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  1. Article ; Online: Lipoprotein(a), Residual Cardiovascular Risk, and the Search for Targeted Therapy.

    Blaha, Michael J / Bhatia, Harpreet S

    Journal of the American College of Cardiology

    2024  Volume 83, Issue 16, Page(s) 1540–1542

    MeSH term(s) Humans ; Cardiovascular Diseases ; Lipoprotein(a) ; Risk Factors ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Heart Disease Risk Factors ; Triglycerides ; Hypertriglyceridemia
    Chemical Substances Lipoprotein(a) ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Triglycerides
    Language English
    Publishing date 2024-03-25
    Publishing country United States
    Document type Editorial
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2024.03.370
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    Zs.A 1846: Show issues Location:
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  2. Article ; Online: Type 2 Diabetes Mellitus: Now in the Cardiologist's Wheelhouse.

    Blaha, Michael J / Khorsandi, Michael

    Journal of the American College of Cardiology

    2023  Volume 82, Issue 16, Page(s) 1595–1597

    MeSH term(s) Humans ; Diabetes Mellitus, Type 2/epidemiology ; Cardiologists ; Hypoglycemic Agents ; Cardiovascular Diseases/epidemiology
    Chemical Substances Hypoglycemic Agents
    Language English
    Publishing date 2023-10-11
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2023.08.033
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  3. Article ; Online: Predicting Age of Conversion to CAC >0: A Role for Polygenic Risk Scores?

    Blaha, Michael J

    JACC. Cardiovascular imaging

    2021  Volume 14, Issue 7, Page(s) 1407–1409

    MeSH term(s) Humans ; Predictive Value of Tests ; Risk Factors
    Language English
    Publishing date 2021-01-13
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2491503-8
    ISSN 1876-7591 ; 1936-878X
    ISSN (online) 1876-7591
    ISSN 1936-878X
    DOI 10.1016/j.jcmg.2020.12.007
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    Zs.A 6846: Show issues Location:
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  4. Article ; Online: Coronary calcium scoring for guiding lipid-lowering therapy is cost-effective: time to remove barriers to its use.

    Tasdighi, Erfan / Blaha, Michael J

    The Medical journal of Australia

    2023  Volume 218, Issue 5, Page(s) 214–215

    MeSH term(s) Humans ; Calcium/therapeutic use ; Cost-Benefit Analysis ; Coronary Artery Disease/drug therapy ; Coronary Angiography ; Lipids
    Chemical Substances Calcium (SY7Q814VUP) ; Lipids
    Language English
    Publishing date 2023-02-21
    Publishing country Australia
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 186082-3
    ISSN 1326-5377 ; 0025-729X
    ISSN (online) 1326-5377
    ISSN 0025-729X
    DOI 10.5694/mja2.51861
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  5. Article ; Online: Coronary artery calcium: from risk prediction to treatment allocation and clinical trials.

    Whelton, Seamus P / Blaha, Michael J

    Heart (British Cardiac Society)

    2023  Volume 109, Issue 22, Page(s) 1714–1721

    Abstract: Coronary artery calcium (CAC) is a direct measure of an individual's coronary atherosclerotic burden. Higher levels of CAC are strongly associated with an increased risk of cardiovascular disease (CVD) events and individuals with very high CAC levels ... ...

    Abstract Coronary artery calcium (CAC) is a direct measure of an individual's coronary atherosclerotic burden. Higher levels of CAC are strongly associated with an increased risk of cardiovascular disease (CVD) events and individuals with very high CAC levels have a CVD risk similar to stable persons with a prior CVD event. Conversely, the absence of CAC (CAC=0) is associated with a low long-term risk of CVD, even among groups classified as high risk based on traditional risk factors. Accordingly, the guideline-based role of CAC in allocation of CVD prevention therapies has expanded to include both statin and non-statin medications. Beyond prevention therapies, it is now widely recognised that the total burden of atherosclerosis is a stronger risk factor for CVD than a sole focus on coronary stenosis. Furthermore, evidence is accruing to support expanding the value of CAC=0 among low-risk symptomatic patients given its very high negative predictive value for ruling out obstructive coronary artery disease. There is now an appreciation of the value of routine assessment of CAC on all non-gated chest CTs and with the advent of artificial intelligence, automated interpretation is now possible. Additionally, CAC is now firmly established in randomised trials as a tool to identify high-risk patients most likely to benefit from pharmacotherapies. Future studies incorporating measures of atherosclerosis beyond the Agatston score will lead to continued refinement of CAC scoring, further improvements in personalisation of CVD risk prediction and more individualised allocation of prevention therapies to the patients at highest CVD risk.
    MeSH term(s) Humans ; Calcium ; Coronary Angiography/adverse effects ; Coronary Vessels/diagnostic imaging ; Artificial Intelligence ; Vascular Calcification/diagnostic imaging ; Vascular Calcification/therapy ; Vascular Calcification/complications ; Coronary Artery Disease/diagnosis ; Coronary Artery Disease/therapy ; Coronary Artery Disease/etiology ; Atherosclerosis ; Risk Factors ; Cardiovascular Diseases/complications ; Risk Assessment
    Chemical Substances Calcium (SY7Q814VUP)
    Language English
    Publishing date 2023-10-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 1303417-0
    ISSN 1468-201X ; 1355-6037
    ISSN (online) 1468-201X
    ISSN 1355-6037
    DOI 10.1136/heartjnl-2022-321711
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    Zs.MO 112: Show issues

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  6. Article ; Online: Long-Term Risk Prediction for Heart Failure, Disparities, and Early Prevention.

    Shea, Steven / Blaha, Michael J

    Circulation research

    2022  Volume 130, Issue 2, Page(s) 210–212

    MeSH term(s) Heart Failure/diagnosis ; Heart Failure/epidemiology ; Heart Failure/prevention & control ; Humans ; Risk Factors
    Language English
    Publishing date 2022-01-20
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. ; Comment
    ZDB-ID 80100-8
    ISSN 1524-4571 ; 0009-7330 ; 0931-6876
    ISSN (online) 1524-4571
    ISSN 0009-7330 ; 0931-6876
    DOI 10.1161/CIRCRESAHA.121.320598
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  7. Article ; Online: Subclinical Coronary Atherosclerosis and Risk for Myocardial Infarction in a Danish Cohort.

    Budoff, Matthew J / Nasir, Khurram / Blaha, Michael J

    Annals of internal medicine

    2023  Volume 176, Issue 10, Page(s) eL230262

    MeSH term(s) Humans ; Coronary Artery Disease/complications ; Coronary Artery Disease/epidemiology ; Myocardial Infarction/epidemiology ; Coronary Angiography ; Denmark/epidemiology ; Risk Factors
    Language English
    Publishing date 2023-10-16
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/L23-0262
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  8. Article ; Online: Assessment of cardiovascular disease risk: a 2023 update.

    Goldsborough, Earl / Tasdighi, Erfan / Blaha, Michael J

    Current opinion in lipidology

    2023  Volume 34, Issue 4, Page(s) 162–173

    Abstract: Purpose of review: The aim of this study was to highlight the current best practice for atherosclerotic cardiovascular disease (CVD) risk evaluation, including selective use of adjunctive tools for risk stratification [e.g. coronary artery calcium (CAC) ...

    Abstract Purpose of review: The aim of this study was to highlight the current best practice for atherosclerotic cardiovascular disease (CVD) risk evaluation, including selective use of adjunctive tools for risk stratification [e.g. coronary artery calcium (CAC) scoring] and risk enhancement [e.g. lipoprotein(a) [Lp(a)], polygenic risk scoring (PRS)].
    Recent findings: New studies have evaluated the efficacy of various risk assessment tools. These studies demonstrate the role of Lp(a) as a risk-enhancing factor ready for more widespread use. CAC is the gold standard method of assessing subclinical atherosclerosis, enabling true risk stratification of patients, and informing net benefit assessment for initiating or titrating lipid-lowering therapy (LLT).
    Summary: Lp(a) concentration and CAC scoring, apart from the traditional risk factors, add the most value to the current CVD risk assessment approaches of all available tools, especially in terms of guiding LLT. In addition to new integrative tools such as the MESA CHD Risk Score and Coronary Age calculator, the future of risk assessment may include PRS and more advanced imaging techniques for atherosclerosis burden. Soon, polygenic risk scoring may be used to identify the age at which to begin CAC scoring, with CAC scores guiding preventive strategies.
    MeSH term(s) Humans ; Cardiovascular Diseases/epidemiology ; Atherosclerosis ; Lipoprotein(a) ; Multifactorial Inheritance ; Risk Assessment
    Chemical Substances Lipoprotein(a)
    Language English
    Publishing date 2023-05-15
    Publishing country England
    Document type Review ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1045394-5
    ISSN 1473-6535 ; 0957-9672
    ISSN (online) 1473-6535
    ISSN 0957-9672
    DOI 10.1097/MOL.0000000000000887
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  9. Article ; Online: Management of dyslipidemia in older adults.

    Obisesan, Olufunmilayo H / Purohit, Aarti M / Blaha, Michael J / Blumenthal, Roger S

    American heart journal plus : cardiology research and practice

    2023  Volume 33, Page(s) 100315

    Language English
    Publishing date 2023-08-12
    Publishing country United States
    Document type Editorial
    ISSN 2666-6022
    ISSN (online) 2666-6022
    DOI 10.1016/j.ahjo.2023.100315
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  10. Article ; Online: Coronary Artery Calcium: A Risk Factor for Brain Aging?

    Johansen, Michelle C / Blaha, Michael J

    Circulation. Cardiovascular imaging

    2021  Volume 14, Issue 7, Page(s) e013062

    MeSH term(s) Aging ; Brain/diagnostic imaging ; Calcium ; Coronary Artery Disease/diagnostic imaging ; Coronary Artery Disease/epidemiology ; Coronary Vessels/diagnostic imaging ; Humans ; Risk Factors
    Chemical Substances Calcium (SY7Q814VUP)
    Language English
    Publishing date 2021-07-14
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2435045-X
    ISSN 1942-0080 ; 1941-9651
    ISSN (online) 1942-0080
    ISSN 1941-9651
    DOI 10.1161/CIRCIMAGING.121.013062
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