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Article ; Online: Reseña de "Visitas «ad limina» de la diócesis de Cartagena (1589-1901)" de Antonio Irigoyen López, José Jesús García Hourcade y Miguel Ángel García Olmo

F. Requena

Anuario de Historia de la Iglesia, Iss 12, p

2003 Volume 503

Keywords	History (General) ; D1-2009 ; History (General) and history of Europe ; D
Language	Spanish
Publishing date	2003-01-01T00:00:00Z
Publisher	Universidad de Navarra
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Dual SGLT1 and SGLT2 inhibition: more than the sum of its parts.

Sánchez-Muñoz, Enrique / Requena-Ibáñez, Juan Antonio / Badimón, Juan José

Revista espanola de cardiologia (English ed.)

2024

Language	Spanish
Publishing date	2024-03-22
Publishing country	Spain
Document type	Journal Article
ZDB-ID	2592481-3
ISSN	1885-5857 ; 1885-5857
ISSN (online)	1885-5857
ISSN	1885-5857
DOI	10.1016/j.rec.2024.01.011
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Article ; Online: Improving success rates by applying interventions in clinical practice and measuring their impact: A multicenter retrospective analysis of more than 240,000 cycles.

Vergara, Vanessa / Prados, Nicolás / Cruz, María / Requena, Antonio / Pellicer, Antonio

European journal of obstetrics, gynecology, and reproductive biology

2023 Volume 287, Page(s) 186–194

Abstract: Background: Systematic monitoring of key performance indicators (KPI) is an important component of quality management within the IVF laboratory and, as success of assisted reproduction depends on many variables, it is important to examine how each ... ...

Abstract	Background: Systematic monitoring of key performance indicators (KPI) is an important component of quality management within the IVF laboratory and, as success of assisted reproduction depends on many variables, it is important to examine how each variable can be optimized to achieve the best possible outcome for patients. Objective: To analyze how the design of a QMS impacts homogenization, safety, and efficacy in multiple fertility centers. Study Design Multicenter, retrospective cohort study with 188,251 patients who underwent 246,988 assisted reproductive treatments at 14 private centers belonging to IVI-RMA clinics between January 2005 and December 2019. Data were stratified by year, clinic, and patient group (standard patient cycles with no PGT-A, standard patients with PGT-A, and oocyte donation patients). Unadjusted and adjusted logistic regression models with other known predictors were made to analyze the impact and the interactions of policies. Main outcomes were determined per clinic and summarized per year as the median of the rates of the clinics; each clinic had the same weight independent of the number of cycles. Results: Up to 188,251 patients were treated, for a total of 246,988 IVF cycles and 356,433 procedures. The introduction of standard operating procedures, trophectoderm biopsies, and blastocyst-stage transfers, coupled with an increased proportion of PGT-A cycles, led to improved outcomes while maximizing the number of single embryo transfers, driving a significant decrease in the number of multiple pregnancies while improving live birth rates. In terms of the live-birth rate per transfer, the interventions with greater impact over time in logistic regression analysis were 24-chromosome analysis and the introduction of benchtop incubators (odds ratio 1.92 [95% confidence interval 1.81 to 2.05]; p < 0.001). The odd ratios of the policies remained significant and very similar in the unadjusted and adjusted models. Conclusions: The greatest impact on live-birth rate per cycle was obtained with a cumulative effect of all policies, especially in egg donation patients. In patients without PGT-A changing embryo culture conditions and blastocyst stage transfer had the greatest impact; in patients with PGT-A, trophectoderm biopsy. Standardizing procedures was essential in reducing variability among clinics and implementing changes.
MeSH term(s)	Pregnancy ; Female ; Humans ; Retrospective Studies ; Live Birth ; Embryo Transfer/methods ; Pregnancy, Multiple ; Birth Rate ; Fertilization in Vitro/methods ; Pregnancy Rate ; Blastocyst
Language	English
Publishing date	2023-06-07
Publishing country	Ireland
Document type	Multicenter Study ; Journal Article
ZDB-ID	190605-7
ISSN	1872-7654 ; 0301-2115 ; 0028-2243
ISSN (online)	1872-7654
ISSN	0301-2115 ; 0028-2243
DOI	10.1016/j.ejogrb.2023.06.007
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Zs.A 837: Show issues

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Article ; Online: Assessment of climate change impact on maximum precipitation in Spain

Requena, Ana I. / Jiménez‐Álvarez, Antonio / García, Celia

Hydrological Processes. 2023 Jan., v. 37, no. 1 p.e14803-

2023

Abstract: The potential effect of climate change on maximum precipitation is studied by considering several temporal intervals for its incorporation into flood risk management in Spain. The methodology used allows for a complete assessment of the effect of climate ...

Abstract	The potential effect of climate change on maximum precipitation is studied by considering several temporal intervals for its incorporation into flood risk management in Spain. The methodology used allows for a complete assessment of the effect of climate change on maximum precipitation by accounting for uncertainty, and may be applied to other case studies. Behaviour regarding observations, trends and changes in climate model maximum precipitation series are evaluated. In turn, multi‐model mean (and percentile) relative changes accounting for statistical significance, torrential rate changes, and relative changes in daily annual maximum precipitation accumulated along river network are estimated. Results show a large variability in climate model outcomes. In general, a suitable behaviour is found for the climate model ensemble regarding observations: it properly represents seasonality of daily annual maximum precipitation for all regions, and observation‐based statistics are found to be within range of simulation‐based statistics for most regions. As an exception, daily annual maximum precipitation is underestimated in Mediterranean regions, which may be attributed to known limitations of current climate models in adequately reproducing convective precipitation typical of those areas. Results also show an intensifying increase in trends and changes as precipitation duration decreases, a torrentiality rise, and relative changes related to accumulated maximum precipitation of up to 35%. These findings support the notion that the effect of climate change may be stronger for extreme precipitation associated with short precipitation durations. This may be attributed to a stronger scaling between change in extreme precipitation and mean surface temperature increase for shorter durations. The findings also highlight the importance of analysing statistical significance of relative changes in quantile for allowing its attribution to climate change. Statistical model choice is found to be essential for identifying significant changes.
Keywords	climate ; climate change ; climate models ; hydrology ; risk management ; rivers ; statistical models ; surface temperature ; uncertainty ; Spain
Language	English
Dates of publication	2023-01
Publishing place	John Wiley & Sons, Inc.
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	1479953-4
ISSN	1099-1085 ; 0885-6087
ISSN (online)	1099-1085
ISSN	0885-6087
DOI	10.1002/hyp.14803
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: How to provide fertility treatment during COVID-19 pandemic.

Cruz, M / Requena, Antonio

Current opinion in obstetrics & gynecology

2021 Volume 33, Issue 3, Page(s) 159–163

Abstract: Purpose of review: The emergence of the novel coronavirus infection that arose in Wuhan, China in December 2019 has resulted in an epidemic that has quickly expanded to become one of the most significant public health threats in recent times. The ... ...

Abstract	Purpose of review: The emergence of the novel coronavirus infection that arose in Wuhan, China in December 2019 has resulted in an epidemic that has quickly expanded to become one of the most significant public health threats in recent times. The objective of this review is to summarize how this pandemic has affected the activity of a Reproductive Medicine Center, which established a series of measures in parallel with governments decisions and scientific societies. Recent findings: The control measures adopted for restarting the healthcare activity should be equitable and inclusive. Moreover, this pandemic has implied changes in treatments and strategies to be alert regarding the daily changing information. Finally, for ensuring a safe practice both for patients and staff, it is important to detect asymptomatic patients, so Reproductive Medicine centers must take special care with screening and testing procedures. Summary: The pandemic has pushed up toward a new reality in terms of Assisted Reproductive treatments, where social distance and responsibility are protagonists. We face a new challenge of balancing between responding to the committed efforts of infertile couples to achieve pregnancy and safeguarding the health of the future parents and their children during this time of pandemic.
MeSH term(s)	COVID-19/epidemiology ; Disease Outbreaks ; Female ; Fertility ; Humans ; Infertility/therapy ; Pandemics ; Pregnancy ; Reproductive Medicine/methods ; Reproductive Medicine/trends ; Reproductive Techniques, Assisted ; Risk Assessment ; Spain/epidemiology
Language	English
Publishing date	2021-03-17
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1049382-7
ISSN	1473-656X ; 1040-872X
ISSN (online)	1473-656X
ISSN	1040-872X
DOI	10.1097/GCO.0000000000000705
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Zs.A 3048: Show issues

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Article: Application of Machine Learning to Characterize the Permeate Quality in Pilot-Scale Vacuum-Assisted Air Gap Membrane Distillation Operation.

Requena, Isabel / Andrés-Mañas, Juan Antonio / Gil, Juan Diego / Zaragoza, Guillermo

Membranes

2023 Volume 13, Issue 11

Abstract: Membrane distillation (MD) is a thermal desalination technique proposed for the valorization of residual brines that other operations such as reverse osmosis cannot treat. Previous studies have shown that vacuum-assisted air gap (V-AGMD) operation in ... ...

Abstract	Membrane distillation (MD) is a thermal desalination technique proposed for the valorization of residual brines that other operations such as reverse osmosis cannot treat. Previous studies have shown that vacuum-assisted air gap (V-AGMD) operation in commercial multi-envelope modules improves the performance of MD noticeably. However, the permeate quality at pilot scale has not been thoroughly characterized so far. The aim of this study is, therefore, to assess and model the effect of the main operating conditions (feed flow rate, inlet temperatures, and feed salinity) on the permeate quality. Results from different steady-state experiments allowed to estimate descriptive metrics such as the salt rejection factor (SRF) and the membrane leak ratio (MLR). Given their non-linear behavior, these metrics were subsequently modeled using artificial neural networks (ANN) to estimate the permeate quality in the whole scope of operating conditions. Acceptable SRF results with MLR values lower than 0.2% confirmed the validity of MD as an operation for the treatment of concentrated brines, although the salinity of the resulting permeate does not comply in all cases with that permitted for human consumption.
Language	English
Publishing date	2023-10-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2614641-1
ISSN	2077-0375
ISSN	2077-0375
DOI	10.3390/membranes13110857
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Article ; Online: Impact of parental chromosomal polymorphisms on the incidence of congenital anomalies and perinatal complications in a cohort of newborns conceived after ICSI + PGT-A.

Rodriguez, Freddy / Cruz, Maria / Requena, Antonio

Reproductive biology and endocrinology : RB&E

2022 Volume 20, Issue 1, Page(s) 145

Abstract: Background: To assess the association between chromosomal polymorphisms (CPM) with congenital anomalies and perinatal complications in a cohort of newborns from couples undergoing intracytoplasmic sperm injection (ICSI), trophectoderm biopsy, and ... ...

Abstract	Background: To assess the association between chromosomal polymorphisms (CPM) with congenital anomalies and perinatal complications in a cohort of newborns from couples undergoing intracytoplasmic sperm injection (ICSI), trophectoderm biopsy, and preimplantation genetic testing for aneuploidy (PGT-A). Methods: A retrospective cohort of singletons conceived after ICSI, trophectoderm biopsy, and PGT-A cycles performed at IVIRMA clinics in Spain over 4 years was involved in the study. Newborns were classified according to the parental karyotype analysis: Group I: non-carriers, Group II: CPM carriers. Couples with chromosomal anomalies and instances when both partners were CPM carriers were excluded from the study. The groups were compared for several perinatal complications. Results: There was a significant decrease in the number of NB with complications in the carrier group compared to the non-carriers (19.7% vs 31.9%, p = 0.0406). There were no statistical differences among the two groups regarding congenital anomalies, preterm birth, alterations in birth length and weight, cranial perimeter, Apgar test score, or sex ratio (p > 0.05). Conclusions: Chromosomal polymorphisms appear to have no adverse effects on congenital anomalies or perinatal complications on newborns from ICSI + PGT-A cycles.
MeSH term(s)	Aneuploidy ; Female ; Fertilization in Vitro/adverse effects ; Genetic Testing ; Humans ; Incidence ; Infant, Newborn ; Male ; Parents ; Pregnancy ; Premature Birth/etiology ; Retrospective Studies ; Semen ; Sperm Injections, Intracytoplasmic/adverse effects
Language	English
Publishing date	2022-09-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2119215-7
ISSN	1477-7827 ; 1477-7827
ISSN (online)	1477-7827
ISSN	1477-7827
DOI	10.1186/s12958-022-01012-2
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Article ; Online: Adenomyosis decreases the live birth rate but may not affect perinatal outcomes in assisted reproductive cycles.

Trinchant, Rafael / Cruz, María / Requena, Antonio

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

2022 Volume 159, Issue 3, Page(s) 918–922

Abstract: Objective: To determine if uterine adenomyosis is associated with worse perinatal outcomes in ovum donation assisted reproductive treatment cycles.: Materials and methods: A multicenter and retrospective cohort study in which a total of 3307 patients ...

Abstract	Objective: To determine if uterine adenomyosis is associated with worse perinatal outcomes in ovum donation assisted reproductive treatment cycles. Materials and methods: A multicenter and retrospective cohort study in which a total of 3307 patients undergoing an ovum donation cycle in 2018-2019 were included and divided into two groups: adenomyosis (n = 179) and controls (n = 3128). Clinical, obstetrical, and perinatal outcomes were analyzed. Results: A lower live birth rate per embryo transfer was observed in women diagnosed with adenomyosis versus control women: 67/179 (37%) versus 1560/3128 (49.9%), respectively (odds ratio 0.6, 95% confidence interval 0.43-0.83, P = 0.002). There was no statistically significant difference in childbirth delivery method (vaginal versus cesarean section) between the adenomyosis and control groups. Mean gestational age at the time of delivery, newborn length and weight, and incidences of low birth weight, preterm birth, and admission to the neonatal intensive care unit did not differ between the two groups. In addition, in vitro fertilization and perinatal outcomes were similar in patients with diffuse compared with focal adenomyosis. Conclusions: Adenomyosis affects clinical but may not affect perinatal outcomes in ovum donation cycles.
MeSH term(s)	Infant, Newborn ; Humans ; Pregnancy ; Female ; Birth Rate ; Adenomyosis/epidemiology ; Adenomyosis/complications ; Cesarean Section ; Retrospective Studies ; Premature Birth/epidemiology ; Premature Birth/etiology ; Fertilization in Vitro/methods ; Live Birth/epidemiology
Language	English
Publishing date	2022-05-23
Publishing country	United States
Document type	Multicenter Study ; Journal Article
ZDB-ID	80149-5
ISSN	1879-3479 ; 0020-7292
ISSN (online)	1879-3479
ISSN	0020-7292
DOI	10.1002/ijgo.14256
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Zs.A 355: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Editorial

Juan Antonio González de Requena Farré

Revista Stultifera, Vol 5, Iss 1, Pp 7-

La mitificación de la política y los adalides del Orden

2022 Volume 18

Keywords	Social sciences (General) ; H1-99 ; Literature (General) ; PN1-6790
Language	Spanish
Publishing date	2022-01-01T00:00:00Z
Publisher	Universidad Austral de Chile
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Enhanced oxidative stress resistance in Ustilago maydis and its implications on the virulence.

Cuamatzi-Flores, Jorge / Colón-González, Maritrini / Requena-Romo, Fernanda / Quiñones-Galeana, Samuel / Cervantes-Chávez, José Antonio / Morales, Lucia

International microbiology : the official journal of the Spanish Society for Microbiology

2024

Abstract: The phytopathogenic fungus Ustilago maydis causes corn smut by suppressing host plant defenses, including the oxidative burst response. While many studies have investigated how U. maydis responds to oxidative stress during infection, the consequences of ... ...

Abstract	The phytopathogenic fungus Ustilago maydis causes corn smut by suppressing host plant defenses, including the oxidative burst response. While many studies have investigated how U. maydis responds to oxidative stress during infection, the consequences of heightened resistance to oxidative stress on virulence remain understudied. This study aimed to identify the effects on virulence in U. maydis strains exhibiting enhanced resistance to hydrogen peroxide (H
Language	English
Publishing date	2024-02-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1454951-7
ISSN	1618-1905 ; 1139-6709
ISSN (online)	1618-1905
ISSN	1139-6709
DOI	10.1007/s10123-024-00489-8
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