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  1. Article ; Online: Seeing Through Psychosis.

    Türközer, Halide Bilge / Ross, David A

    Biological psychiatry

    2021  Volume 89, Issue 10, Page(s) e51–e53

    MeSH term(s) Emotions ; Humans ; Psychotic Disorders ; Schizophrenia
    Language English
    Publishing date 2021-05-05
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 209434-4
    ISSN 1873-2402 ; 0006-3223
    ISSN (online) 1873-2402
    ISSN 0006-3223
    DOI 10.1016/j.biopsych.2021.03.025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 720: Show issues Location:
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  2. Article ; Online: A projection for psychiatry in the post-COVID-19 era: potential trends, challenges, and directions.

    Türközer, Halide Bilge / Öngür, Dost

    Molecular psychiatry

    2020  Volume 25, Issue 10, Page(s) 2214–2219

    Abstract: The COVID-19 pandemic has transformed the face of psychiatry over a very short time period. Given the detrimental impact of the pandemic on mental health and the economy, more difficult days are ahead for psychiatry. The rising public health burden of ... ...

    Abstract The COVID-19 pandemic has transformed the face of psychiatry over a very short time period. Given the detrimental impact of the pandemic on mental health and the economy, more difficult days are ahead for psychiatry. The rising public health burden of mental illnesses will inevitably exceed the capacity of psychiatric services in the United States and worldwide. The pandemic has also profoundly affected psychiatric research due to safety concerns and containment efforts. Intermediate and long-term ramifications may even be more serious. In addition to the effects of the economic downturn on available research funding, existing research tools and protocols may not meet the emerging needs in the post-COVID-19 era. This paper discusses potential trends and challenges that psychiatric practice and research may encounter in this period from the viewpoint of workers in the field. We outline some measures that clinicians and researchers can implement to adapt to the emerging changes in psychiatry and to mitigate the forthcoming effects of the crisis.
    MeSH term(s) Biomedical Research ; COVID-19 ; Coronavirus Infections/psychology ; Humans ; Mental Disorders/etiology ; Pandemics ; Pneumonia, Viral/psychology ; Psychiatry/trends ; Psychotherapy/trends ; Research Support as Topic
    Keywords covid19
    Language English
    Publishing date 2020-07-17
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1330655-8
    ISSN 1476-5578 ; 1359-4184
    ISSN (online) 1476-5578
    ISSN 1359-4184
    DOI 10.1038/s41380-020-0841-2
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  3. Article ; Online: A projection for psychiatry in the post-COVID-19 era

    Türközer, Halide Bilge / Öngür, Dost

    Molecular Psychiatry

    potential trends, challenges, and directions

    2020  Volume 25, Issue 10, Page(s) 2214–2219

    Keywords Molecular Biology ; Cellular and Molecular Neuroscience ; Psychiatry and Mental health ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    ZDB-ID 1330655-8
    ISSN 1476-5578 ; 1359-4184
    ISSN (online) 1476-5578
    ISSN 1359-4184
    DOI 10.1038/s41380-020-0841-2
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: A projection for psychiatry in the post-COVID-19 era: potential trends, challenges, and directions

    Türközer, Halide Bilge / Öngür, Dost

    Mol Psychiatry

    Abstract: The COVID-19 pandemic has transformed the face of psychiatry over a very short time period. Given the detrimental impact of the pandemic on mental health and the economy, more difficult days are ahead for psychiatry. The rising public health burden of ... ...

    Abstract The COVID-19 pandemic has transformed the face of psychiatry over a very short time period. Given the detrimental impact of the pandemic on mental health and the economy, more difficult days are ahead for psychiatry. The rising public health burden of mental illnesses will inevitably exceed the capacity of psychiatric services in the United States and worldwide. The pandemic has also profoundly affected psychiatric research due to safety concerns and containment efforts. Intermediate and long-term ramifications may even be more serious. In addition to the effects of the economic downturn on available research funding, existing research tools and protocols may not meet the emerging needs in the post-COVID-19 era. This paper discusses potential trends and challenges that psychiatric practice and research may encounter in this period from the viewpoint of workers in the field. We outline some measures that clinicians and researchers can implement to adapt to the emerging changes in psychiatry and to mitigate the forthcoming effects of the crisis.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #653749
    Database COVID19

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  5. Article ; Online: We both say tomato: Intact lexical alignment in schizophrenia and bipolar disorder.

    Sharpe, Victoria / Schoot, Lotte / Lewandowski, Kathryn Eve / Öngür, Dost / Türközer, Halide Bilge / Hasoğlu, Tuna / Kuperberg, Gina R

    Schizophrenia research

    2022  Volume 243, Page(s) 138–146

    Abstract: In people with schizophrenia and related disorders, impairments in communication and social functioning can negatively impact social interactions and quality of life. In the present study, we investigated the cognitive basis of a specific aspect of ... ...

    Abstract In people with schizophrenia and related disorders, impairments in communication and social functioning can negatively impact social interactions and quality of life. In the present study, we investigated the cognitive basis of a specific aspect of linguistic communication-lexical alignment-in people with schizophrenia and bipolar disorder. We probed lexical alignment as participants played a collaborative picture-naming game with the experimenter, in which the two players alternated between naming a dual-name picture (e.g., rabbit/bunny) and listening to their partner name a picture. We found evidence of lexical alignment in all three groups, with no differences between the patient groups and the controls. We argue that these typical patterns of lexical alignment in patients were supported by preserved-and in some cases increased-bottom-up mechanisms, which balanced out impairments in top-down perspective-taking.
    MeSH term(s) Animals ; Bipolar Disorder ; Communication ; Humans ; Solanum lycopersicum ; Quality of Life ; Rabbits ; Schizophrenia/complications
    Language English
    Publishing date 2022-03-12
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 639422-x
    ISSN 1573-2509 ; 0920-9964
    ISSN (online) 1573-2509
    ISSN 0920-9964
    DOI 10.1016/j.schres.2022.02.032
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    Zs.MO 543: Show issues

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  6. Article ; Online: Regional and Sex-Specific Alterations in the Visual Cortex of Individuals With Psychosis Spectrum Disorders.

    Türközer, Halide Bilge / Lizano, Paulo / Adhan, Iniya / Ivleva, Elena I / Lutz, Olivia / Zeng, Victor / Zeng, Alexandria / Raymond, Nicholas / Bannai, Deepthi / Lee, Adam / Bishop, Jeffrey R / Clementz, Brett A / Pearlson, Godfrey D / Sweeney, John A / Gershon, Elliot S / Keshavan, Matcheri S / Tamminga, Carol A

    Biological psychiatry

    2022  Volume 92, Issue 5, Page(s) 396–406

    Abstract: Background: Impairments of the visual system are implicated in psychotic disorders. However, studies exploring visual cortex (VC) morphology in this population are limited. Using data from the Bipolar-Schizophrenia Network on Intermediate Phenotypes ... ...

    Abstract Background: Impairments of the visual system are implicated in psychotic disorders. However, studies exploring visual cortex (VC) morphology in this population are limited. Using data from the Bipolar-Schizophrenia Network on Intermediate Phenotypes consortium, we examined VC structure in psychosis probands and their first-degree relatives (RELs), sex differences in VC measures, and their relationships with cognitive and peripheral inflammatory markers.
    Methods: Cortical thickness, surface area, and volume of the primary (Brodmann area 17/V1) and secondary (Brodmann area 18/V2) visual areas and the middle temporal (V5/MT) region were quantified using FreeSurfer version 6.0 in psychosis probands (n = 530), first-degree RELs (n = 544), and healthy control subjects (n = 323). Familiality estimates were determined for probands and RELs. General cognition, response inhibition, and emotion recognition functions were assessed. Systemic inflammation was measured in a subset of participants.
    Results: Psychosis probands demonstrated significant area, thickness, and volume reductions in V1, V2, and MT, and their first-degree RELs demonstrated area and volume reductions in MT compared with control subjects. There was a higher degree of familiality for VC area than thickness. Area and volume reductions in V1 and V2 were sex dependent, affecting only female probands in a regionally specific manner. Reductions in some VC regions were correlated with poor general cognition, worse response inhibition, and increased C-reactive protein levels.
    Conclusions: The visual cortex is a site of significant pathology in psychotic disorders, with distinct patterns of area and thickness changes, sex-specific and regional effects, potential contributions to cognitive impairments, and association with C-reactive protein levels.
    MeSH term(s) Bipolar Disorder/pathology ; C-Reactive Protein ; Female ; Humans ; Male ; Psychotic Disorders/complications ; Schizophrenia/pathology ; Visual Cortex/diagnostic imaging
    Chemical Substances C-Reactive Protein (9007-41-4)
    Language English
    Publishing date 2022-04-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 209434-4
    ISSN 1873-2402 ; 0006-3223
    ISSN (online) 1873-2402
    ISSN 0006-3223
    DOI 10.1016/j.biopsych.2022.03.023
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    Zs.A 720: Show issues Location:
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  7. Article ; Online: Biomarker Profiles in Psychosis Risk Groups Within Unaffected Relatives Based on Familiality and Age.

    Türközer, Halide Bilge / Ivleva, Elena I / Palka, Jayme / Clementz, Brett A / Shafee, Rebecca / Pearlson, Godfrey D / Sweeney, John A / Keshavan, Matcheri S / Gershon, Elliot S / Tamminga, Carol A

    Schizophrenia bulletin

    2021  Volume 47, Issue 4, Page(s) 1058–1067

    Abstract: Investigating biomarkers in unaffected relatives (UR) of individuals with psychotic disorders has already proven productive in research on psychosis neurobiology. However, there is considerable heterogeneity among UR based on features linked to psychosis ...

    Abstract Investigating biomarkers in unaffected relatives (UR) of individuals with psychotic disorders has already proven productive in research on psychosis neurobiology. However, there is considerable heterogeneity among UR based on features linked to psychosis vulnerability. Here, using the Bipolar-Schizophrenia Network for Intermediate Phenotypes (B-SNIP) dataset, we examined cognitive and neurophysiologic biomarkers in first-degree UR of psychosis probands, stratified by 2 widely used risk factors: familiality status of the respective proband (the presence or absence of a first- or second-degree relative with a history of psychotic disorder) and age (within or older than the common age range for developing psychosis). We investigated biomarkers that best differentiate the above specific risk subgroups. Additionally, we examined the relationship of biomarkers with Polygenic Risk Scores for Schizophrenia (PRSSCZ) in a subsample of Caucasian probands and healthy controls (HC). Our results demonstrate that the Brief Assessment of Cognition in Schizophrenia (BACS) score, antisaccade error (ASE) factor, and stop-signal task (SST) factor best differentiate UR (n = 169) from HC (n = 137) (P = .013). Biomarker profiles of UR of familial (n = 82) and non-familial (n = 83) probands were not significantly different. Furthermore, ASE and SST factors best differentiated younger UR (age ≤ 30) (n = 59) from older UR (n = 110) and HC from both age groups (age ≤ 30 years, n=49; age > 30 years, n = 88) (P < .001). In addition, BACS (r = -0.175, P = .006) and ASE factor (r = 0.188, P = .006) showed associations with PRSSCZ. Taken together, our findings indicate that cognitive biomarkers-"top-down inhibition" impairments in particular-may be of critical importance as indicators of psychosis vulnerability.
    MeSH term(s) Adult ; Age Distribution ; Biomarkers/analysis ; Cognition/physiology ; Family/psychology ; Female ; Humans ; Male ; Middle Aged ; Nervous System Physiological Phenomena ; Psychotic Disorders/genetics ; Psychotic Disorders/physiopathology ; Risk Factors
    Chemical Substances Biomarkers
    Language English
    Publishing date 2021-03-10
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 439173-1
    ISSN 1745-1701 ; 0586-7614
    ISSN (online) 1745-1701
    ISSN 0586-7614
    DOI 10.1093/schbul/sbab013
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  8. Article ; Online: Integrated assessment of visual perception abnormalities in psychotic disorders and relationship with clinical characteristics.

    Türközer, Halide Bilge / Hasoğlu, Tuna / Chen, Yue / Norris, Lesley Anne / Brown, Meredith / Delaney-Busch, Nathaniel / Kale, Emre H / Pamir, Zahide / Boyacı, Hüseyin / Kuperberg, Gina / Lewandowski, Kathryn E / Topçuoğlu, Volkan / Öngür, Dost

    Psychological medicine

    2018  Volume 49, Issue 10, Page(s) 1740–1748

    Abstract: Background: The visual system is recognized as an important site of pathology and dysfunction in schizophrenia. In this study, we evaluated different visual perceptual functions in patients with psychotic disorders using a potentially clinically ... ...

    Abstract Background: The visual system is recognized as an important site of pathology and dysfunction in schizophrenia. In this study, we evaluated different visual perceptual functions in patients with psychotic disorders using a potentially clinically applicable task battery and assessed their relationship with symptom severity in patients, and with schizotypal features in healthy participants.
    Methods: Five different areas of visual functioning were evaluated in patients with schizophrenia and schizoaffective disorder (n = 28) and healthy control subjects (n = 31) using a battery that included visuospatial working memory (VSWM), velocity discrimination (VD), contour integration, visual context processing, and backward masking tasks.
    Results: The patient group demonstrated significantly lower performance in VD, contour integration, and VSWM tasks. Performance did not differ between the two groups on the visual context processing task and did not differ across levels of interstimulus intervals in the backward masking task. Performances on VSWM, VD, and contour integration tasks were correlated with negative symptom severity but not with other symptom dimensions in the patient group. VSWM and VD performances were also correlated with negative sychizotypal features in healthy controls.
    Conclusion: Taken together, these results demonstrate significant abnormalities in multiple visual processing tasks in patients with psychotic disorders, adding to the literature implicating visual abnormalities in these conditions. Furthermore, our results show that visual processing impairments are associated with the negative symptom dimension in patients as well as healthy individuals.
    MeSH term(s) Adolescent ; Adult ; Female ; Humans ; Male ; Memory, Short-Term/physiology ; Middle Aged ; Motion Perception/physiology ; Pattern Recognition, Visual/physiology ; Perceptual Disorders/etiology ; Perceptual Disorders/physiopathology ; Psychotic Disorders/complications ; Psychotic Disorders/physiopathology ; Schizophrenia/complications ; Schizophrenia/physiopathology ; Schizotypal Personality Disorder/complications ; Schizotypal Personality Disorder/physiopathology ; Space Perception/physiology ; Visual Perception/physiology ; Young Adult
    Language English
    Publishing date 2018-09-04
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 217420-0
    ISSN 1469-8978 ; 0033-2917
    ISSN (online) 1469-8978
    ISSN 0033-2917
    DOI 10.1017/S0033291718002477
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