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  1. Article ; Online: A population mental health perspective on the impact of COVID-19.

    Koushik, Nikhil S

    Psychological trauma : theory, research, practice and policy

    2020  Volume 12, Issue 5, Page(s) 529–530

    Abstract: The global pandemic of coronavirus disease 2019 (COVID-19) has resulted in massive societal, economic, and environmental impacts that have both short- and long-term mental health influences. This commentary serves to tie existing literature on mental ... ...

    Abstract The global pandemic of coronavirus disease 2019 (COVID-19) has resulted in massive societal, economic, and environmental impacts that have both short- and long-term mental health influences. This commentary serves to tie existing literature on mental health and COVID-19 to the clinical experiences of a psychologist working in the Canadian hospital sector. (PsycInfo Database Record (c) 2020 APA, all rights reserved).
    MeSH term(s) Adolescent ; Adult ; Anxiety Disorders/psychology ; COVID-19 ; Child ; Coronavirus Infections ; Depressive Disorder/psychology ; Hospital Departments ; Humans ; Mental Health Services ; Ontario ; Pandemics ; Personnel, Hospital ; Pneumonia, Viral ; Psychological Trauma/psychology ; Psychology, Clinical ; Symptom Flare Up
    Keywords covid19
    Language English
    Publishing date 2020-06-18
    Publishing country United States
    Document type Journal Article ; Personal Narrative
    ZDB-ID 2497028-1
    ISSN 1942-969X ; 1942-9681
    ISSN (online) 1942-969X
    ISSN 1942-9681
    DOI 10.1037/tra0000737
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  2. Article ; Online: A population mental health perspective on the impact of COVID-19.

    Koushik, Nikhil S.

    Psychological Trauma: Theory, Research, Practice, and Policy

    2020  Volume 12, Issue 5, Page(s) 529–530

    Keywords Clinical Psychology ; Social Psychology ; covid19
    Language English
    Publisher American Psychological Association (APA)
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2497028-1
    ISSN 1942-969X ; 1942-9681
    ISSN (online) 1942-969X
    ISSN 1942-9681
    DOI 10.1037/tra0000737
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: A population mental health perspective on the impact of COVID-19

    Koushik, Nikhil S

    Psychol Trauma

    Abstract: The global pandemic of coronavirus disease 2019 (COVID-19) has resulted in massive societal, economic, and environmental impacts that have both short- and long-term mental health influences. This commentary serves to tie existing literature on mental ... ...

    Abstract The global pandemic of coronavirus disease 2019 (COVID-19) has resulted in massive societal, economic, and environmental impacts that have both short- and long-term mental health influences. This commentary serves to tie existing literature on mental health and COVID-19 to the clinical experiences of a psychologist working in the Canadian hospital sector. (PsycInfo Database Record (c) 2020 APA, all rights reserved).
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #607246
    Database COVID19

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  4. Article ; Online: Designing a New Class of Mechanophoric Polymer Based on Epoxy-Functionalized Rhodamine Derivative.

    Chakraborty, Swadhin / Bhattacharya, Koushik / Choudhury, Soumyadip / Singha, Nikhil K

    Macromolecular rapid communications

    2024  , Page(s) e2400065

    Abstract: Mechanophoric polymers are an interesting class of smart polymers which contains a special force-sensitive molecular motif that can lead to a chemical change within the polymer network in response to mechanical force. This investigation reports the ... ...

    Abstract Mechanophoric polymers are an interesting class of smart polymers which contains a special force-sensitive molecular motif that can lead to a chemical change within the polymer network in response to mechanical force. This investigation reports the design of a mechanophoric polymer based on epoxy-functionalized rhodamine via a monomeric approach. In this case, rhodamine (Rh) is modified with glycidyl methacrylate (GMA) through an epoxy-amine reaction to design a vinyl-functionalized multi-armed macromonomer (Rh-GMA), which is reacted with butyl acrylate (BA) to prepare the crosslinked polymeric film. The crosslinked polymeric film demonstrates mechanophoric properties under UV and stretching conditions.
    Language English
    Publishing date 2024-03-07
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1475027-2
    ISSN 1521-3927 ; 1022-1336
    ISSN (online) 1521-3927
    ISSN 1022-1336
    DOI 10.1002/marc.202400065
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  5. Article ; Online: Chemically Designed Nanoscale Materials for Controlling Cellular Processes.

    Debnath, Koushik / Pal, Suman / Jana, Nikhil R

    Accounts of chemical research

    2021  Volume 54, Issue 14, Page(s) 2916–2927

    Abstract: Nanoparticles are widely used in various biomedical applications as drug delivery carriers, imaging probes, single-molecule tracking/detection probes, artificial chaperones for inhibiting protein aggregation, and photodynamic therapy materials. One key ... ...

    Abstract Nanoparticles are widely used in various biomedical applications as drug delivery carriers, imaging probes, single-molecule tracking/detection probes, artificial chaperones for inhibiting protein aggregation, and photodynamic therapy materials. One key parameter of these applications is the ability of the nanoparticles to enter into the cell cytoplasm, target different subcellular compartments, and control intracellular processes. This is particularly the case because nanoparticles are designed to interact with subcellular components for the required biomedical performance. However, cells are protected from their surroundings by the cell membrane, which exerts strict control over entry of foreign materials. Thus, nanoparticles need to be designed appropriately so that they can readily cross the cell membrane, target subcellular compartments, and control intracellular processes.In the past few decades there have been great advancements in understanding the principles of cellular uptake of foreign materials. In particular, it has been shown that internalization of foreign materials (small molecules, macromolecules, nanoparticles) is size-dependent: endocytotic uptake of materials requires sizes greater than 10 nm, and materials with sizes of 10-100 nm usually enter into cells by energy-dependent endocytosis via biomembrane-coated vesicles. Direct access to the cytosol is limited to very specific conditions, and endosomal escape of material appears to be the most practical approach for intracellular processing.In this Account, we describe how cellular uptake and intracellular processing of nanoscale materials can be controlled by appropriate design of size and surface chemistry. We first describe the cell membrane structure and principles of cellular uptake of foreign materials followed by their subcellular trafficking. Next, we discuss the designed surface chemistry of a 5-50 nm particle that offers preferential lipid-raft/caveolae-mediated endocytosis over clathrin-mediated endocytosis with minimum endosomal/lysosomal trafficking or energy-independent direct cell membrane translocation (without endocytosis) followed by cytosolic delivery without endosomal/lysosomal trafficking. In particular, we emphasize that the zwitterionic-lipophilic surface property of a nanoparticle offers preferential interaction with the lipid raft region of the cell membrane followed by lipid raft uptake, whereas a lower number of affinity biomolecules (<25) on the nanoparticle surface offers caveolae/lipid-raft uptake, while an arginine/guanidinium-terminated surface along with a size of <10 nm offers direct cell membrane translocation. Finally, we discuss how nanoprobes can be designed by adapting these surface chemistry and size preference principles so that they can readily enter into the cell, label different subcellular compartments, and control intracellular processes such as trafficking kinetics, exocytosis, autophagy, amyloid aggregation, and clearance of toxic amyloid aggregates. The Account ends with a Conclusions and Outlook where we discuss a vision for the development of subcellular targeting nanodrugs and imaging nanoprobes by adapting to these surface chemistry principles.
    MeSH term(s) Biological Transport/physiology ; Caveolae/metabolism ; Cell Membrane/metabolism ; Hydrophobic and Hydrophilic Interactions ; Membrane Microdomains/metabolism ; Nanoparticles/chemistry ; Nanoparticles/metabolism ; Particle Size ; Pinocytosis/physiology ; Surface Properties
    Language English
    Publishing date 2021-07-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1483291-4
    ISSN 1520-4898 ; 0001-4842
    ISSN (online) 1520-4898
    ISSN 0001-4842
    DOI 10.1021/acs.accounts.1c00215
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Beyond traditional therapy: Mucoadhesive polymers as a new frontier in oral cancer management.

    Das, Subhayan / Bhattacharya, Koushik / Blaker, Jonny J / Singha, Nikhil K / Mandal, Mahitosh

    Biopolymers

    2023  Volume 114, Issue 9, Page(s) e23556

    Abstract: In recent times mucoadhesive drug delivery systems are gaining popularity in oral cancer. It is a malignancy with high global prevalence. Despite significant advances in cancer therapeutics, improving the prognosis of late-stage oral cancer remains ... ...

    Abstract In recent times mucoadhesive drug delivery systems are gaining popularity in oral cancer. It is a malignancy with high global prevalence. Despite significant advances in cancer therapeutics, improving the prognosis of late-stage oral cancer remains challenging. Targeted therapy using mucoadhesive polymers can improve oral cancer patients' overall outcome by offering enhanced oral mucosa bioavailability, better drug distribution and tissue targeting, and minimizing systemic side effects. Mucoadhesive polymers can also be delivered via different formulations such as tablets, films, patches, gels, and nanoparticles. These polymers can deliver an array of medicines, making them an adaptable drug delivery approach. Drug delivery techniques based on these mucoadhesive polymers are gaining traction and have immense potential as a prospective treatment for late-stage oral cancer. This review examines leading research in mucoadhesive polymers and discusses their potential applications in treating oral cancer.
    MeSH term(s) Humans ; Polymers ; Drug Delivery Systems/methods ; Pharmaceutical Preparations ; Mouth Mucosa ; Mouth Neoplasms/drug therapy
    Chemical Substances Polymers ; Pharmaceutical Preparations
    Language English
    Publishing date 2023-06-21
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1123-x
    ISSN 1097-0282 ; 0006-3525
    ISSN (online) 1097-0282
    ISSN 0006-3525
    DOI 10.1002/bip.23556
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    In stock of ZB MED Cologne/Königswinter

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  7. Article ; Online: Graphene Quantum Dots-Ornamented Waterborne Epoxy-Based Fluorescent Adhesive via Reversible Addition-Fragmentation Chain Transfer-Mediated Miniemulsion Polymerization: A Potential Material for Art Conservation.

    Samanta, Sarthik / Banerjee, Sovan Lal / Bhattacharya, Koushik / Singha, Nikhil K

    ACS applied materials & interfaces

    2021  Volume 13, Issue 30, Page(s) 36307–36319

    Abstract: Epoxy-based adhesives have gotten significant attention in the conservation of antiquities and repair or reconstruction of artifacts due to their excellent adhesion strength. However, it has become hard to detect repaired work in artifacts due to the ... ...

    Abstract Epoxy-based adhesives have gotten significant attention in the conservation of antiquities and repair or reconstruction of artifacts due to their excellent adhesion strength. However, it has become hard to detect repaired work in artifacts due to the transparent nature of epoxy-based adhesives. Hence, the making of fluorescent adhesives has become an exciting topic for art conservators. Here, we have synthesized a new kind of waterborne epoxy-based fluorescent adhesive decorated with graphene quantum dots (GQDs) via reversible addition-fragmentation chain transfer (RAFT)-mediated surfactant-free miniemulsion polymerization. In this case, a new block copolymer (BCP), poly(1-vinyl-2-pyrrolidone)-
    Language English
    Publishing date 2021-07-23
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.1c08812
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  8. Article: Graphene Quantum Dots-Ornamented Waterborne Epoxy-Based Fluorescent Adhesive via Reversible Addition–Fragmentation Chain Transfer-Mediated Miniemulsion Polymerization: A Potential Material for Art Conservation

    Samanta, Sarthik / Banerjee, Sovan Lal / Bhattacharya, Koushik / Singha, Nikhil K

    ACS applied materials & interfaces. 2021 July 23, v. 13, no. 30

    2021  

    Abstract: Epoxy-based adhesives have gotten significant attention in the conservation of antiquities and repair or reconstruction of artifacts due to their excellent adhesion strength. However, it has become hard to detect repaired work in artifacts due to the ... ...

    Abstract Epoxy-based adhesives have gotten significant attention in the conservation of antiquities and repair or reconstruction of artifacts due to their excellent adhesion strength. However, it has become hard to detect repaired work in artifacts due to the transparent nature of epoxy-based adhesives. Hence, the making of fluorescent adhesives has become an exciting topic for art conservators. Here, we have synthesized a new kind of waterborne epoxy-based fluorescent adhesive decorated with graphene quantum dots (GQDs) via reversible addition–fragmentation chain transfer (RAFT)-mediated surfactant-free miniemulsion polymerization. In this case, a new block copolymer (BCP), poly(1-vinyl-2-pyrrolidone)-block-poly(glycidyl methacrylate), has been synthesized via surfactant-free RAFT-mediated miniemulsion polymerization using a polymerization-induced self-assembly technique. The GQDs were prepared from citric acid by a hydrothermal process, and this was used for making a fluorescence-active BCP/GQD nanocomposite emulsion. The obtained BCP/GQD nanocomposite adhesive was transparent and showed blue fluorescence under ultraviolet–visible light, indicating the easy detection of its mark on the artifacts. The BCP and BCP/GQD emulsions were applied to adhere ceramic and glass substrates, and their adhesion strength was evaluated by lap shear tests. The BCP/GQDs showed better adhesion strength than the BCP only, indicating better adhesive performance. Additionally, the synthesis process was carried out in aqueous media, indicating the sustainability and environment-friendliness of the process. We believe that this kind of new waterborne epoxy-based fluorescent adhesive will provide a new contrivance among art conservators to repair or reconstruct artifacts.
    Keywords adhesion ; ceramics ; citric acid ; composite polymers ; fluorescence ; glass ; graphene ; nanocomposites ; nanoemulsions ; polymerization
    Language English
    Dates of publication 2021-0723
    Size p. 36307-36319.
    Publishing place American Chemical Society
    Document type Article
    ISSN 1944-8252
    DOI 10.1021/acsami.1c08812
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: Trehalose-Conjugated, Catechin-Loaded Polylactide Nanoparticles for Improved Neuroprotection against Intracellular Polyglutamine Aggregates.

    Mandal, Suman / Debnath, Koushik / Jana, Nihar R / Jana, Nikhil R

    Biomacromolecules

    2020  Volume 21, Issue 4, Page(s) 1578–1586

    Abstract: Intracellular/extracellular protein aggregation is linked to a variety of neurodegenerative diseases. Current research focuses on identifying antiamyloidogenic small molecules to inhibit such protein aggregation and associated cytotoxicity. We have ... ...

    Abstract Intracellular/extracellular protein aggregation is linked to a variety of neurodegenerative diseases. Current research focuses on identifying antiamyloidogenic small molecules to inhibit such protein aggregation and associated cytotoxicity. We have recently demonstrated that transforming these antiamyloidogenic small molecules into nanoparticle forms can greatly improve their performance, and biocompatible/biodegradable formulation of such nanoparticles is critical for therapeutic applications. Here, we report polylactide (PL)-based biodegradable nanoparticles for improved neuroprotection against polyglutamine (polyQ) aggregation that is responsible for Huntington's disease. PL is terminated with an antiamyloidogenic trehalose molecule or the neurotransmitter dopamine, and the resultant nanoparticle is loaded with the antiamyloidogenic catechin molecule. The self-assembled nanoparticle is ∼200 nm in size and enters into the neuronal cell, inhibits polyQ aggregation, lowers oxidative stress, and enhances cell proliferation against polyQ aggregates. This biodegradable polymer can be used in nanoformulation of other reported antiamyloidogenic molecules for testing various animal models of neurodegenerative diseases.
    MeSH term(s) Animals ; Catechin/pharmacology ; Nanoparticles ; Neuroprotection ; Peptides ; Polyesters ; Trehalose/pharmacology
    Chemical Substances Peptides ; Polyesters ; polyglutamine (26700-71-0) ; poly(lactide) (459TN2L5F5) ; Catechin (8R1V1STN48) ; Trehalose (B8WCK70T7I)
    Language English
    Publishing date 2020-03-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1526-4602
    ISSN (online) 1526-4602
    DOI 10.1021/acs.biomac.0c00143
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  10. Article ; Online: Glycopolymer Decorated pH-Dependent Ratiometric Fluorescent Probe Based on Förster Resonance Energy Transfer for the Detection of Cancer Cells.

    Bhattacharya, Koushik / Kundu, Moumita / Das, Subhayan / Samanta, Sarthik / Roy, Sib Sankar / Mandal, Mahitosh / Singha, Nikhil K

    Macromolecular rapid communications

    2022  Volume 44, Issue 2, Page(s) e2200594

    Abstract: Development of fluorescent imaging probes is an important topic of research for the early diagnosis of cancer. Based on the difference between the cellular environment of tumor cells and normal cells, several "smart" fluorescent probes have been ... ...

    Abstract Development of fluorescent imaging probes is an important topic of research for the early diagnosis of cancer. Based on the difference between the cellular environment of tumor cells and normal cells, several "smart" fluorescent probes have been developed. In this work, a glycopolymer functionalized Förster resonance energy transfer (FRET) based fluorescent sensor is developed, which can monitor the pH change in cellular system. One-pot sequential reversible addition-fragmentation chain transfer (RAFT)polymerization technique is employed to synthesize fluorescent active triblock glycopolymer that can undergo FRET change on the variation of pH. A FRET pair, fluorescein o-acrylate (FA) and 7-amino-4-methylcoumarin (AMC) is linked via a pH-responsive polymer poly [2-(diisopropylamino)ethyl methacrylate] (PDPAEMA), which can undergo reversible swelling/deswelling under acidic/neutral condition. The presence of glycopolymer segment provides stability, water solubility, and specificity toward cancer cells. The cellular FRET experiments on cancer cells (MDA MB 231) and normal cells (3T3 fibroblast cells) demonstrate that the material is capable of distinguishing cells as a function of pH change.
    MeSH term(s) Fluorescence Resonance Energy Transfer/methods ; Fluorescent Dyes ; Quantum Dots ; Polymerization ; Hydrogen-Ion Concentration ; Neoplasms
    Chemical Substances Fluorescent Dyes
    Language English
    Publishing date 2022-11-10
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1475027-2
    ISSN 1521-3927 ; 1022-1336
    ISSN (online) 1521-3927
    ISSN 1022-1336
    DOI 10.1002/marc.202200594
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