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  1. Article ; Online: Approaches for Optimal Use of Different COVID-19 Vaccines: Issues of Viral Variants and Vaccine Efficacy.

    Moore, John P

    JAMA

    2021  Volume 325, Issue 13, Page(s) 1251–1252

    MeSH term(s) COVID-19/immunology ; COVID-19 Vaccines/administration & dosage ; COVID-19 Vaccines/immunology ; Humans ; Mass Vaccination/organization & administration ; SARS-CoV-2
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2021-03-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2021.3465
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Strigolactones GR-24 and Nijmegen Applications Result in Reduced Susceptibility of Tobacco and Grapevine Plantlets to

    Vogel, Dominic / Hills, Paul / Moore, John P

    Plants (Basel, Switzerland)

    2023  Volume 12, Issue 18

    Abstract: Priming agents are plant defence-inducing compounds which can prompt a state of protection but may also aid in plant growth and interactions with beneficial microbes. The synthetic strigolactones (±)-GR24 and Nijmegen-1 were evaluated as potential ... ...

    Abstract Priming agents are plant defence-inducing compounds which can prompt a state of protection but may also aid in plant growth and interactions with beneficial microbes. The synthetic strigolactones (±)-GR24 and Nijmegen-1 were evaluated as potential priming agents for induced resistance against
    Language English
    Publishing date 2023-09-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants12183202
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Reappraising the Value of HIV-1 Vaccine Correlates of Protection Analyses.

    Klasse, P J / Moore, John P

    Journal of virology

    2022  Volume 96, Issue 8, Page(s) e0003422

    Abstract: With the much-debated exception of the modestly reduced acquisition reported for the RV144 efficacy trial, HIV-1 vaccines have not protected humans against infection, and a vaccine of similar design to that tested in RV144 was not protective in a later ... ...

    Abstract With the much-debated exception of the modestly reduced acquisition reported for the RV144 efficacy trial, HIV-1 vaccines have not protected humans against infection, and a vaccine of similar design to that tested in RV144 was not protective in a later trial, HVTN 702. Similar vaccine regimens have also not consistently protected nonhuman primates (NHPs) against viral acquisition. Conversely, experimental vaccines of different designs have protected macaques from viral challenges but then failed to protect humans, while many other HIV-1 vaccine candidates have not protected NHPs. While efficacy varies more in NHPs than humans, vaccines have failed to protect in the most stringent NHP model. Intense investigations have aimed to identify correlates of protection (CoPs), even in the absence of net protection. Unvaccinated animals and humans vary vastly in their susceptibility to infection and in their innate and adaptive responses to the vaccines; hence, merely statistical associations with factors that do not protect are easily found. Systems biological analyses, including artificial intelligence, have identified numerous candidate CoPs but with no clear consistency within or between species. Proposed CoPs sometimes have only tenuous mechanistic connections to immune protection. In contrast, neutralizing antibodies (NAbs) are a central mechanistic CoP for vaccines that succeed against other viruses, including SARS-CoV-2. No HIV-1 vaccine candidate has yet elicited potent and broadly active NAbs in NHPs or humans, but narrow-specificity NAbs against the HIV-1 isolate corresponding to the immunogen do protect against infection by the autologous virus. Here, we analyze why so many HIV-1 vaccines have failed, summarize the outcomes of vaccination in NHPs and humans, and discuss the value and pitfalls of hunting for CoPs other than NAbs. We contrast the failure to find a consistent CoP for HIV-1 vaccines with the identification of NAbs as the principal CoP for SARS-CoV-2.
    MeSH term(s) AIDS Vaccines/standards ; Animals ; Antibodies, Neutralizing ; Artificial Intelligence ; COVID-19 Vaccines/standards ; Data Interpretation, Statistical ; HIV Infections/prevention & control ; HIV-1 ; Humans ; SARS-CoV-2
    Chemical Substances AIDS Vaccines ; Antibodies, Neutralizing ; COVID-19 Vaccines
    Language English
    Publishing date 2022-04-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 80174-4
    ISSN 1098-5514 ; 0022-538X
    ISSN (online) 1098-5514
    ISSN 0022-538X
    DOI 10.1128/jvi.00034-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 609: Show issues Location:
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  4. Article ; Online: Beta testing the monkey model.

    Moore, John P / Gounder, Celine R

    Nature immunology

    2021  Volume 22, Issue 10, Page(s) 1201–1203

    Language English
    Publishing date 2021-09-16
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/s41590-021-01033-w
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  5. Article ; Online: SARS-CoV-2 Vaccines and the Growing Threat of Viral Variants.

    Moore, John P / Offit, Paul A

    JAMA

    2021  Volume 325, Issue 9, Page(s) 821–822

    MeSH term(s) Antibodies, Monoclonal/therapeutic use ; COVID-19/prevention & control ; COVID-19/transmission ; COVID-19/virology ; COVID-19 Vaccines ; Humans ; Mutation ; RNA, Messenger ; SARS-CoV-2/genetics ; Virus Shedding
    Chemical Substances Antibodies, Monoclonal ; COVID-19 Vaccines ; RNA, Messenger
    Language English
    Publishing date 2021-01-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2021.1114
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Publishing: Journals, do your own formatting.

    Moore, John P

    Nature

    2017  Volume 542, Issue 7639, Page(s) 31

    MeSH term(s) Editorial Policies ; Periodicals as Topic/economics ; Research Personnel ; Time Factors
    Language English
    Publishing date 2017--01
    Publishing country England
    Document type Letter
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/542031e
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  7. Article ; Online: Virus vaccines: proteins prefer prolines.

    Sanders, Rogier W / Moore, John P

    Cell host & microbe

    2021  Volume 29, Issue 3, Page(s) 327–333

    Abstract: Most viral vaccines are based on inducing neutralizing antibodies (NAbs) against the virus envelope or spike glycoproteins. Many viral surface proteins exist as trimers that transition from a pre-fusion state when key NAb epitopes are exposed to a post- ... ...

    Abstract Most viral vaccines are based on inducing neutralizing antibodies (NAbs) against the virus envelope or spike glycoproteins. Many viral surface proteins exist as trimers that transition from a pre-fusion state when key NAb epitopes are exposed to a post-fusion form in which the potential for virus-cell fusion no longer exists. For optimal vaccine performance, these viral proteins are often engineered to enhance stability and presentation of these NAb epitopes. The method involves the structure-guided introduction of proline residues at key positions that maintain the trimer in the pre-fusion configuration. We review how this technique emerged during HIV-1 Env vaccine development and its subsequent wider application to other viral vaccines including SARS-CoV-2.
    MeSH term(s) Antibodies, Neutralizing/immunology ; COVID-19 Vaccines/chemistry ; COVID-19 Vaccines/genetics ; COVID-19 Vaccines/immunology ; Humans ; Models, Molecular ; Proline/chemistry ; Proline/genetics ; Proline/immunology ; Protein Engineering ; Viral Vaccines/chemistry ; Viral Vaccines/genetics ; Viral Vaccines/immunology
    Chemical Substances Antibodies, Neutralizing ; COVID-19 Vaccines ; Viral Vaccines ; Proline (9DLQ4CIU6V)
    Language English
    Publishing date 2021-03-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2278004-X
    ISSN 1934-6069 ; 1931-3128
    ISSN (online) 1934-6069
    ISSN 1931-3128
    DOI 10.1016/j.chom.2021.02.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6578: Show issues Location:
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  8. Article ; Online: Antibodies to SARS-CoV-2 and their potential for therapeutic passive immunization.

    Klasse, P J / Moore, John P

    eLife

    2020  Volume 9

    Abstract: We review aspects of the antibody response to SARS-CoV-2, the causative agent of the COVID-19 pandemic. The topics we cover are relevant to immunotherapy with plasma from recovered patients, monoclonal antibodies against the viral S-protein, and soluble ... ...

    Abstract We review aspects of the antibody response to SARS-CoV-2, the causative agent of the COVID-19 pandemic. The topics we cover are relevant to immunotherapy with plasma from recovered patients, monoclonal antibodies against the viral S-protein, and soluble forms of the receptor for the virus, angiotensin converting enzyme 2. The development of vaccines against SARS-CoV-2, an essential public health tool, will also be informed by an understanding of the antibody response in infected patients. Although virus-neutralizing antibodies are likely to protect, antibodies could potentially trigger immunopathogenic events in SARS-CoV-2-infected patients or enhance infection. An awareness of these possibilities may benefit clinicians and the developers of antibody-based therapies and vaccines.
    MeSH term(s) Antibodies, Monoclonal ; Antibodies, Viral ; Betacoronavirus/immunology ; Broadly Neutralizing Antibodies/immunology ; COVID-19 ; Coronavirus Infections/immunology ; Coronavirus Infections/therapy ; Humans ; Immunization, Passive ; Pandemics ; Pneumonia, Viral/immunology ; Pneumonia, Viral/therapy ; Severe acute respiratory syndrome-related coronavirus/immunology ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus/chemistry ; COVID-19 Serotherapy
    Chemical Substances Antibodies, Monoclonal ; Antibodies, Viral ; Broadly Neutralizing Antibodies ; Spike Glycoprotein, Coronavirus
    Keywords covid19
    Language English
    Publishing date 2020-06-23
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.57877
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  9. Article ; Online: Coronavirus Disease (COVID-19) Detected at the Lung Apices During CT Angiography in Acute Stroke Assessment.

    Hynes, John P / Moore, Paul / Murray, John G

    AJR. American journal of roentgenology

    2020  Volume 215, Issue 3, Page(s) W40

    MeSH term(s) Betacoronavirus ; COVID-19 ; Computed Tomography Angiography ; Coronavirus ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Stroke
    Keywords covid19
    Language English
    Publishing date 2020-06-15
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 82076-3
    ISSN 1546-3141 ; 0361-803X ; 0092-5381
    ISSN (online) 1546-3141
    ISSN 0361-803X ; 0092-5381
    DOI 10.2214/AJR.20.23484
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  10. Article: The Novel Use of Bipolar Radiofrequency Microneedling in the Treatment of Lichen Sclerosus.

    Blusewicz, Tracy A / Coley, Katherine P / Moore, Robert D / Miklos, John R

    Surgical technology international

    2023  Volume 43

    Abstract: Introduction: Lichen sclerosus (LS) is a chronic, distressing, inflammatory process that has a huge impact on quality of life in women. Uncontrolled vulvar LS can lead to chronic symptoms of itching and pain and can lead to anatomic changes, scarring, ... ...

    Abstract Introduction: Lichen sclerosus (LS) is a chronic, distressing, inflammatory process that has a huge impact on quality of life in women. Uncontrolled vulvar LS can lead to chronic symptoms of itching and pain and can lead to anatomic changes, scarring, and elevated risk of cancer. First-line therapy with corticosteroids is often not successful in controlling symptoms, especially over the long term. This is the first study to review the effects of bipolar radiofrequency (RF) with microneedling to treat the vaginal and vulvar symptoms of LS.
    Materials and methods: This retrospective study was initiated due to the recognition of improvement in vulvar skin condition and resolution of lichen sclerosus symptoms in patients who had already failed traditional treatment and underwent radio frequency with microneedling procedures of the vulva, perineum, and perianal regions. Patients were treated with three treatments of bipolar RF and bipolar RF with microneedling four to eight weeks apart. Patient questionnaires were used to assess improvement in the symptoms of LS including itching, tearing of tissue, changes in the appearance and color of tissue, and dryness of skin and mucosa.
    Results: The data from the questionnaires showed a significant reduction or complete resolution in these symptoms, with 86% of the patients reporting either significant or complete resolution. In the case of itching, which is typically one of the most severe symptoms of LS, 91% of patients reported significant or complete resolution. 87% of patients reported symptom resolution lasting at least six months, with 39% of the patients having results lasting 12 months or more before recurrence. Recurrences can be retreated on an as-needed basis or with annual maintenance therapy consisting typically of just one treatment.
    Conclusion: Radiofrequency with microneedling treatments for persistent LS showed significant improvement in LS symptoms. As LS is a chronic recurring condition, the treatment protocol resulted in high patient satisfaction for these women who had not experienced these results in terms of amount of symptom resolution or duration of symptom resolution with prior treatments using topical steroid cream or other modalities.
    Language English
    Publishing date 2023-12-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1225512-9
    ISSN 1090-3941
    ISSN 1090-3941
    DOI 10.52198/23.STI.43.GY1743
    Database MEDical Literature Analysis and Retrieval System OnLINE

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