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  1. Article ; Online: The possible effects of sodium fluoroscein to primary cell culture sampling in glioblastoma surgery.

    Aydın, Serdar Onur / Erdem, İlknur Sur / Köse, Selin Güven / Solaroğlu, İhsan

    Brain & spine

    2022  Volume 3, Page(s) 101702

    Abstract: FL increases beta-galactosidase activity in GBM cell cultures.•FL cause a decrease in GBM cell numbers.•Sampling in GBM cell culture should be performed before using FL. ...

    Abstract •FL increases beta-galactosidase activity in GBM cell cultures.•FL cause a decrease in GBM cell numbers.•Sampling in GBM cell culture should be performed before using FL.
    Language English
    Publishing date 2022-12-17
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2772-5294
    ISSN (online) 2772-5294
    DOI 10.1016/j.bas.2022.101702
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Tumor Cell Infiltration into the Brain in Glioblastoma: From Mechanisms to Clinical Perspectives.

    Seker-Polat, Fidan / Pinarbasi Degirmenci, Nareg / Solaroglu, Ihsan / Bagci-Onder, Tugba

    Cancers

    2022  Volume 14, Issue 2

    Abstract: Glioblastoma is the most common and malignant primary brain tumor, defined by its highly aggressive nature. Despite the advances in diagnostic and surgical techniques, and the development of novel therapies in the last decade, the prognosis for ... ...

    Abstract Glioblastoma is the most common and malignant primary brain tumor, defined by its highly aggressive nature. Despite the advances in diagnostic and surgical techniques, and the development of novel therapies in the last decade, the prognosis for glioblastoma is still extremely poor. One major factor for the failure of existing therapeutic approaches is the highly invasive nature of glioblastomas. The extreme infiltrating capacity of tumor cells into the brain parenchyma makes complete surgical removal difficult; glioblastomas almost inevitably recur in a more therapy-resistant state, sometimes at distant sites in the brain. Therefore, there are major efforts to understand the molecular mechanisms underpinning glioblastoma invasion; however, there is no approved therapy directed against the invasive phenotype as of now. Here, we review the major molecular mechanisms of glioblastoma cell invasion, including the routes followed by glioblastoma cells, the interaction of tumor cells within the brain environment and the extracellular matrix components, and the roles of tumor cell adhesion and extracellular matrix remodeling. We also include a perspective of high-throughput approaches utilized to discover novel players for invasion and clinical targeting of invasive glioblastoma cells.
    Language English
    Publishing date 2022-01-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14020443
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Spreading Depolarization Waves in Neurological Diseases: A Short Review about its Pathophysiology and Clinical Relevance.

    Taş, Yağmur Çetin / Solaroğlu, İhsan / Gürsoy-Özdemir, Yasemin

    Current neuropharmacology

    2017  Volume 17, Issue 2, Page(s) 151–164

    Abstract: Lesion growth following acutely injured brain tissue after stroke, subarachnoid hemorrhage and traumatic brain injury is an important issue and a new target area for promising therapeutic interventions. Spreading depolarization or peri-lesion ... ...

    Abstract Lesion growth following acutely injured brain tissue after stroke, subarachnoid hemorrhage and traumatic brain injury is an important issue and a new target area for promising therapeutic interventions. Spreading depolarization or peri-lesion depolarization waves were demonstrated as one of the significant contributors of continued lesion growth. In this short review, we discuss the pathophysiology for SD forming events and try to list findings detected in neurological disorders like migraine, stroke, subarachnoid hemorrhage and traumatic brain injury in both human as well as experimental studies. Pharmacological and non-pharmacological treatment strategies are highlighted and future directions and research limitations are discussed.
    MeSH term(s) Animals ; Brain Injuries, Traumatic/complications ; Brain Ischemia/complications ; Cortical Spreading Depression ; Humans ; Migraine Disorders/complications ; Nervous System Diseases/complications ; Nervous System Diseases/physiopathology ; Stroke/complications ; Subarachnoid Hemorrhage/complications
    Language English
    Publishing date 2017-09-14
    Publishing country United Arab Emirates
    Document type Journal Article ; Review
    ZDB-ID 2192352-8
    ISSN 1875-6190 ; 1570-159X
    ISSN (online) 1875-6190
    ISSN 1570-159X
    DOI 10.2174/1570159X15666170915160707
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6150: Show issues Location:
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  4. Article ; Online: GLP-1's role in neuroprotection: a systematic review.

    Erbil, Damla / Eren, Candan Yasemin / Demirel, Cağrı / Küçüker, Mehmet Utku / Solaroğlu, Ihsan / Eser, Hale Yapıcı

    Brain injury

    2019  Volume 33, Issue 6, Page(s) 734–819

    Abstract: Glucagon-like peptide 1 (GLP-1) is a target for treatment of diabetes; however, its function in the brain is not well studied. In this systematic review, we aimed to analyze the neuroprotective role of GLP-1 and its defined mechanisms. ...

    Abstract Glucagon-like peptide 1 (GLP-1) is a target for treatment of diabetes; however, its function in the brain is not well studied. In this systematic review, we aimed to analyze the neuroprotective role of GLP-1 and its defined mechanisms.
    MeSH term(s) Clinical Trials as Topic ; Glucagon-Like Peptide 1/physiology ; Humans ; Neurodegenerative Diseases/physiopathology ; Neurodegenerative Diseases/therapy ; Neuroprotection/drug effects ; Neuroprotective Agents/pharmacology ; Signal Transduction/drug effects
    Chemical Substances Neuroprotective Agents ; Glucagon-Like Peptide 1 (89750-14-1)
    Language English
    Publishing date 2019-04-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Systematic Review
    ZDB-ID 639115-1
    ISSN 1362-301X ; 0269-9052
    ISSN (online) 1362-301X
    ISSN 0269-9052
    DOI 10.1080/02699052.2019.1587000
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2242: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  5. Article ; Online: Editorial:Brain Hemorrhages and Future Management.

    Chen, Gang / Lackner, Peter / Solaroğlu, Ihsan / Zhang, John H

    Current drug targets

    2017  Volume 18, Issue 12, Page(s) 1315

    MeSH term(s) Disease Management ; Humans ; Intracranial Hemorrhages/blood ; Intracranial Hemorrhages/etiology ; Intracranial Hemorrhages/therapy ; Molecular Targeted Therapy/methods ; Molecular Targeted Therapy/trends ; Monitoring, Physiologic/methods ; Monitoring, Physiologic/trends
    Language English
    Publishing date 2017-10-24
    Publishing country United Arab Emirates
    Document type Editorial
    ZDB-ID 2064859-5
    ISSN 1873-5592 ; 1389-4501
    ISSN (online) 1873-5592
    ISSN 1389-4501
    DOI 10.2174/138945011812170824125820
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5578: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Chronically Radiation-Exposed Survivor Glioblastoma Cells Display Poor Response to Chk1 Inhibition under Hypoxia.

    Pinarbasi-Degirmenci, Nareg / Sur-Erdem, Ilknur / Akcay, Vuslat / Bolukbasi, Yasemin / Selek, Ugur / Solaroglu, Ihsan / Bagci-Onder, Tugba

    International journal of molecular sciences

    2022  Volume 23, Issue 13

    Abstract: Glioblastoma is the most malignant primary brain tumor, and a cornerstone in its treatment is radiotherapy. However, tumor cells surviving after irradiation indicates treatment failure; therefore, better understanding of the mechanisms regulating ... ...

    Abstract Glioblastoma is the most malignant primary brain tumor, and a cornerstone in its treatment is radiotherapy. However, tumor cells surviving after irradiation indicates treatment failure; therefore, better understanding of the mechanisms regulating radiotherapy response is of utmost importance. In this study, we generated clinically relevant irradiation-exposed models by applying fractionated radiotherapy over a long time and selecting irradiation-survivor (IR-Surv) glioblastoma cells. We examined the transcriptomic alterations, cell cycle and growth rate changes and responses to secondary radiotherapy and DNA damage response (DDR) modulators. Accordingly, IR-Surv cells exhibited slower growth and partly retained their ability to resist secondary irradiation. Concomitantly, IR-Surv cells upregulated the expression of DDR-related genes, such as
    MeSH term(s) Cell Cycle Proteins/metabolism ; Cell Line, Tumor ; Checkpoint Kinase 1/genetics ; DNA Damage ; Glioblastoma/genetics ; Humans ; Hypoxia ; Radiation Tolerance/genetics ; Survivors
    Chemical Substances Cell Cycle Proteins ; Checkpoint Kinase 1 (EC 2.7.11.1)
    Language English
    Publishing date 2022-06-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23137051
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  7. Article ; Online: Cell Death Mechanisms in Stroke and Novel Molecular and Cellular Treatment Options.

    Sekerdag, Emine / Solaroglu, Ihsan / Gursoy-Ozdemir, Yasemin

    Current neuropharmacology

    2018  Volume 16, Issue 9, Page(s) 1396–1415

    Abstract: As a result of ischemia or hemorrhage, blood supply to neurons is disrupted which subsequently promotes a cascade of pathophysiological responses resulting in cell loss. Many mechanisms are involved solely or in combination in this disorder including ... ...

    Abstract As a result of ischemia or hemorrhage, blood supply to neurons is disrupted which subsequently promotes a cascade of pathophysiological responses resulting in cell loss. Many mechanisms are involved solely or in combination in this disorder including excitotoxicity, mitochondrial death pathways, and the release of free radicals, protein misfolding, apoptosis, necrosis, autophagy and inflammation. Besides neuronal cell loss, damage to and loss of astrocytes as well as injury to white matter contributes also to cerebral injury. The core problem in stroke is the loss of neuronal cells which makes recovery difficult or even not possible in the late states. Acute treatment options that can be applied for stroke are mainly targeting re-establishment of blood flow and hence, their use is limited due to the effective time window of thrombolytic agents. However, if the acute time window is exceeded, neuronal loss starts due to the activation of cell death pathways. This review will explore the most updated cellular death mechanisms leading to neuronal loss in stroke. Ischemic and hemorrhagic stroke as well as subarachnoid hemorrhage will be debated in the light of cell death mechanisms and possible novel molecular and cellular treatment options will be discussed.
    MeSH term(s) Animals ; Cell Death/drug effects ; Cell Death/physiology ; Cell- and Tissue-Based Therapy ; Humans ; Stroke/metabolism ; Stroke/therapy
    Language English
    Publishing date 2018-03-08
    Publishing country United Arab Emirates
    Document type Journal Article ; Review
    ZDB-ID 2192352-8
    ISSN 1875-6190 ; 1570-159X
    ISSN (online) 1875-6190
    ISSN 1570-159X
    DOI 10.2174/1570159X16666180302115544
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6150: Show issues Location:
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  8. Article ; Online: Label-Free Identification of Exosomes using Raman Spectroscopy and Machine Learning.

    Parlatan, Ugur / Ozen, Mehmet Ozgun / Kecoglu, Ibrahim / Koyuncu, Batuhan / Torun, Hulya / Khalafkhany, Davod / Loc, Irem / Ogut, Mehmet Giray / Inci, Fatih / Akin, Demir / Solaroglu, Ihsan / Ozoren, Nesrin / Unlu, Mehmet Burcin / Demirci, Utkan

    Small (Weinheim an der Bergstrasse, Germany)

    2023  Volume 19, Issue 9, Page(s) e2205519

    Abstract: Exosomes, nano-sized extracellular vesicles (EVs) secreted from cells, carry various cargo molecules reflecting their cells of origin. As EV content, structure, and size are highly heterogeneous, their classification via cargo molecules by determining ... ...

    Abstract Exosomes, nano-sized extracellular vesicles (EVs) secreted from cells, carry various cargo molecules reflecting their cells of origin. As EV content, structure, and size are highly heterogeneous, their classification via cargo molecules by determining their origin is challenging. Here, a method is presented combining surface-enhanced Raman spectroscopy (SERS) with machine learning algorithms to employ the classification of EVs derived from five different cell lines to reveal their cellular origins. Using an artificial neural network algorithm, it is shown that the label-free Raman spectroscopy method's prediction ratio correlates with the ratio of HT-1080 exosomes in the mixture. This machine learning-assisted SERS method enables a new direction through label-free investigation of EV preparations by differentiating cancer cell-derived exosomes from those of healthy. This approach will potentially open up new avenues of research for early detection and monitoring of various diseases, including cancer.
    MeSH term(s) Humans ; Exosomes/metabolism ; Spectrum Analysis, Raman/methods ; Extracellular Vesicles/metabolism ; Neoplasms/diagnosis ; Neoplasms/metabolism ; Cell Line
    Language English
    Publishing date 2023-01-15
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2168935-0
    ISSN 1613-6829 ; 1613-6810
    ISSN (online) 1613-6829
    ISSN 1613-6810
    DOI 10.1002/smll.202205519
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  9. Article ; Online: The Role of Pericytes in Neurovascular Unit: Emphasis on Stroke.

    Oztop-Cakmak, Ozgur / Solaroglu, Ihsan / Gursoy-Ozdemir, Yasemin

    Current drug targets

    2017  Volume 18, Issue 12, Page(s) 1386–1391

    Abstract: Background: Among the central nervous system (CNS) disorders, diseases like ischemic and hemorrhagic stroke which are important health care problems as well as leading causes for emergency admissions, primarily affect neurovascular structure. Despite ... ...

    Abstract Background: Among the central nervous system (CNS) disorders, diseases like ischemic and hemorrhagic stroke which are important health care problems as well as leading causes for emergency admissions, primarily affect neurovascular structure. Despite their high rate of mortality and morbidity, very few efficient treatment targets have been established until now.
    Objective: Blood-brain barrier (BBB) is the mostly effected structure in stroke as detected in both clinical studies and experimental settings. BBB is composed of endothelia, astrocyte end-foot, pericytes and basal lamina. Neurovascular unit, pericytes and BBB forming endothelia play significant pathophysiological roles in both ischemic and hemorrhagic stroke.
    Discussion: In this mini-review, the role of microcirculation and cells of blood-brain barrier in stroke pathophysiology will be discussed with a special emphasis based on pericytes. Pericytes are especially important for providing adequate microcirculatory supply according to needs of neuronal tissue and form one of the functionally important part of BBB and take role in neurovascular coupling. Understanding the role and disease producing mechanisms of neurovascular unit elements in different neurological conditions will provide novel targets for future treatments.
    Language English
    Publishing date 2017
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2064859-5
    ISSN 1873-5592 ; 1389-4501
    ISSN (online) 1873-5592
    ISSN 1389-4501
    DOI 10.2174/1389450117666160613104523
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5578: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Chronically Radiation-Exposed Survivor Glioblastoma Cells Display Poor Response to Chk1 Inhibition under Hypoxia

    Nareg Pinarbasi-Degirmenci / Ilknur Sur-Erdem / Vuslat Akcay / Yasemin Bolukbasi / Ugur Selek / Ihsan Solaroglu / Tugba Bagci-Onder

    International Journal of Molecular Sciences, Vol 23, Iss 7051, p

    2022  Volume 7051

    Abstract: Glioblastoma is the most malignant primary brain tumor, and a cornerstone in its treatment is radiotherapy. However, tumor cells surviving after irradiation indicates treatment failure; therefore, better understanding of the mechanisms regulating ... ...

    Abstract Glioblastoma is the most malignant primary brain tumor, and a cornerstone in its treatment is radiotherapy. However, tumor cells surviving after irradiation indicates treatment failure; therefore, better understanding of the mechanisms regulating radiotherapy response is of utmost importance. In this study, we generated clinically relevant irradiation-exposed models by applying fractionated radiotherapy over a long time and selecting irradiation-survivor (IR-Surv) glioblastoma cells. We examined the transcriptomic alterations, cell cycle and growth rate changes and responses to secondary radiotherapy and DNA damage response (DDR) modulators. Accordingly, IR-Surv cells exhibited slower growth and partly retained their ability to resist secondary irradiation. Concomitantly, IR-Surv cells upregulated the expression of DDR-related genes, such as CHK1 , ATM , ATR , and MGMT , and had better DNA repair capacity. IR-Surv cells displayed downregulation of hypoxic signature and lower induction of hypoxia target genes, compared to naïve glioblastoma cells. Moreover, Chk1 inhibition alone or in combination with irradiation significantly reduced cell viability in both naïve and IR-Surv cells. However, IR-Surv cells’ response to Chk1 inhibition markedly decreased under hypoxic conditions. Taken together, we demonstrate the utility of combining DDR inhibitors and irradiation as a successful approach for both naïve and IR-Surv glioblastoma cells as long as cells are refrained from hypoxic conditions.
    Keywords glioblastoma ; radiotherapy ; radioresistance ; hypoxia ; DNA damage response ; Chk1 ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 570
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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