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Article ; Online: Downstream Regulatory Element Antagonist Modulator (DREAM), a target for anti-thrombotic agents.

Cho, Jaehyung

2017 Volume 117, Page(s) 283–287

Abstract: Circulating platelets participate in the process of numerous diseases including thrombosis, inflammation, and cancer. Thus, it is of great importance to understand the underlying mechanisms mediating platelet activation under disease conditions. Emerging ...

Abstract	Circulating platelets participate in the process of numerous diseases including thrombosis, inflammation, and cancer. Thus, it is of great importance to understand the underlying mechanisms mediating platelet activation under disease conditions. Emerging evidence indicates that despite the lack of a nucleus, platelets possess molecules that are involved in gene transcription in nucleated cells. This review will summarize downstream regulatory element antagonist modulator (DREAM), a transcriptional repressor, and highlight recent findings suggesting its novel non-transcriptional role in hemostasis and thrombosis.
MeSH term(s)	Animals ; Blood Platelets/drug effects ; Blood Platelets/metabolism ; Cell Nucleus/drug effects ; Cell Nucleus/metabolism ; Fibrinolytic Agents/pharmacology ; Fibrinolytic Agents/therapeutic use ; Humans ; Kv Channel-Interacting Proteins/metabolism ; Thrombosis/drug therapy ; Thrombosis/metabolism
Chemical Substances	Fibrinolytic Agents ; Kv Channel-Interacting Proteins
Language	English
Publishing date	2017-01-05
Publishing country	Netherlands
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1003347-6
ISSN	1096-1186 ; 0031-6989 ; 1043-6618
ISSN (online)	1096-1186
ISSN	0031-6989 ; 1043-6618
DOI	10.1016/j.phrs.2017.01.002
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Article ; Online: Effect of tobacco outlet density on quit attempts in Korea

Jaehyung Kong / Sung-il Cho

Epidemiology and Health, Vol

a multi-level analysis of the 2015 Korean Community Health Survey

2021 Volume 43

Abstract: OBJECTIVES This study aimed to examine whether the regional density of tobacco outlets in Korea was associated with the likelihood of attempting to quit among smokers METHODS This study was designed as a secondary data analysis of a cross-sectional study. ...

Abstract	OBJECTIVES This study aimed to examine whether the regional density of tobacco outlets in Korea was associated with the likelihood of attempting to quit among smokers METHODS This study was designed as a secondary data analysis of a cross-sectional study. Data from the 2015 Korean Community Health Survey and tobacco outlet registrations in 17 metropolitan cities and provinces with 254 communities in Korea were used for the analysis. In total, 41,013 current smokers (≥19 years of age) were included. Multi-level logistic regression analysis was conducted to investigate regional differences associated with smokers’ attempts to quit and to evaluate the effects of individual and regional characteristics on quit attempts. RESULTS Higher tobacco outlet density was associated with lower odds of attempting to quit. Smokers who resided in districts with the highest tobacco outlet density were 18% less likely to attempt quitting (odds ratio, 0.82; 95% confidence interval, 0.70 to 0.98) than smokers who resided in the regions with the lowest tobacco outlet density (intraclass correlation coefficient, 0.030). CONCLUSIONS This study showed that quit attempts were related to community-level factors, such as tobacco outlet density, as well as other individual factors. These findings support the implementation of national policies restricting the number of tobacco outlets within communities or zones and limiting tobacco marketing in tobacco outlets.
Keywords	tobacco ; tobacco product ; tobacco industry ; smoking cessation ; multilevel analysis ; Medicine ; R
Subject code	616
Language	English
Publishing date	2021-08-01T00:00:00Z
Publisher	Korean Society of Epidemiology
Document type	Article ; Online
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Article ; Online: Effect of tobacco outlet density on quit attempts in Korea: a multi-level analysis of the 2015 Korean Community Health Survey.

Kong, Jaehyung / Cho, Sung-Il

Epidemiology and health

2021 Volume 43, Page(s) e2021048

Abstract: Objectives: This study aimed to examine whether the regional density of tobacco outlets in Korea was associated with the likelihood of attempting to quit among smokers.: Methods: This study was designed as a secondary data analysis of a cross- ... ...

Abstract	Objectives: This study aimed to examine whether the regional density of tobacco outlets in Korea was associated with the likelihood of attempting to quit among smokers. Methods: This study was designed as a secondary data analysis of a cross-sectional study. Data from the 2015 Korean Community Health Survey and tobacco outlet registrations in 17 metropolitan cities and provinces with 254 communities in Korea were used for the analysis. In total, 41,013 current smokers (≥19 years of age) were included. Multi-level logistic regression analysis was conducted to investigate regional differences associated with smokers' attempts to quit and to evaluate the effects of individual and regional characteristics on quit attempts. Results: Higher tobacco outlet density was associated with lower odds of attempting to quit. Smokers who resided in districts with the highest tobacco outlet density were 18% less likely to attempt quitting (odds ratio, 0.82; 95% confidence interval, 0.70 to 0.98) than smokers who resided in the regions with the lowest tobacco outlet density (intraclass correlation coefficient, 0.030). Conclusions: This study showed that quit attempts were related to community-level factors, such as tobacco outlet density, as well as other individual factors. These findings support the implementation of national policies restricting the number of tobacco outlets within communities or zones and limiting tobacco marketing in tobacco outlets.
MeSH term(s)	Adult ; Aged ; Commerce/statistics & numerical data ; Cross-Sectional Studies ; Female ; Health Surveys ; Humans ; Male ; Middle Aged ; Multilevel Analysis ; Republic of Korea/epidemiology ; Smokers/psychology ; Smokers/statistics & numerical data ; Smoking/epidemiology ; Smoking Cessation/statistics & numerical data ; Tobacco Products/supply & distribution ; Young Adult
Language	English
Publishing date	2021-08-03
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2590698-7
ISSN	2092-7193 ; 2092-7193
ISSN (online)	2092-7193
ISSN	2092-7193
DOI	10.4178/epih.e2021048
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Article ; Online: Odorant G protein-coupled receptors as potential therapeutic targets for adult diffuse gliomas: a systematic analysis and review.

Cho, Hee Jin / Koo, JaeHyung

BMB reports

2021 Volume 54, Issue 12, Page(s) 601–607

Abstract: Odorant receptors (ORs) account for about 60% of all human G protein-coupled receptors (GPCRs). OR expression outside of the nose has functions distinct from odor perception, and may contribute to the pathogenesis of disorders including brain diseases ... ...

Abstract	Odorant receptors (ORs) account for about 60% of all human G protein-coupled receptors (GPCRs). OR expression outside of the nose has functions distinct from odor perception, and may contribute to the pathogenesis of disorders including brain diseases and cancers. Glioma is the most common adult malignant brain tumor and requires novel therapeutic strategies to improve clinical outcomes. Here, we outlined the expression of brain ORs and investigated OR expression levels in glioma. Although most ORs were not ubiquitously expressed in gliomas, a subset of ORs displayed glioma subtype-specific expression. Moreover, through systematic survival analysis on OR genes, OR51E1 (mouse Olfr558) was identified as a potential biomarker of unfavorable overall survival, and OR2C1 (mouse Olfr15) was identified as a potential biomarker of favorable overall survival in isocitrate dehydrogenase (IDH) wild-type glioma. In addition to transcriptomic analysis, mutational profiles revealed that somatic mutations in OR genes were detected in ＞ 60% of glioma samples. OR5D18 (mouse Olfr1155) was the most frequently mutated OR gene, and OR5AR1 (mouse Olfr1019) showed IDH wild-type-specific mutation. Based on this systematic analysis and review of the genomic and transcriptomic profiles of ORs in glioma, we suggest that ORs are potential biomarkers and therapeutic targets for glioma. [BMB Reports 2021; 54(12): 601-607].
MeSH term(s)	Animals ; Brain Neoplasms/pathology ; Glioma/metabolism ; Isocitrate Dehydrogenase/genetics ; Mice ; Mutation ; Odorants ; Receptors, G-Protein-Coupled/genetics ; Receptors, Odorant/genetics
Chemical Substances	Olfr558 protein, mouse ; Receptors, G-Protein-Coupled ; Receptors, Odorant ; Isocitrate Dehydrogenase (EC 1.1.1.41)
Language	English
Publishing date	2021-12-01
Publishing country	Korea (South)
Document type	News
ZDB-ID	2410389-5
ISSN	1976-670X ; 1976-6696
ISSN (online)	1976-670X
ISSN	1976-6696
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Article ; Online: A paradigm shift in platelet transfusion therapy.

Cho, Jaehyung

Blood

2015 Volume 125, Issue 23, Page(s) 3523–3525

Abstract: In this issue of Blood, Wang et al report that ex vivo–derived human megakaryocytes infused into mice are trapped in the pulmonary vasculature and release functional platelets into the circulation. Because of the difficulty in scalable generation of ex ... ...

Abstract	In this issue of Blood, Wang et al report that ex vivo–derived human megakaryocytes infused into mice are trapped in the pulmonary vasculature and release functional platelets into the circulation. Because of the difficulty in scalable generation of ex vivo–derived functional platelets, this strategy may be a substitute for platelet transfusion therapy.
MeSH term(s)	Animals ; Blood Platelets ; Humans ; Macrophages ; Megakaryocytes
Language	English
Publishing date	2015-06-03
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	80069-7
ISSN	1528-0020 ; 0006-4971
ISSN (online)	1528-0020
ISSN	0006-4971
DOI	10.1182/blood-2015-04-640649
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Uh III Zs.140: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Analysis of neutrophil gelatinase-associated lipocalin, vascular endothelial growth factor, and soluble receptor for advanced glycation end-products in bone marrow supernatant in hematologic malignancies.

Cho, Chi-Hyun / Cha, Jaehyung

Clinical biochemistry

2020 Volume 80, Page(s) 19–24

Abstract: Background: Inflammation is a known risk factor of cancer development, including inflammation-driven leukemogenesis. Evaluation of inflammation-related cytokines in early diagnosis stages is crucial to understand the development of hematologic ... ...

Abstract	Background: Inflammation is a known risk factor of cancer development, including inflammation-driven leukemogenesis. Evaluation of inflammation-related cytokines in early diagnosis stages is crucial to understand the development of hematologic malignancy. Our aim was to measure three cytokines- neutrophil gelatinase-associated lipocalin (NGAL), vascular endothelial growth factor (VEGF), and soluble receptor for advanced glycation end-products (sRAGE) in bone marrow (BM) samples from patients diagnosed with hematologic malignancy and compare these measurements with the control. Additionally, we evaluated whether NGAL was significantly associated with sRAGE, VEGF, and several hematological parameters. Methods: BM samples were collected from 73 patients, who were classified into myeloproliferative neoplasm (MPN), acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), plasma cell neoplasm (PCN) and control groups according to the BM smear and pathology review. An immunoassay, a Luminex assay, and an enzyme-linked immunosorbent assay were used to quantitate NGAL, VEGF, and sRAGE, respectively, while all measurements of NGAL, VEGF and sRAGE were performed on BM supernatants. Data on hematological parameters were collected from medical records. Intergroup comparisons were performed using the Kruskal-Wallis H-test and Pearson Chi-Square test. Single and multiple regression analyses were performed to analyze the relationships among the parameters. Results: The independent factors associated with NGAL were neutrophil counts and VEGF. As for both NGAL and VEGF, the MPN (n = 23) group showed the highest level, while the MDS (n = 12) group showed low levels. NGAL levels in the AML (n = 13) and MDS groups were lower than in the control group (n = 14). The MPN group demonstrated higher VEGF levels than the AML and MDS groups. The MDS group showed lower VEGF levels than the PCN (n = 11) group. No statistical difference between the hematologic malignancy and control groups or among the hematologic malignancy groups was observed for sRAGE levels. Conclusion: NGAL was related to neutrophil count and VEGF. NGAL and VEGF showed similar intergroup patterns, reflecting that NGAL was associated with VEGF.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Bone Marrow/metabolism ; Bone Marrow/pathology ; Case-Control Studies ; Female ; Hematologic Neoplasms/metabolism ; Humans ; Lipocalin-2/metabolism ; Male ; Middle Aged ; Receptor for Advanced Glycation End Products/metabolism ; Vascular Endothelial Growth Factor A/metabolism
Chemical Substances	AGER protein, human ; LCN2 protein, human ; Lipocalin-2 ; Receptor for Advanced Glycation End Products ; VEGFA protein, human ; Vascular Endothelial Growth Factor A
Language	English
Publishing date	2020-04-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	390372-2
ISSN	1873-2933 ; 0009-9120
ISSN (online)	1873-2933
ISSN	0009-9120
DOI	10.1016/j.clinbiochem.2020.04.002
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Article ; Online: Odorant receptors in cancer.

Chung, Chan / Cho, Hee Jin / Lee, ChaeEun / Koo, JaeHyung

BMB reports

2022 Volume 55, Issue 2, Page(s) 72–80

Abstract: Odorant receptors (ORs), the largest subfamily of G protein-coupled receptors, detect odorants in the nose. In addition, ORs were recently shown to be expressed in many nonolfactory tissues and cells, indicating that these receptors have physiological ... ...

Abstract	Odorant receptors (ORs), the largest subfamily of G protein-coupled receptors, detect odorants in the nose. In addition, ORs were recently shown to be expressed in many nonolfactory tissues and cells, indicating that these receptors have physiological and pathophysiological roles beyond olfaction. Many ORs are expressed by tumor cells and tissues, suggesting that they may be associated with cancer progression or may be cancer biomarkers. This review describes OR expression in various types of cancer and the association of these receptors with various types of signaling mechanisms. In addition, the clinical relevance and significance of the levels of OR expression were evaluated. Namely, levels of OR expression in cancer were analyzed based on RNA-sequencing data reported in the Cancer Genome Atlas; OR expression patterns were visualized using t-distributed stochastic neighbor embedding (t-SNE); and the associations between patient survival and levels of OR expression were analyzed. These analyses of the relationships between patient survival and expression patterns obtained from an open mRNA database in cancer patients indicate that ORs may be cancer biomarkers and therapeutic targets. [BMB Reports 2022;55(2): 72-80].
MeSH term(s)	Biomarkers, Tumor/genetics ; Humans ; Neoplasms/genetics ; Neoplasms/metabolism ; Odorants ; Receptors, G-Protein-Coupled ; Receptors, Odorant/genetics ; Receptors, Odorant/metabolism ; Smell
Chemical Substances	Biomarkers, Tumor ; Receptors, G-Protein-Coupled ; Receptors, Odorant
Language	English
Publishing date	2022-02-12
Publishing country	Korea (South)
Document type	News ; Review
ZDB-ID	2410389-5
ISSN	1976-670X ; 1976-6696
ISSN (online)	1976-670X
ISSN	1976-6696
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Article ; Online: Protein disulfide isomerase in cardiovascular disease

Bei Xiong / Vishwanath Jha / Jeong-Ki Min / Jaehyung Cho

Experimental and Molecular Medicine, Vol 52, Iss 3, Pp 390-

2020 Volume 399

Abstract: ... biological activity. Jaehyung Cho of the University of Illinois at Chicago, USA and coworkers have reviewed numerous ...

Abstract	Exploring enzymes’ influence on cardiovascular disease Efforts to untangle the functions of a large family of enzymes could lead researchers to new therapies for diverse cardiovascular diseases. Members of the protein disulfide isomerase (PDI) family chemically modify other proteins in ways that can alter both their structure and biological activity. Jaehyung Cho of the University of Illinois at Chicago, USA and coworkers have reviewed numerous studies linking PDI with cardiovascular diseases, including thrombosis, heart attack, vascular inflammation, and stroke. The authors also report progress in developing small-molecule PDI inhibitors that could yield the treatment for these conditions.
Keywords	Medicine ; R ; Biochemistry ; QD415-436
Language	English
Publishing date	2020-03-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
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Article: Prediction of Inflammatory Breast Cancer Survival Outcomes Using Computed Tomography-Based Texture Analysis.

Song, Sung Eun / Seo, Bo Kyoung / Cho, Kyu Ran / Woo, Ok Hee / Ganeshan, Balaji / Kim, Eun Sil / Cha, Jaehyung

Frontiers in bioengineering and biotechnology

2021 Volume 9, Page(s) 695305

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2021-07-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2719493-0
ISSN	2296-4185
ISSN	2296-4185
DOI	10.3389/fbioe.2021.695305
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Article: Comparison of CT- and MRI-Based Quantification of Tumor Heterogeneity and Vascularity for Correlations with Prognostic Biomarkers and Survival Outcomes: A Single-Center Prospective Cohort Study.

Kim, Hyo-Young / Bae, Min-Sun / Seo, Bo-Kyoung / Lee, Ji-Young / Cho, Kyu-Ran / Woo, Ok-Hee / Song, Sung-Eun / Cha, Jaehyung

Bioengineering (Basel, Switzerland)

2023 Volume 10, Issue 5

Abstract: Background: Tumor heterogeneity and vascularity can be noninvasively quantified using histogram and perfusion analyses on computed tomography (CT) and magnetic resonance imaging (MRI). We compared the association of histogram and perfusion features with ...

Abstract	Background: Tumor heterogeneity and vascularity can be noninvasively quantified using histogram and perfusion analyses on computed tomography (CT) and magnetic resonance imaging (MRI). We compared the association of histogram and perfusion features with histological prognostic factors and progression-free survival (PFS) in breast cancer patients on low-dose CT and MRI. Methods: This prospective study enrolled 147 women diagnosed with invasive breast cancer who simultaneously underwent contrast-enhanced MRI and CT before treatment. We extracted histogram and perfusion parameters from each tumor on MRI and CT, assessed associations between imaging features and histological biomarkers, and estimated PFS using the Kaplan-Meier analysis. Results: Out of 54 histogram and perfusion parameters, entropy on T2- and postcontrast T1-weighted MRI and postcontrast CT, and perfusion (blood flow) on CT were significantly associated with the status of subtypes, hormone receptors, and human epidermal growth factor receptor 2 ( Conclusions: Low-dose CT histogram and perfusion analysis were comparable to MRI, and the entropy of postcontrast CT could be a feasible parameter to predict PFS in breast cancer patients.
Language	English
Publishing date	2023-04-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2746191-9
ISSN	2306-5354
ISSN	2306-5354
DOI	10.3390/bioengineering10050504
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