostasis. No data are reported in literature about its involvement in cancer but only in neurodegenerative diseases. In this paper we evaluated the SelM expression in two hepatoma cell lines, HepG2 and Huh7, compared to normal hepatocytes. The results suggested its involvement in hepatocellular carcinoma (HCC) as well as its possible use to follow the progression of this cancer as putative marker. The aim of this study has been to analyze the structure–function relationships of SelM. Hence, firstly we studied the evolutionary history of this protein by phylogenetic analysis and GC content of genes from various species. So, we modeled the three-dimensional structure of the human SelM evaluating its energetic stability by molecular dynamics simulations. Moreover, we modeled some of its mutants to obtain structural information helpful for structure-based drug design.
    Keywords calcium ; disease course ; disulfide bonds ; drugs ; genes ; hepatocytes ; hepatoma ; homeostasis ; humans ; immune system ; molecular dynamics ; mutants ; neurodegenerative diseases ; phylogeny ; selenium ; selenocysteine ; selenoproteins ; structure-activity relationships ; thiols
    Language English
    Dates of publication 2014-02
    Size p. 447-456.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 2918798-9
    ISSN 1878-1454 ; 1570-9639
    ISSN (online) 1878-1454
    ISSN 1570-9639
    DOI 10.1016/j.bbapap.2013.12.001
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 7161: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Cortical laminar necrosis due to hypoglycemia in anti-CV2/CRMP5 paraneoplastic encephalitis: a curious association.

    Altomare, S / Colonna, I / Leone, R / Giorelli, M

    Acta neurologica Belgica

    2024  

    Language English
    Publishing date 2024-04-02
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 127315-2
    ISSN 2240-2993 ; 0300-9009
    ISSN (online) 2240-2993
    ISSN 0300-9009
    DOI 10.1007/s13760-024-02498-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ui I Zs.57: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article: Papulosi linfomatoide con evoluzione in m. di Hodgkin.

    Bernengo, M G / Colonna, S M / Aloi, F G

    Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia

    1984  Volume 119, Issue 5, Page(s) 319–325

    Title translation Lymphomatoid papulosis transforming to Hodgkin's disease.
    MeSH term(s) Biopsy ; Cell Transformation, Neoplastic/pathology ; Hodgkin Disease/pathology ; Humans ; Male ; Middle Aged ; Skin/pathology ; Skin Diseases, Vesiculobullous/pathology
    Language Italian
    Publishing date 1984-09
    Publishing country Italy
    Document type Case Reports ; English Abstract ; Journal Article
    ZDB-ID 604114-0
    ISSN 1827-1820 ; 0392-0488 ; 0026-4741
    ISSN (online) 1827-1820
    ISSN 0392-0488 ; 0026-4741
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 119: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: The microglial immunoreceptor tyrosine-based motif-Syk signaling pathway is a promising target of immunotherapy for Alzheimer's disease.

    Wang, Shoutang / Colonna, Marco

    Clinical and translational medicine

    2023  Volume 13, Issue 2, Page(s) e1200

    MeSH term(s) Humans ; Tyrosine/metabolism ; Alzheimer Disease/therapy ; Microglia/metabolism ; Signal Transduction ; Immunotherapy ; Syk Kinase/metabolism
    Chemical Substances Tyrosine (42HK56048U) ; SYK protein, human (EC 2.7.10.2) ; Syk Kinase (EC 2.7.10.2)
    Language English
    Publishing date 2023-01-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2697013-2
    ISSN 2001-1326 ; 2001-1326
    ISSN (online) 2001-1326
    ISSN 2001-1326
    DOI 10.1002/ctm2.1200
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top