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  1. Article ; Online: Discussion on the Application of Rapid Immunoblot Assay for AQP4-IgG Detection.

    Su, Yang / Wang, Minjin

    JAMA neurology

    2024  

    Language English
    Publishing date 2024-03-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2702023-X
    ISSN 2168-6157 ; 2168-6149
    ISSN (online) 2168-6157
    ISSN 2168-6149
    DOI 10.1001/jamaneurol.2024.0299
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    Ui II Zs.191: Show issues Location:
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  2. Article ; Online: The potential role of tACS in improving cognitive dysfunction associated with anti-NMDAR encephalitis.

    Su, Yang / Wang, Zhiyin / Li, Yi / Wang, Minjin

    Asian journal of psychiatry

    2024  Volume 95, Page(s) 104001

    Language English
    Publishing date 2024-03-11
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 2456678-0
    ISSN 1876-2026 ; 1876-2018
    ISSN (online) 1876-2026
    ISSN 1876-2018
    DOI 10.1016/j.ajp.2024.104001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Letter regarding "Regulatory T-cell phenotypes in prenatal psychological distress".

    Ren, Yan / Song, Xingbo / Wang, Minjin

    Brain, behavior, and immunity

    2024  Volume 118, Page(s) 310–311

    MeSH term(s) Pregnancy ; Female ; Humans ; T-Lymphocytes, Regulatory ; Depression/psychology ; Anxiety/psychology ; Psychological Distress ; Stress, Psychological/psychology
    Language English
    Publishing date 2024-03-08
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 639219-2
    ISSN 1090-2139 ; 0889-1591
    ISSN (online) 1090-2139
    ISSN 0889-1591
    DOI 10.1016/j.bbi.2024.03.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2276: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 327: Show issues

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  4. Article ; Online: The effect of ferroptosis-related mitochondrial dysfunction in the development of temporal lobe epilepsy.

    Su, Yang / Cao, Ningrui / Zhang, Dingkun / Wang, Minjin

    Ageing research reviews

    2024  Volume 96, Page(s) 102248

    Abstract: Temporal lobe epilepsy (TLE) is the most common form of epileptic syndrome. It has been established that due to its complex pathogenesis, a considerable proportion of TLE patients often progress to drug-resistant epilepsy. Ferroptosis has emerged as an ... ...

    Abstract Temporal lobe epilepsy (TLE) is the most common form of epileptic syndrome. It has been established that due to its complex pathogenesis, a considerable proportion of TLE patients often progress to drug-resistant epilepsy. Ferroptosis has emerged as an important neuronal death mechanism in TLE, which is primarily influenced by lipid accumulation and oxidative stress. In previous studies of ferroptosis, more attention has been focused on the impact of changes in the levels of proteins related to the redox equilibrium and signaling pathways on epileptic seizures. However, it is worth noting that the oxidative-reduction changes in different organelles may have different pathophysiological significance in the process of ferroptosis-related diseases. Mitochondria, as a key organelle involved in ferroptosis, its structural damage and functional impairment can lead to energy metabolism disorders and disruption of the excitatory inhibitory balance, significantly increasing the susceptibility to epileptic seizures. Therefore, secondary mitochondrial dysfunction in the process of ferroptosis could play a crucial role in TLE pathogenesis. This review focuses on ferroptosis and mitochondria, discussing the pathogenic role of ferroptosis-related mitochondrial dysfunction in TLE, thus aiming to provide novel insights and potential implications of ferroptosis-related secondary mitochondrial dysfunction in epileptic seizures and to offer new insights for the precise exploration of ferroptosis-related therapeutic targets for TLE patients.
    MeSH term(s) Humans ; Epilepsy, Temporal Lobe/metabolism ; Epilepsy, Temporal Lobe/pathology ; Ferroptosis ; Seizures/complications ; Seizures/metabolism ; Seizures/pathology ; Mitochondria/metabolism ; Mitochondrial Diseases/complications ; Mitochondrial Diseases/metabolism ; Mitochondrial Diseases/pathology
    Language English
    Publishing date 2024-02-24
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2075672-0
    ISSN 1872-9649 ; 1568-1637
    ISSN (online) 1872-9649
    ISSN 1568-1637
    DOI 10.1016/j.arr.2024.102248
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5579: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Mitochondrial Dysfunction of Astrocytes Mediates Lipid Accumulation in Temporal Lobe Epilepsy.

    Su, Yang / Tang, Meng / Wang, Minjin

    Aging and disease

    2023  

    Abstract: Lipid-accumulated reactive astrocytes (LARAs) have recently been confirmed to be a pivotal cell type present in temporal lobe epilepsy (TLE) lesions. These cells not only induce anomalous lipid accumulation within the epileptic foci but also decrease the ...

    Abstract Lipid-accumulated reactive astrocytes (LARAs) have recently been confirmed to be a pivotal cell type present in temporal lobe epilepsy (TLE) lesions. These cells not only induce anomalous lipid accumulation within the epileptic foci but also decrease the seizure threshold by employing upregulated activation of the adenosine A2A receptor (A2AR). Furthermore, disturbances in mitochondrial oxidative phosphorylation (OxPhos) have been noted as significant drivers of lipid accumulation in astrocytes. Moreover, the deficiency of OxPhos in astrocytes can induce severe neuroinflammation, which can worsen the progression of TLE. Accordingly, further exploration of the correlation between mitochondrial dysfunction, LARAs-mediated lipid accumulation, and A2AR activation within epilepsy lesions is warranted. It could potentially elucidate the vital role of mitochondrial dysfunction in the pathogenesis of TLE.
    Language English
    Publishing date 2023-07-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2625789-0
    ISSN 2152-5250
    ISSN 2152-5250
    DOI 10.14336/AD.2023.0624
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Performance of assessment tools in predicting neural autoantibody positivity in patients with seizures.

    Peng, Wei / Wang, Minjin / Shi, Wenyan / Wang, Jierui / Zhou, Dong / Li, Jinmei

    International immunopharmacology

    2024  Volume 130, Page(s) 111763

    Abstract: Background: The identification of patients with seizures of unknown etiology who would benefit from neural antibody testing necessitates effective assessment tools. The study aimed to compare the performance of the Antibody Prevalence in Epilepsy and ... ...

    Abstract Background: The identification of patients with seizures of unknown etiology who would benefit from neural antibody testing necessitates effective assessment tools. The study aimed to compare the performance of the Antibody Prevalence in Epilepsy and Encephalopathy (APE2) score and the "Obvious" Indications for Neural Antibody Testing in Epilepsy or Seizures (ONES) checklist. We also intended to evaluate whether the performance of the tools varied by types of antibody.
    Methods: Patients diagnosed with epilepsy, seizures, or status epilepticus of unknown etiology at West China Hospital from January 2019 to December 2021 were included. Paired serum/cerebrospinal fluid samples were analyzed for antineuronal and antiglial antibodies. The APE2 score and ONES checklist were applied, and their outcomes were compared to laboratory antibody test results. Possible false positive neuronal antibody results were excluded in sensitivity/specificity analysis reasonably.
    Results: A total of 113 antibody-positive and 159 antibody-negative patients were enrolled in sensitivity/specificity analysis. The ONES checklist showed superior sensitivity than APE2 score (95.6 % vs.79.6 %, P < 0.001). Specificity was not statistically different (60.4 % vs. 57.9 %, P = 0.557). The negative predictive value (NPV) of ONES checklist was higher than that of APE2 score (94.8 % vs 80.7 %, P < 0.001). The positive predictive value of them was not statistically different (61.7 % vs 58.8 %, P = 0.557). APE2 score exhibited lower sensitivity for predicting LGI-Abs (52.9 % vs. 80.3 %, P = 0.022) compared to NMDAR-Abs. Similarly, ONES checklist showed lower sensitivity for LGI1-Abs than NMDAR-Abs (82.4 % vs. 100.0 %, P = 0.009).
    Conclusions: The ONES checklist demonstrates superior sensitivity for neural antibody positivity than APE2 score. Specificity of the two assessment tools was similar. ONES checklist performed better NPV than the APE2 score. Both assessment tools performed less well in predicting the presence of LGI1- Abs when compared to NMDAR-Abs.
    MeSH term(s) Humans ; Autoantibodies ; Seizures ; Brain Diseases ; Epilepsy/complications ; Neurons
    Chemical Substances Autoantibodies
    Language English
    Publishing date 2024-02-27
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2043785-7
    ISSN 1878-1705 ; 1567-5769
    ISSN (online) 1878-1705
    ISSN 1567-5769
    DOI 10.1016/j.intimp.2024.111763
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5408: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Case report: Amphiphysin-IgG autoimmunity: a paraneoplastic presentation of appendiceal goblet cell carcinoma.

    Lin, Jingfang / Yu, Tianping / Wang, Minjin / Wang, Jierui / Li, Jinmei

    Frontiers in immunology

    2023  Volume 13, Page(s) 1001264

    Abstract: Background: Appendiceal goblet cell carcinoma (aGCC) is a rare neoplasm with mixed endocrine and exocrine features. No paraneoplastic neurological syndromes or autoantibodies have been identified in cases of aGCC or even appendiceal tumors. Amphiphysin- ... ...

    Abstract Background: Appendiceal goblet cell carcinoma (aGCC) is a rare neoplasm with mixed endocrine and exocrine features. No paraneoplastic neurological syndromes or autoantibodies have been identified in cases of aGCC or even appendiceal tumors. Amphiphysin-immunoglobulin G (IgG) autoimmunity was first described in stiff-person syndrome with breast cancer. We firstly described the clinical course and pathological findings of a patient with aGCC-associated amphiphysin-IgG autoimmunity.
    Case presentation: A 54-year-old man who developed aGCC was admitted for acute disturbance of consciousness, psychiatric symptoms, cognitive impairment, seizure and hypotension. Amphiphysin-IgG was detected in the patient's serum and CSF by immunoblotting and tissue-based indirect immunofluorescence assay confirming the diagnosis of definite paraneoplastic amphiphysin-IgG-positive encephalitis. Histopathology revealed amphiphysin protein expression and accompanying immune cell infiltration (predominantly CD20+ B cells, CD3+ and CD8+ T cells) within the tumor tissue, suggesting a possible paraneoplastic origin of amphiphysin-associated paraneoplastic neurological syndromes (PNSs) in this case. Although the patient's symptoms resolved after high-dose corticosteroid therapy, he experienced recurrence 6 months later, manifesting as paraneoplastic cerebellar dysfunction. Despite treatment with IV cyclophosphamide and oral mycophenolate mofetil, no improvement was noted.
    Conclusions: This case suggests that aGCC may trigger amphiphysin-IgG autoimmunity.
    MeSH term(s) Male ; Humans ; Middle Aged ; Autoimmunity ; Immunoglobulin G ; Appendiceal Neoplasms ; Goblet Cells ; Autoantibodies ; Paraneoplastic Syndromes/diagnosis ; Paraneoplastic Syndromes/etiology ; Encephalitis ; Carcinoma
    Chemical Substances amphiphysin (147954-52-7) ; Immunoglobulin G ; Autoantibodies
    Language English
    Publishing date 2023-01-04
    Publishing country Switzerland
    Document type Case Reports ; Research Support, Non-U.S. Gov't ; Journal Article
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.1001264
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Novel compound heterozygous mutations of the COL7A1 gene in a Chinese patient with recessive dystrophic epidermolysis bullosa pruriginosa and digestive symptoms successfully treated with tofacitinib.

    Zhou, Xingli / Geng, Jia / Wang, Minjin / Yang, Jinlin / Zou, Jian / Li, Wei

    The Journal of dermatology

    2023  Volume 51, Issue 1, Page(s) e8–e10

    MeSH term(s) Humans ; China ; Collagen Type VII/genetics ; Epidermolysis Bullosa Dystrophica/complications ; Epidermolysis Bullosa Dystrophica/drug therapy ; Epidermolysis Bullosa Dystrophica/genetics ; Genes, Recessive ; Mutation ; Pedigree ; Phenotype
    Chemical Substances COL7A1 protein, human ; Collagen Type VII ; tofacitinib (87LA6FU830)
    Language English
    Publishing date 2023-09-19
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 800103-0
    ISSN 1346-8138 ; 0385-2407
    ISSN (online) 1346-8138
    ISSN 0385-2407
    DOI 10.1111/1346-8138.16945
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    Zs.B 1950: Show issues Location:
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  9. Article ; Online: Late-onset paraneoplastic encephalitis originates from dopamine 2 receptor autoimmunity associated with prostate adenocarcinoma.

    Cai, Hanlin / Gao, Hui / Chen, Xueqin / Qin, Linyuan / Wang, Ruihan / Yuan, Qiang / Hong, Zhen / Li, Jinmei / Zhou, Dong / Wang, Minjin / Chen, Qin

    Asian journal of psychiatry

    2024  Volume 93, Page(s) 103910

    MeSH term(s) Male ; Humans ; Autoimmunity ; Dopamine ; Prostate ; Encephalitis ; Adenocarcinoma/complications
    Chemical Substances Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 2024-01-03
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 2456678-0
    ISSN 1876-2026 ; 1876-2018
    ISSN (online) 1876-2026
    ISSN 1876-2018
    DOI 10.1016/j.ajp.2024.103910
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  10. Article: Ovarian Teratoma-Related Paraneoplastic Neurological Syndromes.

    Lin, Jingfang / Wang, Minjin / Wang, Jierui / Li, Jinmei

    Frontiers in oncology

    2022  Volume 12, Page(s) 892539

    Abstract: Paraneoplastic neurological syndromes (PNSs) are a group of neurological disorders triggered by an underlying remote tumor. Ovarian teratoma (OT) is the most common histologic type of germ cell tumor in females. The most common PNSs associated with OT is ...

    Abstract Paraneoplastic neurological syndromes (PNSs) are a group of neurological disorders triggered by an underlying remote tumor. Ovarian teratoma (OT) is the most common histologic type of germ cell tumor in females. The most common PNSs associated with OT is anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis. However, with the increasing number of new antibodies reported over the last decade, the clinical spectrum of OT-related PNSs is also expanding. Our knowledge of OT-related PNSs is still far from complete. Here, we provide a comprehensive review of the most recent findings in the field of OT-related PNSs, with a particular focus on their clinical and pathological characteristics. Overall, the description of neuronal antibodies in PNSs associated with OT strongly suggests that antibodies may be responsible for the clinical symptoms in some cases. OT-related PNSs are associated with various clinical manifestations, including anti-NMDAR encephalitis, limbic encephalitis, encephalomyelitis, progressive cerebellar syndrome and opsoclonus-myoclonus syndrome. The pathological characteristics of the OT suggest that the mechanism of PNSs is probably due to heteromorphic neurons in the tumor tissue, the ectopic expression of the antigens in neural tissue within the teratomas and patients' unusual immune response. Despite the severity of the neurological syndromes, most patients with OT-related PNSs showed good neurologic response to early tumor resection combined with immunotherapy. To further advance the management of OT-related PNSs, additional studies are needed to explore this complex topic.
    Language English
    Publishing date 2022-05-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2022.892539
    Database MEDical Literature Analysis and Retrieval System OnLINE

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