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Article ; Online: Tumor Genetics Are Thrombogenic: The Need for Action.

Mahé, Isabelle / Scotté, Florian / Elalamy, Ismail

JACC. CardioOncology

2023 Volume 5, Issue 2, Page(s) 256–258

Language	English
Publishing date	2023-04-18
Publishing country	United States
Document type	Editorial
ISSN	2666-0873
ISSN (online)	2666-0873
DOI	10.1016/j.jaccao.2023.03.002
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Article: Supportive Care: The "Keystone" of Modern Oncology Practice.

Scotté, Florian / Taylor, Amy / Davies, Andrew

Cancers

2023 Volume 15, Issue 15

Abstract: The Multinational Association of Supportive Care in Cancer (MASCC) defines supportive care as "the prevention and management of the adverse effects of cancer and its treatment. This includes management of physical and psychological symptoms and side ... ...

Abstract	The Multinational Association of Supportive Care in Cancer (MASCC) defines supportive care as "the prevention and management of the adverse effects of cancer and its treatment. This includes management of physical and psychological symptoms and side effects across the continuum of the cancer journey from diagnosis through treatment to post-treatment care. Supportive care aims to improve the quality of rehabilitation, secondary cancer prevention, survivorship, and end-of-life care". This article will provide an overview of modern supportive care in cancer, discussing its definition, its relationship with palliative care, models of care, "core" service elements (multi-professional/multidisciplinary involvement), the evidence that supportive care improves morbidity, quality of life, and mortality in various groups of patients with cancer, and the health economic benefits of supportive care. The article will also discuss the current and future challenges to providing optimal supportive care to all oncology patients.
Language	English
Publishing date	2023-07-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15153860
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Article ; Online: Single-dose NEPA versus an aprepitant regimen for prevention of chemotherapy-induced nausea and vomiting in patients receiving moderately emetogenic chemotherapy.

Zelek, Laurent / Navari, Rudolph / Aapro, Matti / Scotté, Florian

Cancer medicine

2023 Volume 12, Issue 15, Page(s) 15769–15776

Abstract: Introduction: Non-inferiority of NEPA (fixed combination of NK: Methods: This was a pragmatic, multicenter, randomized, prospective study. Oral NEPA was administered as a single dose on day 1, while aprepitant was given on days 1-3 + ondansetron on ... ...

Abstract	Introduction: Non-inferiority of NEPA (fixed combination of NK Methods: This was a pragmatic, multicenter, randomized, prospective study. Oral NEPA was administered as a single dose on day 1, while aprepitant was given on days 1-3 + ondansetron on day 1; all patients were to receive dexamethasone on days 1-4. Patients were chemotherapy-naïve and receiving MEC, with a subset evaluation of those with a risk factor for developing CINV (i.e., female, male <60 years, male ≥60 years who received carboplatin, or male ≥60 years with anxiety). CR rates were compared during the extended overall (0-144 h) phase. Results: The MEC group included 211 patients; of these 181 were in the risk factor subset. Significantly higher CR rates were seen for NEPA than aprepitant during the extended overall phase for the total MEC group (NEPA 77.1%, aprepitant 57.8%, p = 0.003) and also in the subset of patients with CINV risk factors (NEPA 73.9%, aprepitant 56.2%, p = 0.012). Conclusion: A single dose of NEPA, administered on day 1 only, was more effective than a 3-day aprepitant regimen in preventing CINV for an extended duration in patients receiving MEC and in those with emetic risk factors.
MeSH term(s)	Humans ; Male ; Female ; Aprepitant/therapeutic use ; Antiemetics/therapeutic use ; Vomiting/chemically induced ; Vomiting/prevention & control ; Vomiting/drug therapy ; Prospective Studies ; Isoquinolines ; Quinuclidines ; Drug Combinations ; Nausea/chemically induced ; Nausea/prevention & control ; Nausea/drug therapy ; Cyclophosphamide/therapeutic use ; Anthracyclines/adverse effects ; Antineoplastic Agents/adverse effects ; Dexamethasone
Chemical Substances	Aprepitant (1NF15YR6UY) ; Antiemetics ; Isoquinolines ; Quinuclidines ; Drug Combinations ; Cyclophosphamide (8N3DW7272P) ; Anthracyclines ; Antineoplastic Agents ; Dexamethasone (7S5I7G3JQL)
Language	English
Publishing date	2023-08-03
Publishing country	United States
Document type	Randomized Controlled Trial ; Multicenter Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2659751-2
ISSN	2045-7634 ; 2045-7634
ISSN (online)	2045-7634
ISSN	2045-7634
DOI	10.1002/cam4.6121
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Article ; Online: Motivation of patients with chronic cancer during COVID-19: a qualitative analysis.

Georgescu, Irène / Minvielle, Etienne / Scotté, Florian

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

2023 Volume 31, Issue 5, Page(s) 296

Abstract: Purpose: Motivation to treat cancer and prevent its negative impact has been largely explored in a non-pandemic context. However, little is known about the motivation to comply with the treatment, especially during a pandemic. To fill this gap, we have ... ...

Abstract	Purpose: Motivation to treat cancer and prevent its negative impact has been largely explored in a non-pandemic context. However, little is known about the motivation to comply with the treatment, especially during a pandemic. To fill this gap, we have explored the individual and contextual factors impacting patients' motivation during the COVID-19 period using the integrated model. Methods: We have conducted two qualitative studies before (study 1) and during the COVID-19 (study 2) period in a cancer centre. We respectively interviewed 30 and 22 patients with various chronic cancers in study 1 and also with COVID-19 in study 2. Data analysis was based on content analysis and grounded theory approach identifying the factors affecting patient motivations during both periods, and then comparing them. Results: Our results show the mechanisms that allow patients to maintain their motivation despite the threats related to COVID-19. They underline the importance of respecting the rules and laws for patients' motivation. Conclusion: Compliance with legislation fuels the psychological need of protection in patients, which is a key determinant of motivation in the context of the pandemic. Considering patients' self-regulatory activities to assess motivational factors, going beyond clinical aspects, to include organisational and quality-of-life-related aspects throughout their care pathway is crucial.
MeSH term(s)	Humans ; Motivation ; COVID-19 ; Neoplasms/therapy ; Patient Compliance ; Quality of Life/psychology
Language	English
Publishing date	2023-04-24
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1134446-5
ISSN	1433-7339 ; 0941-4355
ISSN (online)	1433-7339
ISSN	0941-4355
DOI	10.1007/s00520-023-07735-1
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Article: La place des soins de support.

Frelaut, Maxime / Aupomerol, Marion / Degousée, Lena / Scotté, Florian

Soins. Gerontologie

2022 Volume 27, Issue 157, Page(s) 21–29

Abstract: Supportive care, in the context of breast cancer in the elderly, is part of standard oncogeriatric care. Nevertheless, the multidisciplinary reinforcement of the different transversal teams can support the global approach, that is essential to the ... ...

Title translation	The place of support care.
Abstract	Supportive care, in the context of breast cancer in the elderly, is part of standard oncogeriatric care. Nevertheless, the multidisciplinary reinforcement of the different transversal teams can support the global approach, that is essential to the quality of care and the life course. Evaluation is the basis of this management. As a result of this evaluation, the approach to sexual health is a novelty that is often insufficiently considered with elderly patients suffering from breast malignancy.
MeSH term(s)	Aged ; Humans ; Quality of Health Care ; Breast Neoplasms/therapy
Language	French
Publishing date	2022-09-16
Publishing country	France
Document type	English Abstract ; Journal Article
ZDB-ID	2246755-5
ISSN	1268-6034
ISSN	1268-6034
DOI	10.1016/j.sger.2022.09.006
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Zs.A 6353: Show issues

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Article ; Online: Nausées et vomissements chimio-induits en oncohématologie pédiatrique : actualisation 2023 des recommandations du comité soins de support de la SFCE.

Renaux Torres, Marie Charlotte / Bouttefroy, Séverine / Letort-Bertrand, Maïna / Maurel, Véronique / Mouffak, Samia / Scotté, Florian / Slimano, Florian / Treguier, Pauline / Dupuis, L Lee / Poirée, Marilyne / Thouvenin-Doulet, Sandrine

Bulletin du cancer

2024

Abstract: Chemotherapy-induced nausea and vomiting (CINV) are frequent and dreaded side effects in cancer treatments. CINV has a major impact on patient's condition and quality of life. Prophylaxis is tailored to patient's profile and the emetogenic level of their ...

Title translation	Chemotherapy-induced nausea and vomiting in pediatric oncology patients: 2023 recommendations from the Supportive Care Committee of the French Society of Cancer in Children and Adolescents.
Abstract	Chemotherapy-induced nausea and vomiting (CINV) are frequent and dreaded side effects in cancer treatments. CINV has a major impact on patient's condition and quality of life. Prophylaxis is tailored to patient's profile and the emetogenic level of their chemotherapy. The aim of this study is to update the recommendations for CINV prevention and management in pediatric onco-hematology for use in France, by adapting the guidelines of the Pediatric Oncology Group of Ontario (POGO). Clinical practice guideline adaptation is a recognized method for tailoring existing clinical practice guidelines to local context. A multidisciplinary French-speaking panel was formed to discuss about POGO guideline recommendations for the acute and delayed phases, breakthrough, refractory and anticipatory CINV and the evidence supporting them. Panel members were asked whether they wanted to adopt, modify or reject each of the POGO guideline recommendations. Panel members translated each recommendation and adapted recommendations for an implementation in France. Their acceptance required agreement at least 80 % of panel members. Algorithms and tables were created, listing all the recommendations and providing a better overview for decision-making process adapted to the patient's profile. These recommendations should be reviewed for implementation at French institutions caring for pediatric cancer patients and once implemented, the rates of adherence to recommendations and CINV control should be reported.
Language	French
Publishing date	2024-04-25
Publishing country	France
Document type	English Abstract ; Practice Guideline
ZDB-ID	213270-9
ISSN	1769-6917 ; 0007-4551
ISSN (online)	1769-6917
ISSN	0007-4551
DOI	10.1016/j.bulcan.2024.02.017
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Article ; Online: The importance of supportive care in optimizing treatment outcomes of patients with advanced prostate cancer.

Scotté, Florian

The oncologist

2012 Volume 17 Suppl 1, Page(s) 23–30

Abstract: Optimal oncologic care of older men with prostate cancer, including effective prevention and management of the disease and treatment side effects (so-called best supportive care measures) can prolong survival, improve quality of life, and reduce ... ...

Abstract	Optimal oncologic care of older men with prostate cancer, including effective prevention and management of the disease and treatment side effects (so-called best supportive care measures) can prolong survival, improve quality of life, and reduce depressive symptoms. In addition, the proportion of treatment discontinuations can be reduced through early reporting and management of side effects. Pharmacologic care may be offered to manage the side effects of androgen-deprivation therapy and chemotherapy, which may include hot flashes, febrile neutropenia, fatigue, and diarrhea. Nonpharmacologic care (e.g., physical exercise, acupuncture, relaxation) has also been shown to benefit patients. At the Georges Pompidou European Hospital, the Program of Optimization of Chemotherapy Administration has demonstrated that improved outpatient follow-up by supportive care measures can reduce the occurrence of chemotherapy-related side effects, reduce cancellations and modifications of treatment, reduce chemotherapy wastage, and reduce the length of stay in the outpatient unit. The importance of supportive care measures to optimize management and outcomes of older men with advanced prostate cancer should not be overlooked.
MeSH term(s)	Acupuncture ; Aged ; Androgen Antagonists/adverse effects ; Androgen Antagonists/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Diarrhea/etiology ; Diarrhea/physiopathology ; Exercise ; Fatigue/etiology ; Fatigue/physiopathology ; Hot Flashes/etiology ; Hot Flashes/physiopathology ; Humans ; Length of Stay ; Male ; Neutropenia/etiology ; Neutropenia/physiopathology ; Palliative Care ; Prostatic Neoplasms/complications ; Prostatic Neoplasms/therapy ; Quality of Life ; Randomized Controlled Trials as Topic ; Treatment Outcome ; Yoga
Chemical Substances	Androgen Antagonists
Language	English
Publishing date	2012-09-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	1409038-7
ISSN	1549-490X ; 1083-7159
ISSN (online)	1549-490X
ISSN	1083-7159
DOI	10.1634/theoncologist.2012-S1-23
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Zs.A 4845: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Netupitant-palonosetron (NEPA) for Preventing Chemotherapy-induced Nausea and Vomiting: From Clinical Trials to Daily Practice.

Aapro, Matti / Jordan, Karin / Scotté, Florian / Celio, Luigi / Karthaus, Meinolf / Roeland, Eric

Current cancer drug targets

2022 Volume 22, Issue 10, Page(s) 806–824

Abstract: Chemotherapy-induced nausea and vomiting (CINV) is a common adverse event associated with many anticancer therapies and can negatively impact patients' quality of life and potentially limit the effectiveness of chemotherapy. Currently, CINV can be ... ...

Abstract	Chemotherapy-induced nausea and vomiting (CINV) is a common adverse event associated with many anticancer therapies and can negatively impact patients' quality of life and potentially limit the effectiveness of chemotherapy. Currently, CINV can be prevented in most patients with guideline-recommended antiemetic regimens. However, clinicians do not always follow guidelines, and patients often face difficulties adhering to their prescribed treatments. Therefore, approaches to increase guideline adherence need to be implemented. NEPA is the first and only fixed combination antiemetic, composed of netupitant (oral)/fosnetupitant (intravenous) and palonosetron, which, together with dexamethasone, constitute a triple antiemetic combination recommended for the prevention of CINV for patients receiving highly emetogenic chemotherapy and for certain patients receiving moderately emetogenic chemotherapy. Thus, NEPA offers a convenient and straightforward antiemetic treatment that could improve adherence to guidelines. This review provides an overview of CINV, evaluates the accumulated evidence of NEPA's antiemetic activity and safety from clinical trials and real-world practice, and examines the preliminary evidence of antiemetic control with NEPA in daily clinical settings beyond those described in pivotal trials. Moreover, we review the utility of NEPA in controlling nausea and preserving patients' quality of life during chemotherapy, two major concerns in managing patients with cancer.
MeSH term(s)	Antiemetics/adverse effects ; Antiemetics/therapeutic use ; Antineoplastic Agents/adverse effects ; Benzeneacetamides ; Dexamethasone ; Humans ; Nausea/chemically induced ; Nausea/prevention & control ; Palonosetron/adverse effects ; Palonosetron/therapeutic use ; Piperazines ; Pyridines ; Quality of Life ; Vomiting/chemically induced ; Vomiting/drug therapy ; Vomiting/prevention & control
Chemical Substances	Antiemetics ; Antineoplastic Agents ; Benzeneacetamides ; Piperazines ; Pyridines ; Palonosetron (5D06587D6R) ; netupitant (7732P08TIR) ; Dexamethasone (7S5I7G3JQL)
Language	English
Publishing date	2022-05-07
Publishing country	Netherlands
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2064824-8
ISSN	1873-5576 ; 1568-0096
ISSN (online)	1873-5576
ISSN	1568-0096
DOI	10.2174/1568009622666220513094352
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Article ; Online: Treatment of cancer-associated venous thromboembolism in patients under palliative care.

Debourdeau, Philippe / Sevestre, Marie-Antoinette / Bertoletti, Laurent / Mayeur, Didier / Girard, Philippe / Scotté, Florian / Sanchez, Olivier / Mahé, Isabelle

Archives of cardiovascular diseases

2023 Volume 117, Issue 1, Page(s) 94–100

Abstract: Many patients with cancer require palliative care at some stage and the vast majority of people followed in palliative care are cancer patients. Patients with cancer are at high risk of venous thromboembolism (VTE), and this is particularly true during ... ...

Abstract	Many patients with cancer require palliative care at some stage and the vast majority of people followed in palliative care are cancer patients. Patients with cancer are at high risk of venous thromboembolism (VTE), and this is particularly true during the advanced palliative phase when mobility is limited or absent. Patients with cancer in palliative cancer are at higher bleeding risk compared to non-cancer patients. Decisions to treat VTE or withhold anticoagulation for these patients have proven to be difficult and depend largely on an individual clinician's judgment. For this reason, we have developed a consensus proposal for appropriate management of cancer-associated thromboembolism (CAT) in patients in palliative care, which is presented in this article. The proposal was informed by the recent scientific literature retrieved through a systematic literature review. In cancer patients in advanced palliative care, the benefit-risk ratio of anticoagulation seems unfavourable with a higher haemorrhagic risk than the benefit associated with prevention of CAT recurrence and, above all, in the absence of any benefit on quality of life. For this reason, we recommend that patients should be prescribed anticoagulants on a case-by-case basis. The choice of whether to treat, and with which type of treatment, should take into account anticipated life expectancy and patient preferences, as well as clinical factors such as the estimated bleeding risk, the type of VTE experienced and the time since the VTE event.
MeSH term(s)	Humans ; Anticoagulants/adverse effects ; Hemorrhage/chemically induced ; Neoplasms/complications ; Neoplasms/diagnosis ; Palliative Care ; Quality of Life ; Venous Thromboembolism/diagnosis ; Venous Thromboembolism/drug therapy ; Venous Thromboembolism/epidemiology ; Practice Guidelines as Topic
Chemical Substances	Anticoagulants
Language	English
Publishing date	2023-11-23
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2408778-6
ISSN	1875-2128 ; 1875-2136
ISSN (online)	1875-2128
ISSN	1875-2136
DOI	10.1016/j.acvd.2023.11.008
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Article ; Online: 2023 updated MASCC/ESMO Consensus recommendations: Prevention of nausea and vomiting following moderately emetic risk antineoplastic agents.

Scotté, Florian / Schwartzberg, Lee / Iihara, Hirotoshi / Aapro, Matti / Gralla, Richard / Hesketh, Paul J / Jordan, Karin / Chow, Ronald / Herrstedt, Jørn

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

2023 Volume 32, Issue 1, Page(s) 45

Abstract: Purpose: Review the literature to update the MASCC guidelines from 2015 for controlling nausea and vomiting with systemic cancer treatment of moderate emetic potential.: Methods: A systematic literature review was completed using Medline, Embase, and ...

Abstract	Purpose: Review the literature to update the MASCC guidelines from 2015 for controlling nausea and vomiting with systemic cancer treatment of moderate emetic potential. Methods: A systematic literature review was completed using Medline, Embase, and Scopus databases. The literature search was done from June 2015 to January 2023 of the management of antiemetic prophylaxis for anticancer therapy of moderate emetic potential. Results: Of 342 papers identified, 19 were relevant to update recommendations about managing antiemetic prophylaxis for systemic cancer treatment regimens of moderate emetic potential. Important practice changing updates include the use of emetic prophylaxis based on a triple combination of neurokinin (NK) Conclusion: This antiemetic MASCC-ESMO guideline update includes new recommendations considering individual risk factors and the optimization of supportive anti-emetic treatments.
MeSH term(s)	Humans ; Female ; Emetics/adverse effects ; Antiemetics/therapeutic use ; Vomiting/chemically induced ; Vomiting/prevention & control ; Vomiting/drug therapy ; Carboplatin/therapeutic use ; Consensus ; Nausea/chemically induced ; Nausea/prevention & control ; Nausea/drug therapy ; Antineoplastic Agents/adverse effects ; Neurokinin-1 Receptor Antagonists/therapeutic use ; Steroids
Chemical Substances	Emetics ; Antiemetics ; Carboplatin (BG3F62OND5) ; Antineoplastic Agents ; Neurokinin-1 Receptor Antagonists ; Steroids
Language	English
Publishing date	2023-12-20
Publishing country	Germany
Document type	Systematic Review ; Journal Article
ZDB-ID	1134446-5
ISSN	1433-7339 ; 0941-4355
ISSN (online)	1433-7339
ISSN	0941-4355
DOI	10.1007/s00520-023-08222-3
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