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Article ; Online: A perspective from a NYC chief oral and maxillofacial surgery resident during the COVID-19 pandemic.

Saggese, N P / Cardo, V A

The British journal of oral & maxillofacial surgery

2020 Volume 58, Issue 6, Page(s) 730–731

MeSH term(s)	Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; New York ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Surgery, Oral
Keywords	covid19
Language	English
Publishing date	2020-05-06
Publishing country	Scotland
Document type	Letter
ZDB-ID	605685-4
ISSN	1532-1940 ; 0266-4356
ISSN (online)	1532-1940
ISSN	0266-4356
DOI	10.1016/j.bjoms.2020.04.042
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Article: A perspective from a NYC chief oral and maxillofacial surgery resident during the COVID-19 pandemic

Saggese, N P / Cardo, V A

Br J Oral Maxillofac Surg

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #186398
Database	COVID19

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Article ; Online: A perspective from a NYC chief oral and maxillofacial surgery resident during the COVID-19 pandemic

Saggese, N.P. / Cardo, V.A.

British Journal of Oral and Maxillofacial Surgery

2020 Volume 58, Issue 6, Page(s) 730–731

Keywords	Surgery ; Oral Surgery ; Otorhinolaryngology ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ZDB-ID	605685-4
ISSN	1532-1940 ; 0266-4356
ISSN (online)	1532-1940
ISSN	0266-4356
DOI	10.1016/j.bjoms.2020.04.042
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Anti-Herpes Zoster Vaccination of Fragile Patients in Hospital Setting: A Nudge Intervention in Italy.

De Caro, Francesco / Malatesta, Francesca / Pecoraro, Nadia / Capunzo, Mario / Carpinelli, Luna / Caruccio, Simona / Cersosimo, Giuseppina / Costantino, Maria / Giordano, Claudio / Longanella, Walter / Patella, Vincenzo / Saggese Tozzi, Arcangelo / Savarese, Giulia / Sinopoli, Pio / Vozzella, Emilia Anna / Moccia, Giuseppina

Vaccines

2024 Volume 12, Issue 4

Abstract: Background: A nudge intervention against Herpes Zoster, created and implemented in Italy, is presented in order to administer the Shingrix vaccine on a sample of frail patients, as required by the National Prevention Plan. Individual and contextual ... ...

Abstract	Background: A nudge intervention against Herpes Zoster, created and implemented in Italy, is presented in order to administer the Shingrix vaccine on a sample of frail patients, as required by the National Prevention Plan. Individual and contextual factors associated with vaccine adherence were investigated. Method: 300 frail adult subjects underwent a full vaccine cycle with recombinant-Shingrix vaccine (RZV vaccine). Hospital Presidia of the Salerno University Hospital Authority, a Hospital Presidium of the Salerno Local Health Authority, and the Public Health Laboratory of the University of Salerno (Campania) participated in the intervention. An ad hoc questionnaire was administered with the following scales: EQ-5D, PSS-10, MSPSS, and representations of HZ and its consequences. Results: Some variables, such as peer support, doctor-patient relationship, level of education, and perception of health, are important in vaccine adherence and information processing. The following factors emerged from the factor analysis: Trust in collective knowledge and collective responsibility (F1); beliefs about virus risk and vaccine function (F2); information about virus and symptomatology (F3); and vaccine distrust (F4). Factor 4 correlates negatively with social support indices (R = -0.363; Conclusions: Future vaccination campaigns should be built with the aim of personalizing information and developing contextualized strategies, starting from understanding the stakeholders involved, cultural contexts, and organizational settings.
Language	English
Publishing date	2024-04-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2703319-3
ISSN	2076-393X
ISSN	2076-393X
DOI	10.3390/vaccines12040442
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Book ; Online: Who are the arbitrageurs? Empirical evidence from Bitcoin traders in the Mt. Gox exchange platform

Saggese, Pietro / Belmonte, Alessandro / Dimitri, Nicola / Facchini, Angelo / Böhme, Rainer

2021

Abstract: We mine the leaked history of trades on Mt. Gox, the dominant Bitcoin exchange from 2011 to early 2014, to detect the triangular arbitrage activity conducted within the platform. The availability of user identifiers per trade allows us to focus on the ... ...

Abstract	We mine the leaked history of trades on Mt. Gox, the dominant Bitcoin exchange from 2011 to early 2014, to detect the triangular arbitrage activity conducted within the platform. The availability of user identifiers per trade allows us to focus on the historical record of 440 investors, detected as arbitrageurs, and consequently to describe their trading behavior. We begin by showing that a considerable difference appears between arbitrageurs when indicators of their expertise are taken into account. In particular, we distinguish between those who conducted arbitrage in a single or in multiple markets: using this element as a proxy for trade ability, we find that arbitrage actions performed by expert users are on average non-profitable when transaction costs are accounted for, while skilled investors conduct arbitrage at a positive and statistically significant premium. Next, we show that specific trading strategies, such as splitting orders or conducting arbitrage non aggressively, are further indicators of expertise that increase the profitability of arbitrage. Most importantly, we exploit within-user (across hours and markets) variation and document that expert users make profits on arbitrage by reacting quickly to plausible exogenous variations on the official exchange rates. We present further evidence that such differences are chiefly due to a better ability of the latter in incorporating information, both on the transactions costs and on the exchange rates volatility, eventually resulting in a better timing choice at small time scale intervals. Our results support the hypothesis that arbitrageurs are few and sophisticated users.
Keywords	Quantitative Finance - General Finance ; Computer Science - Cryptography and Security ; Economics - General Economics ; Quantitative Finance - Portfolio Management
Subject code	330
Publishing date	2021-09-22
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Chemopreventive effect of a milk whey by-product derived from Buffalo (Bubalus bubalis) in protecting from colorectal carcinogenesis.

Cacciola, Nunzio Antonio / Venneri, Tommaso / Salzano, Angela / D'Onofrio, Nunzia / Martano, Manuela / Saggese, Anella / Vinale, Francesco / Neglia, Gianluca / Campanile, Ciro / Baccigalupi, Loredana / Maiolino, Paola / Cuozzo, Mariarosaria / Russo, Roberto / Balestrieri, Maria Luisa / D'Occhio, Michael John / Ricca, Ezio / Borrelli, Francesca / Campanile, Giuseppe

Cell communication and signaling : CCS

2023 Volume 21, Issue 1, Page(s) 245

Abstract: ... mechanism of action.: Results: Pretreatment of AOM-treated mice with DMW significantly (P < 0.05) reduced ...

Abstract	Background: Several studies show that natural foods are a source of compounds with anticancer properties that affect the gut microbiota and its metabolites. In the present study, we investigate the effect of a delactosed buffalo milk whey by-product (DMW) on colorectal carcinogenesis. Methods: The effect of DMW on colorectal carcinoma (CRC) was investigated in the established mouse model of azoxymethane (AOM)-induced colon carcinoma, which closely resembles the human clinical condition of CRC. The effect of DMW on CRC immortalized cell lines was also evaluated to further identify the antineoplastic mechanism of action. Results: Pretreatment of AOM-treated mice with DMW significantly (P < 0.05) reduced the percentage of mice bearing both aberrant crypt foci with more than four crypts (which are early precancerous lesions that progress to CRC) and tumors. In addition, DMW completely counteracted the effect of AOM on protein expression of caspase-9, cleaved caspase-3 and poly ADP-ribose polymerase in colonic tissue. Administration of DMW alone (i.e. without AOM) resulted in changes in the composition of the gut microbiota, leading to enrichment or depletion of genera associated with health and disease, respectively. DMW was also able to restore AOM-induced changes in specific genera of the gut microbiota. Specifically, DMW reduced the genera Atopobiaceae, Ruminococcus 1 and Lachnospiraceae XPB1014 and increased the genera Parabacteroides and Candidatus Saccharimonas, which were increased and reduced, respectively, by AOM. Blood levels of butyric acid and cancer diagnostic markers (5-methylcytidine and glycerophosphocholine), which were increased by AOM treatment, were reduced by DMW. Furthermore, DMW exerted cytotoxic effects on two human CRC cell lines (HCT116 and HT29) and these effects were associated with the induction of apoptotic signaling. Conclusions: Our results suggest that DMW exerts chemopreventive effects and restores the gut microbiota in AOM-induced CRC, and induces cytotoxic effect on CRC cells. DMW could be an important dietary supplement to support a healthy gut microbiota and reduce the prevalence of CRC in humans. Video Abstract.
MeSH term(s)	Humans ; Animals ; Mice ; Whey ; Buffaloes ; Milk ; Carcinogenesis ; Colorectal Neoplasms/drug therapy ; Azoxymethane/toxicity ; Butyric Acid
Chemical Substances	Azoxymethane (MO0N1J0SEN) ; Butyric Acid (107-92-6)
Language	English
Publishing date	2023-09-20
Publishing country	England
Document type	Video-Audio Media ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2126315-2
ISSN	1478-811X ; 1478-811X
ISSN (online)	1478-811X
ISSN	1478-811X
DOI	10.1186/s12964-023-01271-5
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Article: Evaluation of Multidrug Therapy With Azithromycin, Rifampin, and Ethambutol for the Treatment of Mycobacterium avium subsp avium in Ring-neck Doves (Streptopelia risoria): An Uncontrolled Clinical Study.

Saggese, Miguel D / Tizard, Ian / Gray, Patricia / Phalen, David N

Journal of avian medicine and surgery

2014 Volume 28, Issue 4, Page(s) 280–289

Abstract: An uncontrolled clinical study was conducted to evaluate the efficacy of a multidrug protocol in 16 ring-neck doves ( Streptopelia risoria ) from a flock naturally infected with Mycobacterium avium subsp avium. The doves were considered infected on the ... ...

Abstract	An uncontrolled clinical study was conducted to evaluate the efficacy of a multidrug protocol in 16 ring-neck doves ( Streptopelia risoria ) from a flock naturally infected with Mycobacterium avium subsp avium. The doves were considered infected on the basis of a high prevalence of infection in a group of 29 birds that were euthanatized from the same flock and clinical signs and pathologic results consistent with infection in the remaining birds. All birds were treated with azithromycin (43 mg/kg), rifampin (45 mg/kg), and ethambutol (30 mg/kg) administered orally once daily for 180 days. Five birds died during treatment and were confirmed positive for mycobacteriosis on postmortem examination. Of the remaining 11 birds, infection and disease were present in 9 (81.8%) at the end of the treatment. Postmortem investigation showed that 2 mycobacterial isolates were resistant to ethambutol, intermediately sensitive to rifampin, and sensitive to azithromycin. Microscopic examination of liver sections equivalent of those that would be taken for biopsy showed that biopsy as a method of monitoring birds for treatment success had poor sensitivity. Toxicity associated with drug therapy was not observed in these doves nor in 6 outwardly healthy ring-neck doves exposed to the same treatment. The results of this study showed that this protocol of azithromycin, rifampin, and ethambutol has poor efficacy when administered for 180 days for treatment of doves infected with M avium subsp avium.
Language	English
Publishing date	2014-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2174190-6
ISSN	1938-2871 ; 1082-6742
ISSN (online)	1938-2871
ISSN	1082-6742
DOI	10.1647/2012-067R1
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Article ; Online: A phase I/II study of epertinib plus trastuzumab with or without chemotherapy in patients with HER2-positive metastatic breast cancer.

Macpherson, Iain R / Spiliopoulou, Pavlina / Rafii, Saeed / Saggese, Matilde / Baird, Richard D / Garcia-Corbacho, Javier / Italiano, Antoine / Bonneterre, Jacques / Campone, Mario / Cresti, Nicola / Posner, John / Takeda, Yousuke / Arimura, Akinori / Spicer, James

Breast cancer research : BCR

2019 Volume 22, Issue 1, Page(s) 1

Abstract: ... at the recommended doses of epertinib combined with trastuzumab was 67% (N = 9), with trastuzumab plus vinorelbine ... was 0% (N = 5) and with trastuzumab plus capecitabine was 56% (N = 9). Notably, 4 of 6 patients ...

Abstract	Background: Epertinib (S-222611) is a potent reversible inhibitor of HER2, EGFR and HER4. This trial evaluated the safety, tolerability, pharmacokinetics and antitumour activity of daily oral epertinib combined with trastuzumab (arm A), with trastuzumab plus vinorelbine (arm B) or with trastuzumab plus capecitabine (arm C), in patients with HER2-positive metastatic breast cancer (MBC). Methods: Eligible patients, with or without brain metastases, had received prior HER2-directed therapy. A dose-escalation phase determined the tolerability of each combination and established a dose for further study. Further, patients were recruited to expansion cohorts in each of the 3 arms to further explore efficacy and safety. Results: The recommended doses of epertinib were 600 mg, 200 mg and 400 mg in arms A, B and C, respectively. The most frequent grade 3/4 adverse event (AE) was diarrhoea in all arms, which was manageable with medical intervention and dose modification. The objective response rate (complete response [CR] plus partial response [PR]) in heavily pre-treated HER2-positive MBC patients at the recommended doses of epertinib combined with trastuzumab was 67% (N = 9), with trastuzumab plus vinorelbine was 0% (N = 5) and with trastuzumab plus capecitabine was 56% (N = 9). Notably, 4 of 6 patients previously treated with T-DM1 responded in the arm A expansion cohort (epertinib plus trastuzumab). In the arm C expansion cohort (epertinib plus trastuzumab plus capecitabine), 4 of 7 patients responded despite previous exposure to capecitabine. Measurable regression of brain metastases was observed in patients with CNS target lesions treated in both arms A and C. Conclusion: We observed safety, tolerability and encouraging antitumour activity of epertinib combined with trastuzumab, or with trastuzumab plus capecitabine. This supports further evaluation of these combinations in patients with pre-treated HER2-positive MBC, with or without brain metastases. Trial registration: EudraCT Number: 2013-003894-87; registered 09-September-2013.
MeSH term(s)	Adult ; Aged ; Antineoplastic Combined Chemotherapy Protocols/administration & dosage ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Brain Neoplasms/drug therapy ; Brain Neoplasms/secondary ; Breast Neoplasms/drug therapy ; Breast Neoplasms/pathology ; Capecitabine/administration & dosage ; Capecitabine/adverse effects ; Capecitabine/therapeutic use ; Dose-Response Relationship, Drug ; Drug Administration Schedule ; Female ; Humans ; Male ; Middle Aged ; Quinazolines/administration & dosage ; Quinazolines/adverse effects ; Quinazolines/therapeutic use ; Receptor, ErbB-2/antagonists & inhibitors ; Receptor, ErbB-2/metabolism ; Trastuzumab/administration & dosage ; Trastuzumab/adverse effects ; Trastuzumab/therapeutic use ; Treatment Outcome ; Vinorelbine/administration & dosage ; Vinorelbine/adverse effects ; Vinorelbine/therapeutic use
Chemical Substances	Quinazolines ; S-222611 ; Capecitabine (6804DJ8Z9U) ; ERBB2 protein, human (EC 2.7.10.1) ; Receptor, ErbB-2 (EC 2.7.10.1) ; Trastuzumab (P188ANX8CK) ; Vinorelbine (Q6C979R91Y)
Language	English
Publishing date	2019-12-31
Publishing country	England
Document type	Clinical Trial, Phase I ; Clinical Trial, Phase II ; Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID	2015059-3
ISSN	1465-542X ; 1465-5411
ISSN (online)	1465-542X
ISSN	1465-5411
DOI	10.1186/s13058-019-1178-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Humoral response to Mycobacterium avium subsp. avium in naturally infected ring-neck doves (Streptopelia risoria).

Gray, P L / Saggese, M D / Phalen, D N / Tizard, I

Veterinary immunology and immunopathology

2008 Volume 125, Issue 3-4, Page(s) 216–224

Abstract: Creation of a reliable and easy to use serologic test would greatly improve ante mortem diagnosis of Mycobacterium avium subsp. avium and aid in the control of avian mycobacteriosis, particularly in captive birds. In order to determine whether ... ...

Abstract	Creation of a reliable and easy to use serologic test would greatly improve ante mortem diagnosis of Mycobacterium avium subsp. avium and aid in the control of avian mycobacteriosis, particularly in captive birds. In order to determine whether serodiagnostics could be of value in testing ring-neck doves (Streptopelia risoria) for M. a. avium infection, Western blot analysis was used to assess the humoral response of ring-neck doves exposed to M. a. avium, and to evaluate whether an association could be made between the humoral response and necropsy findings, histopathology, culture, and PCR testing. Western blot results were examined for reactivity patterns associating humoral response with infection status, severity and type of lesions (diffuse vs. multifocal granulomatous inflammation) and phenotype (white vs. non-white). A sensitivity of 88.24% and a specificity of 100% were achieved utilizing Western blot analysis to detect M. a. avium infection in ring-neck doves, offering a negative predictive value of 93% and a positive predictive value of 100%. While Western blot analysis results did not reflect lesion severity, lesion type did partially correspond with the humoral response. The findings of the present study indicate that serologic testing can be used as a valuable ante mortem screening tool for identifying ring-neck doves infected with M. a. avium.
MeSH term(s)	Animals ; Antibodies, Bacterial/blood ; Antibody Formation/immunology ; Antigens, Bacterial/chemistry ; Antigens, Bacterial/immunology ; Blotting, Western ; Columbidae ; Mycobacterium avium/immunology ; Predictive Value of Tests ; Sensitivity and Specificity ; Tuberculosis, Avian/diagnosis ; Tuberculosis, Avian/immunology ; Tuberculosis, Avian/microbiology
Chemical Substances	Antibodies, Bacterial ; Antigens, Bacterial
Language	English
Publishing date	2008-10-15
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	754160-0
ISSN	1873-2534 ; 0165-2427
ISSN (online)	1873-2534
ISSN	0165-2427
DOI	10.1016/j.vetimm.2008.05.032
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Article: Neutralization of “Chaco eagle” (Buteogallus coronatus) serum on some activities of Bothrops spp. venoms

Regner, Pablo I. / Saggese, Miguel D. / de Oliveira, Vanessa C. / Lanari, Laura C. / Desio, Marcela A. / Quaglia, Agustín I.E. / Wiemeyer, Guillermo / Capdevielle, Andrés / Zuñiga, Silvina N. / de Roodt, Carolina J.I. / de Roodt, Adolfo R.

Toxicon. 2022 May 19,

2022

Abstract: ... from animal species in which inhibitors of snake venoms have not been described (p < 0.05), while it is lower or ...

Abstract	Several species of reptiles and mammals have components in their sera that can neutralize toxic components present in snake venoms. In this manuscript, we studied the neutralizing capacity of Chaco eagle's (Buteogallus coronatus) serum. This South American bird of prey eats snakes as a regular part of its diet and has anatomical features that protect from snakes’ bites. The neutralizing potency of the Chaco eagle's serum was tested on lethal, hemorrhagic, procoagulant, and phospholipase activities of the venom of “yarará grande” (Bothrops alternatus) and on phospholipase activity of “yarará ñata” (Bothrops ammodytoides) venom; both snakes are known to be the prey of Chaco eagle. Sera of crested caracara (Caracara plancus-a scavenger, omnivorous pan-American bird of prey), secretary bird (Saggitarius serpentarius-an omnivorous bird of prey from Africa that can include venomous snakes in its diet), common hen (Gallus gallus), rat (Rattus norvegicus), mouse (Mus musculus), horse (Equus caballus), and dog (Canis lupus familiaris) were also tested to compare the inhibitory capacity of neutralization. To test isologous and xenologous neutralization, sera from Bothrops alternatus and white-eared opossum (Didelphis albiventris), respectively, were used due to their known inhibitory activity on Bothrops venoms. As a control for the neutralization activity, antibothropic antivenom was used. Chaco eagle's serum neutralized hemorrhagic and phospholipasic activity and slightly neutralized the coagulation and the lethal activity of Bothrops spp. venom. The neutralizing capacity was present in the non-immunoglobulin fraction of the serum, which showed components of acidic characteristics and lower molecular weight than IgY, in correspondence with the characteristics of PLA₂s and SVMPs inhibitors described in sera from some snakes and mammals. These studies showed that Chaco eagle's serum neutralizes all toxic activities tested at a higher level than sera from animal species in which inhibitors of snake venoms have not been described (p < 0.05), while it is lower or similar in neutralizing capacity to white-eared opossum and B. alternatus sera.
Keywords	Bothrops ; Buteogallus coronatus ; Canis lupus ; Didelphis albiventris ; Gallus gallus ; Rattus norvegicus ; antivenoms ; birds of prey ; blood serum ; coagulation ; diet ; dogs ; eagles ; hens ; horses ; mice ; molecular weight ; neutralization ; omnivores ; opossums ; phospholipases ; rats ; snakes ; toxicity ; Africa
Language	English
Dates of publication	2022-0519
Publishing place	Elsevier Ltd
Document type	Article
Note	Pre-press version
ZDB-ID	204479-1
ISSN	1879-3150 ; 0041-0101
ISSN (online)	1879-3150
ISSN	0041-0101
DOI	10.1016/j.toxicon.2022.05.038
Database	NAL-Catalogue (AGRICOLA)

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