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Article ; Online: Low incidence rate of diarrhoea in COVID-19 patients is due to integrin.

Gao, Shan / Lu, Yue / Luan, Junwen / Zhang, Leiliang

2021 Volume 83, Issue 4, Page(s) 496–522

MeSH term(s)	COVID-19 ; Diarrhea/epidemiology ; Humans ; Incidence ; Integrins ; SARS-CoV-2
Chemical Substances	Integrins
Language	English
Publishing date	2021-07-15
Publishing country	England
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	424417-5
ISSN	1532-2742 ; 0163-4453
ISSN (online)	1532-2742
ISSN	0163-4453
DOI	10.1016/j.jinf.2021.07.007
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Zs.MG 48: Show issues

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Article: Corrigendum: Meta-analysis of the association between toll-like receptor gene polymorphisms and hepatitis C virus infection.

Du, Yuxuan / Li, Shumin / Wang, Xinyu / Liu, Jialu / Gao, Yan / Lv, Weimiao / Liu, Ping / Huang, Haiyan / Luan, Junwen / Zhang, Leiliang

Frontiers in microbiology

2023 Volume 14, Page(s) 1330170

Abstract: This corrects the article DOI: 10.3389/fmicb.2023.1254805.]. ...

Abstract	[This corrects the article DOI: 10.3389/fmicb.2023.1254805.].
Language	English
Publishing date	2023-11-21
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2023.1330170
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Article ; Online: High level of defensin alpha 5 in intestine may explain the low incidence of diarrhoea in COVID-19 patients.

Luan, Junwen / Ren, Yongwen / Gao, Shan / Zhang, Leiliang

European journal of gastroenterology & hepatology

2020 Volume 34, Issue 1, Page(s) e3–e4

MeSH term(s)	COVID-19/complications ; Diarrhea/epidemiology ; Diarrhea/virology ; Humans ; Incidence ; Intestines/metabolism ; alpha-Defensins/metabolism
Chemical Substances	DEFA5 protein, human ; alpha-Defensins
Keywords	covid19
Language	English
Publishing date	2020-08-29
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1034239-4
ISSN	1473-5687 ; 0954-691X
ISSN (online)	1473-5687
ISSN	0954-691X
DOI	10.1097/MEG.0000000000001941
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Zs.A 2932: Show issues

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Article ; Online: A potential inhibitory role for integrin in the receptor targeting of SARS-CoV-2.

Luan, Junwen / Lu, Yue / Gao, Shan / Zhang, Leiliang

The Journal of infection

2020 Volume 81, Issue 2, Page(s) 318–356

MeSH term(s)	Betacoronavirus/drug effects ; Binding Sites ; COVID-19 ; Coronavirus Infections/drug therapy ; Humans ; Integrins/therapeutic use ; Pandemics ; Pneumonia, Viral/drug therapy ; Receptors, Immunologic/drug effects ; Receptors, Peptide/drug effects ; Receptors, Virus/drug effects ; SARS Virus/drug effects ; SARS-CoV-2 ; Severe Acute Respiratory Syndrome/drug therapy ; Spike Glycoprotein, Coronavirus/drug effects ; Virus Internalization/drug effects
Chemical Substances	Integrins ; Receptors, Immunologic ; Receptors, Peptide ; Receptors, Virus ; Spike Glycoprotein, Coronavirus ; arginyl-glycyl-aspartic acid directed cell adhesion receptor ; spike protein, SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-04-10
Publishing country	England
Document type	Letter
ZDB-ID	424417-5
ISSN	1532-2742 ; 0163-4453
ISSN (online)	1532-2742
ISSN	0163-4453
DOI	10.1016/j.jinf.2020.03.046
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Zs.A 1501: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Molecular docking of potential SARS-CoV-2 papain-like protease inhibitors.

Li, Daoqun / Luan, Junwen / Zhang, Leiliang

Biochemical and biophysical research communications

2020 Volume 538, Page(s) 72–79

Abstract: SARS-CoV-2 papain-like protease is considered as an important potential target for anti-SARS-CoV-2 drug discovery due to its crucial roles in viral spread and innate immunity. Here, we have utilized an in silico molecular docking approach to identify the ...

Abstract	SARS-CoV-2 papain-like protease is considered as an important potential target for anti-SARS-CoV-2 drug discovery due to its crucial roles in viral spread and innate immunity. Here, we have utilized an in silico molecular docking approach to identify the possible inhibitors of the SARS-CoV-2 papain-like protease, by screening 21 antiviral, antifungal and anticancer compounds. Among them, Neobavaisoflavone has the highest binding energy for SARS-CoV-2 papain-like protease. These molecules could bind near the SARS-CoV-2 papain-like protease crucial catalytic triad, ubiquitination and ISGylation residues: Trp106, Asn109, Cys111, Met208, Lys232, Pro247, Tyr268, Gln269, His272, Asp286 and Thr301. Because blocking the papain-like protease is an important strategy in fighting against viruses, these compounds might be promising candidates for therapeutic intervention against COVID-19.
MeSH term(s)	Coronavirus Papain-Like Proteases/antagonists & inhibitors ; Coronavirus Papain-Like Proteases/chemistry ; Coronavirus Protease Inhibitors/chemistry ; Coronavirus Protease Inhibitors/pharmacology ; Cysteine Proteinase Inhibitors/chemistry ; Cysteine Proteinase Inhibitors/pharmacology ; Drug Discovery/methods ; Humans ; Isoflavones/chemistry ; Isoflavones/pharmacology ; Ligands ; Molecular Docking Simulation ; Protein Binding ; SARS-CoV-2/drug effects ; SARS-CoV-2/enzymology
Chemical Substances	Coronavirus Protease Inhibitors ; Cysteine Proteinase Inhibitors ; Isoflavones ; Ligands ; neobavaisoflavone ; Coronavirus Papain-Like Proteases (EC 3.4.22.2)
Language	English
Publishing date	2020-11-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	205723-2
ISSN	1090-2104 ; 0006-291X ; 0006-291X
ISSN (online)	1090-2104 ; 0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2020.11.083
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Zs.A 116: Show issues

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Article ; Online: Spike protein recognition of mammalian ACE2 predicts the host range and an optimized ACE2 for SARS-CoV-2 infection.

Luan, Junwen / Lu, Yue / Jin, Xiaolu / Zhang, Leiliang

Biochemical and biophysical research communications

2020 Volume 526, Issue 1, Page(s) 165–169

Abstract: SARS-CoV-2 causes the recent global COVID-19 public health emergency. ACE2 is the receptor for both SARS-CoV-2 and SARS-CoV. To predict the potential host range of SARS-CoV-2, we analyzed the key residues of ACE2 for recognizing S protein. We found that ... ...

Abstract	SARS-CoV-2 causes the recent global COVID-19 public health emergency. ACE2 is the receptor for both SARS-CoV-2 and SARS-CoV. To predict the potential host range of SARS-CoV-2, we analyzed the key residues of ACE2 for recognizing S protein. We found that most of the selected mammals including pets (dog and cat), pangolin and Circetidae mammals remained the most of key residues for association with S protein from SARS-CoV and SARS-CoV-2. The interaction interface between cat/dog/pangolin/Chinese hamster ACE2 and SARS-CoV/SARS-CoV-2 S protein was simulated through homology modeling. We identified that N82 in ACE2 showed a closer contact with SARS-CoV-2 S protein than M82 in human ACE2. Our finding will provide important insights into the host range of SARS-CoV-2 and a new strategy to design an optimized ACE2 for SARS-CoV-2 infection.
MeSH term(s)	Amino Acid Sequence ; Angiotensin-Converting Enzyme 2 ; Animals ; Betacoronavirus/physiology ; COVID-19 ; Coronavirus Infections/metabolism ; Coronavirus Infections/transmission ; Coronavirus Infections/virology ; Humans ; Mammals/classification ; Mammals/metabolism ; Models, Molecular ; Pandemics ; Peptidyl-Dipeptidase A/chemistry ; Peptidyl-Dipeptidase A/metabolism ; Pneumonia, Viral/metabolism ; Pneumonia, Viral/transmission ; Pneumonia, Viral/virology ; SARS-CoV-2 ; Sequence Alignment ; Spike Glycoprotein, Coronavirus/chemistry ; Spike Glycoprotein, Coronavirus/metabolism ; Viral Tropism
Chemical Substances	Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 ; Peptidyl-Dipeptidase A (EC 3.4.15.1) ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
Keywords	covid19
Language	English
Publishing date	2020-03-19
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	205723-2
ISSN	1090-2104 ; 0006-291X ; 0006-291X
ISSN (online)	1090-2104 ; 0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2020.03.047
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Article ; Online: ACE2 isoform diversity predicts the host susceptibility of SARS-CoV-2.

Gao, Shan / Luan, Junwen / Cui, Haoran / Zhang, Leiliang

Transboundary and emerging diseases

2020 Volume 68, Issue 3, Page(s) 1026–1032

Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the ongoing coronavirus disease 2019 (COVID-19) pandemic. Angiotensin-converting enzyme 2 (ACE2) is the functional receptor for SARS-CoV-2. In our current study, we found that two types ... ...

Abstract	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the ongoing coronavirus disease 2019 (COVID-19) pandemic. Angiotensin-converting enzyme 2 (ACE2) is the functional receptor for SARS-CoV-2. In our current study, we found that two types of deficient ACE2 isoforms from different mammals compete with full-length ACE2 for association with S protein. One type of ACE2 is a natural soluble isoform, the other type of ACE2 only associates with one loop of the receptor-binding domain (RBD) of the SARS-CoV-2 S protein. Mammals with either type of ACE2 will be deficient in support of SARS-CoV-2 entry. By combining S recognition and isoform analysis of ACE2, we predict that felids, mustelids, hamsters, and sheep are susceptible to SARS-CoV-2, while canids, swines, cattle, and goats are not permissive for SARS-CoV-2. Thus, the differential susceptibilities of mammals with SARS-CoV-2 infection could be partially explained by the ACE2 isoform diversity. Our findings will shed important light on predicting the host range of other zoonotic viruses.
MeSH term(s)	Angiotensin-Converting Enzyme 2/genetics ; Angiotensin-Converting Enzyme 2/metabolism ; Animals ; Gene Expression Regulation, Enzymologic ; Genetic Predisposition to Disease ; Humans ; Isoenzymes ; Mammals/genetics ; Protein Binding ; SARS-CoV-2/physiology ; Species Specificity ; Spike Glycoprotein, Coronavirus/physiology
Chemical Substances	Isoenzymes ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
Keywords	covid19
Language	English
Publishing date	2020-09-29
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2414822-2
ISSN	1865-1682 ; 1865-1674
ISSN (online)	1865-1682
ISSN	1865-1674
DOI	10.1111/tbed.13773
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Article: ACE2 isoform diversity predicts the host susceptibility of SARS‐CoV‐2

Gao, Shan / Luan, Junwen / Cui, Haoran / Zhang, Leiliang

Transboundary and emerging diseases. 2021 May, v. 68, no. 3

2021

Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) causes the ongoing coronavirus disease 2019 (COVID‐19) pandemic. Angiotensin‐converting enzyme 2 (ACE2) is the functional receptor for SARS‐CoV‐2. In our current study, we found that two types ... ...

Abstract	Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) causes the ongoing coronavirus disease 2019 (COVID‐19) pandemic. Angiotensin‐converting enzyme 2 (ACE2) is the functional receptor for SARS‐CoV‐2. In our current study, we found that two types of deficient ACE2 isoforms from different mammals compete with full‐length ACE2 for association with S protein. One type of ACE2 is a natural soluble isoform, the other type of ACE2 only associates with one loop of the receptor‐binding domain (RBD) of the SARS‐CoV‐2 S protein. Mammals with either type of ACE2 will be deficient in support of SARS‐CoV‐2 entry. By combining S recognition and isoform analysis of ACE2, we predict that felids, mustelids, hamsters, and sheep are susceptible to SARS‐CoV‐2, while canids, swines, cattle, and goats are not permissive for SARS‐CoV‐2. Thus, the differential susceptibilities of mammals with SARS‐CoV‐2 infection could be partially explained by the ACE2 isoform diversity. Our findings will shed important light on predicting the host range of other zoonotic viruses.
Keywords	COVID-19 infection ; Canidae ; Felidae ; Severe acute respiratory syndrome coronavirus 2 ; cattle ; host range ; pandemic ; peptidyl-dipeptidase A ; sheep
Language	English
Dates of publication	2021-05
Size	p. 1026-1032.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	NAL-AP-2-clean ; JOURNAL ARTICLE
ZDB-ID	2414822-2
ISSN	1865-1682 ; 1865-1674
ISSN (online)	1865-1682
ISSN	1865-1674
DOI	10.1111/tbed.13773
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: SARS-CoV-2 spike protein favors ACE2 from Bovidae and Cricetidae.

Luan, Junwen / Jin, Xiaolu / Lu, Yue / Zhang, Leiliang

Journal of medical virology

2020 Volume 92, Issue 9, Page(s) 1649–1656

Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the recent COVID-19 public health crisis. Bat is the widely believed original host of SARS-CoV-2. However, its intermediate host before transmitting to humans is not clear. Some studies ... ...

Abstract	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the recent COVID-19 public health crisis. Bat is the widely believed original host of SARS-CoV-2. However, its intermediate host before transmitting to humans is not clear. Some studies proposed pangolin, snake, or turtle as the intermediate hosts. Angiotensin-converting enzyme 2 (ACE2) is the receptor for SARS-CoV-2, which determines the potential host range for SARS-CoV-2. On the basis of structural information of the complex of human ACE2 and SARS-CoV-2 receptor-binding domain (RBD), we analyzed the affinity to S protein of the 20 key residues in ACE2 from mammal, bird, turtle, and snake. Several ACE2 proteins from Primates, Bovidae, Cricetidae, and Cetacea maintained the majority of key residues in ACE2 for associating with SARS-CoV-2 RBD. The simulated structures indicated that ACE2 proteins from Bovidae and Cricetidae were able to associate with SARS-CoV-2 RBD. We found that nearly half of the key residues in turtle, snake, and bird were changed. The simulated structures showed several key contacts with SARS-CoV-2 RBD in turtle and snake ACE2 were abolished. This study demonstrated that neither snake nor turtle was the intermediate hosts for SARS-CoV-2, which further reinforced the concept that the reptiles are resistant against infection of coronavirus. This study suggested that Bovidae and Cricetidae should be included in the screening of intermediate hosts for SARS-CoV-2.
MeSH term(s)	Amino Acid Sequence ; Angiotensin-Converting Enzyme 2/chemistry ; Angiotensin-Converting Enzyme 2/metabolism ; Animals ; Arvicolinae ; COVID-19/metabolism ; COVID-19/virology ; Cattle ; Humans ; Models, Molecular ; Multiprotein Complexes/chemistry ; Multiprotein Complexes/metabolism ; Protein Binding ; Receptors, Virus/chemistry ; Receptors, Virus/metabolism ; SARS-CoV-2/physiology ; Sequence Alignment ; Spike Glycoprotein, Coronavirus/chemistry ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/metabolism ; Structure-Activity Relationship ; Viral Tropism
Chemical Substances	Multiprotein Complexes ; Receptors, Virus ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
Keywords	covid19
Language	English
Publishing date	2020-04-10
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.25817
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Article: Meta-analysis of the association between toll-like receptor gene polymorphisms and hepatitis C virus infection.

Du, Yuxuan / Li, Shumin / Wang, Xinyu / Liu, Jialu / Gao, Yan / Lv, Weimiao / Liu, Ping / Huang, Haiyan / Luan, Junwen / Zhang, Leiliang

Frontiers in microbiology

2023 Volume 14, Page(s) 1254805

Abstract: Objective: The objective of this study is to investigate the association between toll-like receptor (TLR) 3/7 gene polymorphisms and the infection by hepatitis C virus (HCV).: Methods: PubMed, Embase, Web of Science, Scopus, CNKI, Wanfang Data, and ... ...

Abstract	Objective: The objective of this study is to investigate the association between toll-like receptor (TLR) 3/7 gene polymorphisms and the infection by hepatitis C virus (HCV). Methods: PubMed, Embase, Web of Science, Scopus, CNKI, Wanfang Data, and SinoMed were searched to identify studies focusing on the association between the TLR3 rs3775290 or the TLR7 rs179008 single nucleotide polymorphisms (SNPs) and the HCV infection. All the related articles were collected from the inception of each database to 15 January 2023. Our meta-analysis was conducted using the allelic model, the dominant model, and the recessive model. Outcomes were presented by odds ratio (ORs) and 95% confidence interval (95%CI). The heterogeneity across studies was assessed by the I Results: Ten articles were finally included, among which six studies were analyzed for rs3775290 and five studies were analyzed for rs179008. Studies relating to rs3775290 included 801 patients and 1,045 controls, whereas studies relating to rs179008 included 924 patients and 784 controls. The results of the meta-analysis showed that there is no significant association between rs3775290 gene polymorphism and HCV infection (T vs. C: OR = 1.12, 95%CI 0.97-1.30; TT+CT vs. CC: OR = 1.20, 95%CI 0.73-1.96; TT vs. CT+CC: OR = 1.13, 95%CI 0.68-1.89). The recessive model showed that rs179008-T allele homozygotes had an 89% increased risk of infection by HCV compared with rs179008-A allele carriers (TT vs. AT+AA: OR = 1.89, 95%CI 1.13-3.16). The results of the subgroup analysis demonstrated that the characteristics of the control population may serve as an important source of heterogeneity. In the African populations, individuals with homozygous rs179008-T alleles had a higher risk of infection by HCV than rs179008-A allele carriers (OR = 2.14, 95%CI 1.18-3.87). We did not find that this difference existed in the European populations (OR = 1.24, 95%CI 0.43-3.56). Conclusion: There is no significant association between rs3775290 single nucleotide polymorphism and the infection by HCV. Individuals with homozygous rs179008-T alleles have a higher risk of an infection by HCV than rs179008-A allele carriers, which is statistically significant in the African populations.
Language	English
Publishing date	2023-10-05
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2023.1254805
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