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Article ; Online: Application of the LADA Strategy for the Synthesis of Unnatural Amino Acids through 1,2-Aryl Migration of Allylic Alcohols.

Miao, Pannan / Zhang, Mengyao / Ni, Zhuojun / Chen, Qi / Sun, Zhankui

2024 Volume 89, Issue 3, Page(s) 1543–1551

Abstract: Unnatural amino acids are versatile building blocks. Herein, we report the application of the LADA strategy for the direct synthesis of unnatural amino acids through 1,2-aryl migration of allylic alcohols. This reaction proceeds under mild conditions, ... ...

Abstract	Unnatural amino acids are versatile building blocks. Herein, we report the application of the LADA strategy for the direct synthesis of unnatural amino acids through 1,2-aryl migration of allylic alcohols. This reaction proceeds under mild conditions, tolerates diverse functionalities, and works smoothly on different thiols.
Language	English
Publishing date	2024-01-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	123490-0
ISSN	1520-6904 ; 0022-3263
ISSN (online)	1520-6904
ISSN	0022-3263
DOI	10.1021/acs.joc.3c02173
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Zs.A 4473: Show issues

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Article ; Online: Advances and challenges in the purification of recombinant coagulation factors: A review.

Yu, Linling / Yang, Dongmei / Chu, Mengyao / Sun, Yan

Journal of chromatography. A

2024 Volume 1716, Page(s) 464662

Abstract: Hemostasis is a complex process for the cessation of bleeding from an injured blood vessel, involving the interplay of 12 coagulation factors in the coagulation cascade with activated blood platelets and the vessel wall. Hence, the coagulation factors ... ...

Abstract	Hemostasis is a complex process for the cessation of bleeding from an injured blood vessel, involving the interplay of 12 coagulation factors in the coagulation cascade with activated blood platelets and the vessel wall. Hence, the coagulation factors are important to control hemorrhage. However, the low abundance of many coagulation factors in human plasma proteins limited their production in therapeutic drugs and their clinical applications. With the development of modern biotechnology, commercially manufactured recombinant coagulation factors became available as hemostatic therapeutics, emerging a huge potential in pharmaceutical manufacturing market. Unlike antibodies, whose standard operation unit or platform purification processes in the industrial-scale downstream processing has been well-established, the complexity in post-translational modification and differences in structures of the coagulation factors posed specific challenges with respect to the downstream processing, which have long been limiting their industrial-scale production. This review presents a comprehensive overview of the technological development of commercially manufactured recombinant coagulation factors, with emphasis on their advances and challenges in the separation and purification processes. Firstly, the licensed products of the plasma derived and recombinant coagulation factors are summarized. Then, typical recombinant coagulation factors, i.e. factors VII, VIII and IX, are introduced with detailed discussion on their preparative separation procedures for both the licensed products of industrial-scale and the experimental cases of laboratory-scale. Finally, perspectives and challenges in the future development of the purification technology of recombinant coagulation factors are highlighted to provide new insight into the design of cost-effective purification processes of recombinant coagulation factors.
MeSH term(s)	Humans ; Blood Coagulation Factors ; Biotechnology ; Recombinant Proteins
Chemical Substances	Blood Coagulation Factors ; Recombinant Proteins
Language	English
Publishing date	2024-01-16
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	1171488-8
ISSN	1873-3778 ; 0021-9673
ISSN (online)	1873-3778
ISSN	0021-9673
DOI	10.1016/j.chroma.2024.464662
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Zs.A 813: Show issues

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Article ; Online: [No title information]

Yang, Jinke / Wang, Yue / Hou, Yuanpan / Sun, Mengyao / Xia, Tian / Wu, Xin

Cell insight

2023 Volume 3, Issue 1, Page(s) 100143

Title translation	Evasion of host defense by
Language	English
Publishing date	2023-12-17
Publishing country	Netherlands
Document type	Journal Article ; Review
ISSN	2772-8927
ISSN (online)	2772-8927
DOI	10.1016/j.cellin.2023.100143
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Article ; Online: High-Performance Sulfurized Polyacrylonitrile Cathode by Using MXene as a Conductive and Catalytic Binder for Room-Temperature Na/S Batteries.

Sun, Tao / Wang, Shuo / Xu, Mengyao / Qiao, Ning / Zhu, Qizhen / Xu, Bin

ACS applied materials & interfaces

2024 Volume 16, Issue 8, Page(s) 10093–10103

Abstract: Sulfurized polyacrylonitrile (PAN@S) is a promising cathode material for room-temperature Na/S batteries but suffers from low conductivity and insufficient electrochemical activity, resulting in unsatisfactory actual capacity and rate performance. Herein, ...

Abstract	Sulfurized polyacrylonitrile (PAN@S) is a promising cathode material for room-temperature Na/S batteries but suffers from low conductivity and insufficient electrochemical activity, resulting in unsatisfactory actual capacity and rate performance. Herein, Ti
Language	English
Publishing date	2024-02-15
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.3c17874
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Article ; Online: Covalent organic framework isomers with divergent photocatalytic properties.

Ren, Xitong / Wen, Mengyao / Hou, Xiaobin / Sun, Jiajie / Bai, Feng / Li, Yusen

Chemical communications (Cambridge, England)

2024 Volume 60, Issue 33, Page(s) 4423–4426

Abstract: A pair of isomeric Py-BT-COFs with the same composition, but slightly different atomic arrangements, were designed and synthesized. The minute structural variations of the Py-BT-COF isomers generated significantly different redox and photophysical ... ...

Abstract	A pair of isomeric Py-BT-COFs with the same composition, but slightly different atomic arrangements, were designed and synthesized. The minute structural variations of the Py-BT-COF isomers generated significantly different redox and photophysical properties and correspondingly led to different photocatalytic manifestations in H
Language	English
Publishing date	2024-04-18
Publishing country	England
Document type	Journal Article
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/d4cc00130c
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Article ; Online: Dietary protein sources, genetics, and cardiovascular disease incidence.

Qian, Suying / Fu, Mengyao / Han, Liyuan / Sun, Weifeng / Sun, Hongpeng

Journal of affective disorders

2024 Volume 354, Page(s) 116–125

Abstract: Background: To explore the potential correlation between the amount and source of dietary protein and cardiovascular disease (CVD), as well as the potential impact of genetic susceptibility on these connections.: Methods: We performed a prospective ... ...

Abstract	Background: To explore the potential correlation between the amount and source of dietary protein and cardiovascular disease (CVD), as well as the potential impact of genetic susceptibility on these connections. Methods: We performed a prospective analysis of 98,224 participants from the UK. We measured dietary protein intake using two 24-hour dietary recall interviews. To analyze the data, we used multivariable-adjusted Cox regression models and restricted cubic spline models. Additionally, we calculated weighted genetic risk scores. Results: A total of 8818 new cases of CVD were documented, which included 4076 cases of coronary artery disease (CAD) and 1126 cases of stroke. The study found a J-shaped association (p nonlinearity = 0.005) between CVD risk and the percentage of energy obtained from consuming plant protein. Higher intake of plant protein and whole protein was associated with a decreased risk of CVD. On the other hand, larger intakes of animal protein was linked to a higher occurrence of CAD. Additionally, increased intake of plant protein was also linked to a lower incidence of stroke. Replacing 5 % of animal protein-based energy intake with plant protein-based energy intake resulted in a 5 % decrease in CVD risk. Limitations: There remains an effect of residual confounders. Conclusion: The consumption of larger amounts of plant protein, whole protein, and nut protein was found to be associated with a lower risk of CVD events. Conversely, higher intakes of animal protein was associated with an increased risk of CAD events. Furthermore, replacing 5 % of energy intake from animal protein with energy intake from plant protein was found to reduce the risk of CVD by 5 %.
MeSH term(s)	Animals ; Humans ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/genetics ; Incidence ; Risk Factors ; Dietary Proteins ; Prospective Studies ; Diet ; Stroke/epidemiology ; Stroke/genetics ; Plant Proteins
Chemical Substances	Dietary Proteins ; Plant Proteins
Language	English
Publishing date	2024-02-05
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	135449-8
ISSN	1573-2517 ; 0165-0327
ISSN (online)	1573-2517
ISSN	0165-0327
DOI	10.1016/j.jad.2024.01.233
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Zs.A 1485: Show issues

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Article ; Online: The investigation on sialic acid-modified pectin nanoparticles loaded with oxymatrine for orally targeting and inhibiting the of ulcerative colitis.

Zhao, Chunying / Yang, Xin / Fan, Mengyao / Tian, Linan / Sun, Tongtong / Sun, Changshan / Jiang, Tongying

Colloids and surfaces. B, Biointerfaces

2024 Volume 236, Page(s) 113809

Abstract: The aim of the study was to develop an oral targeting drug delivery system (OTDDS) of oxymatrine (OMT) to effectively treat ulcerative colitis (UC). The OTDDS of OMT (OMT/SA-NPs) was constructed with OMT, pectin, ... ...

Abstract	The aim of the study was to develop an oral targeting drug delivery system (OTDDS) of oxymatrine (OMT) to effectively treat ulcerative colitis (UC). The OTDDS of OMT (OMT/SA-NPs) was constructed with OMT, pectin, Ca
MeSH term(s)	Humans ; Colitis, Ulcerative/drug therapy ; N-Acetylneuraminic Acid ; Pectins ; Drug Delivery Systems ; Anti-Inflammatory Agents/pharmacology ; Nanoparticles ; Matrines
Chemical Substances	N-Acetylneuraminic Acid (GZP2782OP0) ; Pectins (89NA02M4RX) ; oxymatrine (85U4C366QS) ; Anti-Inflammatory Agents ; Matrines
Language	English
Publishing date	2024-02-23
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1500523-9
ISSN	1873-4367 ; 0927-7765
ISSN (online)	1873-4367
ISSN	0927-7765
DOI	10.1016/j.colsurfb.2024.113809
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Article ; Online: Operative treatment of pulmonary primitive neuroectodermal tumor: a case report and literature review.

Zhang, Yiyuan / Shang, Ke / Li, Jialin / Sun, Mengyao / Gu, Xiaoying

Journal of cardiothoracic surgery

2024 Volume 19, Issue 1, Page(s) 109

Abstract: Background: Pulmonary primitive neuroectodermal tumor (PNET), a member of the Ewing sarcoma family of tumors, is a rare malignancy that is associated with a grim prognosis. To date, fewer than 30 cases of pulmonary PNET have been reported. In this case ... ...

Abstract	Background: Pulmonary primitive neuroectodermal tumor (PNET), a member of the Ewing sarcoma family of tumors, is a rare malignancy that is associated with a grim prognosis. To date, fewer than 30 cases of pulmonary PNET have been reported. In this case report, we present the clinical details of a 12-year-old girl with pulmonary PNET who underwent surgical treatment. We also conducted an analysis and summary of other relevant studies and the surgical outcomes. Case presentation: In May 2018, a 12-year-old girl was admitted with symptoms of cough and blood-tinged phlegm. A computed tomography scan revealed a large mass, measuring 12.9 cm × 8.1 cm, in the right middle and lower lungs. A percutaneous lung biopsy confirmed poorly differentiated tumor cells with a nested growth pattern. Immunohistochemical staining demonstrated positive expression of CD99, CD56, Vimentin, and Synaptophysin. The patient was diagnosed with pulmonary PNET. Following three cycles of neoadjuvant chemotherapy, a substantial reduction in tumor volume was observed. Subsequently, the patient underwent a surgical procedure involving pneumonectomy and partial resection of the left atrium with the assistance of cardiopulmonary bypass. The patient was discharged 37 days after surgery. During a three-year follow-up period, she exhibited no signs of tumor recurrence and has successfully returned to school. Conclusions: This case highlights the successful management of an advanced PNET with neoadjuvant chemotherapy, pneumonectomy, and partial resection of the left atrium employing cardiopulmonary bypass. The patient remained disease-free after three years. Our analysis of surgically treated cases indicates that neoadjuvant chemotherapy can contribute to improved prognoses for PNET patients. It is crucial to emphasize that complete surgical excision remains the cornerstone of treatment, underscoring the importance of surgeons considering radical surgical approaches whenever feasible for patients with pulmonary PNETs.
MeSH term(s)	Female ; Humans ; Child ; Neoplasm Recurrence, Local ; Pneumonectomy ; Neoadjuvant Therapy ; Lung ; Neuroectodermal Tumors, Primitive/diagnosis ; Neuroectodermal Tumors, Primitive/surgery
Language	English
Publishing date	2024-03-05
Publishing country	England
Document type	Review ; Case Reports ; Journal Article
ZDB-ID	2227224-0
ISSN	1749-8090 ; 1749-8090
ISSN (online)	1749-8090
ISSN	1749-8090
DOI	10.1186/s13019-024-02563-8
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Article ; Online: Microplastics induced endoplasmic reticulum stress to format an inflammation and cell death in hepatocytes of carp (Cyprinus carpio).

Cui, Jie / Zhu, Mengran / Sun, Xiaoran / Yang, Jie / Guo, Mengyao

Aquatic toxicology (Amsterdam, Netherlands)

2024 Volume 269, Page(s) 106870

Abstract: Microplastics (MPs) are a serious threat to the living environment of aquatic organisms. However, there are fewer studies on the toxicity of microplastics to freshwater organisms. This study aimed to establish a polystyrene microplastics (PS-MPs) model ... ...

Abstract	Microplastics (MPs) are a serious threat to the living environment of aquatic organisms. However, there are fewer studies on the toxicity of microplastics to freshwater organisms. This study aimed to establish a polystyrene microplastics (PS-MPs) model by feeding carp (Cyprinus carpio) PS-MP (1000 ng/L) particles 8 μm in size. HE staining revealed a mass of inflammatory cells infiltrated in the carp hepatopancreas. The activities of alkaline phosphatase (AKP), aspartate transaminase (AST), lactate dehydrogenase (LDH), and alanine transaminase (ALT) were strengthened considerably, suggesting that PS-MPs cause injury to the hepatopancreas of carp. Real-Time polymerase chain reaction and western blotting results indicated increased levels of glucose-regulated protein 78 (GRP78), (PKR)-like ER kinase (PERK), eukaryotic translation initiation Factor 2α (EIF2α) and activating transcription Factor 4 (ATF4) genes and increased levels of inflammatory factors downstream of endoplasmic reticulum stress (ERs) thioredoxin-interacting protein (TXNIP), NOD-like receptor protein 3 (NLRP3), interleukin-18 (IL-18), interleukin-1β (IL-1β), and caspase 1. Increased expression of microtubule-associated protein-2 (LC3II), autophagy-related 5 (ATG5) and autophagy-related 12 (ATG12) genes revealed that PS-MPs promoted autophagy in carp hepatocytes. The enhanced expression of the Caspase 12, Caspase 3, and Bax genes suggested that PS-MPs led to the apoptosis of carp hepatocytes. These results suggest that PS-MPs result in serious injury to the hepatopancreas of carp. The present study of PS-MPs in freshwater fish from the aspect of endoplasmic reticulum stress was conducted to provide references and suggestions for toxicological studies of PS-MPs in freshwater environments.
MeSH term(s)	Animals ; Microplastics ; Plastics ; Carps ; Water Pollutants, Chemical/toxicity ; Cell Death ; Apoptosis ; Hepatocytes ; Polystyrenes/toxicity ; Inflammation ; Endoplasmic Reticulum Stress
Chemical Substances	Microplastics ; Plastics ; Water Pollutants, Chemical ; Polystyrenes
Language	English
Publishing date	2024-02-19
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	782699-0
ISSN	1879-1514 ; 0166-445X
ISSN (online)	1879-1514
ISSN	0166-445X
DOI	10.1016/j.aquatox.2024.106870
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Zs.A 4376: Show issues

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Article ; Online: Simultaneous Regulation of Surface Properties and Microstructure of Graphene Oxide Membranes for Enhanced Nanofiltration Performance.

Wu, Daowen / Sun, Mengyao / Zhang, Wenbin / Zhang, Weiming

ACS applied materials & interfaces

2023

Abstract: The surface properties and microstructure of graphene oxide (GO)-based membranes are both crucial for enhanced nanofiltration performance. Herein, a GO nanofiltration membrane is fabricated with regulatable surface properties and microstructure via a ... ...

Abstract	The surface properties and microstructure of graphene oxide (GO)-based membranes are both crucial for enhanced nanofiltration performance. Herein, a GO nanofiltration membrane is fabricated with regulatable surface properties and microstructure via a facile two-step impregnation in KOH and following HCl aqueous solutions. The type and number of oxygen-containing groups in GO membranes change with fewer C-O-C/C-OH and C═O but more COOH groups, and they are readily regulated by alkaline treatment time, which enables enhanced surface hydrophilicity and larger surface ζ potentials. Meanwhile, a few tiny defects are present in the GO sheets, which could increase the number of pores and decrease the length of water nanochannels. Such surface properties and microstructure together determine the excellent nanofiltration performance of the GO membranes with fast and selective water permeation, e.g., ∼99.5% rejection toward CBB G250 and flux of 56.9 ± 1.0 L m
Language	English
Publishing date	2023-10-27
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.3c14049
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