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Article: The evaluation of the delayed swollen breast in patients with a history of breast implants.

Keane, Grace C / Keane, Alexandra M / Diederich, Ryan / Kennard, Kaitlyn / Duncavage, Eric J / Myckatyn, Terence M

2023 Volume 13, Page(s) 1174173

Abstract: Breast implants, whether placed for reconstructive or cosmetic purposes, are rarely lifetime devices. Rupture, resulting from compromised implant shell integrity, and capsular contracture caused by constriction of the specialized scar tissue that ... ...

Abstract	Breast implants, whether placed for reconstructive or cosmetic purposes, are rarely lifetime devices. Rupture, resulting from compromised implant shell integrity, and capsular contracture caused by constriction of the specialized scar tissue that normally forms around breast implants, have long been recognized, and remain the leading causes of implant failure. It is apparent, however, that women with breast implants may also experience delayed breast swelling due to a range of etiologic factors. While a majority of delayed seromas associated with breast implants have a benign etiology, this presentation cannot be ignored without an adequate workup as malignancies such as breast implant associated anaplastic large cell lymphoma (BIA-ALCL), breast implant associated diffuse large B-cell lymphoma (BIA-DLBCL), and breast implant associated squamous cell carcinoma (BIA-SCC) can have a similar clinical presentation. Since these malignancies occur with sufficient frequency, and with sometimes lethal consequences, their existence must be recognized, and an appropriate diagnostic approach implemented. A multidisciplinary team that involves a plastic surgeon, radiologist, pathologist, and, as required, surgical and medical oncologists can expedite judicious care. Herein we review and further characterize conditions that can lead to delayed swelling around breast implants.
Language	English
Publishing date	2023-07-05
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2023.1174173
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Leisure and social occupational choice within nursing home facilities in Ireland: Residents perspectives.

Keane, Jenna / Ryan, Ciara / Usher, Ruth

Scandinavian journal of occupational therapy

2023 Volume 31, Issue 1, Page(s) 2259222

Abstract: Background: National standards for nursing homes in Ireland require that residents are offered a choice of recreational and stimulating activities to meet their needs and preferences.: Aims/objectives: To investigate residents' perceptions of leisure ...

Abstract	Background: National standards for nursing homes in Ireland require that residents are offered a choice of recreational and stimulating activities to meet their needs and preferences. Aims/objectives: To investigate residents' perceptions of leisure and social occupational choice in nursing homes in Ireland to determine if occupational choice is facilitated. Materials and method: Qualitative-descriptive design - nursing home residents completed two semi-structured interviews that explored their experiences of leisure and social occupational engagement. Results: Two overarching themes with six associated sub-themes emerged. From residents' perspectives, social and leisure occupational choice was dependent on: Environmental factors (nursing homes' Cultural, Social, Physical, and Temporal Environments) and Personal factors (residents' Health Status and Personal Attitudes). Conclusion: The cultural environment had the most significant influence on residents' leisure and social occupational choice, highlighting the importance of person-centred care within nursing homes, to promote occupational choice. Resident's health status was also identified as a contributing factor. Significance: Occupational therapists could play a critical role in supporting the leisure and social occupational choices of nursing home residents by developing residents' skills, educating staff and adapting tasks and the environment to limit/reduce occupational deprivation.
MeSH term(s)	Humans ; Ireland ; Qualitative Research ; Nursing Homes ; Attitude ; Leisure Activities
Language	English
Publishing date	2023-11-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2144132-7
ISSN	1651-2014 ; 1103-8128
ISSN (online)	1651-2014
ISSN	1103-8128
DOI	10.1080/11038128.2023.2259222
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Article ; Online: Diagnostic decisions of specialist optometrists exposed to ambiguous deep-learning outputs.

Carmichael, Josie / Costanza, Enrico / Blandford, Ann / Struyven, Robbert / Keane, Pearse A / Balaskas, Konstantinos

Scientific reports

2024 Volume 14, Issue 1, Page(s) 6775

Abstract: Artificial intelligence (AI) has great potential in ophthalmology. We investigated how ambiguous outputs from an AI diagnostic support system (AI-DSS) affected diagnostic responses from optometrists when assessing cases of suspected retinal disease. ... ...

Abstract	Artificial intelligence (AI) has great potential in ophthalmology. We investigated how ambiguous outputs from an AI diagnostic support system (AI-DSS) affected diagnostic responses from optometrists when assessing cases of suspected retinal disease. Thirty optometrists (15 more experienced, 15 less) assessed 30 clinical cases. For ten, participants saw an optical coherence tomography (OCT) scan, basic clinical information and retinal photography ('no AI'). For another ten, they were also given AI-generated OCT-based probabilistic diagnoses ('AI diagnosis'); and for ten, both AI-diagnosis and AI-generated OCT segmentations ('AI diagnosis + segmentation') were provided. Cases were matched across the three types of presentation and were selected to include 40% ambiguous and 20% incorrect AI outputs. Optometrist diagnostic agreement with the predefined reference standard was lowest for 'AI diagnosis + segmentation' (204/300, 68%) compared to 'AI diagnosis' (224/300, 75% p = 0.010), and 'no Al' (242/300, 81%, p = < 0.001). Agreement with AI diagnosis consistent with the reference standard decreased (174/210 vs 199/210, p = 0.003), but participants trusted the AI more (p = 0.029) with segmentations. Practitioner experience did not affect diagnostic responses (p = 0.24). More experienced participants were more confident (p = 0.012) and trusted the AI less (p = 0.038). Our findings also highlight issues around reference standard definition.
MeSH term(s)	Humans ; Optometrists ; Artificial Intelligence ; Deep Learning ; Ophthalmology/methods ; Retinal Diseases ; Tomography, Optical Coherence/methods
Language	English
Publishing date	2024-03-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-55410-0
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Article ; Online: Elevated CO

Taylor, Christopher R / England, Luke C / Keane, J Ben / Davies, Jessica A C / Leake, Jonathan R / Hartley, Iain P / Smart, Simon M / Janes-Bassett, Victoria / Phoenix, Gareth K

Global change biology

2024 Volume 30, Issue 1, Page(s) e17104

Abstract: Globally pervasive increases in atmospheric ... ...

Abstract	Globally pervasive increases in atmospheric CO
MeSH term(s)	Grassland ; Carbon Dioxide/analysis ; Phosphorus ; Plants ; Poaceae ; Nitrogen ; Soil/chemistry ; Calcium Carbonate
Chemical Substances	Carbon Dioxide (142M471B3J) ; Phosphorus (27YLU75U4W) ; Nitrogen (N762921K75) ; Soil ; Calcium Carbonate (H0G9379FGK)
Language	English
Publishing date	2024-01-25
Publishing country	England
Document type	Journal Article
ZDB-ID	1281439-8
ISSN	1365-2486 ; 1354-1013
ISSN (online)	1365-2486
ISSN	1354-1013
DOI	10.1111/gcb.17104
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Article: IFI207, a young and fast-evolving antiviral factor, stabilizes STING.

Moran, Eileen A / Salas-Briceno, Karen / Aguilera, Alexya N / Keane, Thomas M / Adams, David J / Lilue, Jingtao / Ross, Susan R

bioRxiv : the preprint server for biology

2023

Abstract: Mammalian ALR proteins bind nucleic acids and initiate production of type I interferons or inflammasome assembly, thereby contributing to host innate immunity. ...

Abstract	Mammalian ALR proteins bind nucleic acids and initiate production of type I interferons or inflammasome assembly, thereby contributing to host innate immunity.
Language	English
Publishing date	2023-01-19
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.01.19.524411
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Article ; Online: Bridging Heterogeneity Dictates the Microstructure and Yielding Response of Polymer-Linked Emulsions.

Keane, Daniel P / Constantine, Colby J / Mellor, Matthew D / Poling-Skutvik, Ryan

Langmuir : the ACS journal of surfaces and colloids

2023 Volume 39, Issue 22, Page(s) 7852–7862

Abstract: Soft materials possessing tunable rheological properties are desirable in applications ranging from 3D printing to biological scaffolds. Here, we use a telechelic, triblock copolymer polystyrene- ...

Abstract	Soft materials possessing tunable rheological properties are desirable in applications ranging from 3D printing to biological scaffolds. Here, we use a telechelic, triblock copolymer polystyrene-
Language	English
Publishing date	2023-05-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2005937-1
ISSN	1520-5827 ; 0743-7463
ISSN (online)	1520-5827
ISSN	0743-7463
DOI	10.1021/acs.langmuir.3c00707
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Article ; Online: Microfluidics produced ATRA-loaded PLGA NPs reduced tuberculosis burden in alveolar epithelial cells and enabled high delivered dose under simulated human breathing pattern in 3D printed head models.

Bahlool, Ahmad Z / Cavanagh, Brenton / Sullivan, Andrew O' / MacLoughlin, Ronan / Keane, Joseph / Sullivan, Mary P O' / Cryan, Sally-Ann

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

2024 Volume 196, Page(s) 106734

Abstract: Tuberculosis, caused by Mycobacterium tuberculosis (Mtb), is second only to COVID-19 as the top infectious disease killer worldwide. Multi-drug resistant TB (MDR-TB) may arise because of poor patient adherence to medications due to lengthy treatment ... ...

Abstract	Tuberculosis, caused by Mycobacterium tuberculosis (Mtb), is second only to COVID-19 as the top infectious disease killer worldwide. Multi-drug resistant TB (MDR-TB) may arise because of poor patient adherence to medications due to lengthy treatment duration and side effects. Delivering novel host directed therapies (HDT), like all trans retinoic acid (ATRA) may help to improve drug regimens and reduce the incidence of MDR-TB. Local delivery of ATRA to the site of infection leads to higher bioavailability and reduced systemic side effects. ATRA is poorly soluble in water and has a short half-life in plasma. Therefore, it requires a formulation step before it can be administered in vivo. ATRA loaded PLGA nanoparticles suitable for nebulization were manufactured and optimized using a scalable nanomanufacturing microfluidics (MF) mixing approach (MF-ATRA-PLGA NPs). MF-ATRA-PLGA NPs demonstrated a dose dependent inhibition of Mtb growth in TB-infected A549 alveolar epithelial cell model while preserving cell viability. The MF-ATRA-PLGA NPs were nebulized with the Aerogen Solo vibrating mesh nebulizer, with aerosol droplet size characterized using laser diffraction and the estimated delivered dose was determined. The volume median diameter (VMD) of the MF-ATRA-PLGA NPs was 3.00 ± 0.18 μm. The inhaled dose delivered in adult and paediatric 3D printed head models under a simulated normal adult and paediatric breathing pattern was found to be 47.05 ± 3 % and 20.15 ± 3.46 % respectively. These aerosol characteristics of MF-ATRA-PLGA NPs supports its suitability for delivery to the lungs via inhalation. The data generated on the efficacy of an inhalable, scalable and regulatory friendly ATRA-PLGA NPs formulation provides a foundation on which further pre-clinical testing can be built. Overall, the results of this project are promising for future research into ATRA loaded NPs formulations as inhaled host directed therapies for TB.
Language	English
Publishing date	2024-02-26
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1154366-8
ISSN	1879-0720 ; 0928-0987
ISSN (online)	1879-0720
ISSN	0928-0987
DOI	10.1016/j.ejps.2024.106734
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Article ; Online: Risk factors for, and genetic association with, intestinal atresia in dairy calves.

Keane, Orla M / Carthy, Tara R / Hanrahan, James P / Matthews, Daragh / McEwan, John C / Rowe, Suzanne J / Kenneally, Jonathon / Mee, John F

Animal genetics

2023 Volume 54, Issue 2, Page(s) 104–112

Abstract: Intestinal atresia is an under-diagnosed congenital defect in cattle. It results in complete occlusion of the intestinal lumen and, unless surgically corrected, results in death or euthanasia of the affected calf. There is limited information on the ... ...

Abstract	Intestinal atresia is an under-diagnosed congenital defect in cattle. It results in complete occlusion of the intestinal lumen and, unless surgically corrected, results in death or euthanasia of the affected calf. There is limited information on the incidence of this condition or on risk factors, including predisposing alleles, associated with the defect. In this study, active surveillance of 39 dairy farms over 8 years identified 197 cases of intestinal atresia among 56 454 calves born, an incidence of 0.35%. The majority of cases (83%) had occlusion of the jejunum, although cases with blockage of the colon (14%) or anus (4%) were also identified. The defect was twice as common in male as in female calves (p < 0.0001), and was more common in progeny of older cows than in progeny of first or second lactation cows (p < 0.001). Year and farm of birth were also significantly associated with incidence (p < 0.05). The incidence of intestinal atresia was highest among the progeny of three related Jersey sires, suggesting that a gene for intestinal atresia was segregating within this family. Linkage analysis utilising 28 affected progeny of two half-sib putative carrier sires identified two putative quantitative trait loci associated with the defect, on chromosomes 14 and 26, although no clear candidate genes were identified. There was no evidence of a sire-effect among the progeny of Holstein-Friesian sires. However, a case-control genome-wide association study involving 91 cases and 375 healthy controls, identified 31 SNP in 18 loci as associated with the defect in this breed. These data suggest that intestinal atresia in dairy calves is not a simple Mendelian trait as previously reported but a complex multigenic disorder.
MeSH term(s)	Pregnancy ; Animals ; Cattle/genetics ; Female ; Male ; Intestinal Atresia/genetics ; Intestinal Atresia/veterinary ; Genome-Wide Association Study ; Parturition ; Risk Factors ; Lactation
Language	English
Publishing date	2023-01-13
Publishing country	England
Document type	Journal Article
ZDB-ID	632766-7
ISSN	1365-2052 ; 0268-9146 ; 0268-9154
ISSN (online)	1365-2052
ISSN	0268-9146 ; 0268-9154
DOI	10.1111/age.13291
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Article: Immunological mechanisms of tolerance: Central, peripheral and the role of T and B cells.

Meng, Xun / Layhadi, Janice A / Keane, Sean T / Cartwright, Natanya J K / Durham, Stephen R / Shamji, Mohamed H

Asia Pacific allergy

2023 Volume 13, Issue 4, Page(s) 175–186

Abstract: T and B cells are key components of the adaptive immune system. Through their immune properties and their interactions with other immune cells and cytokines around them, they build a complex network to achieve immune tolerance and maintain homeostasis of ...

Abstract	T and B cells are key components of the adaptive immune system. Through their immune properties and their interactions with other immune cells and cytokines around them, they build a complex network to achieve immune tolerance and maintain homeostasis of the body. This is achieved through mechanisms of central and peripheral tolerance, both of which are associated with advantages and disadvantages. For this reason, the immune system is tightly regulated and their dysregulation can result in the subsequent initiation of various diseases. In this review, we will summarize the roles played by T cells and B cells within immune tolerance with specific examples in the context of different diseases that include allergic disease. In addition, we will also provide an overview on their suitability as biomarkers of allergen-specific immunotherapy.
Language	English
Publishing date	2023-12-08
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2614800-6
ISSN	2233-8268 ; 2233-8276
ISSN (online)	2233-8268
ISSN	2233-8276
DOI	10.5415/apallergy.0000000000000128
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Article ; Online: Evaluating the translation of implementation science to clinical artificial intelligence: a bibliometric study of qualitative research.

Hogg, H D J / Al-Zubaidy, M / Keane, P A / Hughes, G / Beyer, F R / Maniatopoulos, G

Frontiers in health services

2023 Volume 3, Page(s) 1161822

Abstract: Introduction: Whilst a theoretical basis for implementation research is seen as advantageous, there is little clarity over if and how the application of theories, models or frameworks (TMF) impact implementation outcomes. Clinical artificial ... ...

Abstract	Introduction: Whilst a theoretical basis for implementation research is seen as advantageous, there is little clarity over if and how the application of theories, models or frameworks (TMF) impact implementation outcomes. Clinical artificial intelligence (AI) continues to receive multi-stakeholder interest and investment, yet a significant implementation gap remains. This bibliometric study aims to measure and characterize TMF application in qualitative clinical AI research to identify opportunities to improve research practice and its impact on clinical AI implementation. Methods: Qualitative research of stakeholder perspectives on clinical AI published between January 2014 and October 2022 was systematically identified. Eligible studies were characterized by their publication type, clinical and geographical context, type of clinical AI studied, data collection method, participants and application of any TMF. Each TMF applied by eligible studies, its justification and mode of application was characterized. Results: Of 202 eligible studies, 70 (34.7%) applied a TMF. There was an 8-fold increase in the number of publications between 2014 and 2022 but no significant increase in the proportion applying TMFs. Of the 50 TMFs applied, 40 (80%) were only applied once, with the Technology Acceptance Model applied most frequently ( Conclusion: TMFs have not been commonly applied in qualitative research of clinical AI. When TMFs have been applied there has been (i) little consensus on TMF selection (ii) limited description of selection rationale and (iii) lack of clarity over how TMFs inform research. We consider this to represent an opportunity to improve implementation science's translation to clinical AI research and clinical AI into practice by promoting the rigor and frequency of TMF application. We recommend that the finite resources of the implementation science community are diverted toward increasing accessibility and engagement with theory informed practices. The considered application of theories, models and frameworks (TMF) are thought to contribute to the impact of implementation science on the translation of innovations into real-world care. The frequency and nature of TMF use are yet to be described within digital health innovations, including the prominent field of clinical AI. A well-known implementation gap, coined as the "AI chasm" continues to limit the impact of clinical AI on real-world care. From this bibliometric study of the frequency and quality of TMF use within qualitative clinical AI research, we found that TMFs are usually not applied, their selection is highly varied between studies and there is not often a convincing rationale for their selection. Promoting the rigor and frequency of TMF use appears to present an opportunity to improve the translation of clinical AI into practice.
Language	English
Publishing date	2023-07-10
Publishing country	Switzerland
Document type	Journal Article ; Review
ISSN	2813-0146
ISSN (online)	2813-0146
DOI	10.3389/frhs.2023.1161822
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