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  1. Article ; Online: Work-Life Integration for Academic Surgeons.

    White, Rebekah R

    JAMA surgery

    2023  Volume 158, Issue 12, Page(s) 1235–1236

    MeSH term(s) Humans ; Surgeons ; Surveys and Questionnaires
    Language English
    Publishing date 2023-09-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2701841-6
    ISSN 2168-6262 ; 2168-6254
    ISSN (online) 2168-6262
    ISSN 2168-6254
    DOI 10.1001/jamasurg.2023.2767
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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: Local ablation in pancreatic cancer: some answers and more questions.

    Berman, Zachary T / White, Rebekah R

    The lancet. Gastroenterology & hepatology

    2024  Volume 9, Issue 5, Page(s) 398–400

    MeSH term(s) Humans ; Pancreatic Neoplasms/surgery
    Language English
    Publishing date 2024-03-19
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2468-1253
    ISSN (online) 2468-1253
    DOI 10.1016/S2468-1253(24)00046-3
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  3. Article ; Online: Local ablative therapies and the effect on antitumor immune responses in pancreatic cancer – A review

    Suna Erdem / Jayanth Shankara Narayanan / Mathias Worni / Martin Bolli / Rebekah R. White

    Heliyon, Vol 10, Iss 1, Pp e23551- (2024)

    1481  

    Abstract: Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease, projected to rank as the second most prevalent cause of cancer-related mortality by 2030. Despite significant progress in advances in surgical techniques and chemotherapy protocols, the ... ...

    Abstract Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease, projected to rank as the second most prevalent cause of cancer-related mortality by 2030. Despite significant progress in advances in surgical techniques and chemotherapy protocols, the overall survival (OS) remains to be less than 10 % for all stages combined.In recent years, local ablative techniques have been introduced and utilized as additional therapeutic approaches for locally advanced pancreatic cancer (LAPC), with promising results with respect to local tumor control and OS. In addition to successful cytoreduction, there is emerging evidence that local ablation induces antitumor immune activity that could prevent or even treat distant metastatic tumors. The enhancement of antitumor immune responses could potentially make ablative therapy a therapeutic option for the treatment of metastatic PDAC. In this review, we summarize current ablative techniques used in the management of LAPC and their impact on systemic immune responses.
    Keywords Pancreatic cancer ; Locally advanced pancreatic cancer ; local ablative techniques ; Immune modulation ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
    Subject code 610
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Incidental Gallbladder Cancer: Permission to Operate.

    Erdem, Suna / White, Rebekah R

    Annals of surgical oncology

    2019  Volume 27, Issue 4, Page(s) 980–982

    MeSH term(s) Cholecystectomy ; Gallbladder Neoplasms/diagnosis ; Gallbladder Neoplasms/epidemiology ; Gallbladder Neoplasms/surgery ; Humans ; Incidental Findings ; Netherlands/epidemiology ; Precision Medicine ; Reoperation ; Treatment Outcome
    Language English
    Publishing date 2019-11-13
    Publishing country United States
    Document type Editorial
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-019-08080-6
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4042: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  5. Article: Local ablative therapies and the effect on antitumor immune responses in pancreatic cancer - A review.

    Erdem, Suna / Narayanan, Jayanth Shankara / Worni, Mathias / Bolli, Martin / White, Rebekah R

    Heliyon

    2023  Volume 10, Issue 1, Page(s) e23551

    Abstract: Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease, projected to rank as the second most prevalent cause of cancer-related mortality by 2030. Despite significant progress in advances in surgical techniques and chemotherapy protocols, the ... ...

    Abstract Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease, projected to rank as the second most prevalent cause of cancer-related mortality by 2030. Despite significant progress in advances in surgical techniques and chemotherapy protocols, the overall survival (OS) remains to be less than 10 % for all stages combined. In recent years, local ablative techniques have been introduced and utilized as additional therapeutic approaches for locally advanced pancreatic cancer (LAPC), with promising results with respect to local tumor control and OS. In addition to successful cytoreduction, there is emerging evidence that local ablation induces antitumor immune activity that could prevent or even treat distant metastatic tumors. The enhancement of antitumor immune responses could potentially make ablative therapy a therapeutic option for the treatment of metastatic PDAC. In this review, we summarize current ablative techniques used in the management of LAPC and their impact on systemic immune responses.
    Language English
    Publishing date 2023-12-12
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e23551
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  6. Article ; Online: The Landmark Series: Locally Advanced Pancreatic Cancer and Ablative Therapy Options.

    White, Rebekah R / Murphy, James D / Martin, Robert C G

    Annals of surgical oncology

    2021  Volume 28, Issue 8, Page(s) 4173–4180

    Abstract: Locally advanced pancreatic cancer (LAPC) is a challenging disease to treat. There is consensus that systemic chemotherapy should be the first line of therapy for most patients. However, there is no consensus on how to manage those patients who do not ... ...

    Abstract Locally advanced pancreatic cancer (LAPC) is a challenging disease to treat. There is consensus that systemic chemotherapy should be the first line of therapy for most patients. However, there is no consensus on how to manage those patients who do not have sufficient response to become candidates for resection but also do not have distant progression after weeks or months of systemic therapy. Radiation therapy is the most commonly used and best-studied local ablative therapy. One recent randomized controlled trial (LAP-07) failed to demonstrate an overall survival benefit for conventional chemoradiation therapy after induction chemotherapy versus chemotherapy alone. This study had several limitations, and ongoing studies are re-evaluating the role of chemoradiation after more effective chemotherapy regimens as well as more advanced radiation techniques. In parallel, there has been increasing interest in other thermal and non-thermal methods of ablation. In particular, irreversible electroporation has gained traction for treatment of LAPC, with at least one ongoing randomized controlled trial designed to address its role compared with systemic chemotherapy alone. Multiple preclinical and clinical studies are investigating combinations of local ablation and immunotherapy with the goal of generating immune responses that will meaningfully improve outcomes.
    MeSH term(s) Chemoradiotherapy ; Electroporation ; Humans ; Induction Chemotherapy ; Pancreas ; Pancreatic Neoplasms/drug therapy
    Language English
    Publishing date 2021-02-14
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-021-09662-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4042: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Longitudinal Analysis of Social Isolation and Cognitive Functioning among Hispanic Older Adults with Sensory Impairments.

    Trujillo Tanner, Corinna / Yorgason, Jeremy / White, Avalon / Armstrong, Chresten / Cash, Antonia / Case, Rebekah / Ehrlich, Joshua R

    International journal of environmental research and public health

    2023  Volume 20, Issue 15

    Abstract: Objectives: Understanding the intersection of age, ethnicity, and disability will become increasingly important as the global population ages and becomes more diverse. By 2060, Hispanics will comprise 28% of the U.S.: Population: This study examines ... ...

    Abstract Objectives: Understanding the intersection of age, ethnicity, and disability will become increasingly important as the global population ages and becomes more diverse. By 2060, Hispanics will comprise 28% of the U.S.
    Population: This study examines critical associations between sensory impairment, social isolation, and cognitive functioning among Hispanic older adults.
    Methods: Our sample consisted of 557 Hispanic older adults that participated in Rounds 1-3 or Rounds 5-7 of the National Health and Aging Trends Study. Longitudinal mediation models across a three-year span were estimated using Mplus, with vision, hearing, and dual sensory impairments predicting cognitive functioning directly and indirectly through social isolation.
    Results: Findings indicated that cognitive functioning was concurrently and, in certain cases, longitudinally predicted by vision and dual sensory impairments and by social isolation. Contrary to expectations, vision and hearing impairments were not predictive of social isolation. Dual sensory impairment was associated with social isolation, yet no significant indirect associations were found for sensory impairments predicting cognitive functioning through social isolation.
    Discussion: The finding that social isolation did not mediate the relationship between sensory impairment and cognitive decline among Hispanic older adults in the U.S. is contrary to findings from other studies that were not specifically focused on this population. This finding may be evidence that culturally motivated family support and intergenerational living buffer the impact of sensory impairments in later life. Findings suggest that Hispanic older adults experiencing dual sensory impairments may benefit from interventions that foster social support and include family members.
    MeSH term(s) Humans ; Aged ; Vision Disorders/epidemiology ; Hearing Loss/complications ; Cognition ; Cognitive Dysfunction/psychology ; Social Isolation ; Hispanic or Latino ; Longitudinal Studies
    Language English
    Publishing date 2023-07-27
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph20156456
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  8. Article: Cholangitis Caused by a Migrated Pancreatic Duct Stent Into the Bile Duct After Pancreaticoduodenectomy.

    Yang, Edward / Eskandari, Armen / Chang, Michael A / White, Rebekah R / Savides, Thomas J

    ACG case reports journal

    2020  Volume 7, Issue 11, Page(s) e00477

    Language English
    Publishing date 2020-11-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2814825-3
    ISSN 2326-3253
    ISSN 2326-3253
    DOI 10.14309/crj.0000000000000477
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  9. Article: Cell-SELEX Identifies a "Sticky" RNA Aptamer Sequence.

    Ray, Partha / White, Rebekah R

    Journal of nucleic acids

    2017  Volume 2017, Page(s) 4943072

    Abstract: Cell-SELEX is performed to select for cell binding aptamers. We employed an additional selection pressure by using RNAse to remove surface-binding aptamers and select for cell-internalizing aptamers. A common RNA sequence was identified from independent ... ...

    Abstract Cell-SELEX is performed to select for cell binding aptamers. We employed an additional selection pressure by using RNAse to remove surface-binding aptamers and select for cell-internalizing aptamers. A common RNA sequence was identified from independent cell-SELEX procedures against two different pancreatic cancer cell lines, indicating a strong selection pressure towards this sequence from the large pool of other available sequences present in the aptamer library. The aptamer is not specific for the pancreatic cancer cell lines, and a similar sequence motif is present in previously published internalizing aptamers. The identified sequence forms a structural motif that binds to a surface protein, which either is highly abundant or has strong affinity for the selected aptamer sequence. Deselecting (removing) this sequence during cell-SELEX may increase the probability of identifying aptamers against cell type-specific targets on the cell surface.
    Language English
    Publishing date 2017-01-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2549000-X
    ISSN 2090-021X ; 2090-0201
    ISSN (online) 2090-021X
    ISSN 2090-0201
    DOI 10.1155/2017/4943072
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Pancreatic neuroendocrine tumors: selection, selection, selection….

    White, Rebekah R

    The Journal of surgical research

    2011  Volume 167, Issue 2, Page(s) 211–213

    MeSH term(s) Databases as Topic ; Hospital Mortality ; Humans ; Neuroendocrine Tumors/mortality ; Neuroendocrine Tumors/surgery ; Pancreatectomy ; Pancreatic Neoplasms/mortality ; Pancreatic Neoplasms/surgery ; Patient Selection ; Risk Factors
    Language English
    Publishing date 2011-05-15
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 80170-7
    ISSN 1095-8673 ; 0022-4804
    ISSN (online) 1095-8673
    ISSN 0022-4804
    DOI 10.1016/j.jss.2010.07.024
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    Zs.A 178: Show issues Location:
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