LIVIVO - Search results -

Search results

Result 1 - 10 of total 147400

Search options

Article ; Online: Development of Yin-Yang ligand for cannabinoid receptors.

Qiu, Yanli / Zhao, Yitian / Hu, Tao / Yang, Meifang / Li, Fei / Li, Cuixia / Gu, Weiliang / Yang, Xiaodi / Zhao, Suwen / Tao, Houchao

Bioorganic chemistry

2023 Volume 133, Page(s) 106377

Abstract: ... effect, Yin-Yang ligands with opposite pharmacological activities simultaneously on two subtypes, offer ... unique therapeutic potential. Herein we report the development of a new Yin-Yang ligand which functions ... activities. As such, the ortho-morpholine substitution exerted the desired Yin-Yang bifunctionality ...

Abstract	Cannabinoid receptors (CBs), including CB1 and CB2, are the key components of a lipid signaling endocannabinoid system (ECS). Development of synthetic cannabinoids has been attractive to modulate ECS functions. CB1 and CB2 are structurally closely related subtypes but with distinct functions. While most efforts focus on the development of selective ligands for single subtype to circumvent the undesired off-target effect, Yin-Yang ligands with opposite pharmacological activities simultaneously on two subtypes, offer unique therapeutic potential. Herein we report the development of a new Yin-Yang ligand which functions as an antagonist for CB1 and concurrently an agonist for CB2. We found that in the pyrazole-cored scaffold, the arm of N1-phenyl group could be a switch, modification of which yielded various ligands with distinct activities. As such, the ortho-morpholine substitution exerted the desired Yin-Yang bifunctionality which, based on the docking study and molecular dynamic simulation, was proposed to be resulted from the hydrogen bonding with S173 and S285 in CB1 and CB2, respectively. Our results demonstrated the feasibility of structure guided ligand evolution for challenging Yin-Yang ligand.
MeSH term(s)	Cannabinoids/pharmacology ; Cannabinoids/chemistry ; Endocannabinoids ; Ligands ; Pyrazoles/chemistry ; Pyrazoles/pharmacology ; Receptor, Cannabinoid, CB1/chemistry ; Receptor, Cannabinoid, CB1/metabolism ; Receptors, Cannabinoid/chemistry ; Receptors, Cannabinoid/metabolism ; Yin-Yang
Chemical Substances	Cannabinoids ; Endocannabinoids ; Ligands ; Pyrazoles ; Receptor, Cannabinoid, CB1 ; Receptors, Cannabinoid
Language	English
Publishing date	2023-01-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	120080-x
ISSN	1090-2120 ; 0045-2068
ISSN (online)	1090-2120
ISSN	0045-2068
DOI	10.1016/j.bioorg.2023.106377
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4207: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article: Yang-xin-xue keli exerts therapeutic effects

Long, Kunlan / Zhao, Ziyi / Chen, Jun / Zhi, Lijia / Wang, Chunxia / Liao, Dan / Wang, Meng / Gao, Peiyang

Frontiers in pharmacology

2022 Volume 13, Page(s) 931453

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2022-08-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2022.931453
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Mechanism of action of vinegared Cornu Cervi Degelatinatum in suppressing spleen kidney yang deficient ulcerative colitis through NCK2-JNK pathway.

Li, Tianshi / Shi, Mengqi / Zhao, Yan / He, Zhongmei / Zong, Ying / Chen, Weijia / Du, Rui

Heliyon

2024 Volume 10, Issue 2, Page(s) e24782

Abstract: ... the kidney to support yang, astringing, and stopping bleeding, and is used for spleen kidney yang deficient ...

Abstract	As a traditional Chinese herbal medicine, Cornu Cervi Degelatinatum (CCD) has the effect of warming the kidney to support yang, astringing, and stopping bleeding, and is used for spleen kidney yang deficient (SKYD). This experiment was to investigate the therapeutic effects of different processes of CCD on SKYD type ulcerative colitis (UC) rats and to explore its impact on the intestinal flora of rats. Methods: ELISA was used to study the anti-inflammatory activity of Cornu Cervi Degelatinatum processed with water (WCCD) and Cornu Cervi Degelatinatum processed with vinegar (VCCD). 16SrRNA and transcriptome sequencing were used to detect the composition of rat intestinal flora and gene expression; RT-PCR and Western blot were used to verify the role of WCCD and VCCD in treating UC. Results: WCCD and VCCD have therapeutic effects on UC, could reduce tissue damage. VCCD performed better in improving Bacteroidetes/Firmicutes ratios and species evenness and abundance; performed better in increasing the quantity of lactobacillus. VCCD simultaneously inhibit the intestinal inflammatory response through NCK2, PAK4, and JNK signaling pathways. Conclusions: WCCD and VCCD play a therapeutic role in UC by regulating the proportion of different flora in the intestinal flora. VCCD regulates the intestinal flora and inflammatory response by interfering with the NCK2, PAK4 and JNK signaling pathways.
Language	English
Publishing date	2024-01-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e24782
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: The miR-17-92 cluster: Yin and Yang in human cancers.

Zhao, Wenyuan / Gupta, Ananya / Krawczyk, Janusz / Gupta, Sanjeev

Cancer treatment and research communications

2022 Volume 33, Page(s) 100647

Abstract: MicroRNAs (miRNAs) are non-coding RNAs which modulate gene expression via multiple post-transcriptional mechanisms. They are involved in a variety of biological processes, including cell proliferation, metastasis, metabolism, tumorigenesis, and apoptosis. ...

Abstract	MicroRNAs (miRNAs) are non-coding RNAs which modulate gene expression via multiple post-transcriptional mechanisms. They are involved in a variety of biological processes, including cell proliferation, metastasis, metabolism, tumorigenesis, and apoptosis. Dysregulation of miRNA expression has been implicated in human cancers, and they may also serve as biomarkers of disease progression and prognosis. The miR-17-92 cluster is one of the most widely studied miRNA clusters, which was initially reported as an oncogene, but was later reported to exhibit tumour suppressive effects in some human cancers. This review summarizes the recent progress and context-dependant role of this cluster in various cancers. We summarize the known mechanisms which regulate miR-17-92 expression and molecular pathways that are in turn controlled by it. We discuss examples where it acts as an oncogene or a tumour suppressor along with key targets affecting hallmarks of cancer. We discuss how cellular contexts regulate the biological effects of miR-17-92. The plausible mechanisms of its paradoxical roles are explained, and mechanisms are described that may contribute to cell fate regulation by miR-17-92. Further, we discuss recently developed strategies to target miR-17-92 cluster in human cancers. MiR-17-92 may serve as a potential biomarker for prognosis and response to therapy as well as a target for cancer prevention and therapeutics.
Language	English
Publishing date	2022-10-14
Publishing country	England
Document type	Journal Article ; Review
ISSN	2468-2942
ISSN (online)	2468-2942
DOI	10.1016/j.ctarc.2022.100647
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- Full text online
- Order with fees

Article ; Online: The yin and yang of intracellular delivery of amphipathic optical probes using

Agarwal, Hitesh K / Janicek, Radoslav / Zhao, Jun / Sambath, Karthik / Egger, Marcel / Niggli, Ernst / Ellis-Davies, Graham C R

Chemical communications (Cambridge, England)

2022 Volume 58, Issue 17, Page(s) 2826–2829

Abstract: Monitoring and manipulation of ionized intracellular calcium concentrations within intact, living cells using optical probes with organic chromophores is a core method for cell physiology. Since all these probes have multiple negative charges, they must ... ...

Abstract	Monitoring and manipulation of ionized intracellular calcium concentrations within intact, living cells using optical probes with organic chromophores is a core method for cell physiology. Since all these probes have multiple negative charges, they must be smuggled through the plasma membrane in a transiently neutral form, with intracellular esterases used to deprotect the masked anions. Here we explore the ability of the synthetically easily accessible
MeSH term(s)	Calcium/chemistry ; Calcium/metabolism ; Cell Membrane/chemistry ; Cell Membrane/metabolism ; Cytosol/chemistry ; Cytosol/metabolism ; Esterases/chemistry ; Esterases/metabolism ; Fluorescent Dyes/chemistry ; Fluorescent Dyes/metabolism ; Humans ; Molecular Structure ; Myocytes, Cardiac/chemistry ; Myocytes, Cardiac/metabolism ; Particle Size
Chemical Substances	Fluorescent Dyes ; Esterases (EC 3.1.-) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2022-02-24
Publishing country	England
Document type	Journal Article
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/d1cc06792c
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: The Yin Yang 1 of Penaeus vannamei regulates transcription of the small subunit hemocyanin gene during Vibrio parahaemolyticus infection.

Yang, Peikui / Zhao, Xianliang / Aweya, Jude Juventus / Zhang, Yueling

Developmental and comparative immunology

2023 Volume 151, Page(s) 105087

Abstract: ... the Yin Yang 1 transcription factor homolog in Penaeus vannamei (PvYY1) as a key factor that modulates ...

Abstract	Hemocyanin is a respiratory protein, it is also a multifunctional immune molecule that plays a vital role against pathogen invasion in shrimp. However, the regulation of hemocyanin gene expression in shrimp hemocytes and the mechanisms involved during pathogen infection remains unclear. Here, we used DNA pull-down followed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) to identify the Yin Yang 1 transcription factor homolog in Penaeus vannamei (PvYY1) as a key factor that modulates transcription of the small subunit hemocyanin gene of P. vannamei (PvHMCs) in hemocytes during Vibrio parahaemolyticus AHPND (VP
MeSH term(s)	Animals ; Hemocyanins ; Arthropod Proteins/genetics ; Penaeidae ; Vibrio parahaemolyticus ; Chromatography, Liquid ; Yin-Yang ; Tandem Mass Spectrometry ; Immunity, Innate/genetics
Chemical Substances	Hemocyanins (9013-72-3) ; Arthropod Proteins
Language	English
Publishing date	2023-10-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	752411-0
ISSN	1879-0089 ; 0145-305X
ISSN (online)	1879-0089
ISSN	0145-305X
DOI	10.1016/j.dci.2023.105087
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1327: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Yin/Yang associated differential responses to Psoralea corylifolia Linn. In rat models: an integrated metabolomics and transcriptomics study.

Zhang, Ming-Liang / Zhao, Xu / Li, Wei-Xia / Wang, Xiao-Yan / Niu, Ming / Zhang, Hui / Chen, Yu-Long / Kong, De-Xin / Gao, Yuan / Guo, Yu-Ming / Bai, Zhao-Fang / Zhao, Yan-Ling / Tang, Jin-Fa / Xiao, Xiao-He

Chinese medicine

2023 Volume 18, Issue 1, Page(s) 102

Abstract: ... traditional Chinese medicine (TCM) for the treatment of kidney-yang deficiency syndrome (Yang: Aim of the study: Liver ... to investigate the differential responses to BGZ in Yang: Materials and methods: The corresponding ... animal models of Yang: Results: The level changes of liver organ index, alanine aminotransferase (ALT), and ...

Abstract	Ethnopharmacological relevance: Psoralea corylifolia Linn. (BGZ) is a commonly used traditional Chinese medicine (TCM) for the treatment of kidney-yang deficiency syndrome (Yang Aim of the study: Liver injury caused by TCM is a rare but potentially serious adverse drug reaction, and the identification of predisposed individuals for drug-induced liver injury (DILI) remains challenging. The study aimed to investigate the differential responses to BGZ in Yang Materials and methods: The corresponding animal models of Yang Results: The level changes of liver organ index, alanine aminotransferase (ALT), and aspartate aminotransferase (AST), suggested that BGZ has liver-protective and liver-damaging effects on Yang Conclusions: Yin
Language	English
Publishing date	2023-08-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2260322-0
ISSN	1749-8546
ISSN	1749-8546
DOI	10.1186/s13020-023-00793-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

Details ▾
- Full text online
- Order with fees

Article ; Online: Restricted Phase Space Thermodynamics of Einstein-Power-Yang-Mills AdS Black Hole.

Du, Yun-Zhi / Li, Huai-Fan / Zhang, Yang / Zhou, Xiang-Nan / Zhao, Jun-Xin

Entropy (Basel, Switzerland)

2023 Volume 25, Issue 4

Abstract: We consider the thermodynamics of the Einstein-power-Yang-Mills AdS black holes in the context ... of the non-linear Yang-Mills parameter on these thermodynamic properties is also investigated. ...

Abstract	We consider the thermodynamics of the Einstein-power-Yang-Mills AdS black holes in the context of the gauge-gravity duality. Under this framework, Newton's gravitational constant and the cosmological constant are varied in the system. We rewrite the thermodynamic first law in a more extended form containing both the pressure and the central charge of the dual conformal field theory, i.e., the restricted phase transition formula. A novel phenomena arises: the dual quantity of pressure is the effective volume, not the geometric one. That leads to a new behavior of the Van de Waals-like phase transition for this system with the fixed central charge: the supercritical phase transition. From the Ehrenfest's scheme perspective, we check out the second-order phase transition of the EPYM AdS black hole. Furthermore the effect of the non-linear Yang-Mills parameter on these thermodynamic properties is also investigated.
Language	English
Publishing date	2023-04-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2014734-X
ISSN	1099-4300 ; 1099-4300
ISSN (online)	1099-4300
ISSN	1099-4300
DOI	10.3390/e25040687
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Metabolomics and serum pharmacochemistry revealed the preventive mechanism of Gushudan in kidney-yang-deficiency-syndrome rats.

Lu, Qing / Feng, Qisheng / Yu, Jiaxin / Tong, Lin / Zhang, Jing / Sun, Jinghan / Zhao, Jing / Xiong, Zhili

Biomedical chromatography : BMC

2023 Volume 37, Issue 3, Page(s) e5569

Abstract: Kidney-yang-deficiency-syndrome (KYDS) is a metabolic disease caused by neuroendocrine disorder ...

Abstract	Kidney-yang-deficiency-syndrome (KYDS) is a metabolic disease caused by neuroendocrine disorder. Gushudan (GSD) is a traditional Chinese medicine prescription with the effect of nourishing kidney and strengthening bones. In this study, the mechanism of preventive effect of GSD on KYDS was explored by integrating metabolomics and serum pharmacochemistry. Reversed-phase/hydrophilic interaction chromatography-ultra-high-performance liquid chromatography-Quadrupole-Orbitrap high-resolution mass spectrometry (RP/HILIC-UHPLC-Q-Orbitrap HRMS)-based serum metabolomics indicated metabolic disturbances of KYDS rats, and 50 potential biomarkers including l-threonine, succinic acid and phytosphingosine were obtained, which were mainly involved in alanine, aspartate and glutamate metabolism, citrate cycle (tricarboxylic acid cycle) and glycerophospholipid metabolism, among others. Serum pharmacochemistry identified 29 prototypical ingredients and 9 metabolites of GSD after administration, such as icaritin and xanthotoxol. The combination of 10 serum migration ingredients in GSD, including icaritin and osthole, with 7 important targets, including AKT serine/threonine kinase 1 (AKT1) and MAPK14, was found to be key for GSD to prevent KYDS in the network pharmacology study. This study provided a new idea for the research of pathogenesis of diseases and the pharmacodynamic mechanism of traditional Chinese medicine.
MeSH term(s)	Rats ; Animals ; Drugs, Chinese Herbal/pharmacology ; Metabolomics/methods ; Yang Deficiency/metabolism ; Kidney/metabolism ; Biomarkers ; Chromatography, High Pressure Liquid
Chemical Substances	gushudan ; Drugs, Chinese Herbal ; Biomarkers
Language	English
Publishing date	2023-01-20
Publishing country	England
Document type	Journal Article
ZDB-ID	632848-9
ISSN	1099-0801 ; 0269-3879
ISSN (online)	1099-0801
ISSN	0269-3879
DOI	10.1002/bmc.5569
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2166: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Investigation of He's Yang Chao recipe against oxidative stress-related mitophagy and pyroptosis to improve ovarian function.

Miao, Chenyun / Zhao, Ying / Chen, Yun / Wang, Ruye / Ren, Ning / Chen, Bixia / Dong, Pingpei / Zhang, Qin

Frontiers in endocrinology

2023 Volume 14, Page(s) 1077315

Abstract: ... of cyclophosphamide (CTX) and He's Yang Chao Recipe (HSYC) concentrate was used for intragastric administration. Serum ...

Abstract	Background: Primary ovarian insufficiency (POI) is a common gynecological disease with serious ramifications including low pregnancy rate and low estrogen symptoms. Traditional Chinese medicine is regarded as an effective treatment for POI. However, the therapeutic mechanism of it is unclear. Methods: In this study, a mouse model of primary ovarian insufficiency was established by intraperitoneal injection of cyclophosphamide (CTX) and He's Yang Chao Recipe (HSYC) concentrate was used for intragastric administration. Serum hormone levels (Anti-Müllerian Hormone, Estradiol, Progesterone, Luteinizing Hormone and Follicle Stimulating Hormone) and Oxidative Stress (OS) related products, superoxide dismutase (SOD), GSH-Px, and malondialdehyde (MDA) were measured by enzyme-linked immunosorbent assay. Pathological changes in ovarian tissue were evaluated by hematoxylin and eosin staining, and flow cytometry was used to determine reactive oxygen species content and mitochondrial membrane potential levels in granulosa cells. Mitochondrial distribution and morphology were investigated using immunofluorescence staining. The level of mitophagy was evaluated by LC3 immunofluorescence staining and autophagosome counts using electron microscopy. Western blotting and qPCR were used to detect the expression of proteins and genes related to mitophagy and the NLRP3 inflammasome. Results: After HSYC treatment, the ovarian damage was milder than in the CTX group. Compared with the CTX group; SOD, GSH-Px, and the total antioxidant capacity were significantly increased, while MDA and ROS were decreased in the HSYC treatment groups. Furthermore, mitochondrial distribution and membrane potential levels were improved after HSYC treatment compared to the CTX group. After the HSYC treatment, the LC3 fluorescent intensity and autophagosome counts were decreased. Similarly, mitophagy related markers PINK1, Parkin, LC3, and Beclin1 were decreased, while p62 was significantly increased, compared with the CTX groups. The mRNA and protein expression of NLRP3 inflammasome, NLRP3, caspase-1, GSDMD, IL-18, and IL-1β were significantly decreased in the HSYC treatment groups. Conclusion: This is the first study in molecular mechanisms underlying HSYC against granulosa cell injury in POI. HSYC protects ovaries from CTX-induced ovarian damage and oxidative stress. HSYC enhanced ovarian function in mice with primary ovarian insufficiency by inhibiting PINK1-Parkin mitophagy and NLRP3 inflammasome activation.
MeSH term(s)	Humans ; Female ; Mice ; Animals ; Inflammasomes/metabolism ; Mitophagy ; Pyroptosis ; NLR Family, Pyrin Domain-Containing 3 Protein/genetics ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Primary Ovarian Insufficiency/chemically induced ; Primary Ovarian Insufficiency/drug therapy ; Primary Ovarian Insufficiency/metabolism ; Oxidative Stress/physiology ; Ubiquitin-Protein Ligases ; Protein Kinases/metabolism ; Superoxide Dismutase/metabolism
Chemical Substances	Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein ; Ubiquitin-Protein Ligases (EC 2.3.2.27) ; Protein Kinases (EC 2.7.-) ; Superoxide Dismutase (EC 1.15.1.1)
Language	English
Publishing date	2023-01-27
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2023.1077315
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito