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  1. Article: Laparoscopic Surgical Options as a Minimally Invasive Procedure for a Patient With Recurrent Postoperative Pain in Anterior Cutaneous Nerve Entrapment Syndrome: A Case Report.

    Kondo, Yoshitaka / Fujiwara, Toshiyoshi

    Cureus

    2023  Volume 15, Issue 5, Page(s) e39366

    Abstract: This report presents a case of a 70-year-old woman who developed anterior cutaneous nerve entrapment syndrome (ACNES) three years ago and had an anterior cutaneous neurectomy in the left Th10 region. Postoperatively, the pain had improved entirely, but ... ...

    Abstract This report presents a case of a 70-year-old woman who developed anterior cutaneous nerve entrapment syndrome (ACNES) three years ago and had an anterior cutaneous neurectomy in the left Th10 region. Postoperatively, the pain had improved entirely, but 10 weeks later, she developed a recurrence in the vicinity of the wound. The anterior intercostal nerve branch (Th10), located between the transversus abdominis and internal oblique muscles, was dissected laparoscopically six months after the initial surgery. There was no re-recurrence of pain for four months postoperatively. The postoperative recurrence of ACNES was refractory to various treatments, including surgical neurectomy, and is often difficult to treat. In cases in which transversus abdominis plane block is effective, laparoscopic neurectomy through an intraperitoneal approach may be effective, and minimally invasive laparoscopic treatment may be an effective surgical option for patients with recurrent and refractory ACNES who have a low pain threshold and are prone to prolonged complaints due to wound pain.
    Language English
    Publishing date 2023-05-23
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.39366
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Multidisciplinary oncolytic virotherapy for gastrointestinal cancer.

    Fujiwara, Toshiyoshi

    Annals of gastroenterological surgery

    2019  Volume 3, Issue 4, Page(s) 396–404

    Abstract: Replication-selective tumor-specific viruses represent a novel approach for treating neoplastic diseases. These vectors are designed to induce virus-mediated lysis of tumor cells after selective intracellular virus propagation. For targeting cancer cells, ...

    Abstract Replication-selective tumor-specific viruses represent a novel approach for treating neoplastic diseases. These vectors are designed to induce virus-mediated lysis of tumor cells after selective intracellular virus propagation. For targeting cancer cells, the use of tissue- or cell-specific promoters that are expressed in diverse tumor types but silent in normal cells is required. Human telomerase is highly active in more than 85% of primary cancers, regardless of tissue origin, and its activity is closely correlated with human telomerase reverse transcriptase (hTERT) expression. We constructed an attenuated adenovirus 5 vector (telomelysin, OBP-301) in which the hTERT promoter element drives expression of E1 genes. As only tumor cells that express the telomerase can activate this promoter, the hTERT proximal promoter allows for preferential expression of viral genes in tumor cells, leading to selective viral replication and oncolytic cell death. Upon US Food and Drug Administration approval, a phase 1 dose-escalation study of intratumoral injection of telomelysin for various solid tumors has been completed to confirm the safety, tolerability, and feasibility of the agent. Moreover, we found that adenoviral E1B 55-kDa protein in telomelysin inhibits the radiation-induced DNA repair machinery. Thus, tumor cells infected with telomelysin could be rendered sensitive to ionizing radiation. Recently, we assessed the safety and efficacy of intratumoral injection of telomelysin with radiotherapy in esophageal cancer patients not suited for standard treatments. This review highlights some very promising clinical advances in cancer therapeutic technologies using telomerase-specific oncolytic virotherapy.
    Language English
    Publishing date 2019-07-05
    Publishing country Japan
    Document type Journal Article ; Review
    ISSN 2475-0328
    ISSN (online) 2475-0328
    DOI 10.1002/ags3.12270
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  3. Article ; Online: ASO Author Reflections: The Role of Robotic Surgery in Patients with Portal Annular Pancreas.

    Takagi, Kosei / Fuji, Tomokazu / Yasui, Kazuya / Umeda, Yuzo / Fujiwara, Toshiyoshi

    Annals of surgical oncology

    2023  Volume 31, Issue 3, Page(s) 1943

    MeSH term(s) Humans ; Robotic Surgical Procedures ; Pancreas ; Pancreatic Diseases ; Patients
    Language English
    Publishing date 2023-12-10
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-023-14778-5
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4042: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  4. Article: [The Chugoku-Shikoku GanPro Produces Advanced Cancer Specialists to Provide Whole Person Medical Care].

    Kagawa, Shunsuke / Fujiwara, Toshiyoshi

    Gan to kagaku ryoho. Cancer & chemotherapy

    2022  Volume 49, Issue 6, Page(s) 638–641

    Abstract: The 3rd Chugoku-Shikoku GanPro has set a plan to train advanced cancer specialists to provide whole person medical care, and 11 partner universities have formed a consortium, and 18 working groups have been working to provide graduate school education. ... ...

    Abstract The 3rd Chugoku-Shikoku GanPro has set a plan to train advanced cancer specialists to provide whole person medical care, and 11 partner universities have formed a consortium, and 18 working groups have been working to provide graduate school education. Through a unique e-learning system and an exercise to learn team medicine, we trained medical professionals who have advanced expertise and can provide cancer care through multidisciplinary team medicine. The project has produced a wide range of personnel including doctors, dentists, pharmacists, nurses, radiologists, medical physicists, and nutritionists. The graduates who have acquired various specialized cancer qualifications practice at regional cancer treatment centers, contributing to the enhancement and improvement of cancer treatment in the Chugoku and Shikoku regions.
    MeSH term(s) Humans ; Neoplasms/therapy ; Physicians
    Language Japanese
    Publishing date 2022-07-07
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 604842-0
    ISSN 0385-0684
    ISSN 0385-0684
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    Zs.B 2573: Show issues Location:
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  5. Article: [Novel Therapy Targeting the Cancer Microenvironment Using Near-Infrared Photoimmunotherapy Leading to Tumor Immune Activation].

    Kato, Takuya / Noma, Kazuhiro / Furusawa, Aki / Kobayashi, Hisataka / Fujiwara, Toshiyoshi

    Gan to kagaku ryoho. Cancer & chemotherapy

    2024  Volume 50, Issue 13, Page(s) 1361–1363

    Abstract: Near-infrared photoimmunotherapy(NIR-PIT)is a novel cancer treatment modality that employs antibody-IRDye700DX (IR700)conjugates. Recently, the clinical application of NIR-PIT has received approval in Japan for patients with inoperable head and neck ... ...

    Abstract Near-infrared photoimmunotherapy(NIR-PIT)is a novel cancer treatment modality that employs antibody-IRDye700DX (IR700)conjugates. Recently, the clinical application of NIR-PIT has received approval in Japan for patients with inoperable head and neck cancer, specifically targeting the human epidermal growth factor receptor(hEGFR). Furthermore, NIR-PIT extends beyond the scope of tumor antigens and can be employed to eliminate specific host cells that contribute to the creation of immune-permissive environments supporting tumor growth. One of the distinguishing features of NIR-PIT is its ability to selectively eliminate various cell types within the tumor microenvironment(TME)by specifically targeting distinct antigens. By employing podoplanin(PDPN)-targeted NIR-PIT, PDPN-expressing fibroblasts were selectively eradicated, resulting in the suppression of tumor progression and a notable extension of overall survival. Additionally, we investigated the efficacy of depleting myeloid-derived suppressor cells(MDSCs)using NIR-PIT. This approach led to the selective elimination of MDSCs within tumors, and remarkable abscopal effects were observed in bilateral tumor models. Hence, NIR-PIT holds immense promise for the treatment of diverse cancer types by precisely targeting tumor cells, fibroblasts, and immune cells.
    MeSH term(s) Humans ; Tumor Microenvironment ; Cell Line, Tumor ; Phototherapy/methods ; Immunotherapy ; ErbB Receptors ; Xenograft Model Antitumor Assays ; Photosensitizing Agents ; Neoplasms/drug therapy
    Chemical Substances ErbB Receptors (EC 2.7.10.1) ; Photosensitizing Agents
    Language Japanese
    Publishing date 2024-02-01
    Publishing country Japan
    Document type English Abstract ; Journal Article
    ZDB-ID 604842-0
    ISSN 0385-0684
    ISSN 0385-0684
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2573: Show issues Location:
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  6. Article ; Online: Robot-assisted laparoscopic surgery for rectal cancer in a patient with a horseshoe kidney: A case report.

    Shoji, Ryohei / Teraishi, Fuminori / Matsumi, Yuki / Kashima, Hajime / Fujiwara, Toshiyoshi

    Asian journal of endoscopic surgery

    2024  Volume 17, Issue 2, Page(s) e13296

    Abstract: A 52-year-old, Japanese man presented to the hospital with a complaint of anal bleeding, and detailed examination resulted in a diagnosis of locally advanced rectal cancer. The patient underwent total neoadjuvant therapy followed by short-course ... ...

    Abstract A 52-year-old, Japanese man presented to the hospital with a complaint of anal bleeding, and detailed examination resulted in a diagnosis of locally advanced rectal cancer. The patient underwent total neoadjuvant therapy followed by short-course radiation therapy and consolidation chemotherapy, which provided a partial response. After preoperative contrast-enhanced computed tomography showed a horseshoe kidney, robot-assisted, precise, laparoscopic, low anterior resection with D3 dissection and ileostomy construction was performed. The horseshoe renal isthmus was elevated surrounding the inferior mesenteric artery, and the left ureter and seminal vessels ran in front of the kidney. The hypogastric nerve traveled ventral to the horseshoe kidney. With robotic surgery, it was possible to perform more precise surgery while recognizing vascular and nerve anatomy in a rectal cancer patient with a horseshoe kidney due to good three-dimensional visibility and articulated forceps manipulation.
    MeSH term(s) Male ; Humans ; Middle Aged ; Fused Kidney/complications ; Fused Kidney/diagnostic imaging ; Fused Kidney/surgery ; Robotic Surgical Procedures ; Robotics ; Rectal Neoplasms/complications ; Rectal Neoplasms/diagnostic imaging ; Rectal Neoplasms/surgery ; Laparoscopy/methods
    Language English
    Publishing date 2024-02-28
    Publishing country Japan
    Document type Case Reports
    ZDB-ID 2503256-2
    ISSN 1758-5910 ; 1758-5902
    ISSN (online) 1758-5910
    ISSN 1758-5902
    DOI 10.1111/ases.13296
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6788: Show issues Location:
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  7. Article ; Online: Robotic Pancreaticoduodenectomy Using the Right Posterior Superior Mesenteric Artery Approach.

    Takagi, Kosei / Umeda, Yuzo / Fuji, Tomokazu / Yasui, Kazuya / Fujiwara, Toshiyoshi

    Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract

    2023  Volume 27, Issue 12, Page(s) 3069–3070

    MeSH term(s) Humans ; Pancreaticoduodenectomy ; Mesenteric Artery, Superior/surgery ; Robotic Surgical Procedures ; Pancreas/surgery ; Pancreatic Neoplasms/surgery
    Language English
    Publishing date 2023-08-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2012365-6
    ISSN 1873-4626 ; 1934-3213 ; 1091-255X
    ISSN (online) 1873-4626 ; 1934-3213
    ISSN 1091-255X
    DOI 10.1007/s11605-023-05806-6
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5207: Show issues Location:
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    Zs.MO 354: Show issues

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  8. Article: [A PARTIAL REVISION OF SURGICAL GLOSSARY (WEB EDITION)].

    Fujiwara, Toshiyoshi

    Nihon Geka Gakkai zasshi

    2016  Volume 117, Issue 2, Page(s) 91

    MeSH term(s) Dictionaries, Medical ; Internet ; Societies, Medical
    Language Japanese
    Publishing date 2016-03
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 412544-7
    ISSN 1880-1129 ; 0301-4894
    ISSN (online) 1880-1129
    ISSN 0301-4894
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    Zs.B 1737: Show issues Location:
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  9. Article: Laparoscopic and Endoscopic Cooperative Surgery for Gastric Submucosal Tumor Near Esophagogastric Junction With Sliding Hiatal Hernia.

    Kashima, Hajime / Kikuchi, Satoru / Kuroda, Shinji / Fujiwara, Toshiyoshi

    Cureus

    2023  Volume 15, Issue 4, Page(s) e37902

    Abstract: The usefulness of laparoscopic and endoscopic cooperative surgery (LECS) for gastric submucosal tumors in the cardiac region has been reported in recent years. However, LECS for submucosal tumors at the esophagogastric junction with hiatal sliding ... ...

    Abstract The usefulness of laparoscopic and endoscopic cooperative surgery (LECS) for gastric submucosal tumors in the cardiac region has been reported in recent years. However, LECS for submucosal tumors at the esophagogastric junction with hiatal sliding esophageal hernia has not been reported, and its validity as a treatment method is unknown. The patient was a 51-year-old man with a growing submucosal tumor in the cardiac region. Surgical resection was indicated because a definitive diagnosis of the tumor was not determined. The lesion was a luminal protrusion tumor, located on the posterior wall of the stomach 20 mm from the esophagogastric junction, and had a maximum diameter of 16.3 mm on endoscopic ultrasound examination. Because of the hiatal hernia, the lesion could not be detected from the gastric side by endoscopy. Local resection was considered to be feasible because the resection line did not extend into the esophageal mucosa and the resection site could be less than half the circumference of the lumen. The submucosal tumor was resected completely and safely by LECS. The tumor was diagnosed as a gastric smooth muscle tumor finally. Nine months after surgery, a follow-up endoscopy showed reflux esophagitis. LECS was a useful technique for submucosal tumors of the cardiac region with hiatal hernia, but fundoplication might be considered for preventing backflow of gastric acid.
    Language English
    Publishing date 2023-04-20
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.37902
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  10. Article: Role of Surgery for Pancreatic Ductal Adenocarcinoma in the Era of Multidisciplinary Treatment.

    Takagi, Kosei / Umeda, Yuzo / Yoshida, Ryuichi / Fuji, Tomokazu / Yasui, Kazuya / Yagi, Takahito / Fujiwara, Toshiyoshi

    Journal of clinical medicine

    2023  Volume 12, Issue 2

    Abstract: The incidence and mortality rates of pancreatic ductal adenocarcinoma (PDAC) have increased in recent years worldwide [ ... ]. ...

    Abstract The incidence and mortality rates of pancreatic ductal adenocarcinoma (PDAC) have increased in recent years worldwide [...].
    Language English
    Publishing date 2023-01-06
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12020465
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