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  1. Article ; Online: Re-Dispersion of Platinum From CNTs Substrate to α-MoC

    Cai, Huizhu / Wang, Li / Liu, Wei / Zhang, Xiao / Chen, Bingbing / Mao, Peiyuan / Fang, Jiancong / Gao, Rui / Shi, Chuan

    Small (Weinheim an der Bergstrasse, Germany)

    2023  Volume 19, Issue 21, Page(s) e2207146

    Abstract: Developing high-performance electrocatalysts toward hydrogen evolution reaction (HER) is important for clean and sustainable hydrogen energy, yet still challenging. Herein, an α- ... ...

    Abstract Developing high-performance electrocatalysts toward hydrogen evolution reaction (HER) is important for clean and sustainable hydrogen energy, yet still challenging. Herein, an α-MoC
    Language English
    Publishing date 2023-02-11
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2168935-0
    ISSN 1613-6829 ; 1613-6810
    ISSN (online) 1613-6829
    ISSN 1613-6810
    DOI 10.1002/smll.202207146
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  2. Article ; Online: NEDD4L is a promoter for angiogenesis and cell proliferation in human umbilical vein endothelial cells.

    Liu, Binghong / Song, Fei / Zhou, Xiaoxia / Wu, Chan / Huang, Huizhu / Wu, Weiyin / Li, Gang / Wang, Yan

    Journal of cellular and molecular medicine

    2024  Volume 28, Issue 8, Page(s) 1–11

    Abstract: Dysregulated angiogenesis leads to neovascularization, which can promote or exacerbate various diseases. Previous studies have proved that NEDD4L plays an important role in hypertension and atherosclerosis. Hence, we hypothesized that NEDD4L may be a ... ...

    Abstract Dysregulated angiogenesis leads to neovascularization, which can promote or exacerbate various diseases. Previous studies have proved that NEDD4L plays an important role in hypertension and atherosclerosis. Hence, we hypothesized that NEDD4L may be a critical regulator of endothelial cell (EC) function. This study aimed to define the role of NEDD4L in regulating EC angiogenesis and elucidate their underlying mechanisms. Loss- and gain-of-function of NEDD4L detected the angiogenesis and mobility role in human umbilical vein endothelial cells (HUVECs) using Matrigel tube formation assay, cell proliferation and migration. Pharmacological pathway inhibitors and western blot were used to determine the underlying mechanism of NEDD4L-regulated endothelial functions. Knockdown of NEDD4L suppressed tube formation, cell proliferation and cell migration in HUVECs, whereas NEDD4L overexpression promoted these functions. Moreover, NEDD4L-regulated angiogenesis and cell progression are associated with the phosphorylation of Akt, Erk1/2 and eNOS and the expression of VEGFR2 and cyclin D1 and D3. Mechanically, further evidence was confirmed by using Akt blocker MK-2206, Erk1/2 blocker U0126 and eNOS blocker L-NAME. Overexpression NEDD4L-promoted angiogenesis, cell migration and cell proliferation were restrained by these inhibitors. In addition, overexpression NEDD4L-promoted cell cycle-related proteins cyclin D1 and D3 were also suppressed by Akt blocker MK-2206, Erk1/2 blocker U0126 and eNOS blocker L-NAME. Our results demonstrated a novel finding that NEDD4L promotes angiogenesis and cell progression by regulating the Akt/Erk/eNOS pathways.
    MeSH term(s) Humans ; Human Umbilical Vein Endothelial Cells/metabolism ; Signal Transduction ; Cyclin D1/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; NG-Nitroarginine Methyl Ester ; Angiogenesis ; Neovascularization, Physiologic/genetics ; Cell Proliferation ; Cell Movement/genetics ; Butadienes ; Nitriles
    Chemical Substances U 0126 ; Cyclin D1 (136601-57-5) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; NG-Nitroarginine Methyl Ester (V55S2QJN2X) ; Butadienes ; Nitriles
    Language English
    Publishing date 2024-03-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2074559-X
    ISSN 1582-4934 ; 1582-4934 ; 1582-1838
    ISSN (online) 1582-4934
    ISSN 1582-4934 ; 1582-1838
    DOI 10.1111/jcmm.18233
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5752: Show issues Location:
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  3. Article ; Online: Integrated assessment of ecological risk for multi-hazards in Guangdong province in southeastern China

    Xilin Liu / Huizhu Chen

    Geomatics, Natural Hazards & Risk, Vol 10, Iss 1, Pp 2069-

    2019  Volume 2093

    Abstract: Guangdong Province is the most populous and economically developed province in southeastern China. Tropical cyclones, rainstorm waterlogging, and geohazards are the principal natural hazards in this region. Using information acquisition analysis, entropy ...

    Abstract Guangdong Province is the most populous and economically developed province in southeastern China. Tropical cyclones, rainstorm waterlogging, and geohazards are the principal natural hazards in this region. Using information acquisition analysis, entropy weighting, the ArcGIS technique, the concept of hazard chains, the spatial heterogeneity of hazards, vulnerability, and ecological risk from single hazards and multi-hazards were determined for grids of 1 × 1 km2; the ecological risks for each administrative city were ranked. Jiangmen City was the top one ranking in the 21 cities with highest ecological risks for multi-hazards, tropical cyclones, and rainstorm waterlogging; Qingyuan City was the highest one for the ecological risk of geohazards. Areas with grades of very high, high, moderate, low, and very low ecological risk accounted for 1.78%, 7.10%, 18.22%, 34.39%, and 38.51% of Guangdong Province, respectively. Most areas of Guangdong Province had favorable ecological environments and low ecological risks. Natural hazard assessment greatly benefits from ArcGIS because spatial methodologies can be fully explored during the entire risk evaluation process, from data integration to risk appraisal, and finally for decision-making. This study concludes that integrated approaches to multi-hazard assessment may assist in risk management of natural hazards in Guangdong Province in southeastern China.
    Keywords multi-hazard ; ecological vulnerability ; ecological risk ; arcgis technique ; Environmental technology. Sanitary engineering ; TD1-1066 ; Environmental sciences ; GE1-350 ; Risk in industry. Risk management ; HD61
    Subject code 910
    Language English
    Publishing date 2019-01-01T00:00:00Z
    Publisher Taylor & Francis Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Cooperative interactions between

    Li, Na / Wang, Hejing / Zhao, Huizhu / Wang, Mengyang / Cai, Jin / Hao, Yi / Yu, Jia / Jiang, Yun / Lü, Xin / Liu, Bianfang

    Food & function

    2023  Volume 14, Issue 23, Page(s) 10475–10492

    Abstract: ... ...

    Abstract Veillonella
    MeSH term(s) Animals ; Mice ; Colitis, Ulcerative/therapy ; Colitis, Ulcerative/drug therapy ; Lactobacillus acidophilus ; Veillonella ; Mice, Inbred C57BL ; Colitis/chemically induced ; Colon/metabolism ; Inflammation/metabolism ; Probiotics ; Glucose/metabolism ; Lactic Acid/metabolism ; Dextran Sulfate/adverse effects ; Disease Models, Animal
    Chemical Substances Glucose (IY9XDZ35W2) ; Lactic Acid (33X04XA5AT) ; Dextran Sulfate (9042-14-2)
    Language English
    Publishing date 2023-11-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2612033-1
    ISSN 2042-650X ; 2042-6496
    ISSN (online) 2042-650X
    ISSN 2042-6496
    DOI 10.1039/d3fo03898j
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 7872: Show issues

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  5. Article ; Online: Development and validation of a prediction model for in-hospital death in patients with heart failure and atrial fibrillation.

    Yan, Meiyu / Liu, Huizhu / Xu, Qunfeng / Yu, Shushu / Tang, Ke / Xie, Yun

    BMC cardiovascular disorders

    2023  Volume 23, Issue 1, Page(s) 505

    Abstract: Background: To develop a prediction model for in-hospital mortality of patients with heart failure (HF) and atrial fibrillation (AF).: Methods: This cohort study extracted the data of 10,236 patients with HF and AF upon intensive care unit (ICU) from ...

    Abstract Background: To develop a prediction model for in-hospital mortality of patients with heart failure (HF) and atrial fibrillation (AF).
    Methods: This cohort study extracted the data of 10,236 patients with HF and AF upon intensive care unit (ICU) from the Medical Information Mart for Intensive Care (MIMIC). The subjects from MIMIC-IV were divided into the training set to construct the prediction model, and the testing set to verify the performance of the model. The samples from MIMIC-III database and eICU-CRD were included as the internal and external validation set to further validate the predictive value of the model, respectively. Univariate and multivariable Logistic regression analyses were used to explore predictors for in-hospital death in patients with HF and AF. The receiver operator characteristic (ROC), calibration curves and the decision curve analysis (DCA) curves were plotted to evaluate the predictive values of the model.
    Results: The mean survival time of participants from MIMIC-III was 11.29 ± 10.05 days and the mean survival time of participants from MIMIC-IV was 10.56 ± 9.19 days. Simplified acute physiology score (SAPSII), red blood cell distribution width (RDW), beta-blocker, race, respiratory rate, urine output, coronary artery bypass grafting (CABG), Charlson comorbidity index, renal replacement therapies (RRT), antiarrhythmic, age, and anticoagulation were predictors finally included in the prediction model. The AUC of our prediction model was 0.810 (95%CI: 0.791-0.828) in the training set, 0.757 (95%CI: 0.729-0.786) in the testing set, 0.792 (95%CI: 0.774-0.810) in the internal validation set, and 0.724 (95%CI: 0.687-0.762) in the external validation set. The calibration curves of revealed that the predictive probabilities of our model for the in-hospital death in patients with HF and AF deviated slightly from the ideal model. The DCA curves revealed that the use of our prediction model increased the net benefit than use no model.
    Conclusion: The prediction model had good discriminative ability, and might provide a tool to timely identify patients with HF complicated with AF who were at high risk of in-hospital mortality.
    MeSH term(s) Humans ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/therapy ; Hospital Mortality ; Cohort Studies ; Heart Failure/diagnosis ; Heart Failure/therapy ; Anti-Arrhythmia Agents ; Intensive Care Units
    Chemical Substances Anti-Arrhythmia Agents
    Language English
    Publishing date 2023-10-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2059859-2
    ISSN 1471-2261 ; 1471-2261
    ISSN (online) 1471-2261
    ISSN 1471-2261
    DOI 10.1186/s12872-023-03521-3
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  6. Article: Simultaneous Trapping of Two Types of Particles with Focused Elegant Third-Order Hermite-Gaussian Beams.

    Su, Jingjing / Li, Nan / Mou, Jiapeng / Liu, Yishi / Chen, Xingfan / Hu, Huizhu

    Micromachines

    2021  Volume 12, Issue 7

    Abstract: The focusing properties of elegant third-order Hermite-Gaussian beams ( ... ...

    Abstract The focusing properties of elegant third-order Hermite-Gaussian beams (TH
    Language English
    Publishing date 2021-06-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2620864-7
    ISSN 2072-666X
    ISSN 2072-666X
    DOI 10.3390/mi12070769
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  7. Article ; Online: Effects of Solid Waste Reutilization on Performance of Pervious Concrete

    Hui-Zhu Xie / Leo Gu Li / Pui-Lam Ng / Feng Liu

    Sustainability, Vol 15, Iss 6105, p

    A Review

    2023  Volume 6105

    Abstract: With rapid urban development, natural aggregate resources have become scarce and a large number of ageing buildings are being demolished, which has resulted in a significant reduction in natural resources and a large increase in construction waste. ... ...

    Abstract With rapid urban development, natural aggregate resources have become scarce and a large number of ageing buildings are being demolished, which has resulted in a significant reduction in natural resources and a large increase in construction waste. Therefore, the reuse of solid waste, including waste powder and recycled aggregate, has attracted more and more attention. Additionally, as a prominent way to alleviate the urban heat island effect and manage stormwater runoff, pervious concrete has been widely studied and applied. In this paper, the effects of waste powder (fly ash, volcanic powder and blast furnace slag) and recycled aggregate (recycled concrete aggregate and recycled brick aggregate) on the mechanical properties, water permeability, water filtration and durability of pervious concrete are summarized and introduced, and some prospects are put forward. From the literature review, it can be found that adding the appropriate amount of solid waste or applying proper treatment methods to solid waste will not bring negative effects; rather, it would even improve the performance attributes of pervious concrete. Therefore, the use of solid waste in pervious concrete has great potential for urban construction and environmental protection.
    Keywords eco-friendliness ; pervious concrete ; recycled aggregate ; waste powder ; waste reutilization ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
    Subject code 690
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Suppression of damping in a diamagnetically levitated dielectric sphere via eddy currents and static charge reduction.

    Zhu, Xunmin / Wu, Tong / Yang, Jing / Chen, Zhiming / Guo, Leilei / Liu, Rui / Fu, Zhenhai / Li, Cuihong / Hu, Huizhu

    Optics express

    2023  Volume 31, Issue 21, Page(s) 34493–34502

    Abstract: Diamagnetically levitated micro-nano oscillators play a crucial role in fundamental physics research and the advancement of high-precision sensors. Achieving high sensitivity in acceleration or force sensing is a fundamental requirement within these ... ...

    Abstract Diamagnetically levitated micro-nano oscillators play a crucial role in fundamental physics research and the advancement of high-precision sensors. Achieving high sensitivity in acceleration or force sensing is a fundamental requirement within these research domains. The primary limitation in achieving such sensitivity is thermal noise, which is directly proportional to the motion damping of the oscillator. Theoretical modeling suggests the presence of significant damping mechanisms induced by eddy currents. In this study, we validated the theoretical model by optimizing the structure of the magnet trap, confirming the impact of eddy currents on the damping of the oscillators. Additionally, we observed another type of damping caused by static charge in moving levitated dielectrics. Subsequently, we proposed an innovative theoretical model to explain this phenomenon and verified its validity during the charge neutralization process. Through these efforts, we successfully reduced the total damping from 1.6 mHz to 0.15 mHz, resulting in an order of magnitude improvement in performance. Our sensing system achieved the highest sensitivity of acceleration sensing in diamagnetically levitated submillimeter-scale dielectric to date, measuring 7.6±0.8)×10
    Language English
    Publishing date 2023-10-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1491859-6
    ISSN 1094-4087 ; 1094-4087
    ISSN (online) 1094-4087
    ISSN 1094-4087
    DOI 10.1364/OE.500661
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: SApredictor: An Expert System for Screening Chemicals Against Structural Alerts.

    Hua, Yuqing / Cui, Xueyan / Liu, Bo / Shi, Yinping / Guo, Huizhu / Zhang, Ruiqiu / Li, Xiao

    Frontiers in chemistry

    2022  Volume 10, Page(s) 916614

    Abstract: The rapid and accurate evaluation of chemical toxicity is of great significance for estimation of chemical safety. In the past decades, a great number of excellent computational models have been developed for chemical toxicity prediction. But most ... ...

    Abstract The rapid and accurate evaluation of chemical toxicity is of great significance for estimation of chemical safety. In the past decades, a great number of excellent computational models have been developed for chemical toxicity prediction. But most machine learning models tend to be "black box", which bring about poor interpretability. In the present study, we focused on the identification and collection of structural alerts (SAs) responsible for a series of important toxicity endpoints. Then, we carried out effective storage of these structural alerts and developed a web-server named SApredictor (www.sapredictor.cn) for screening chemicals against structural alerts. People can quickly estimate the toxicity of chemicals with SApredictor, and the specific key substructures which cause the chemical toxicity will be intuitively displayed to provide valuable information for the structural optimization by medicinal chemists.
    Language English
    Publishing date 2022-07-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711776-5
    ISSN 2296-2646
    ISSN 2296-2646
    DOI 10.3389/fchem.2022.916614
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  10. Article ; Online: Clinical characteristics,

    Xu, Xinmin / Du, Pengcheng / Wang, Huizhu / Yang, Xiaoling / Liu, Tingting / Zhang, Yuanyuan / Wang, Yajie

    The Journal of international medical research

    2021  Volume 49, Issue 5, Page(s) 3000605211016197

    Abstract: Cryptococcus ... ...

    Abstract Cryptococcus neoformans
    MeSH term(s) Antifungal Agents/pharmacology ; Antifungal Agents/therapeutic use ; Beijing/epidemiology ; China/epidemiology ; Cryptococcosis/diagnosis ; Cryptococcosis/drug therapy ; Cryptococcosis/epidemiology ; Cryptococcus neoformans/genetics ; Genotype ; HIV ; Humans ; Multilocus Sequence Typing ; Mycological Typing Techniques ; Retrospective Studies
    Chemical Substances Antifungal Agents
    Language English
    Publishing date 2021-05-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 184023-x
    ISSN 1473-2300 ; 0300-0605 ; 0142-2596
    ISSN (online) 1473-2300
    ISSN 0300-0605 ; 0142-2596
    DOI 10.1177/03000605211016197
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 925: Show issues Location:
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