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  1. Article ; Online: Progenitor hierarchy among parietal epithelial cells depicted at the single-cell level.

    Romagnani, Paola / Barisoni, Laura

    Kidney international

    2023  Volume 104, Issue 1, Page(s) 33–35

    Abstract: The role of parietal epithelial cells (PECs) in kidney function and disease was recently revisited. Building on previous studies of human kidney tissue, in the current issue, Liu et al. further characterize PECs using single-cell RNA sequencing data and ... ...

    Abstract The role of parietal epithelial cells (PECs) in kidney function and disease was recently revisited. Building on previous studies of human kidney tissue, in the current issue, Liu et al. further characterize PECs using single-cell RNA sequencing data and confirm the crucial pathophysiological role of PECs in murine kidney biology as a reservoir for different types of progenitors.
    MeSH term(s) Humans ; Mice ; Animals ; Kidney Glomerulus ; Podocytes/physiology ; Epithelial Cells/physiology ; Kidney
    Language English
    Publishing date 2023-06-20
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2023.04.019
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    Zs.A 797: Show issues Location:
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  2. Article: A novel agreement statistic using data on uncertainty in ratings.

    Zee, Jarcy / Mariani, Laura / Barisoni, Laura / Mahajan, Parag / Gillespie, Brenda

    Journal of the Royal Statistical Society. Series C, Applied statistics

    2023  Volume 72, Issue 5, Page(s) 1293–1309

    Abstract: Many existing methods for estimating agreement correct for chance agreement by adjusting the observed proportion agreement by the probability of chance agreement based on different assumptions. These assumptions may not always be appropriate, as ... ...

    Abstract Many existing methods for estimating agreement correct for chance agreement by adjusting the observed proportion agreement by the probability of chance agreement based on different assumptions. These assumptions may not always be appropriate, as demonstrated by pathologists' ratings of kidney biopsy descriptors. We propose a novel agreement statistic that accounts for the empirical probability of chance agreement, estimated by collecting additional data on rater uncertainty for each rating. A standard error estimator for the proposed statistic is derived. Simulation studies show that in most cases, our proposed statistic is unbiased in estimating the probability of agreement after removing chance agreement.
    Language English
    Publishing date 2023-07-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 1482300-7
    ISSN 1467-9876 ; 0035-9254
    ISSN (online) 1467-9876
    ISSN 0035-9254
    DOI 10.1093/jrsssc/qlad063
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  3. Article ; Online: Podocyte biology in segmental sclerosis and progressive glomerular injury.

    Barisoni, Laura

    Advances in chronic kidney disease

    2012  Volume 19, Issue 2, Page(s) 76–83

    Abstract: During the past 2 decades, progress has been made in understanding the biology and mechanisms of podocyte injury and the relationship of these processes to glomerulosclerosis. In addition, studies of human biopsies and animal models have provided ... ...

    Abstract During the past 2 decades, progress has been made in understanding the biology and mechanisms of podocyte injury and the relationship of these processes to glomerulosclerosis. In addition, studies of human biopsies and animal models have provided insights into the mechanisms of glomerular disease progression and repair. These new developments are critical for establishing better therapeutic guidelines that target specific pathways, which otherwise would lead to irreversible injury.
    MeSH term(s) Animals ; Cellular Senescence ; Disease Progression ; Female ; Glomerulosclerosis, Focal Segmental/pathology ; Humans ; Kidney Glomerulus/pathology ; Male ; Mice ; Podocytes/pathology ; Podocytes/physiology ; Rats
    Language English
    Publishing date 2012-03
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1548-5609 ; 1548-5595
    ISSN (online) 1548-5609
    ISSN 1548-5595
    DOI 10.1053/j.ackd.2012.02.018
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    Zs.A 4627: Show issues Location:
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  4. Article ; Online: Clinical Relevance of Computationally Derived Attributes of Peritubular Capillaries from Kidney Biopsies.

    Chen, Yijiang / Zee, Jarcy / Janowczyk, Andrew R / Rubin, Jeremy / Toro, Paula / Lafata, Kyle J / Mariani, Laura H / Holzman, Lawrence B / Hodgin, Jeffrey B / Madabhushi, Anant / Barisoni, Laura

    Kidney360

    2023  Volume 4, Issue 5, Page(s) 648–658

    MeSH term(s) Capillaries/pathology ; Clinical Relevance ; Kidney/pathology ; Kidney Transplantation ; Biopsy
    Language English
    Publishing date 2023-04-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ISSN 2641-7650
    ISSN (online) 2641-7650
    DOI 10.34067/KID.0000000000000116
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  5. Article ; Online: Daratumumab Use Prior to Kidney Transplant and T Cell-Mediated Rejection: A Case Report.

    Scalzo, Riley E / Sanoff, Scott L / Rege, Aparna S / Kwun, Jean / Knechtle, Stuart J / Barisoni, Laura / Byrns, Jennifer S

    American journal of kidney diseases : the official journal of the National Kidney Foundation

    2023  Volume 81, Issue 5, Page(s) 616–620

    Abstract: There is growing interest in daratumumab in the solid organ transplant realm owing to the potential immunomodulatory effects on CD38-expressing cells, primarily plasma cells, as they have a key role in antibody production. In particular there is interest ...

    Abstract There is growing interest in daratumumab in the solid organ transplant realm owing to the potential immunomodulatory effects on CD38-expressing cells, primarily plasma cells, as they have a key role in antibody production. In particular there is interest in use of daratumumab for desensitization and potential treatment for antibody-mediated rejection. However, ongoing investigation with daratumumab has shown potential immunologic concerns in vitro, with a significant increase in populations of CD4-positive cytotoxic T cells and CD8-positive helper T cells in both peripheral blood and bone marrow that could lead to acute T cell-mediated rejection in the solid organ transplant patient. To date, there are no published reports of an association with daratumumab use and T cell-mediated rejection in vivo. In this case report we present what is to our knowledge the first documented case of an early severe T cell-mediated rejection in a low-immunologic-risk living-donor kidney transplant recipient who received daratumumab for multiple myeloma maintenance prior to transplant.
    MeSH term(s) Humans ; Kidney Transplantation ; ADP-ribosyl Cyclase 1 ; Antibodies, Monoclonal/therapeutic use ; Multiple Myeloma/therapy ; T-Lymphocytes
    Chemical Substances daratumumab (4Z63YK6E0E) ; ADP-ribosyl Cyclase 1 (EC 3.2.2.6) ; Antibodies, Monoclonal
    Language English
    Publishing date 2023-01-06
    Publishing country United States
    Document type Case Reports ; Research Support, Non-U.S. Gov't
    ZDB-ID 604539-x
    ISSN 1523-6838 ; 0272-6386
    ISSN (online) 1523-6838
    ISSN 0272-6386
    DOI 10.1053/j.ajkd.2022.11.010
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    Zs.MO 468: Show issues

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  6. Article: ComPRePS: An Automated Cloud-based Image Analysis tool to democratize AI in Digital Pathology.

    Mimar, Sayat / Paul, Anindya S / Lucarelli, Nicholas / Border, Samuel / Santo, Briana A / Naglah, Ahmed / Barisoni, Laura / Hodgin, Jeffrey / Rosenberg, Avi Z / Clapp, William / Sarder, Pinaki

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Artificial intelligence (AI) has extensive applications in a wide range of disciplines including healthcare and clinical practice. Advances in high-resolution whole-slide brightfield microscopy allow for the digitization of histologically stained tissue ... ...

    Abstract Artificial intelligence (AI) has extensive applications in a wide range of disciplines including healthcare and clinical practice. Advances in high-resolution whole-slide brightfield microscopy allow for the digitization of histologically stained tissue sections, producing gigapixel-scale whole-slide images (WSI). The significant improvement in computing and revolution of deep neural network (DNN)-based AI technologies over the last decade allow us to integrate massively parallelized computational power, cutting-edge AI algorithms, and big data storage, management, and processing. Applied to WSIs, AI has created opportunities for improved disease diagnostics and prognostics with the ultimate goal of enhancing precision medicine and resulting patient care. The National Institutes of Health (NIH) has recognized the importance of developing standardized principles for data management and discovery for the advancement of science and proposed the Findable, Accessible, Interoperable, Reusable, (FAIR) Data Principles
    Language English
    Publishing date 2024-04-05
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.03.21.586102
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  7. Article ; Online: Digital pathology in nephrology clinical trials, research, and pathology practice.

    Barisoni, Laura / Hodgin, Jeffrey B

    Current opinion in nephrology and hypertension

    2017  Volume 26, Issue 6, Page(s) 450–459

    Abstract: Purpose of review: In this review, we will discuss (i) how the recent advancements in digital technology and computational engineering are currently applied to nephropathology in the setting of clinical research, trials, and practice; (ii) the benefits ... ...

    Abstract Purpose of review: In this review, we will discuss (i) how the recent advancements in digital technology and computational engineering are currently applied to nephropathology in the setting of clinical research, trials, and practice; (ii) the benefits of the new digital environment; (iii) how recognizing its challenges provides opportunities for transformation; and (iv) nephropathology in the upcoming era of kidney precision and predictive medicine.
    Recent findings: Recent studies highlighted how new standardized protocols facilitate the harmonization of digital pathology database infrastructure and morphologic, morphometric, and computer-aided quantitative analyses. Digital pathology enables robust protocols for clinical trials and research, with the potential to identify previously underused or unrecognized clinically useful parameters. The integration of digital pathology with molecular signatures is leading the way to establishing clinically relevant morpho-omic taxonomies of renal diseases.
    Summary: The introduction of digital pathology in clinical research and trials, and the progressive implementation of the modern software ecosystem, opens opportunities for the development of new predictive diagnostic paradigms and computer-aided algorithms, transforming the practice of renal disease into a modern computational science.
    MeSH term(s) Algorithms ; Biomedical Research ; Biotechnology/education ; Biotechnology/legislation & jurisprudence ; Clinical Trials as Topic ; Computers ; Humans ; Image Processing, Computer-Assisted ; Kidney/pathology ; Kidney Diseases/genetics ; Kidney Diseases/metabolism ; Kidney Diseases/pathology ; Microscopy/methods ; Nephrology/methods ; Pathology/methods ; Precision Medicine ; Software ; Telemedicine
    Language English
    Publishing date 2017-09-18
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1151092-4
    ISSN 1473-6543 ; 1535-3842 ; 1062-4813 ; 1062-4821
    ISSN (online) 1473-6543 ; 1535-3842
    ISSN 1062-4813 ; 1062-4821
    DOI 10.1097/MNH.0000000000000360
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    Zs.A 3686: Show issues Location:
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  8. Article ; Online: Integrin-β

    Yoo, Miran / Barisoni, Laura M C / Lee, Kyung / Gusella, G Luca

    American journal of physiology. Renal physiology

    2020  Volume 318, Issue 5, Page(s) F1306–F1312

    Abstract: Defects in the function of primary cilia are commonly associated with the development of renal cysts. On the other hand, the intact cilium appears to contribute a cystogenic signal whose effectors remain unclear. As integrin- ... ...

    Abstract Defects in the function of primary cilia are commonly associated with the development of renal cysts. On the other hand, the intact cilium appears to contribute a cystogenic signal whose effectors remain unclear. As integrin-β
    MeSH term(s) Animals ; Aquaporin 2/genetics ; Aquaporin 2/metabolism ; Cilia/metabolism ; Cilia/pathology ; Cytokines/metabolism ; Disease Models, Animal ; Fibrosis ; Inflammation Mediators/metabolism ; Integrin beta1/genetics ; Integrin beta1/metabolism ; Kidney/metabolism ; Kidney/pathology ; Kidney/physiopathology ; Kidney Diseases, Cystic/genetics ; Kidney Diseases, Cystic/metabolism ; Kidney Diseases, Cystic/pathology ; Kidney Diseases, Cystic/prevention & control ; Macrophages/metabolism ; Macrophages/pathology ; Mice, Knockout ; Signal Transduction ; Tumor Suppressor Proteins/genetics ; Tumor Suppressor Proteins/metabolism
    Chemical Substances Aqp2 protein, mouse ; Aquaporin 2 ; Cytokines ; Inflammation Mediators ; Integrin beta1 ; Itgb1 protein, mouse ; Tg737Rpw protein, mouse ; Tumor Suppressor Proteins
    Language English
    Publishing date 2020-04-20
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 603837-2
    ISSN 1522-1466 ; 0363-6127
    ISSN (online) 1522-1466
    ISSN 0363-6127
    DOI 10.1152/ajprenal.00070.2020
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  9. Article ; Online: Relationships among Non-Neoplastic Histopathological Features, Kidney Function, Proteinuria, and Other Clinical Factors in Patients Undergoing Nephrectomy.

    Aponte Becerra, Laura / Salcedo Betancourt, Juan D / Elfassy, Tali / Iakymenko, Oleksii / Thomas, David B / Isaac, Farid / Fornoni, Alessia / Zuo, Yiqin / Barisoni, Laura / Contreras, Gabriel / Munoz Mendoza, Jair

    Glomerular diseases

    2023  Volume 3, Issue 1, Page(s) 220–229

    Abstract: Introduction: The non-neoplastic kidney parenchyma from nephrectomies is often overlooked in routine examinations. We aimed to evaluate the associations between global glomerulosclerosis (GS), interstitial fibrosis (IF), or arteriosclerosis (AS) and ... ...

    Abstract Introduction: The non-neoplastic kidney parenchyma from nephrectomies is often overlooked in routine examinations. We aimed to evaluate the associations between global glomerulosclerosis (GS), interstitial fibrosis (IF), or arteriosclerosis (AS) and estimated glomerular filtration rate (eGFR), dipstick proteinuria, and other clinical factors.
    Methods: We performed a cross-sectional analysis of 781 patients with nephrectomy. We used regression models with and without interaction factors. The tested exposures were GS, IF, or AS, and the outcome measures were GFR and dipstick proteinuria.
    Results: In multivariable analyses, increasing degrees of GS, IF, or AS were significantly associated with lower eGFR and proteinuria (
    Conclusion: Greater degrees of each GS, IF, and AS are independently associated with proteinuria and lower eGFR. Obesity, HTN, proteinuria, and CVD modify the relationship between eGFR and specific histopathological features of nephrosclerosis.
    Language English
    Publishing date 2023-09-30
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2673-3633
    ISSN (online) 2673-3633
    DOI 10.1159/000534339
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  10. Article ; Online: Notch signaling: a common pathway of injury in podocytopathies?

    Barisoni, Laura

    Journal of the American Society of Nephrology : JASN

    2008  Volume 19, Issue 6, Page(s) 1045–1046

    MeSH term(s) Animals ; Humans ; Kidney Diseases/etiology ; Podocytes ; Receptors, Notch/physiology
    Chemical Substances Receptors, Notch
    Language English
    Publishing date 2008-06
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.2008040351
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