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Article ; Online: Methyltransferase-like 3 facilitates the stem cell properties of esophageal cancer by upregulating patched homolog 1 via N6-methyladenosine methylation.

Liang, Hao / Fang, Chengyuan / Zhang, Luquan

American journal of physiology. Cell physiology

2023 Volume 325, Issue 3, Page(s) C770–C779

Abstract: Patched homolog 1 (PTCH1) has been proven to facilitate cell proliferation and self-renewal in esophageal cancer (EC). The present study intended to exploit the influence of PTCH1 on EC cells and the potential mechanisms. PTCH1 and methyltransferase-like ...

Abstract	Patched homolog 1 (PTCH1) has been proven to facilitate cell proliferation and self-renewal in esophageal cancer (EC). The present study intended to exploit the influence of PTCH1 on EC cells and the potential mechanisms. PTCH1 and methyltransferase-like 3 (METTL3) expression were examined by quantitative real-time polymerase chain reaction (qRT-PCR) and Western blot in EC cell lines. Following the loss- and gain-of-function assays, cell proliferation was examined by cell counting kit (CCK)-8 and clone formation assays, invasion and migration by Transwell and scratch assays, and the sphere-forming ability of stem cells by cell sphere-forming assay. The expression of stemness genes NANOG homeobox protein (NANOG), octamer-binding transcription factor 4 (Oct4), and sex-determining region Y-box 2 (SOX2) was detected by Western blot. Methylated RNA immunoprecipitation (Me-RIP) assay was performed to test N6-methyladenosine (m
MeSH term(s)	Mice ; Animals ; Humans ; Methylation ; Methyltransferases/genetics ; Mice, Nude ; Patched-1 Receptor/genetics ; Patched-1 Receptor/metabolism ; Stem Cells/metabolism ; Esophageal Neoplasms/genetics ; RNA, Messenger/genetics
Chemical Substances	Methyltransferases (EC 2.1.1.-) ; Patched-1 Receptor ; RNA, Messenger ; METTL3 protein, human (EC 2.1.1.62)
Language	English
Publishing date	2023-08-14
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	392098-7
ISSN	1522-1563 ; 0363-6143
ISSN (online)	1522-1563
ISSN	0363-6143
DOI	10.1152/ajpcell.00136.2023
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Article: The non-specific lipid transfer protein McLTPII.9 of

Chen, Qiutong / Li, Li / Qi, Xiwu / Fang, Hailing / Yu, Xu / Bai, Yang / Chen, Zequn / Liu, Qun / Liu, Dongmei / Liang, Chengyuan

Frontiers in plant science

2023 Volume 14, Page(s) 1188922

Abstract: ... Mentha ... ...

Abstract	Mentha canadensis
Language	English
Publishing date	2023-05-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2613694-6
ISSN	1664-462X
ISSN	1664-462X
DOI	10.3389/fpls.2023.1188922
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Article ; Online: A Comprehensive Overview of the Antibiotics Approved in the Last Two Decades: Retrospects and Prospects.

Shi, Zhenfeng / Zhang, Jie / Tian, Lei / Xin, Liang / Liang, Chengyuan / Ren, Xiaodong / Li, Min

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 4

Abstract: Due to the overuse of antibiotics, bacterial resistance has markedly increased to become a global problem and a major threat to human health. Fortunately, in recent years, various new antibiotics have been developed through both improvements to ... ...

Abstract	Due to the overuse of antibiotics, bacterial resistance has markedly increased to become a global problem and a major threat to human health. Fortunately, in recent years, various new antibiotics have been developed through both improvements to traditional antibiotics and the discovery of antibiotics with novel mechanisms with the aim of addressing the decrease in the efficacy of traditional antibiotics. This manuscript reviews the antibiotics that have been approved for marketing in the last 20 years with an emphasis on the antibacterial properties, mechanisms, structure-activity relationships (SARs), and clinical safety of these antibiotics. Furthermore, the current deficiencies, opportunities for improvement, and prospects of antibiotics are thoroughly discussed to provide new insights for the design and development of safer and more potent antibiotics.
MeSH term(s)	Humans ; Anti-Bacterial Agents/pharmacology ; Structure-Activity Relationship ; Bacterial Infections/drug therapy
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2023-02-13
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28041762
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Article: Modeling and dynamic characteristic simulation of air-cooled proton exchange membrane fuel cell stack for unmanned aerial vehicle

Gong, Chengyuan / Xing, Lu / Liang, Cong / Tu, Zhengkai

Renewable energy. 2022 Apr., v. 188

2022

Abstract: Air-cooled low-temperature proton exchange membrane fuel cell stack applied with metallic bipolar plate is considered as a promising power source for an unmanned aerial vehicle. This paper presents a coupled electrochemical thermal model for simulating ... ...

Abstract	Air-cooled low-temperature proton exchange membrane fuel cell stack applied with metallic bipolar plate is considered as a promising power source for an unmanned aerial vehicle. This paper presents a coupled electrochemical thermal model for simulating its dynamic characteristic. The impact of the applied metallic bipolar plate on the stack thermal balance is considered; an environmental model estimating atmospheric temperature and pressure variations with altitude is included. Our theoretical analysis shows that with altitude increased from 0m to 4000m, the output electric power declined rate is 4.7–6.5% at the current density of 400–800 mA cm⁻². To avoid severe stack degradation due to high stack operating temperature, minimum air stoichiometric ratio is required for maintaining stack thermal balance. When the altitude increases from 0 to 4000m, the minimum required air stoichiometric ratio decreases from 110 to 22 at the current density of 800 mA cm⁻².
Keywords	air ; air temperature ; altitude ; electric power ; electrochemistry ; environmental models ; fuel cells ; stoichiometry ; unmanned aerial vehicles
Language	English
Dates of publication	2022-04
Size	p. 1094-1104.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	2001449-1
ISSN	1879-0682 ; 0960-1481
ISSN (online)	1879-0682
ISSN	0960-1481
DOI	10.1016/j.renene.2022.02.104
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Article ; Online: Bioinspired microenvironment modulation of metal-organic framework-based catalysts for selective methane oxidation.

Sui, Jianfei / Gao, Ming-Liang / Qian, Bing / Liu, Chengyuan / Pan, Yang / Meng, Zheng / Yuan, Daqiang / Jiang, Hai-Long

Science bulletin

2023 Volume 68, Issue 17, Page(s) 1886–1893

Abstract: Inspiration from natural enzymes enabling creationary catalyst design is appealing yet remains extremely challenging for selective methane ( ... ...

Abstract	Inspiration from natural enzymes enabling creationary catalyst design is appealing yet remains extremely challenging for selective methane (CH
Language	English
Publishing date	2023-07-24
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2816140-3
ISSN	2095-9281 ; 2095-9273
ISSN (online)	2095-9281
ISSN	2095-9273
DOI	10.1016/j.scib.2023.07.031
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Article ; Online: A Vectorial Current Density Imaging Method Based on Magnetic Gradient Tensor.

Wu, Yangjing / Zhang, Mingji / Peng, Chengyuan / Zhang, Zehuang / He, Yichen / Zhang, Wenwei / Chang, Liang

Sensors (Basel, Switzerland)

2023 Volume 23, Issue 13

Abstract: Magnetic current imaging is deemed an emerging powerful technique for visualizing electrical currents in electronic devices. However, the existing magnetic-field-based Fourier Transform back-evolution method is limited by its mono-function of imaging the ...

Abstract	Magnetic current imaging is deemed an emerging powerful technique for visualizing electrical currents in electronic devices. However, the existing magnetic-field-based Fourier Transform back-evolution method is limited by its mono-function of imaging the magnitude of current density in devices under test, and subject to background noise distortion. Here, we developed a novel vectorial current density imaging method based on the detection of the magnetic field gradient generated by current carrying conductors. A closed form solution of current density inversion was analytically derived and numerically verified. Experiments were conducted by scanning tri-axial fluxgate sensor over different shapes of electrical wires. The results show that a current density resolution of 24.15 mA/mm
MeSH term(s)	Magnetic Resonance Imaging/methods ; Phantoms, Imaging ; Magnetics ; Magnetic Fields ; Fourier Analysis
Language	English
Publishing date	2023-06-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s23135859
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Article ; Online: Application of Miscanthus substrates in the cultivation of Ganoderma lingzhi.

Liu, Dongmei / Diao, Wentong / Sun, Xueyan / Zong, Junqin / Qi, Xiwu / Liang, Chengyuan

Archives of microbiology

2023 Volume 205, Issue 12, Page(s) 384

Abstract: Ganoderma lingzhi is a traditional Chinese medicine that has been used to improve health and longevity for thousands of years. It is usually cultivated on hardwood log- or sawdust-based formulations. Conversely, in this study, we used Miscanthus ... ...

Abstract	Ganoderma lingzhi is a traditional Chinese medicine that has been used to improve health and longevity for thousands of years. It is usually cultivated on hardwood log- or sawdust-based formulations. Conversely, in this study, we used Miscanthus sacchariflorus (MSF), M. floridulus, and M. sinensis (MSS), fast-growing perennial grasses widely distributed in China, for G. lingzhi cultivation. Mycelial growth rate, activities of lignin-degrading enzymes on colonized mushroom substrates, and expression levels of CAZymes and laccase genes based on different substrates were analyzed. Total triterpenoids, sterols, and polysaccharides content of fruiting bodies obtained from different substrates were investigated. The activities of laccase and manganese peroxidase in mycelia increased in the MSF- and MSS-based formulations compared with that in the sawdust-based formulation. The results of mycelial growth- and cultivation-related experiments showed that the Miscanthus substrates could be used as the substrates for cultivating G. lingzhi. The content of active ingredients, namely triterpenoids, sterols, and polysaccharides, in fruiting bodies cultivated on the Miscanthus substrates did not decrease compared with those in substrate obtained from the sawdust-based formulation. Therefore, the present study provides alternative substrates for the cultivation of G. lingzhi, and a reference for better utilization of inexpensive substrate in future.
MeSH term(s)	Laccase/genetics ; Laccase/metabolism ; Reishi/metabolism ; Poaceae ; Polysaccharides/metabolism ; Triterpenes ; Sterols/metabolism
Chemical Substances	Laccase (EC 1.10.3.2) ; Polysaccharides ; Triterpenes ; Sterols
Language	English
Publishing date	2023-11-17
Publishing country	Germany
Document type	Journal Article
ZDB-ID	124824-8
ISSN	1432-072X ; 0302-8933
ISSN (online)	1432-072X
ISSN	0302-8933
DOI	10.1007/s00203-023-03720-8
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Article ; Online: Genome-wide analysis of the MADS-box gene family in Lonicera japonica and a proposed floral organ identity model.

Lin, Yi / Qi, Xiwu / Wan, Yan / Chen, Zequn / Fang, Hailing / Liang, Chengyuan

BMC genomics

2023 Volume 24, Issue 1, Page(s) 447

Abstract: Background: Lonicera japonica Thunb. is widely used in traditional Chinese medicine. Medicinal L. japonica mainly consists of dried flower buds and partially opened flowers, thus flowers are an important quality indicator. MADS-box genes encode ... ...

Abstract	Background: Lonicera japonica Thunb. is widely used in traditional Chinese medicine. Medicinal L. japonica mainly consists of dried flower buds and partially opened flowers, thus flowers are an important quality indicator. MADS-box genes encode transcription factors that regulate flower development. However, little is known about these genes in L. japonica. Results: In this study, 48 MADS-box genes were identified in L. japonica, including 20 Type-I genes (8 Mα, 2 Mβ, and 10 Mγ) and 28 Type-II genes (26 MIKC Conclusion: This study genome-widely identified and characterized the MADS-box gene family in L. japonica. Eleven floral homeotic MADS-box genes were identified and a possible model for floral organ identity determination was also developed. This study contributes to our understanding of the MADS-box gene family and its possible involvement in floral organ development in L. japonica.
MeSH term(s)	Genome, Plant ; Lonicera/genetics ; Lonicera/metabolism ; MADS Domain Proteins/metabolism ; Transcription Factors/metabolism ; Multigene Family ; Phylogeny ; Gene Expression Regulation, Plant ; Flowers ; Plant Proteins/genetics ; Plant Proteins/metabolism
Chemical Substances	MADS Domain Proteins ; Transcription Factors ; Plant Proteins
Language	English
Publishing date	2023-08-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2041499-7
ISSN	1471-2164 ; 1471-2164
ISSN (online)	1471-2164
ISSN	1471-2164
DOI	10.1186/s12864-023-09509-9
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Article: The spillover effect of fiscal environmental protection spending on residents’ medical and healthcare expenditure: evidence from China

Sheng, Wenxiang / Wan, Liang / Wang, Chengyuan

Environmental geochemistry and health. 2022 Sept., v. 44, no. 9

2022

Abstract: The Chinese government has not only been increasing investments in environmental protection, improving the quality of the ecological environment, but has also been focusing on curbing the excessive growth of medical and healthcare expenses so as to ease ... ...

Abstract	The Chinese government has not only been increasing investments in environmental protection, improving the quality of the ecological environment, but has also been focusing on curbing the excessive growth of medical and healthcare expenses so as to ease the economic burden of China’s residents. Both aspects are significant concerns worldwide and have received much research attention individually, but the relationship between government environmental protection expenditure and residents’ medical and healthcare expenditure remains unclear. Based on panel data from 31 provinces in China from 2007 to 2019, this paper empirically reveals that fiscal environmental protection expenditure is significantly negatively correlated with per capita medical and healthcare expenditure of residents (including outpatient expenditure and inpatient expenditure). This study shows that increasing the fiscal environmental protection expenditure can help curb the rising level of residents’ medical and healthcare expenditure. In addition, the results of heterogeneity analysis indicate that the above relationship is stronger in provinces with a relatively low level of economic development or low proportion of the population over 65 years old. Management implications are discussed.
Keywords	economic development ; environmental protection ; geochemistry ; health care costs ; China
Language	English
Dates of publication	2022-09
Size	p. 2975-2986.
Publishing place	Springer Netherlands
Document type	Article
ZDB-ID	52039-1
ISSN	1573-2983 ; 0142-7245 ; 0269-4042
ISSN (online)	1573-2983
ISSN	0142-7245 ; 0269-4042
DOI	10.1007/s10653-021-01146-z
Database	NAL-Catalogue (AGRICOLA)

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Article: Development of a cuproptosis-related signature for prognosis prediction in lung adenocarcinoma based on WGCNA.

Ling, Xiaodong / Zhang, Luquan / Fang, Chengyuan / Liang, Hao / Zhu, Jinhong / Ma, Jianqun

Translational lung cancer research

2023 Volume 12, Issue 4, Page(s) 754–769

Abstract: Background: Cuproptosis is a novel mitochondrial respiration-dependent cell death mechanism induced by copper that can kill cancer cells via copper carriers in cancer therapy. However, the clinical significance and prognostic value of cuproptosis in ... ...

Abstract	Background: Cuproptosis is a novel mitochondrial respiration-dependent cell death mechanism induced by copper that can kill cancer cells via copper carriers in cancer therapy. However, the clinical significance and prognostic value of cuproptosis in lung adenocarcinoma (LUAD) remains unclear. Methods: We performed a comprehensive bioinformatics analysis of the cuproptosis gene set, including copy number aberration, single-nucleotide variation, clinical characteristics, survival analysis, etc. Cuproptosis-related gene set enrichment scores (cuproptosis Z-scores) were calculated in The Cancer Genome Atlas (TCGA)-LUAD cohort using single-sample gene set enrichment analysis (ssGSEA). Modules significantly associated with cuproptosis Z-scores were screened by weighted gene co-expression network analysis (WGCNA). The hub genes of the module were then further screened by survival analysis and least absolute shrinkage and selection operator (LASSO) analysis, in which TCGA-LUAD (497 samples) and GSE72094 (442 samples) were used as the training and validation cohorts, respectively. Finally, we analyzed the tumor characteristics, immune cell infiltration levels, and potential therapeutic agents. Results: Missense mutation and copy number variant (CNV) events were general in the cuproptosis gene set. We identified 32 modules, of which the MEpurple (107 genes) and MEpink (131 genes) modules significantly positively and negatively correlated with cuproptosis Z-scores, respectively. We identified 35 hub genes significantly related to overall survival and constructed a prognostic model consisting of 7 cuproptosis-related genes in patients with LUAD. Compared with the low-risk group, patients in the high-risk group had a worse overall survival and gene mutation frequency, as well as significantly higher tumor purity. In addition, infiltration of immune cells was also significantly different between the 2 groups. Furthermore, the correlation between the risk scores and half-maximum inhibitory concentration (IC50) of antitumor drugs in the Genomics of Drug Sensitivity in Cancer (GDSC) v. 2 database was explored, revealing differences in drug sensitivity across the 2 risk groups. Conclusions: Our study provided a valid prognostic risk model for LUAD and improved understanding of its heterogeneity, which may aid in the development of personalized treatment strategies.
Language	English
Publishing date	2023-04-18
Publishing country	China
Document type	Journal Article
ZDB-ID	2754335-3
ISSN	2226-4477 ; 2218-6751
ISSN (online)	2226-4477
ISSN	2218-6751
DOI	10.21037/tlcr-23-157
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