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  1. Book: Infectious diseases guidelines

    Blumberg, Emily A.

    (American journal of transplantation ; 13, Suppl. 4)

    2013  

    Institution American Society of Transplantation
    Author's details ed. Emily A. Blumberg ... [The American Society of Transplantation]
    Series title American journal of transplantation ; 13, Suppl. 4
    Collection
    Language English
    Size S371 S. : Ill.
    Edition 3. ed.
    Publisher Wiley-Blackwell
    Publishing place Malden, MA
    Publishing country United States
    Document type Book
    HBZ-ID HT017633846
    Database Catalogue ZB MED Medicine, Health

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    Zs A 5542 -13,Suppl.4- not available for loan Zeitschriften-Lesesaal

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  2. Article ; Online: Organs from Hepatitis C Virus-Positive Donors.

    Blumberg, Emily A

    The New England journal of medicine

    2019  Volume 380, Issue 17, Page(s) 1669–1670

    MeSH term(s) Hepacivirus ; Hepatitis C ; Humans ; Lung Transplantation ; Tissue Donors
    Language English
    Publishing date 2019-04-03
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMe1901957
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: COVID-19 in organ donors: An organ procurement organization perspective.

    Mezochow, Alyssa K / Anesi, Judith / West, Sharon / Hasz, Richard / Edwards, John / Blumberg, Emily A

    Transplant infectious disease : an official journal of the Transplantation Society

    2024  Volume 26, Issue 2, Page(s) e14230

    Abstract: Background: The COVID-19 pandemic presented a significant challenge for Organ Procurement Organizations (OPOs) with the use of SARS-CoV-2 positive donors varying widely. This study used detailed single OPO data to determine the success of using SARS-CoV- ...

    Abstract Background: The COVID-19 pandemic presented a significant challenge for Organ Procurement Organizations (OPOs) with the use of SARS-CoV-2 positive donors varying widely. This study used detailed single OPO data to determine the success of using SARS-CoV-2 positive donors.
    Methods: We performed a retrospective cohort study including all SARS-CoV-2 positive donors referred to the Gift of Life OPO from January 1, 2021, to June 30, 2023. Descriptive analyses were performed to characterize referral and organ utilization.
    Results: There were 861 organ referrals with 1 positive SARS-Cov-2 test: 282 were ruled out with telephone evaluation, 431 referrals were ruled out with onsite evaluation ("evaluated nondonors") and 148 became donors. For donors who had both nasopharyngeal and lower respiratory testing completed, there was notable result discordance observed. Median cycle threshold (Ct) values were similar between donors and evaluated nondonors with no change in median donor Ct values over the study period. Transplanted organs from COVID-positive donors included 27 hearts, 88 livers, 5 pancreata, and 107 kidneys; no lung donation occurred. The proportion of COVID-positive donors significantly increased over the study period.
    Conclusion: This large volume donor referral study demonstrates increasing COVID-19 referrals progressing to donation over time, supporting the increased use of these donors for nonlung transplantation.
    MeSH term(s) Humans ; COVID-19/epidemiology ; Pandemics/prevention & control ; Retrospective Studies ; Organ Transplantation/adverse effects ; SARS-CoV-2 ; Tissue and Organ Procurement ; Tissue Donors
    Language English
    Publishing date 2024-01-08
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 1476094-0
    ISSN 1399-3062 ; 1398-2273
    ISSN (online) 1399-3062
    ISSN 1398-2273
    DOI 10.1111/tid.14230
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  4. Article ; Online: New Perspectives on Antimicrobial Agents: Maribavir.

    Halpern-Cohen, Virginie / Blumberg, Emily A

    Antimicrobial agents and chemotherapy

    2022  Volume 66, Issue 9, Page(s) e0240521

    Abstract: Maribavir was approved by the U.S. Food and Drug Administration in November 2021 for the treatment of adult and pediatric patients with post-transplant cytomegalovirus (CMV) infection/disease that is refractory to treatment (with or without genotypic ... ...

    Abstract Maribavir was approved by the U.S. Food and Drug Administration in November 2021 for the treatment of adult and pediatric patients with post-transplant cytomegalovirus (CMV) infection/disease that is refractory to treatment (with or without genotypic resistance) with ganciclovir, valganciclovir, cidofovir, or foscarnet. Maribavir is an oral benzimidazole riboside with potent and selective multimodal anti-CMV activity. It utilizes a novel mechanism of action which confers activity against CMV strains that are resistant to traditional anti-CMV agents, and also offers a more favorable safety profile relative to the dose-limiting side effects of previously available therapies. Maribavir was initially studied as an agent for CMV prophylaxis in solid organ and hematopoietic stem cell recipients, but initial phase III trials failed to meet clinical efficacy endpoints. It has been more recently studied as a therapeutic agent at higher doses for refractory-resistant (R-R) CMV infections with favorable outcomes. After an overview of maribavir's chemistry and clinical pharmacology, this review will summarize clinical efficacy, safety, tolerability, and resistance data associated with maribavir therapy.
    MeSH term(s) Adult ; Anti-Infective Agents/pharmacology ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Benzimidazoles/pharmacology ; Benzimidazoles/therapeutic use ; Child ; Cidofovir ; Cytomegalovirus Infections/prevention & control ; Dichlororibofuranosylbenzimidazole/analogs & derivatives ; Drug Resistance, Viral ; Foscarnet ; Ganciclovir/therapeutic use ; Humans ; Valganciclovir/therapeutic use
    Chemical Substances Anti-Infective Agents ; Antiviral Agents ; Benzimidazoles ; Foscarnet (364P9RVW4X) ; Dichlororibofuranosylbenzimidazole (53-85-0) ; Valganciclovir (GCU97FKN3R) ; Cidofovir (JIL713Q00N) ; Ganciclovir (P9G3CKZ4P5) ; maribavir (PTB4X93HE1)
    Language English
    Publishing date 2022-08-02
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 217602-6
    ISSN 1098-6596 ; 0066-4804
    ISSN (online) 1098-6596
    ISSN 0066-4804
    DOI 10.1128/aac.02405-21
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    Einzelsignatur: Show issues

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  5. Article ; Online: Infection and clinical xenotransplantation: Guidance from the Infectious Disease Community of Practice of the American Society of Transplantation.

    Mehta, Sapna A / Saharia, Kapil K / Nellore, Anoma / Blumberg, Emily A / Fishman, Jay A

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

    2023  Volume 23, Issue 3, Page(s) 309–315

    Abstract: This guidance was developed to summarize current approaches to the potential transmission of swine-derived organisms to xenograft recipients, health care providers, or the public in clinical xenotransplantation. Limited specific data are available on the ...

    Abstract This guidance was developed to summarize current approaches to the potential transmission of swine-derived organisms to xenograft recipients, health care providers, or the public in clinical xenotransplantation. Limited specific data are available on the zoonotic potential of pig pathogens. It is anticipated that the risk of zoonotic infection in xenograft recipients will be determined by organisms present in source animals and relate to the nature and intensity of the immunosuppression used to maintain xenograft function. Based on experience in allotransplantation and with preclinical models, viral infections are of greatest concern, including porcine cytomegalovirus, porcine lymphotropic herpesvirus, and porcine endogenous retroviruses. Sensitive and specific microbiological assays are required for routine microbiological surveillance of source animals and xenograft recipients. Archiving of blood samples from recipients, contacts, and hospital staff may provide a basis for microbiological investigations if infectious syndromes develop. Carefully implemented infection control practices are required to prevent zoonotic pathogen exposures by clinical care providers. Informed consent practices for recipients and their close contacts must convey the lack of specific data for infectious risk assessment. Available data suggest that infectious risks of xenotransplantation are manageable and that clinical trials can advance with carefully developed protocols for pretransplant assessment, syndrome evaluation, and microbiological monitoring.
    MeSH term(s) Humans ; Animals ; Swine ; Transplantation, Heterologous ; Zoonoses ; Infections ; Virus Diseases ; Communicable Diseases
    Language English
    Publishing date 2023-01-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2060594-8
    ISSN 1600-6143 ; 1600-6135
    ISSN (online) 1600-6143
    ISSN 1600-6135
    DOI 10.1016/j.ajt.2022.12.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: CDC Health Advisory Regarding the Potential for Circulation of Drifted Influenza A (H3N2) Viruses.

    Blumberg, Emily A

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

    2015  Volume 15, Issue 2, Page(s) 568

    Language English
    Publishing date 2015-02
    Publishing country United States
    Document type Editorial
    ZDB-ID 2060594-8
    ISSN 1600-6143 ; 1601-2577 ; 1600-6135
    ISSN (online) 1600-6143
    ISSN 1601-2577 ; 1600-6135
    DOI 10.1111/ajt.13211
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  7. Article: Should Health Care Institutions Mandate SARS-CoV-2 Vaccination for Staff?

    Kates, Olivia S / Diekema, Douglas S / Blumberg, Emily A

    Open forum infectious diseases

    2021  Volume 8, Issue 6, Page(s) ofab155

    Abstract: Health care workers have been prioritized for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination, but vaccine hesitancy among workers may limit uptake. Institutions may wish to consider SARS-CoV-2 vaccine mandates for health care ... ...

    Abstract Health care workers have been prioritized for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination, but vaccine hesitancy among workers may limit uptake. Institutions may wish to consider SARS-CoV-2 vaccine mandates for health care workers, but such proposals raise important ethical questions. Arguments supporting mandates emphasize the proposed favorable balance of harms and benefits for both individuals and communities, as well as moral duties of health care workers and organizations. Arguments in opposition seek to challenge some claims about utility and raise additional concerns about infringement on autonomy, damage to organizational relationships, and injustice. While available SARS-CoV-2 vaccines remain under an experimental designation, mandates may be excessively problematic, but following approval by the Food and Drug Administration mandates may be reconsidered. The authors summarize ethical arguments and practical considerations, concluding that mandates may be ethically permissible in select circumstances.
    Language English
    Publishing date 2021-04-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofab155
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  8. Article ; Online: Solid organ transplantation in the HIV-infected patient: Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice.

    Blumberg, Emily A / Rogers, Christin C

    Clinical transplantation

    2019  Volume 33, Issue 9, Page(s) e13499

    Abstract: These updated guidelines from the Infectious Diseases Community of Practice of the American Society of Transplantation review the management of transplantation in HIV-infected individuals. Transplantation has become the standard of care for patients with ...

    Abstract These updated guidelines from the Infectious Diseases Community of Practice of the American Society of Transplantation review the management of transplantation in HIV-infected individuals. Transplantation has become the standard of care for patients with HIV and end-stage kidney or liver disease. Although less data exist for thoracic organ and pancreas transplantation, it is likely that transplantation is also safe and effective for these recipients as well. Despite what is typically a transient decline in CD4
    MeSH term(s) HIV/isolation & purification ; HIV Infections/therapy ; HIV Infections/virology ; Humans ; Organ Transplantation/methods ; Practice Guidelines as Topic/standards ; Societies, Medical ; Tissue Donors/supply & distribution ; Transplant Recipients/statistics & numerical data
    Language English
    Publishing date 2019-04-21
    Publishing country Denmark
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639001-8
    ISSN 1399-0012 ; 0902-0063
    ISSN (online) 1399-0012
    ISSN 0902-0063
    DOI 10.1111/ctr.13499
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  9. Article ; Online: Water Safety: MMWR and FDA Reports.

    Blumberg, Emily A

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

    2015  Volume 15, Issue 12, Page(s) 3259

    MeSH term(s) Centers for Disease Control and Prevention, U.S. ; Humans ; Research Report ; United States ; United States Food and Drug Administration ; Water Pollution/prevention & control ; Water Quality/standards ; Water Supply/standards
    Language English
    Publishing date 2015-11-10
    Publishing country United States
    Document type Editorial
    ZDB-ID 2060594-8
    ISSN 1600-6143 ; 1600-6135
    ISSN (online) 1600-6143
    ISSN 1600-6135
    DOI 10.1111/ajt.13601
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  10. Article ; Online: Guidance for evaluating and testing patients for COVID-19.

    Blumberg, Emily

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

    2020  Volume 20, Issue 5, Page(s) 1457

    MeSH term(s) Betacoronavirus/isolation & purification ; COVID-19 ; COVID-19 Testing ; Centers for Disease Control and Prevention, U.S. ; Clinical Laboratory Techniques/standards ; Coronavirus Infections/diagnosis ; Coronavirus Infections/prevention & control ; Humans ; Pandemics/prevention & control ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/prevention & control ; Practice Guidelines as Topic ; SARS-CoV-2 ; United States
    Keywords covid19
    Language English
    Publishing date 2020-09-03
    Publishing country United States
    Document type Editorial
    ZDB-ID 2060594-8
    ISSN 1600-6143 ; 1600-6135
    ISSN (online) 1600-6143
    ISSN 1600-6135
    DOI 10.1111/ajt.15895
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