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  1. Article ; Online: Telomeres as hotspots for innate immunity and inflammation.

    Nassour, Joe / Przetocka, Sara / Karlseder, Jan

    DNA repair

    2023  Volume 133, Page(s) 103591

    Abstract: Aging is marked by the gradual accumulation of deleterious changes that disrupt organ function, creating an altered physiological state that is permissive for the onset of prevalent human diseases. While the exact mechanisms governing aging remain a ... ...

    Abstract Aging is marked by the gradual accumulation of deleterious changes that disrupt organ function, creating an altered physiological state that is permissive for the onset of prevalent human diseases. While the exact mechanisms governing aging remain a subject of ongoing research, there are several cellular and molecular hallmarks that contribute to this biological process. This review focuses on two factors, namely telomere dysfunction and inflammation, which have emerged as crucial contributors to the aging process. We aim to discuss the mechanistic connections between these two distinct hallmarks and provide compelling evidence highlighting the loss of telomere protection as a driver of pro-inflammatory states associated with aging. By reevaluating the interplay between telomeres, innate immunity, and inflammation, we present novel perspectives on the etiology of aging and its associated diseases.
    MeSH term(s) Humans ; Aging/genetics ; Telomere ; Inflammation ; Immunity, Innate ; Cellular Senescence
    Language English
    Publishing date 2023-11-05
    Publishing country Netherlands
    Document type Review ; Journal Article
    ZDB-ID 2071608-4
    ISSN 1568-7856 ; 1568-7864
    ISSN (online) 1568-7856
    ISSN 1568-7864
    DOI 10.1016/j.dnarep.2023.103591
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5555: Show issues Location:
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  2. Article: Techniques - Mini-incision and plication (MIP) cure hydrocele: A minimally invasive surgical variation.

    Nassour, Anthony Joe / Ashrafi, Darius / Patel, Dinesh

    Canadian Urological Association journal = Journal de l'Association des urologues du Canada

    2022  Volume 16, Issue 5, Page(s) E294–E297

    Abstract: In this single-surgeon case series of 92 men, we present the mini-incision and plication (MIP) cure hydrocele technique for the treatment of idiopathic hydrocele. This minimally invasive, open surgical variant achieves the desired eversion and plication ... ...

    Abstract In this single-surgeon case series of 92 men, we present the mini-incision and plication (MIP) cure hydrocele technique for the treatment of idiopathic hydrocele. This minimally invasive, open surgical variant achieves the desired eversion and plication with minimal hydrocele manipulation, providing excellent results independent of hydrocele size, with fewer complications and a recurrence rate of <1%.
    Language English
    Publishing date 2022-01-10
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 2431403-1
    ISSN 1911-6470
    ISSN 1911-6470
    DOI 10.5489/cuaj.7561
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  3. Article: Telomeres and Cancer: Resolving the Paradox.

    Nassour, Joe / Schmidt, Tobias T / Karlseder, Jan

    Annual review of cancer biology

    2021  Volume 5, Issue 1, Page(s) 59–77

    Abstract: Decades of study on cell cycle regulation have provided great insight into human cellular life span barriers, as well as their dysregulation during tumorigenesis. Telomeres, the extremities of linear chromosomes, perform an essential role in implementing ...

    Abstract Decades of study on cell cycle regulation have provided great insight into human cellular life span barriers, as well as their dysregulation during tumorigenesis. Telomeres, the extremities of linear chromosomes, perform an essential role in implementing these proliferative boundaries and preventing the propagation of potentially cancerous cells. The tumor-suppressive function of telomeres relies on their ability to initiate DNA damage signaling pathways and downstream cellular events, ranging from cell cycle perturbation to inflammation and cell death. While the tumor-suppressor role of telomeres is undoubtable, recent advances have pointed to telomeres as a major source of many of the genomic aberrations found in both early- and late-stage cancers, including the most recently discovered mutational phenomenon of chromothripsis. Telomere shortening appears as a double-edged sword that can function in opposing directions in carcinogenesis. This review focuses on the current knowledge of the dual role of telomeres in cancer and suggests a new perspective to reconcile the paradox of telomeres and their implications in cancer etiology.
    Language English
    Publishing date 2021-04-12
    Publishing country United States
    Document type Journal Article
    ISSN 2472-3428
    ISSN 2472-3428
    DOI 10.1146/annurev-cancerbio-050420-023410
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Relative Risk of Bladder and Kidney Cancer in Lynch Syndrome: Systematic Review and Meta-Analysis.

    Nassour, Anthony-Joe / Jain, Anika / Hui, Nicholas / Siopis, George / Symons, James / Woo, Henry

    Cancers

    2023  Volume 15, Issue 2

    Abstract: Background: The association between Lynch syndrome (LS) and a higher risk of upper tract urothelial carcinoma is well established, but its effect on the risk of bladder and kidney cancers remains controversial. This review aimed to compare the relative ... ...

    Abstract Background: The association between Lynch syndrome (LS) and a higher risk of upper tract urothelial carcinoma is well established, but its effect on the risk of bladder and kidney cancers remains controversial. This review aimed to compare the relative risk (RR) of bladder and kidney cancer in confirmed LS germline mutation carriers compared to the general population. Methods: Medline, Embase, Cochrane Central, and Google Scholar were searched on 14 July 2022 for studies published in English that reported on the rates of urological cancer in adults with confirmed LS germline mutation. The quality of included studies was assessed using Cochrane’s tool to evaluate risk of bias in cohort studies. Random effects meta-analysis estimated the pooled relative risk of bladder and kidney cancer in LS carriers compared to the general population. The quality of the overall evidence was evaluated using GRADE. Results: Of the 1839 records identified, 5 studies involving 7120 participants from 3 continents were included. Overall, LS carriers had a statistically significantly higher RR of developing bladder cancer (RR: 7.48, 95% CI: 3.70, 15.13) and kidney cancer (RR: 3.97, 95% CI: 1.23, 12.81) compared to unaffected participants (p < 0.01). The quality of the evidence was assessed as “low” due to the inclusion of cohort studies, the substantial heterogeneity, and moderate-to-high risk of bias. Conclusion: Lynch syndrome is associated with a significant increase in the relative risk of kidney and bladder cancer. Clinicians should adopt a lower threshold for germline mutation genetic testing in individuals who present with bladder cancer. Further studies evaluating the role and cost-effectiveness of novel urine-based laboratory tests are needed. High-quality studies in histologically proven renal cell carcinoma and their underlying germline mutations are necessary to strengthen the association with LS.
    Language English
    Publishing date 2023-01-13
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15020506
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  5. Article ; Online: TZAP overexpression induces telomere dysfunction and ALT-like activity in ATRX/DAXX-deficient cells.

    Moreno, Sara Priego / Fusté, Javier Miralles / Kaiser, Melanie / Li, Julia Su Zhou / Nassour, Joe / Haggblom, Candy / Denchi, Eros Lazzerini / Karlseder, Jan

    iScience

    2023  Volume 26, Issue 4, Page(s) 106405

    Abstract: The appropriate regulation of telomere length homeostasis is crucial for the maintenance of genome integrity. The telomere-binding protein TZAP has been suggested to regulate telomere length by promoting t-circle and c-circle excisions through telomere ... ...

    Abstract The appropriate regulation of telomere length homeostasis is crucial for the maintenance of genome integrity. The telomere-binding protein TZAP has been suggested to regulate telomere length by promoting t-circle and c-circle excisions through telomere trimming, yet the molecular mechanisms by which TZAP functions at telomeres are not understood. Using a system based on TZAP overexpression, we show that efficient TZAP recruitment to telomeres occurs in the context of open telomeric chromatin caused by loss of ATRX/DAXX independently of H3.3 deposition. Moreover, our data indicate that TZAP binding to telomeres induces telomere dysfunction and ALT-like activity, resulting in the generation of t-circles and c-circles in a Bloom-Topoisomerase IIIα-RMI1-RMI2 (BTR)-dependent manner.
    Language English
    Publishing date 2023-03-14
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2023.106405
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  6. Article ; Online: Expanding the role of PSMA PET in active surveillance.

    Jain, Anika / Nassour, Anthony-Joe / Dean, Thomas / Patterson, Imogen / Tarlinton, Lisa / Kim, Lawrence / Woo, Henry

    BMC urology

    2023  Volume 23, Issue 1, Page(s) 77

    Abstract: Introduction: Accurate grading at the time of diagnosis is fundamental to risk stratification and treatment decision making, particularly for men being considered for Active Surveillance (AS). With the introduction of prostate-specific membrane antigen ( ...

    Abstract Introduction: Accurate grading at the time of diagnosis is fundamental to risk stratification and treatment decision making, particularly for men being considered for Active Surveillance (AS). With the introduction of prostate-specific membrane antigen (PSMA) positron emission tomography (PET) there has been considerable improvement in sensitivity and specificity for the detection and staging of clinically significant prostate cancer. Our study aims to determine the role of PSMA PET/CT in men with newly diagnosed low or favourable intermediate risk prostate cancer to better select men for AS.
    Method: This is a retrospective single centre study performed from January 2019 and October 2022. This study includes men identified from electronic medical record system who had undergone a PSMA PET/CT following newly diagnosed low or favourable-intermediate risk prostate cancer. Primary outcome was to assess the change in management for men being considered for AS following PSMA PET/CT results on the basis of PSMA PET characteristics.
    Results: In total, there were 11 of 30 men (36.67%) who were assigned management by AS and 19 of 30 men (63.33%) who had definitive treatment. 15 of the 19 men that needed treatment had concerning features on PSMA PET/CT results. Of the 15 men with concerning features on PSMA PET, 9 (60%) men were found to have adverse pathological features on final prostatectomy features.
    Conclusion: This retrospective study suggests that PSMA PET/CT has potential to influence the management of men with newly diagnosed prostate cancer that would otherwise be appropriate for active surveillance.
    MeSH term(s) Male ; Humans ; Retrospective Studies ; Positron Emission Tomography Computed Tomography/methods ; Watchful Waiting ; Gallium Radioisotopes ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/therapy
    Chemical Substances Gallium Radioisotopes
    Language English
    Publishing date 2023-04-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2059857-9
    ISSN 1471-2490 ; 1471-2490
    ISSN (online) 1471-2490
    ISSN 1471-2490
    DOI 10.1186/s12894-023-01219-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Chilaiditi's sign: a rare presentation of pseudo-pneumoperitoneum masquerading as an acute abdomen.

    Nassour, Anthony-Joe / Ashrafi, Daniel / Gatmaitan, Raleene / Ashrafi, Darius / Raufian, Kasra

    ANZ journal of surgery

    2021  Volume 91, Issue 11, Page(s) 2540–2542

    MeSH term(s) Abdomen ; Abdomen, Acute/diagnosis ; Abdomen, Acute/etiology ; Colon ; Humans ; Pneumoperitoneum/diagnostic imaging ; Pneumoperitoneum/etiology
    Language English
    Publishing date 2021-03-12
    Publishing country Australia
    Document type Case Reports ; Journal Article
    ZDB-ID 2050749-5
    ISSN 1445-2197 ; 1445-1433 ; 0004-8682
    ISSN (online) 1445-2197
    ISSN 1445-1433 ; 0004-8682
    DOI 10.1111/ans.16747
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 180: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  8. Article: A novel role for DNA single-strand breaks in senescence and neoplastic escape of epithelial cells.

    Nassour, Joe / Abbadie, Corinne

    Molecular & cellular oncology

    2016  Volume 3, Issue 5, Page(s) e1190885

    Abstract: In contrast to fibroblasts, epithelial cells spontaneously escape from senescence and develop clones of mutated, transformed, and tumorigenic cells. Recently, we revealed that accumulation of unrepaired DNA single-strand breaks is a trigger of the p16 ( ... ...

    Abstract In contrast to fibroblasts, epithelial cells spontaneously escape from senescence and develop clones of mutated, transformed, and tumorigenic cells. Recently, we revealed that accumulation of unrepaired DNA single-strand breaks is a trigger of the p16 (CDKN2)-dependent cell cycle arrest pathway in senescent epithelial cells and also the mutagenic motor of post-senescence neoplastic escape.
    Language English
    Publishing date 2016-05-31
    Publishing country United States
    Document type Journal Article
    ISSN 2372-3556
    ISSN 2372-3556
    DOI 10.1080/23723556.2016.1190885
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  9. Article ; Online: The effect of different assays on prostate-specific antigen testing.

    Jain, Anika / Nassour, Anthony-Joe / Symons, James L / Chung, Amanda / Goolam, Ahmed S / Wines, Michael P / Chalasani, Venu / Dias, Max / Collins, Ruth / Indrajit, Bala / Woo, Henry H

    BJU international

    2023  Volume 131, Issue 6, Page(s) 689–691

    MeSH term(s) Male ; Humans ; Prostate-Specific Antigen ; Prostatic Neoplasms/diagnosis ; Biological Assay
    Chemical Substances Prostate-Specific Antigen (EC 3.4.21.77)
    Language English
    Publishing date 2023-03-06
    Publishing country England
    Document type Letter
    ZDB-ID 1462191-5
    ISSN 1464-410X ; 1464-4096 ; 1358-8672
    ISSN (online) 1464-410X
    ISSN 1464-4096 ; 1358-8672
    DOI 10.1111/bju.15958
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  10. Article ; Online: Interesting case of an abdominal wall Merkel cell carcinoma highlighting the importance of developing an Australian clinical practice guideline.

    Nassour, Anthony-Joe / Ashrafi, Darius / Lah, Kevin / Sivananthan, Suntharalingham

    BMJ case reports

    2020  Volume 13, Issue 9

    Abstract: A 66-year-old Australian male farmer was referred for management of an asymptomatic, rapidly expanding, anterior abdominal wall mass. It was firm and well circumscribed. There were no overlying skin changes, constitutional symptoms or weight loss. His ... ...

    Abstract A 66-year-old Australian male farmer was referred for management of an asymptomatic, rapidly expanding, anterior abdominal wall mass. It was firm and well circumscribed. There were no overlying skin changes, constitutional symptoms or weight loss. His medical history included small bowel obstruction and resection from a Meckel's diverticulitis and a 40-pack-year smoking history. Core biopsy was suggestive of a neuroendocrine tumour and Gallium-68-Dodecane-Tetraacetic-Acid (68GaTate) positron emission tomography revealed an avid solitary lesion confined to the subcutaneous space in the left anterior abdominal wall. Wide local excision was performed, and histopathology revealed Merkel cell carcinoma (MCC). Although classically regarded as a primary cutaneous neuroendocrine tumour, MCC may originate from the subcutaneous fat without obvious skin involvement. Older patients with asymptomatic, rapidly enlarging lesions, particularly if immunosuppressed, with significant ultraviolet sunlight exposure, should raise a high index of suspicion for MCC. Like melanoma, non-metastatic MCC should be treated aggressively for best prognosis.
    MeSH term(s) Abdominal Wall/diagnostic imaging ; Abdominal Wall/pathology ; Abdominal Wall/surgery ; Aged ; Asymptomatic Diseases ; Biopsy, Large-Core Needle/standards ; Carcinoma, Merkel Cell/diagnosis ; Carcinoma, Merkel Cell/pathology ; Carcinoma, Merkel Cell/therapy ; Humans ; Male ; Margins of Excision ; Medical Oncology/standards ; Neoplasm Staging/standards ; Positron Emission Tomography Computed Tomography ; Practice Guidelines as Topic ; Queensland ; Radiotherapy, Adjuvant/standards ; Sentinel Lymph Node Biopsy/standards ; Skin Neoplasms/diagnosis ; Skin Neoplasms/pathology ; Skin Neoplasms/therapy ; Subcutaneous Fat, Abdominal/diagnostic imaging ; Subcutaneous Fat, Abdominal/pathology ; Subcutaneous Fat, Abdominal/surgery
    Language English
    Publishing date 2020-09-13
    Publishing country England
    Document type Case Reports ; Journal Article ; Review
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2020-235927
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