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  1. Article ; Online: H

    Suzuki, Satoru / Kaikita, Koichi / Yamamoto, Eiichiro / Sueta, Daisuke / Yamamoto, Masahiro / Ishii, Masanobu / Ito, Miwa / Fujisue, Koichiro / Kanazawa, Hisanori / Araki, Satoshi / Arima, Yuichiro / Takashio, Seiji / Usuku, Hiroki / Nakamura, Taishi / Sakamoto, Kenji / Izumiya, Yasuhiro / Soejima, Hirofumi / Kawano, Hiroaki / Jinnouchi, Hideaki /
    Matsui, Kunihiko / Tsujita, Kenichi

    ESC heart failure

    2020  Volume 7, Issue 1, Page(s) 65–74

    Abstract: ... for general practitioners and cardiologists. Recently, the H: Methods and results: In this prospective cohort study ... 171 men, 185 women, mean age 73.2 years) were eligible for the analysis. We calculated the H ... Conclusions: The H ...

    Abstract Aims: The prediction of future heart failure (HF) in stable outpatients is often difficult for general practitioners and cardiologists. Recently, the H
    Methods and results: In this prospective cohort study, after exclusion of 195 from 551 consecutive, stable Japanese outpatients with at least one cardiovascular risk factor who were enrolled between September 2010 and July 2013, the remaining 356 outpatients (171 men, 185 women, mean age 73.2 years) were eligible for the analysis. We calculated the H
    Conclusions: The H
    MeSH term(s) Aged ; Angiotensin Receptor Antagonists ; Angiotensin-Converting Enzyme Inhibitors ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/etiology ; Female ; Heart Disease Risk Factors ; Heart Failure/complications ; Heart Failure/diagnosis ; Heart Failure/epidemiology ; Humans ; Japan/epidemiology ; Male ; Middle Aged ; Outpatients ; Prospective Studies ; Risk Factors ; Stroke Volume ; United States ; Ventricular Function, Left
    Chemical Substances Angiotensin Receptor Antagonists ; Angiotensin-Converting Enzyme Inhibitors
    Language English
    Publishing date 2020-01-22
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2814355-3
    ISSN 2055-5822 ; 2055-5822
    ISSN (online) 2055-5822
    ISSN 2055-5822
    DOI 10.1002/ehf2.12570
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: H

    Itai, Shunsuke / Fujii, Yuki / Kaneko, Mika K / Yamada, Shinji / Nakamura, Takuro / Yanaka, Miyuki / Saidoh, Noriko / Chang, Yao-Wen / Handa, Saori / Takahashi, Maki / Suzuki, Hiroyoshi / Harada, Hiroyuki / Kato, Yukinari

    Monoclonal antibodies in immunodiagnosis and immunotherapy

    2017  Volume 36, Issue 4, Page(s) 143–148

    Abstract: ... mAb clones, only three mAbs reacted with HER2 in Western blot, and clone H ...

    Abstract Human epidermal growth factor receptor 2 (HER2) plays a critical role in the progression of breast cancers, and HER2 overexpression is associated with poor clinical outcomes. Trastuzumab is an anti-HER2 humanized antibody that leads to significant survival benefits in patients with HER2-positive metastatic breast cancers. In this study, we developed novel anti-HER2 monoclonal antibodies (mAbs) and characterized their efficacy in flow cytometry, Western blot, and immunohistochemical analyses. Initially, we expressed the full length or ectodomain of HER2 in LN229 glioblastoma cells and then immunized mice with ectodomain of HER2 or LN229/HER2, and performed the first screening by enzyme-linked immunosorbent assays using ectodomain of HER2. Subsequently, we selected mAbs according to their efficacy in flow cytometry (second screening), Western blot (third screening), and immunohistochemical analyses (fourth screening). Among 100 mAb clones, only three mAbs reacted with HER2 in Western blot, and clone H
    MeSH term(s) Animals ; Antibodies, Monoclonal/immunology ; Antibody Specificity ; CHO Cells ; Cell Line, Tumor ; Cricetulus ; Female ; Flow Cytometry ; HEK293 Cells ; Humans ; Hybridomas ; Immunohistochemistry ; Mice, Inbred BALB C ; Protein Binding ; Receptor, ErbB-2/immunology ; Receptor, ErbB-2/metabolism ; Sensitivity and Specificity
    Chemical Substances Antibodies, Monoclonal ; ERBB2 protein, human (EC 2.7.10.1) ; Receptor, ErbB-2 (EC 2.7.10.1)
    Language English
    Publishing date 2017-07-12
    Publishing country United States
    Document type Journal Article
    ISSN 2167-9436
    ISSN (online) 2167-9436
    DOI 10.1089/mab.2017.0026
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  3. Article ; Online: Conformer-Specific Photoelectron Spectroscopy of Carbonic Acid: H

    Kanayama, Keisuke / Nakamura, Hisashi / Maruta, Kaoru / Bodi, Andras / Hemberger, Patrick

    The journal of physical chemistry letters

    2024  Volume 15, Issue 10, Page(s) 2658–2664

    Abstract: Carbonic acid (H ...

    Abstract Carbonic acid (H
    Language English
    Publishing date 2024-03-01
    Publishing country United States
    Document type Journal Article
    ISSN 1948-7185
    ISSN (online) 1948-7185
    DOI 10.1021/acs.jpclett.4c00343
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book: Handbook of H+-ATPases

    Nakamura, Suguru

    2014  

    Title variant H+-ATPase
    Author's details ed. by Suguru Nakamura
    Language English
    Size XIX, 483 S. : Ill., graph. Darst.
    Publisher Pan Stanford Publ
    Publishing place Singapore
    Publishing country Singapore
    Document type Book
    HBZ-ID HT017704159
    ISBN 978-981-4411-91-2 ; 9789814411929 ; 981-4411-91-4 ; 9814411922
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2014 A 1515 available for loan (reading room) Lesesaal EG

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  5. Article ; Online: Establishment of H

    Yamada, Shinji / Itai, Shunsuke / Nakamura, Takuro / Chang, Yao-Wen / Harada, Hiroyuki / Suzuki, Hiroyoshi / Kaneko, Mika K / Kato, Yukinari

    Monoclonal antibodies in immunodiagnosis and immunotherapy

    2017  Volume 36, Issue 6, Page(s) 287–290

    Abstract: ... we established a novel anti-HER2 monoclonal antibody (mAb), H ...

    Abstract Human epidermal growth factor receptor 2 (HER2) is overexpressed in breast cancer and is associated with poor clinical outcomes. In addition, HER2 expression has been reported in other cancers, such as gastric, colorectal, lung, and pancreatic cancers. An anti-HER2 humanized antibody, trastuzumab, leads to significant survival benefits in patients with HER2-overexpressing breast cancers and gastric cancers. Herein, we established a novel anti-HER2 monoclonal antibody (mAb), H
    MeSH term(s) Animals ; Antibodies, Monoclonal/immunology ; Blotting, Western ; Breast Neoplasms/immunology ; Breast Neoplasms/pathology ; Female ; Flow Cytometry ; Humans ; Immunohistochemistry ; Mice, Inbred BALB C ; Pancreatic Neoplasms/immunology ; Pancreatic Neoplasms/pathology ; Receptor, ErbB-2/immunology
    Chemical Substances Antibodies, Monoclonal ; ERBB2 protein, human (EC 2.7.10.1) ; Receptor, ErbB-2 (EC 2.7.10.1)
    Language English
    Publishing date 2017-12
    Publishing country United States
    Document type Journal Article
    ISSN 2167-9436
    ISSN (online) 2167-9436
    DOI 10.1089/mab.2017.0050
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Enantioselective Synthesis of Oxazaborolidines by Palladium-Catalyzed N-H/B-H Double Activation of 1,2-Azaborines.

    Morita, Taiki / Murakami, Hiroki / Asawa, Yasunobu / Nakamura, Hiroyuki

    Angewandte Chemie (International ed. in English)

    2021  Volume 61, Issue 7, Page(s) e202113558

    Abstract: A palladium-catalyzed N-H/B-H double activation of 1,2-dihydro-1,2-benzazaborines proceeded via ...

    Abstract A palladium-catalyzed N-H/B-H double activation of 1,2-dihydro-1,2-benzazaborines proceeded via cycloaddition with vinyl ethylene carbonate to produce polycyclic oxazaborolidines in 31-96 % yield. The key step in this process is the release of molecular hydrogen from a borate intermediate. Using a SPINOL-derived phosphoramidite as a chiral ligand, chiral oxazaborolidines were synthesized in good to high yields with excellent enantioselectivity (up to 95 % ee). The vinyl group of the resulting oxazaborolidine underwent metathesis, Heck reaction, and Wacker oxidation without affecting the oxazaborolidine framework.
    Language English
    Publishing date 2021-12-29
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202113558
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  7. Article ; Online: Effects of residual H

    Chihara, Riri / Kitajima, Hideki / Ogawa, Yuuki / Nakamura, Hiroaki / Tsutsui, Shozo / Mizutani, Manabu / Kino-Oka, Masahiro / Ezoe, Sachikon

    Regenerative therapy

    2018  Volume 9, Page(s) 111–115

    Abstract: ... considering their effects on cell viability and characteristics. To date, hydrogen peroxide (H: Methods ... In this study, we examined the effects of residual H: Results: We detected residual H: Conclusions: Here ... we show the effects of post-decontamination residual H ...

    Abstract Introduction: Regenerative therapy is a developing field in medicine. In the production of cell products for these therapies, hygienic management is even more critical than in the production of a chemical drug. At the same time, however, care is required with the use of decontamination agents, considering their effects on cell viability and characteristics. To date, hydrogen peroxide (H
    Methods: In this study, we examined the effects of residual H
    Results: We detected residual H
    Conclusions: Here we show the effects of post-decontamination residual H
    Language English
    Publishing date 2018-10-01
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2835333-X
    ISSN 2352-3204 ; 2352-3204
    ISSN (online) 2352-3204
    ISSN 2352-3204
    DOI 10.1016/j.reth.2018.08.003
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  8. Article ; Online: Development and preliminary validation of a prediction formula of sodium and sodium-to-potassium ratio based on multiple regression using 24-h urines.

    Yamagishi, Marina / Takachi, Ribeka / Ishihara, Junko / Maruya, Sachiko / Ishii, Yuri / Kito, Kumiko / Nakamura, Kazutoshi / Tanaka, Junta / Yamaji, Taiki / Iso, Hiroyasu / Iwasaki, Motoki / Tsugane, Shoichiro / Sawada, Norie

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 9704

    Abstract: ... A prediction formula for habitual 24-h urine sodium excretion and sodium-to-potassium ratio might lead to more ... reliable conclusions. Five 24-h urinary samples and two Food Frequency Questionnaires (FFQs) were conducted ...

    Abstract Accurate measurement of sodium intake in the diet is challenging, and epidemiological studies can be hampered by the attenuation of associations due to measurement error in sodium intake. A prediction formula for habitual 24-h urine sodium excretion and sodium-to-potassium ratio might lead to more reliable conclusions. Five 24-h urinary samples and two Food Frequency Questionnaires (FFQs) were conducted among 244 Japanese participants aged 35-80 years. We conducted multivariate linear regression analysis with urinary excretion as dependent variables and eating behaviour and food frequency as independent variables. Empirical weights of sodium excretion and sodium-to-potassium ratio were extracted. Preliminary validity was also assessed by randomly dividing the subjects into development and validation groups based on the correlation coefficient between estimates by the prediction formula and urinary excretion. Taste preference, soy sauce use at the table, frequency of pickled vegetables intake and number of bowls of miso soup were extracted as determinants of sodium excretion. Correlation coefficients between the estimates and urinary excretion for men and women were 0.42 and 0.43, respectively, for sodium and 0.49 and 0.50, respectively, for sodium-to-potassium ratio. This prediction formula may provide more accurate estimation of sodium intake and sodium-to-potassium ratio than the food composition approach.
    MeSH term(s) Humans ; Female ; Male ; Middle Aged ; Aged ; Adult ; Sodium/urine ; Aged, 80 and over ; Potassium/urine ; Sodium, Dietary/urine ; Sodium, Dietary/analysis ; Feeding Behavior ; Surveys and Questionnaires
    Chemical Substances Sodium (9NEZ333N27) ; Potassium (RWP5GA015D) ; Sodium, Dietary
    Language English
    Publishing date 2024-04-27
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Validation Study
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-60349-3
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  9. Article ; Online: Is "within 72 h" sufficiently early?

    Higashibeppu, Naoki / Nakamura, Kensuke / Yatabe, Tomoaki / Kotani, Joji

    Intensive care medicine

    2021  Volume 48, Issue 2, Page(s) 251–252

    Language English
    Publishing date 2021-10-26
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-021-06561-5
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1089: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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  10. Article ; Online: A Novel Potent and Selective Histamine H

    Hino, Noriko / Marumo, Toshiyuki / Kotani, Makiko / Shimazaki, Toshiharu / Kaku-Fukumoto, Ayaka / Hikichi, Hirohiko / Karasawa, Jun-Ichi / Tomishima, Yasumitsu / Komiyama, Hiroko / Tatsuda, Emi / Nozawa, Dai / Nakamura, Toshio / Chaki, Shigeyuki

    The Journal of pharmacology and experimental therapeutics

    2020  Volume 375, Issue 2, Page(s) 276–285

    Abstract: Histamine H ...

    Abstract Histamine H
    MeSH term(s) Animals ; Cognition/drug effects ; Electroencephalography ; Histamine Antagonists/pharmacokinetics ; Histamine Antagonists/pharmacology ; Locomotion/drug effects ; Male ; Mice ; Neurotransmitter Agents/metabolism ; Rats ; Receptors, Histamine H3/metabolism ; Wakefulness/drug effects
    Chemical Substances Histamine Antagonists ; Neurotransmitter Agents ; Receptors, Histamine H3
    Language English
    Publishing date 2020-08-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3106-9
    ISSN 1521-0103 ; 0022-3565
    ISSN (online) 1521-0103
    ISSN 0022-3565
    DOI 10.1124/jpet.120.000185
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    Uf I Zs.40: Show issues Location:
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