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Article: BRAZILIAN CONSENSUS STATEMENT ON VISCOSUPPLEMENTATION OF THE HIP (COBRAVI-Q).

Sousa, Eduardo Branco DE / Hamdan, Paulo César / Menegassi, Zartur José Barcelos / Alchaar, Adrieni Antunes DO Amaral / Tieppo, Antonio Martins / Souza, Caio Gonçalves DE / Pinheiro, Carlos Bruno Reis / Almeida, Cyro Scala DE / Rocha, Eduardo DE Melo Carvalho / Cunha, Fabiano Gonçalves / Pacheco, Ivan / Rezende, Marcia Uchôa DE / Souza, Márcio Passini Gonçalves DE / Britto DA Silva, Marcos / Campos, Gustavo Constantino DE

Acta ortopedica brasileira

2022 Volume 30, Issue 5, Page(s) e250414

Abstract: Objective: The Brazilian Consensus on Hip Viscosupplementation aims to generate a referential and consensual source from the theoretical knowledge and clinical experience of specialists in the field.: Methods: A multidisciplinary panel was formed ... ...

Abstract	Objective: The Brazilian Consensus on Hip Viscosupplementation aims to generate a referential and consensual source from the theoretical knowledge and clinical experience of specialists in the field. Methods: A multidisciplinary panel was formed with 15 specialists (sports medicine, orthopedists, physiatrists and rheumatologists), based on clinical and academic experience in the use of viscosupplementation of the hip. 12 statements were prepared, discussed and voted. Each panelist gave a value between 0 and 10 on a Likert scale, specifying their level of agreement with the statement. Results: The panel reached a consensus on several aspects of viscosupplementation of the hip, with emphasis on the following statements: best indication is for mild to moderate hip arthrosis; it may be indicated in severe osteoarthritis; results may vary according to the characteristics of the viscosupplement used; Viscosupplementation should not be performed as an isolated procedure, but in conjunction with other rehabilitation and pharmacological measures; best injection technique should be based on anatomical references coupled with imaging guidance; it is a cost-effective procedure. Conclusion: Viscosupplementation is a safe and effective therapy for hip osteoarthritis, even in severe cases. Guided injection is recommended.
Language	English
Publishing date	2022-11-11
Publishing country	Brazil
Document type	Journal Article ; Review
ZDB-ID	2105206-2
ISSN	1809-4406 ; 1413-7852
ISSN (online)	1809-4406
ISSN	1413-7852
DOI	10.1590/1413-785220223005e250414
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Article ; Online: High-Q lasing via all-dielectric Bloch-surface-wave platform.

Lee, Yang-Chun / Ho, Ya-Lun / Lin, Bo-Wei / Chen, Mu-Hsin / Xing, Di / Daiguji, Hirofumi / Delaunay, Jean-Jacques

Nature communications

2023 Volume 14, Issue 1, Page(s) 6458

Abstract: Controlling the propagation and emission of light via Bloch surface waves (BSWs) has held promise in the field of on-chip nanophotonics. BSW-based optical devices are being widely investigated to develop on-chip integration systems. However, a coherent ... ...

Abstract	Controlling the propagation and emission of light via Bloch surface waves (BSWs) has held promise in the field of on-chip nanophotonics. BSW-based optical devices are being widely investigated to develop on-chip integration systems. However, a coherent light source that is based on the stimulated emission of a BSW mode has yet to be developed. Here, we demonstrate lasers based on a guided BSW mode sustained by a gain-medium guiding structure microfabricated on the top of a BSW platform. A long-range propagation length of the BSW mode and a high-quality lasing emission of the BSW mode are achieved. The BSW lasers possess a lasing threshold of 6.7 μJ/mm
Language	English
Publishing date	2023-10-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-41471-8
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Article: Rapid Screening of 34 Emerging Contaminants in Surface Water by UHPLC-Q-TOF-MS.

Lü, Chen-Shan / Cao, Yi-Xuan / Mu, Xiao-Xi / Cui, Hai-Yan / Wang, Tao / Wei, Zhi-Wen / Yun, Ke-Ming / Hu, Meng

Fa yi xue za zhi

2024 Volume 40, Issue 1, Page(s) 30–36

Abstract: ... by ultra-high performance liquid chromatography-quadrupole-time of flight mass spectrometry (UHPLC-Q-TOF-MS ...

Abstract	Objectives: To establish a rapid screening method for 34 emerging contaminants in surface water by ultra-high performance liquid chromatography-quadrupole-time of flight mass spectrometry (UHPLC-Q-TOF-MS). Methods: The pretreatment conditions of solid phase extraction (SPE) were optimized by orthogonal experimental design and the surface water samples were concentrated and extracted by Oasis Results: The 34 emerging contaminants exhibited good linearity in the concentration range respectively and the correlation coefficients ( Conclusions: The method is simple and rapid for screening various emerging contaminants at the trace level in surface water.
MeSH term(s)	Tandem Mass Spectrometry/methods ; Chromatography, High Pressure Liquid/methods ; Water ; Formates ; Solid Phase Extraction/methods
Chemical Substances	formic acid (0YIW783RG1) ; Water (059QF0KO0R) ; Formates
Language	Chinese
Publishing date	2024-03-08
Publishing country	China
Document type	Journal Article
ISSN	1004-5619
ISSN	1004-5619
DOI	10.12116/j.issn.1004-5619.2022.320301
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Article: [Analysis of constituents in different parts of Forsythia suspensa by UPLC-Q-TOF-MS and evaluation of their anti-inflammatory activity].

Mu, Yue / Liu, Bo / Zhang, Xuan / Zhang, Ye / Wei, Jie / Wang, Xiao-Qing / Chen, Yu-Wu / Cui, Xiao-Lan / Pan, Ying-Ni / Sun, Yi

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

2024 Volume 49, Issue 4, Page(s) 968–980

Abstract: ... Q-TOF-MS) combined with a self-established chemical constituent database, including leaves, flowers ...

Abstract	This study aims to characterize and identify the chemical constituents in 11 parts of Forsythia suspensa by using ultra-performance liquid chromatography-quadrupole time of flight-mass spectrometry(UPLC-Q-TOF-MS) combined with a self-established chemical constituent database, including leaves, flowers, fruits, green F. suspensa, old F. suspensa, and seeds. The quality attributes and differences of different parts of F. suspensa were evaluated by principal component analysis, partial least square discriminant analysis, and other stoichiometric methods. A total of 79 compounds were identified, including 13 phenylethanol glycosides, 10 lignans, 12 flavonoids, 10 organic acids, 14 terpenoids, and 20 other types of compounds. Among them, 34 compounds were the main variables of difference between the different parts of F. suspensa, and the content of each component was relatively higher in the leaves and green F. suspensa. The LPS-induced inflammation model of RAW264.7 cells was applied to study the anti-inflammatory activity of the extracts of the different parts of F. suspensa and the main constituents. The results show that the extracts of green F. suspensa, flower, twig, and stem exhibited anti-inflammatory activity, and the constituents such as forsythoside A, phyllyrin, phillygenin, and(+)-pinoresinol-β-D-glucopyranoside could significantly inhibit anti-inflammatory activity released by NO. The chemical constituent in different parts of F. suspensa is analyzed comprehensively, and the anti-inflammatory activity is evaluated in this study, which provides a reference for the development and comprehensive utilization of F. suspensa resources.
MeSH term(s)	Plant Extracts/pharmacology ; Plant Extracts/chemistry ; Forsythia/chemistry ; Chromatography, High Pressure Liquid ; Flavonoids ; Anti-Inflammatory Agents/pharmacology
Chemical Substances	Plant Extracts ; Flavonoids ; Anti-Inflammatory Agents
Language	Chinese
Publishing date	2024-03-11
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	1004649-5
ISSN	1001-5302 ; 0254-0029
ISSN	1001-5302 ; 0254-0029
DOI	10.19540/j.cnki.cjcmm.20231106.202
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Article ; Online: Discussion of Details in the Application of Laser-Assisted Fluorescence Angiography With SPY-Q Software Analysis.

Li, Haoran / Mu, Dali

Aesthetic surgery journal

2023 Volume 43, Issue 8, Page(s) NP650–NP651

MeSH term(s)	Humans ; Fluorescein Angiography ; Indocyanine Green ; Lasers ; Software
Chemical Substances	Indocyanine Green (IX6J1063HV)
Language	English
Publishing date	2023-04-04
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	2087022-X
ISSN	1527-330X ; 1090-820X ; 1084-0761
ISSN (online)	1527-330X
ISSN	1090-820X ; 1084-0761
DOI	10.1093/asj/sjad081
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Book ; Online: High Q and high gradient performance of the first medium-temperature baking 1.3 GHz cryomodule

Zhai, Jiyuan / Pan, Weimin / He, Feisi / Ge, Rui / Mi, Zhenghui / Sha, Peng / Jin, Song / Han, Ruixiong / Wang, Qunyao / Lin, Haiying / Wang, Guangwei / Li, Mei / Sang, Minjing / Sun, Liangrui / Ye, Rui / Zhao, Tongxian / Li, Shaopeng / Zhu, Keyu / Liu, Baiqi /

2023

Abstract: World's first 1.3 GHz cryomodule containing eight 9-cell superconducting radio-frequency (RF) cavities treated by medium-temperature furnace baking (mid-T bake) was developed, assembled and tested at IHEP for the Dalian Advanced Light Source (DALS) and ... ...

Abstract	World's first 1.3 GHz cryomodule containing eight 9-cell superconducting radio-frequency (RF) cavities treated by medium-temperature furnace baking (mid-T bake) was developed, assembled and tested at IHEP for the Dalian Advanced Light Source (DALS) and CEPC R&D. The 9-cell cavities in the cryomodule achieved an unprecedented highest average Q0 of 3.8E10 at 16 MV/m and 3.6E10 at 21 MV/m in the horizontal test. The cryomodule can operate stably up to a total CW RF voltage greater than 191 MV, with an average cavity CW accelerating gradient of more than 23 MV/m. The results significantly exceed the specifications of CEPC, DALS and the other high repetition rate free electron laser facilities (LCLS-II, LCLS-II-HE, SHINE, S3FEL). There is evidence that the mid-T bake cavity may not require fast cool-down or long processing time in the cryomodule. This paper reviews the cryomodule performance and discusses some important issues in cryomodule assembly and testing. Comment: 5 pages, 6 figures
Keywords	Physics - Accelerator Physics
Subject code	621
Publishing date	2023-12-02
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Leonurus japonicus Houtt. (Motherwort): Systematic research through chemical profiling, stability under controlled conditions and pharmacokinetic analysis on screening Q-markers for quality control.

Zhao, Zi-Han / Yao, Zhi-Heng / Lin, Su-Jing / Chu, Ge / Mu, Kun-Qian / Wang, Yue / Bi, Kai-Shun / Wang, Tie-Jie / Li, Qing / Liu, Ran

Journal of pharmaceutical and biomedical analysis

2022 Volume 213, Page(s) 114707

Abstract: ... to stability and had pharmacokinetic behavior. Firstly, HPLC-Q-TOF-MS/MS was used to analyze the components ...

Abstract	Leonurus japonicus Houtt. (Motherwort) is the fresh or dried aerial part of Leonurus japonicus Houtt. (Labiaceae), which is widely used in clinical practice and daily life, used to treat gynecological diseases. However, the differences between different parts, single index component in Pharmacopoeias and the less stability of active ingredients affect its clinical efficacy. This study aimed to find the multi-active compounds between different parts of Motherwort to ensure its clinical efficacy, which related to stability and had pharmacokinetic behavior. Firstly, HPLC-Q-TOF-MS/MS was used to analyze the components in vitro and in vivo, as well as multivariate statistical analysis and network pharmacology analysis was conducted to find the significant different components related to activity. Secondly, the content determination methods were established to study the stability of effective components during storage in order to establish the content limit for quality control of Motherwort. Thirdly, UFLC-MS/MS was used to analyze the pharmacokinetic behavior of active components in Motherwort. The results showed that a total of 131 chemical constituents were identified in vitro and 21 prototype absorption compounds and 72 metabolites were found in vivo. Meantime, multivariate statistical analysis and network pharmacology analysis was combined to find that leonurine, stachydrine and trigonelline were activity-related substance, which could be used as active components related to pharmacodynamics in different parts. Then the stability variation trend and content limit of three alkaloids were found, which could be used for the quality control of Motherwort. Furthermore, the results showed that three alkaloids had pharmacokinetic behavior in vivo. 3 alkaloids were screened, which could be used as active components most closely related to pharmacodynamics among different parts. The stable stage, assay tolerance and pharmacokinetic characteristics were studied by the active substances, which could provide a basis for quality control and clinical medication of Motherwort.
MeSH term(s)	Chromatography, High Pressure Liquid/methods ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/pharmacology ; Leonurus/chemistry ; Quality Control ; Tandem Mass Spectrometry
Chemical Substances	Drugs, Chinese Herbal
Language	English
Publishing date	2022-03-04
Publishing country	England
Document type	Journal Article
ZDB-ID	604917-5
ISSN	1873-264X ; 0731-7085
ISSN (online)	1873-264X
ISSN	0731-7085
DOI	10.1016/j.jpba.2022.114707
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Article: [Chemical constituents and anti-liver fibrosis mechanism of Meconopsis quintuplinervia based on UPLC-Q-Exactive-MS/MS and network pharmacology].

Kong, Yuan-Lin / Zhang, Jian-Guang / Su, Hong-Na / LA, Mu-Jia / Lan, Jian-Long / Yang, Zheng-Ming / Ma, Quan / Huang, Yan-Fei / Liu, Yuan

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

2022 Volume 47, Issue 22, Page(s) 6097–6116

Abstract: In this study, UPLC-Q-Exactive-MS/MS was used to rapidly analyze the chemical constituents ...

Abstract	In this study, UPLC-Q-Exactive-MS/MS was used to rapidly analyze the chemical constituents of Meconopsis quintupli-nervia, and the anti-liver fibrosis mechanism of M. quintuplinervia was preliminarily analyzed by network pharmacology, molecular docking, and cell experiments. The chemical constituents of M. quintuplinervia were identified according to the information of MS~1 and MS~2, as well as the data in the literature and databases. SwissTargetPrediction and TargetNet were used to predict the potential targets. The targets related to liver fibrosis were collected from GeneCards and OMIM. The protein-protein interaction(PPI) network was constructed by STRING. Cytoscape 3.6.1 was used to construct and analyze the "constituent-target-disease" network to obtain key targets and their corresponding constituents in the network. DAVID 6.8 was used for GO analysis and KEGG signaling pathway enrichment analysis. Finally, the preliminary verification was carried out by molecular docking and cell experiments. As a result, 106 chemical constituents were identified from M. quintuplinervia, including 66 flavonoids, 16 alkaloids, 18 phenolic acids, 1 anthocyanin, and 5 other constituents. Among them, 3 constituents were identified as potential new compounds, and 59 constituents were reported in M. quintuplinervia for the first time. Network pharmacology analysis showed that M. quintuplinervia presumably acted on AKT1, SRC, JUN, EGFR, STAT3, HSP90 AA1, MAPK3, and other core targets through luteolin, isorhamnetin, quercetin, apigenin, kaempferide, amurine, 2-methylflavinantine, allocryptopine, the multi and other active compounds, thereby regulating the PI3 K/AKT signaling pathway, pathways in cancer, proteoglycans in cancer, FoxO signaling pathway, and other pathways to exert anti-liver fibrosis effects. M. quintuplinervia extract(MQE) could significantly down-regulate PI3 K and AKT protein levels in the HSC-T6 cell model induced by TGF-β1, suggesting that MQE may have the ability to regulate the PI3 K/AKT signaling pathway. The findings of this study indicated that the anti-liver fibrosis effect of M. quintuplinervia had multi-constituent, multi-target, and multi-pathway characteristics, which may provide a scientific basis for the research on the pharmacodynamic materials, action mechanism, and quality markers of M. quintupli-nervia.
Language	Chinese
Publishing date	2022-12-05
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	1004649-5
ISSN	1001-5302 ; 0254-0029
ISSN	1001-5302 ; 0254-0029
DOI	10.19540/j.cnki.cjcmm.20220917.201
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Article: Theoretical insight on the optical centred electrical properties of guanidinium isophthalate NLO crystal for electro-optic Q switches.

Era, Paavai / Jauhar, Ro Mu / Kamalesh, T / Prakash, T / Siva, V

Heliyon

2023 Volume 9, Issue 7, Page(s) e18311

Abstract: Guanidinium isophthalate single crystals with dimensions 16 × 4 x 2 ... ...

Abstract	Guanidinium isophthalate single crystals with dimensions 16 × 4 x 2 mm
Language	English
Publishing date	2023-07-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e18311
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Article ; Online: Protective effect and mechanism of styrax on ischemic stroke rats: metabonomic insights by UPLC-Q/TOF-MS analysis.

Mu, Fei / Lin, Rui / Lu, Xueyan / Zhao, Meina / Zhao, Jiaxin / Huang, Shaojie / Guo, Chao / Guan, Yue / Zhang, Haiyue / Xi, Miaomiao / Wang, Jingwen / Tang, Haifeng

Pharmaceutical biology

2023 Volume 61, Issue 1, Page(s) 1318–1331

Abstract: Context: Styrax is used for prevention and treatment of cerebrovascular diseases. However, the underlying mechanism remains unclear.: Objective: To elucidate styrax's anti-ischemic stroke protective effects and underlying mechanisms.: Materials and ...

Abstract	Context: Styrax is used for prevention and treatment of cerebrovascular diseases. However, the underlying mechanism remains unclear. Objective: To elucidate styrax's anti-ischemic stroke protective effects and underlying mechanisms. Materials and methods: An ischemic-stroke rat model was established based on middle cerebral artery occlusion (MCAO). Sprague-Dawley rats were randomly assigned to the following groups ( Results: The addition of 0.4 g/kg styrax significantly reduced cerebral infarct volume and neurobehavioral abnormality score. Different doses of styrax also decrease MDA, TNF-α, IL-6, and IL-1β, and increase SOD and GSH-Px in ischemic-stroke rats ( Conclusion: Styrax treatment could ameliorate ischemic-stroke rats by intervening with energy metabolism and glutamine metabolism. This can help us understand the mechanism of styrax, inspiring more clinical application and promotion.
MeSH term(s)	Rats ; Animals ; Rats, Sprague-Dawley ; Styrax ; Glutamine ; Metabolomics ; Ischemic Stroke ; Glutathione
Chemical Substances	Glutamine (0RH81L854J) ; Glutathione (GAN16C9B8O)
Language	English
Publishing date	2023-08-24
Publishing country	England
Document type	Journal Article
ZDB-ID	1440131-9
ISSN	1744-5116 ; 1388-0209
ISSN (online)	1744-5116
ISSN	1388-0209
DOI	10.1080/13880209.2023.2246501
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