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Book ; Online ; E-Book: Behavioral neuroscience of motivation

Simpson, Eleanor H. / Balsam, Peter D.

(Current topics in behavioral neurosciences ; 27)

2016

Author's details	Eleanor H. Simpson, Peter D. Balsam editors
Series title	Current topics in behavioral neurosciences ; 27
Collection
Keywords	apathy ; depression ; schizophrenia ; incentive motivation ; addiction
Language	English
Size	1 Online-Ressource (xiv, 587 Seiten), Illustrationen
Publisher	Springer
Publishing place	Cham
Publishing country	Switzerland
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
HBZ-ID	HT019039651
ISBN	978-3-319-26935-1 ; 9783319269337 ; 3-319-26935-6 ; 331926933X
DOI	10.1007/978-3-319-26935-1
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Lights, fiber, action! A primer on in vivo fiber photometry.

Simpson, Eleanor H / Akam, Thomas / Patriarchi, Tommaso / Blanco-Pozo, Marta / Burgeno, Lauren M / Mohebi, Ali / Cragg, Stephanie J / Walton, Mark E

Neuron

2023 Volume 112, Issue 5, Page(s) 718–739

Abstract: Fiber photometry is a key technique for characterizing brain-behavior relationships in vivo. Initially, it was primarily used to report calcium dynamics as a proxy for neural activity via genetically encoded indicators. This generated new insights into ... ...

Abstract	Fiber photometry is a key technique for characterizing brain-behavior relationships in vivo. Initially, it was primarily used to report calcium dynamics as a proxy for neural activity via genetically encoded indicators. This generated new insights into brain functions including movement, memory, and motivation at the level of defined circuits and cell types. Recently, the opportunity for discovery with fiber photometry has exploded with the development of an extensive range of fluorescent sensors for biomolecules including neuromodulators and peptides that were previously inaccessible in vivo. This critical advance, combined with the new availability of affordable "plug-and-play" recording systems, has made monitoring molecules with high spatiotemporal precision during behavior highly accessible. However, while opening exciting new avenues for research, the rapid expansion in fiber photometry applications has occurred without coordination or consensus on best practices. Here, we provide a comprehensive guide to help end-users execute, analyze, and suitably interpret fiber photometry studies.
MeSH term(s)	Neurons/metabolism ; Brain/metabolism ; Photometry/methods ; Calcium/metabolism
Chemical Substances	Calcium (SY7Q814VUP)
Language	English
Publishing date	2023-12-15
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	808167-0
ISSN	1097-4199 ; 0896-6273
ISSN (online)	1097-4199
ISSN	0896-6273
DOI	10.1016/j.neuron.2023.11.016
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Article ; Online: Gender Representation Among Presenters in Ophthalmology Subspecialties in 2019: A Retrospective Review.

Burton, Eleanor / Jebaraj, Abigail / Eddington, Devin / Brintz, Ben J / Simpson, Rachel G / Pettey, Jeff H

American journal of ophthalmology

2022 Volume 242, Page(s) 18–25

Abstract: Purpose: To describe gender representation at 8 national ophthalmology conferences, stratified by role, session category, and subspecialty.: Design: Retrospective cross-sectional study.: Methods: Data were examined on 3817 presenters at the 2019 ... ...

Abstract	Purpose: To describe gender representation at 8 national ophthalmology conferences, stratified by role, session category, and subspecialty. Design: Retrospective cross-sectional study. Methods: Data were examined on 3817 presenters at the 2019 American Academy of Ophthalmology subspecialty days, American Society of Cataract and Refractive Surgery, American Glaucoma Society, American Society of Retina Specialists, American Society of Ophthalmic Plastic and Reconstructive Surgery, American Association for Pediatric Ophthalmology and Strabismus, North American Neuro-Ophthalmology Society, and American Uveitis Society meetings. The main outcome measure was the gender of presenters in 7 subspecialties, stratified by category and role. Results: The proportion of female presenters was less than the American Board of Ophthalmology (ABO)-estimated proportion of women in their respective fields in glaucoma (28.0% vs 39.8%), neuro-ophthalmology (35.3% vs 45.3%), and pediatrics (42.1% vs 53.3%) and greater than expected in retina (24.6% vs 19.8%). Overall, the proportion of female presenters exceeded the ABO-estimated proportion of women in ophthalmology (24.5%) for clinical (mean = 38.5%, 95% CI [35.8%, 41.4%]) and scientific (39.4% [30.3%, 49.2%]) sessions. For clinical subspecialty sessions, the proportion of female leaders exceeded the overall proportion of female leaders in the respective subspecialty in cornea (35.1% [30.4%, 40.1%] vs 24.6% all sessions). Females represented fewer than the expected number of surgical session leaders in cornea (22.0% [19.9%, 24.3%]), glaucoma (18.0% [13.2%, 24.1%]), pediatrics (22.0% [14.4%, 32.1%]), and retina (18.6% [14.2%, 24.1%]). Conclusions: Gender representation varied, with fewer than expected female presenters in glaucoma, neuro-ophthalmology, and pediatrics. Women led relatively more clinical sessions but were underrepresented in surgical sessions in most subspecialties.
MeSH term(s)	Child ; Cross-Sectional Studies ; Female ; Glaucoma/surgery ; Humans ; Ophthalmology ; Retrospective Studies ; Societies, Medical ; Strabismus ; United States
Language	English
Publishing date	2022-05-23
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	80030-2
ISSN	1879-1891 ; 0002-9394
ISSN (online)	1879-1891
ISSN	0002-9394
DOI	10.1016/j.ajo.2022.05.016
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Article ; Online: Insights About Striatal Circuit Function and Schizophrenia From a Mouse Model of Dopamine D

Simpson, Eleanor H / Kellendonk, Christoph

Biological psychiatry

2017 Volume 81, Issue 1, Page(s) 21–30

Abstract: The dopamine hypothesis of schizophrenia is supported by a large number of imaging studies that have identified an increase in dopamine binding at the ... ...

Abstract	The dopamine hypothesis of schizophrenia is supported by a large number of imaging studies that have identified an increase in dopamine binding at the D
MeSH term(s)	Animals ; Brain/metabolism ; Brain/physiopathology ; Corpus Striatum/metabolism ; Corpus Striatum/physiopathology ; Disease Models, Animal ; Humans ; Mice ; Mice, Transgenic ; Receptors, Dopamine D2/metabolism ; Schizophrenia/metabolism ; Schizophrenia/physiopathology ; Schizophrenic Psychology ; Up-Regulation
Chemical Substances	Receptors, Dopamine D2
Language	English
Publishing date	2017-01-01
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	209434-4
ISSN	1873-2402 ; 0006-3223
ISSN (online)	1873-2402
ISSN	0006-3223
DOI	10.1016/j.biopsych.2016.07.004
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Article ; Online: Dopamine encodes real-time reward availability and transitions between reward availability states on different timescales

Abigail Kalmbach / Vanessa Winiger / Nuri Jeong / Arun Asok / Charles R. Gallistel / Peter D. Balsam / Eleanor H. Simpson

Nature Communications, Vol 13, Iss 1, Pp 1-

2022 Volume 13

Abstract: Dopamine in the ventral striatum conveys a complex reward-associated signal. This study demonstrates how dopamine reflects sustained reward availability, and rapidly signals unexpected changes in availability. ...

Abstract	Dopamine in the ventral striatum conveys a complex reward-associated signal. This study demonstrates how dopamine reflects sustained reward availability, and rapidly signals unexpected changes in availability.
Keywords	Science ; Q
Language	English
Publishing date	2022-07-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: How changes in dopamine D2 receptor levels alter striatal circuit function and motivation.

Simpson, Eleanor H / Gallo, Eduardo F / Balsam, Peter D / Javitch, Jonathan A / Kellendonk, Christoph

Molecular psychiatry

2021 Volume 27, Issue 1, Page(s) 436–444

Abstract: It was first posited, more than five decades ago, that the etiology of schizophrenia involves overstimulation of dopamine receptors. Since then, advanced clinical research methods, including brain imaging, have refined our understanding of the ... ...

Abstract	It was first posited, more than five decades ago, that the etiology of schizophrenia involves overstimulation of dopamine receptors. Since then, advanced clinical research methods, including brain imaging, have refined our understanding of the relationship between striatal dopamine and clinical phenotypes as well as disease trajectory. These studies point to striatal dopamine D2 receptors, the main target for all current antipsychotic medications, as being involved in both positive and negative symptoms. Simultaneously, animal models have been central to investigating causal relationships between striatal dopamine D2 receptors and behavioral phenotypes relevant to schizophrenia. We begin this article by reviewing the circuit, cell-type and subcellular locations of dopamine D2 receptors and their downstream signaling pathways. We then summarize results from several mouse models in which D2 receptor levels were altered in various brain regions, cell-types and developmental periods. Behavioral, electrophysiological and anatomical consequences of these D2 receptor perturbations are reviewed with a selective focus on striatal circuit function and alterations in motivated behavior, a core negative symptom of schizophrenia. These studies show that D2 receptors serve distinct physiological roles in different cell types and at different developmental time points, regulating motivated behaviors in sometimes opposing ways. We conclude by considering the clinical implications of this complex regulation of striatal circuit function by D2 receptors.
MeSH term(s)	Animals ; Corpus Striatum/metabolism ; Mice ; Motivation ; Receptors, Dopamine D1/metabolism ; Receptors, Dopamine D2/metabolism ; Schizophrenia/metabolism
Chemical Substances	Receptors, Dopamine D1 ; Receptors, Dopamine D2
Language	English
Publishing date	2021-08-12
Publishing country	England
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1330655-8
ISSN	1476-5578 ; 1359-4184
ISSN (online)	1476-5578
ISSN	1359-4184
DOI	10.1038/s41380-021-01253-4
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Article ; Online: Dopamine encodes real-time reward availability and transitions between reward availability states on different timescales.

Kalmbach, Abigail / Winiger, Vanessa / Jeong, Nuri / Asok, Arun / Gallistel, Charles R / Balsam, Peter D / Simpson, Eleanor H

Nature communications

2022 Volume 13, Issue 1, Page(s) 3805

Abstract: Optimal behavior requires interpreting environmental cues that indicate when to perform actions. Dopamine is important for learning about reward-predicting events, but its role in adapting to inhibitory cues is unclear. Here we show that when mice can ... ...

Abstract	Optimal behavior requires interpreting environmental cues that indicate when to perform actions. Dopamine is important for learning about reward-predicting events, but its role in adapting to inhibitory cues is unclear. Here we show that when mice can earn rewards in the absence but not presence of an auditory cue, dopamine level in the ventral striatum accurately reflects reward availability in real-time over a sustained period (80 s). In addition, unpredictable transitions between different states of reward availability are accompanied by rapid (~1-2 s) dopamine transients that deflect negatively at the onset and positively at the offset of the cue. This Dopamine encoding of reward availability and transitions between reward availability states is not dependent on reward or activity evoked dopamine release, appears before mice learn the task and is sensitive to motivational state. Our findings are consistent across different techniques including electrochemical recordings and fiber photometry with genetically encoded optical sensors for calcium and dopamine.
MeSH term(s)	Animals ; Cues ; Dopamine/physiology ; Mice ; Nucleus Accumbens ; Reward ; Ventral Striatum
Chemical Substances	Dopamine (VTD58H1Z2X)
Language	English
Publishing date	2022-07-01
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-022-31377-2
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Article: The Behavioral Neuroscience of Motivation: An Overview of Concepts, Measures, and Translational Applications.

Simpson, Eleanor H / Balsam, Peter D

Current topics in behavioral neurosciences

2016 Volume 27, Page(s) 1–12

Abstract: Motivation, defined as the energizing of behavior in pursuit of a goal, is a fundamental element of our interaction with the world and with each other. All animals share motivation to obtain their basic needs, including food, water, sex and social ... ...

Abstract	Motivation, defined as the energizing of behavior in pursuit of a goal, is a fundamental element of our interaction with the world and with each other. All animals share motivation to obtain their basic needs, including food, water, sex and social interaction. Meeting these needs is a requirement for survival, but in all cases the goals must be met in appropriate quantities and at appropriate times. Therefore motivational drive must be modulated as a function of both internal states as well as external environmental conditions. The regulation of motivated behaviors is achieved by the coordinated action of molecules (peptides, hormones, neurotransmitters etc), acting within specific circuits that integrate multiple signals in order for complex decisions to be made. In the past few decades, there has been a great deal of research on the biology and psychology of motivation. This work includes the investigation of specific aspects of motived behavior using multiple levels of analyses, which allows for the identification of the underpinning neurobiological mechanisms that support relevant psychological processes. In this chapter we provide an overview to the volume "The Behavioural Neuroscience of Motivation". The volume includes succinct summaries of; The neurobiology of components of healthy motivational drive, neural measures and correlates of motivation in humans and other animals as well as information on disorders in which abnormal motivation plays a major role. Deficits in motivation occur in a number of psychiatric disorders, affecting a large population, and severe disturbance of motivation can be devastating. Therefore, we also include a section on the development of treatments for disorders of motivation. It is hoped that the collection of reviews in the volume will expose scientists to a breadth of ideas from several different subdisciplines, thereby inspiring new directions of research that may increase our understanding of motivational regulation and bring us closer to effective treatments for disorders of motivation.
MeSH term(s)	Brain/physiology ; Cost-Benefit Analysis ; Functional Neuroimaging ; Humans ; Mental Disorders/physiopathology ; Mental Disorders/psychology ; Motivation/physiology ; Neurosciences ; Translational Medical Research
Language	English
Publishing date	2016
Publishing country	Germany
Document type	Introductory Journal Article
ISSN	1866-3370
ISSN	1866-3370
DOI	10.1007/7854_2015_402
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Book: Behavioral neuroscience of motivation

Simpson, Eleanor H / Balsam, Peter D

(Current topics in behavioral neurosciences, ; volume 27)

2016

Author's details	Eleanor H. Simpson, Peter D. Balsam, editors
Series title	Current topics in behavioral neurosciences, ; volume 27
MeSH term(s)	Motivation/physiology ; Neurobiology ; Apathy
Language	English
Size	xiv, 587 pages :, illustrations.
Document type	Book
ISBN	9783319269337 ; 9783319269351 ; 331926933X ; 3319269356
Database	Catalogue of the US National Library of Medicine (NLM)

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Article ; Online: Dopamine transporter blockade during adolescence increases adult dopamine function, impulsivity, and aggression.

Suri, Deepika / Zanni, Giulia / Mahadevia, Darshini / Chuhma, Nao / Saha, Rinki / Spivack, Stephen / Pini, Nicolò / Stevens, Gregory S / Ziolkowski-Blake, Annette / Simpson, Eleanor H / Balsam, Peter / Rayport, Stephen / Ansorge, Mark S

Molecular psychiatry

2023 Volume 28, Issue 8, Page(s) 3512–3523

Abstract: Sensitive developmental periods shape neural circuits and enable adaptation. However, they also engender vulnerability to factors that can perturb developmental trajectories. An understanding of sensitive period phenomena and mechanisms separate from ... ...

Abstract	Sensitive developmental periods shape neural circuits and enable adaptation. However, they also engender vulnerability to factors that can perturb developmental trajectories. An understanding of sensitive period phenomena and mechanisms separate from sensory system development is still lacking, yet critical to understanding disease etiology and risk. The dopamine system is pivotal in controlling and shaping adolescent behaviors, and it undergoes heightened plasticity during that time, such that interference with dopamine signaling can have long-lasting behavioral consequences. Here we sought to gain mechanistic insight into this dopamine-sensitive period and its impact on behavior. In mice, dopamine transporter (DAT) blockade from postnatal (P) day 22 to 41 increases aggression and sensitivity to amphetamine (AMPH) behavioral stimulation in adulthood. Here, we refined this sensitive window to P32-41 and identified increased firing of dopaminergic neurons in vitro and in vivo as a neural correlate to altered adult behavior. Aggression can result from enhanced impulsivity and cognitive dysfunction, and dopamine regulates working memory and motivated behavior. Hence, we assessed these behavioral domains and found that P32-41 DAT blockade increases impulsivity but has no effect on cognition, working memory, or motivation in adulthood. Lastly, using optogenetics to drive dopamine neurons, we find that increased VTA but not SNc dopaminergic activity mimics the increase in impulsive behavior in the Go/NoGo task observed after adolescent DAT blockade. Together our data provide insight into the developmental origins of aggression and impulsivity that may ultimately improve diagnosis, prevention, and treatment strategies for related neuropsychiatric disorders.
MeSH term(s)	Mice ; Animals ; Dopamine ; Dopamine Plasma Membrane Transport Proteins ; Amphetamine/pharmacology ; Impulsive Behavior/physiology ; Aggression
Chemical Substances	Dopamine (VTD58H1Z2X) ; Dopamine Plasma Membrane Transport Proteins ; Amphetamine (CK833KGX7E)
Language	English
Publishing date	2023-08-02
Publishing country	England
Document type	Journal Article
ZDB-ID	1330655-8
ISSN	1476-5578 ; 1359-4184
ISSN (online)	1476-5578
ISSN	1359-4184
DOI	10.1038/s41380-023-02194-w
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