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Article ; Online: Microbes mediated immunogenic cell death in cancer immunotherapy

Huang, Jumin / Duan, Fugang / Xie, Chun / Chui, Kawai / Zhang, Yizhong / Wang, Yuwei / Tang, Yu‐Ping / Leung, Elaine Lai‐Han

Immunological Reviews. 2024 Jan., v. 321, no. 1 p.128-142

2024

Abstract: Immunogenic cell death (ICD) is one of the 12 distinct cell death forms, which can trigger immune system to fight against cancer cells. During ICD, a number of cellular changes occur that can stimulate an immune response, including the release of ... ...

Abstract	Immunogenic cell death (ICD) is one of the 12 distinct cell death forms, which can trigger immune system to fight against cancer cells. During ICD, a number of cellular changes occur that can stimulate an immune response, including the release of molecules called damage‐associated molecular patterns (DAMPs), signaling to immune cells to recognize and attack cancer cells. By virtue of their pivotal role in immune surveillance, ICD‐based drug development has been a new approach to explore novel therapeutic combinations and personalized strategies in cancer therapy. Several small molecules and microbes can induce ICD‐relevant signals and cause cancer cell death. In this review, we highlighted the role of microbe‐mediate ICD in cancer immunotherapy and described the mechanisms through which microbes might serve as ICD inducers in cancer treatment. We also discussed current attempts to combine microbes with chemotherapy regimens or immune checkpoint inhibitors (ICIs) in the treatment of cancer patients. We surmise that manipulation of microbes may guide personalized therapeutic interventions to facilitate anticancer immune response.
Keywords	cancer therapy ; cell death ; drug development ; drug therapy ; immune response ; immune system ; immunotherapy ; monitoring ; neoplasm cells
Language	English
Dates of publication	2024-01
Size	p. 128-142.
Publishing place	John Wiley & Sons, Ltd
Document type	Article ; Online
Note	REVIEW
ZDB-ID	391796-4
ISSN	1600-065X ; 0105-2896
ISSN (online)	1600-065X
ISSN	0105-2896
DOI	10.1111/imr.13261
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Microbes mediated immunogenic cell death in cancer immunotherapy.

Huang, Jumin / Duan, Fugang / Xie, Chun / Xu, Jiahui / Zhang, Yizhong / Wang, Yuwei / Tang, Yu-Ping / Leung, Elaine Lai-Han

Immunological reviews

2023 Volume 321, Issue 1, Page(s) 128–142

Abstract	Immunogenic cell death (ICD) is one of the 12 distinct cell death forms, which can trigger immune system to fight against cancer cells. During ICD, a number of cellular changes occur that can stimulate an immune response, including the release of molecules called damage-associated molecular patterns (DAMPs), signaling to immune cells to recognize and attack cancer cells. By virtue of their pivotal role in immune surveillance, ICD-based drug development has been a new approach to explore novel therapeutic combinations and personalized strategies in cancer therapy. Several small molecules and microbes can induce ICD-relevant signals and cause cancer cell death. In this review, we highlighted the role of microbe-mediate ICD in cancer immunotherapy and described the mechanisms through which microbes might serve as ICD inducers in cancer treatment. We also discussed current attempts to combine microbes with chemotherapy regimens or immune checkpoint inhibitors (ICIs) in the treatment of cancer patients. We surmise that manipulation of microbes may guide personalized therapeutic interventions to facilitate anticancer immune response.
MeSH term(s)	Humans ; Immunogenic Cell Death ; Antineoplastic Agents/therapeutic use ; Neoplasms ; Cell Death ; Immunotherapy
Chemical Substances	Antineoplastic Agents
Language	English
Publishing date	2023-08-08
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	391796-4
ISSN	1600-065X ; 0105-2896
ISSN (online)	1600-065X
ISSN	0105-2896
DOI	10.1111/imr.13261
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Article ; Online: A novel strategy for identifying biomarker in serum of patient with COVID-19 using immune complex

Fugang Duan / Yifan Wang / Taoyu Chen / Zhu Zhu / Meng Yu / Hui Dai / Shangen Zheng / Yinying Lu / Tingting Li / Xiaoyan Qiu

Signal Transduction and Targeted Therapy, Vol 7, Iss 1, Pp 1-

2022 Volume 3

Keywords	Medicine ; R ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Organic pollution control of agricultural land based on straw biochar

Xiaochen, Duan / Yan, Tang / Fen, Liu / Xiuyong, Fu / Fugang, Liu

Acta Agriculturae Scandinavica, Section B — Soil & Plant Science. 2022 Dec. 31, v. 72, no. 1 p.237-247

2022

Abstract: Organic pollution of agricultural land will cause environmental problems and agricultural economic effects. To explore the reliable effect of remediation of organic pollution in agricultural land, wheat straw biochar was prepared in this paper. Moreover, ...

Abstract	Organic pollution of agricultural land will cause environmental problems and agricultural economic effects. To explore the reliable effect of remediation of organic pollution in agricultural land, wheat straw biochar was prepared in this paper. Moreover, this paper uses experimental research and comparison methods to study the difference in the adsorption performance of biochar at different pyrolysis temperatures on polycyclic aromatic hydrocarbons (PAHs) and the effect of pyrolysis biochar on the availability of phenanthrene and pyrene microorganisms in the soil at the same temperature. Additionally, statistical methods are utilised in this research to do analytics and data processing on test data, and test findings are visually displayed using a combination of graphs and tables. Finally, to understand the experimental research findings, this system employs analytical approaches. The results of the experiment show that wheat straw biochar can effectively reduce soil organic pollution, which can expand the research on the restoration of other crop straw biochar on agricultural land.
Keywords	adsorption ; agricultural land ; biochar ; phenanthrenes ; pollution ; pyrolysis ; remediation ; soil ; temperature ; wheat straw ; land pollution ; crop straw
Language	English
Dates of publication	2022-1231
Size	p. 237-247.
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	32458-9
ISSN	1651-1913 ; 0906-4710
ISSN (online)	1651-1913
ISSN	0906-4710
DOI	10.1080/09064710.2021.2008479
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Article ; Online: A novel strategy for identifying biomarker in serum of patient with COVID-19 using immune complex.

Duan, Fugang / Wang, Yifan / Chen, Taoyu / Zhu, Zhu / Yu, Meng / Dai, Hui / Zheng, Shangen / Lu, Yinying / Li, Tingting / Qiu, Xiaoyan

Signal transduction and targeted therapy

2022 Volume 7, Issue 1, Page(s) 63

MeSH term(s)	Antibodies, Viral/blood ; Antigen-Antibody Complex/blood ; Antigens, Viral/blood ; Antigens, Viral/genetics ; Antigens, Viral/immunology ; Biomarkers/blood ; COVID-19/blood ; COVID-19/diagnosis ; COVID-19/immunology ; COVID-19/virology ; Case-Control Studies ; Chromatography, Affinity ; Glycoproteins/blood ; Glycoproteins/genetics ; Glycoproteins/immunology ; Humans ; Immune Sera/chemistry ; Immunoglobulin A/blood ; Immunoglobulin G/blood ; SARS-CoV-2/immunology ; Tandem Mass Spectrometry
Chemical Substances	Antibodies, Viral ; Antigen-Antibody Complex ; Antigens, Viral ; Biomarkers ; Glycoproteins ; Immune Sera ; Immunoglobulin A ; Immunoglobulin G ; LRG1 protein, human
Language	English
Publishing date	2022-02-28
Publishing country	England
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	2886872-9
ISSN	2059-3635 ; 2095-9907
ISSN (online)	2059-3635
ISSN	2095-9907
DOI	10.1038/s41392-022-00909-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: IL-6, IL-8 and IL-10 polymorphisms may impact predisposition of Alzheimer's disease: a meta-analysis.

Yang, Rongmei / Duan, Jinfeng / Luo, Fugang / Tao, Pingyu / Hu, Chenling

Acta neurologica Belgica

2020 Volume 121, Issue 6, Page(s) 1505–1512

Abstract: Gene polymorphisms in interleukin-6 (IL-6), interleukin-8 (IL-8), and interleukin-10 (IL-10) may affect the predisposition of Alzheimer's disease (AD), but the results of the so far published studies remain controversial. The authors conducted this meta- ... ...

Abstract	Gene polymorphisms in interleukin-6 (IL-6), interleukin-8 (IL-8), and interleukin-10 (IL-10) may affect the predisposition of Alzheimer's disease (AD), but the results of the so far published studies remain controversial. The authors conducted this meta-analysis to assess relationships between IL-6/IL-8/IL-10 polymorphisms and predisposition of AD by pooling the findings of so far published studies. A comprehensive search of Pubmed, Embase, Web of Science, and CNKI was endorsed by the authors to identify the already published studies. Forty-five studies were found to be eligible for meta-analyses. The pooled meta-analyses results showed that genotypic frequencies of IL-6 - 174 G/C, IL-6 - 572 G/C and IL-10 - 1082 A/G polymorphisms among patients with AD and controls differed significantly. Moreover, genotypic frequencies of IL-6 - 174 G/C, IL-6 - 572 G/C, and IL-8 - 251 A/T polymorphisms among patients with AD and controls in Asians also differed significantly. But no such genotypic frequencies' differences were observed for IL-10 - 819 C/T and 592 C/A polymorphisms. This meta-analysis suggests that IL-6 - 174 G/C, IL-6 - 572 G/C, and IL-10 - 1082 A/G polymorphisms may affect the predisposition of AD in overall population. Moreover, IL-6 - 174 G/C, IL-6 - 572 G/C, and IL-8 - 251 A/T polymorphisms may affect the predisposition of AD in Asians.
MeSH term(s)	Asians/genetics ; Genetic Predisposition to Disease/epidemiology ; Genetic Predisposition to Disease/genetics ; Humans ; Interleukin-10/genetics ; Interleukin-6/genetics ; Interleukin-8/genetics ; Polymorphism, Single Nucleotide/genetics
Chemical Substances	IL10 protein, human ; IL6 protein, human ; Interleukin-6 ; Interleukin-8 ; Interleukin-10 (130068-27-8)
Language	English
Publishing date	2020-05-12
Publishing country	Italy
Document type	Journal Article ; Meta-Analysis
ZDB-ID	127315-2
ISSN	2240-2993 ; 0300-9009
ISSN (online)	2240-2993
ISSN	0300-9009
DOI	10.1007/s13760-020-01369-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Analysis of TCR Repertoire by High-Throughput Sequencing Indicates the Feature of T Cell Immune Response after SARS-CoV-2 Infection

Yifan Wang / Fugang Duan / Zhu Zhu / Meng Yu / Xiaodong Jia / Hui Dai / Pingzhang Wang / Xiaoyan Qiu / Yinying Lu / Jing Huang

Cells, Vol 11, Iss 68, p

2022 Volume 68

Abstract: Coronavirus disease 2019 (COVID-19) is a global infectious disease caused by the SARS-CoV-2 coronavirus. T cells play an essential role in the body’s fighting against the virus invasion, and the T cell receptor (TCR) is crucial in T cell-mediated virus ... ...

Abstract	Coronavirus disease 2019 (COVID-19) is a global infectious disease caused by the SARS-CoV-2 coronavirus. T cells play an essential role in the body’s fighting against the virus invasion, and the T cell receptor (TCR) is crucial in T cell-mediated virus recognition and clearance. However, little has been known about the features of T cell response in convalescent COVID-19 patients. In this study, using 5′RACE technology and PacBio sequencing, we analyzed the TCR repertoire of COVID-19 patients after recovery for 2 weeks and 6 months compared with the healthy donors. The TCR clustering and CDR3 annotation were exploited to discover groups of patient-specific TCR clonotypes with potential SARS-CoV-2 antigen specificities. We first identified CD4 + and CD8 + T cell clones with certain clonal expansion after infection, and then observed the preferential recombination usage of V(D) J gene segments in CD4 + and CD8 + T cells of COVID-19 patients with different convalescent stages. More important, the TRBV6-5-TRBD2-TRBJ2-7 combination with high frequency was shared between CD4 + T and CD8 + T cells of different COVID-19 patients. Finally, we found the dominant characteristic motifs of the CDR3 sequence between recovered COVID-19 and healthy control. Our study provides novel insights on TCR in COVID-19 with different convalescent phases, contributing to our understanding of the immune response induced by SARS-CoV-2.
Keywords	SARS-CoV-2 ; COVID-19 ; T cell receptor ; CDR3 ; immune memory ; Biology (General) ; QH301-705.5
Subject code	570
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Analysis of TCR Repertoire by High-Throughput Sequencing Indicates the Feature of T Cell Immune Response after SARS-CoV-2 Infection.

Wang, Yifan / Duan, Fugang / Zhu, Zhu / Yu, Meng / Jia, Xiaodong / Dai, Hui / Wang, Pingzhang / Qiu, Xiaoyan / Lu, Yinying / Huang, Jing

Cells

2021 Volume 11, Issue 1

Abstract: Coronavirus disease 2019 (COVID-19) is a global infectious disease caused by the SARS-CoV-2 coronavirus. T cells play an essential role in the body's fighting against the virus invasion, and the T cell receptor (TCR) is crucial in T cell-mediated virus ... ...

Abstract	Coronavirus disease 2019 (COVID-19) is a global infectious disease caused by the SARS-CoV-2 coronavirus. T cells play an essential role in the body's fighting against the virus invasion, and the T cell receptor (TCR) is crucial in T cell-mediated virus recognition and clearance. However, little has been known about the features of T cell response in convalescent COVID-19 patients. In this study, using 5'RACE technology and PacBio sequencing, we analyzed the TCR repertoire of COVID-19 patients after recovery for 2 weeks and 6 months compared with the healthy donors. The TCR clustering and CDR3 annotation were exploited to discover groups of patient-specific TCR clonotypes with potential SARS-CoV-2 antigen specificities. We first identified CD4
MeSH term(s)	Aged ; Amino Acid Sequence ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/metabolism ; CD4-Positive T-Lymphocytes/virology ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/metabolism ; CD8-Positive T-Lymphocytes/virology ; COVID-19/immunology ; COVID-19/metabolism ; COVID-19/virology ; Cells, Cultured ; Complementarity Determining Regions/genetics ; Complementarity Determining Regions/immunology ; Convalescence ; Female ; High-Throughput Nucleotide Sequencing/methods ; Humans ; Immunity/immunology ; Male ; Middle Aged ; Patient Acuity ; Receptors, Antigen, T-Cell/genetics ; Receptors, Antigen, T-Cell/immunology ; Receptors, Antigen, T-Cell/metabolism ; Receptors, Antigen, T-Cell, alpha-beta/genetics ; Receptors, Antigen, T-Cell, alpha-beta/immunology ; Receptors, Antigen, T-Cell, alpha-beta/metabolism ; SARS-CoV-2/immunology ; SARS-CoV-2/physiology ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism ; T-Lymphocytes/virology
Chemical Substances	Complementarity Determining Regions ; Receptors, Antigen, T-Cell ; Receptors, Antigen, T-Cell, alpha-beta
Language	English
Publishing date	2021-12-27
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells11010068
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Article ; Online: A secreted fungal effector suppresses rice immunity through host histone hypoacetylation.

Chen, Xiaoyang / Duan, Yuhang / Qiao, Fugang / Liu, Hao / Huang, Junbin / Luo, Chaoxi / Chen, Xiaolin / Li, Guotian / Xie, Kabin / Hsiang, Tom / Zheng, Lu

The New phytologist

2022 Volume 235, Issue 5, Page(s) 1977–1994

Abstract: Histone acetylation is a critical epigenetic modification that regulates plant immunity. Fungal pathogens secrete effectors that modulate host immunity and facilitate infection, but whether fungal pathogens have evolved effectors that directly target ... ...

Abstract	Histone acetylation is a critical epigenetic modification that regulates plant immunity. Fungal pathogens secrete effectors that modulate host immunity and facilitate infection, but whether fungal pathogens have evolved effectors that directly target plant histone acetylation remains unknown. Here, we identified a secreted protein, UvSec117, from the rice false smut fungus, Ustilaginoidea virens, as a key effector that can target the rice histone deacetylase OsHDA701 and negatively regulates rice broad-spectrum resistance against rice pathogens. UvSec117 disrupts host immunity by recruiting OsHDA701 to the nucleus and enhancing OsHDA701-modulated deacetylation, thereby reducing histone H3K9 acetylation levels in rice plants and interfering with defense gene activation. Host-induced gene silencing of UvSec117 promotes rice resistance to U. virens, thus providing an alternative way for developing rice false smut-resistant plants. This is the first direct evidence demonstrating that a fungal effector targets a histone deacetylase to suppress plant immunity. Our data provided insight into a counter-defense mechanism in a plant pathogen that inactivates host defense responses at the epigenetic level.
MeSH term(s)	Histone Deacetylases ; Histones ; Oryza/genetics ; Oryza/microbiology ; Plant Diseases/microbiology ; Plant Immunity
Chemical Substances	Histones ; Histone Deacetylases (EC 3.5.1.98)
Language	English
Publishing date	2022-06-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	208885-x
ISSN	1469-8137 ; 0028-646X
ISSN (online)	1469-8137
ISSN	0028-646X
DOI	10.1111/nph.18265
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Article ; Online: B-Cell Receptor Features and Database Establishment in Recovered COVID-19 Patients by Combining 5'-RACE with PacBio Sequencing.

Zhu, Zhu / Wang, Pingzhang / Jia, Xiaodong / Yu, Meng / Yan, Huige / Liu, Lei / Liu, Wanbing / Zheng, Yaqiong / Kou, Guomei / Wang, Jie / Xu, Weiyan / Huang, Jing / Duan, Fugang / Lu, Fengmin / Fu, Ning / Zhang, Ning / Lu, Yingying / Dai, Hui / Zheng, Shangen /

Qiu, Xiaoyan

Frontiers in bioscience (Landmark edition)

2022 Volume 28, Issue 2, Page(s) 40

Abstract: Background: Antibodies induced by viral infection can not only prevent subsequent virus infection, but can also mediate pathological injury following infection. Therefore, understanding the B-cell receptor (BCR) repertoire of either specific ... ...

Abstract	Background: Antibodies induced by viral infection can not only prevent subsequent virus infection, but can also mediate pathological injury following infection. Therefore, understanding the B-cell receptor (BCR) repertoire of either specific neutralizing or pathological antibodies from patients convalescing from Coronavirus disease 2019 (COVID-19) infection is of benefit for the preparation of therapeutic or preventive antibodies, and may provide insight into the mechanisms of COVID-19 pathological injury. Methods: In this study, we used a molecular approach of combining 5' Rapid Amplification of cDNA Ends (5'-RACE) with PacBio sequencing to analyze the BCR repertoire of all 5 Results: We observed numerous BCR clonotypes within most COVID-19 patients, but not in healthy controls, which validates the association of the disease with a prototypical immune response. In addition, many clonotypes were found to be frequently shared between different patients or different classes of antibodies. Conclusions: These convergent clonotypes provide a resource to identify potential therapeutic/prophylactic antibodies, or identify antibodies associated with pathological effects following infection with SARS-CoV-2.
MeSH term(s)	Humans ; COVID-19 ; SARS-CoV-2 ; Receptors, Antigen, B-Cell/genetics ; Antibodies ; B-Lymphocytes
Chemical Substances	Receptors, Antigen, B-Cell ; Antibodies
Language	English
Publishing date	2022-11-06
Publishing country	Singapore
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2704569-9
ISSN	2768-6698 ; 2768-6698
ISSN (online)	2768-6698
ISSN	2768-6698
DOI	10.31083/j.fbl2802040
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