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  1. Article ; Online: Is eradication of influenza B viruses possible?

    Koutsakos, Marios / Rockman, Steven / Krammer, Florian

    The Lancet. Infectious diseases

    2024  Volume 24, Issue 5, Page(s) 451–453

    MeSH term(s) Humans ; Influenza B virus ; Influenza, Human/prevention & control ; Disease Eradication ; Influenza Vaccines/administration & dosage ; Influenza Vaccines/immunology ; Global Health
    Chemical Substances Influenza Vaccines
    Language English
    Publishing date 2024-03-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(24)00132-4
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5743: Show issues Location:
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  2. Article ; Online: Immunological imprinting: Understanding COVID-19.

    Koutsakos, Marios / Ellebedy, Ali H

    Immunity

    2023  Volume 56, Issue 5, Page(s) 909–913

    Abstract: ... immune responses to, and eventually protection against, antigenically related viruses. Here, Koutsakos and Ellebedy ...

    Abstract Immunological imprinting generically refers to the effects prior exposures have on subsequent immune responses to, and eventually protection against, antigenically related viruses. Here, Koutsakos and Ellebedy explain different concepts and terms around imprinting and the fundamental immunological principles behind it. They also discuss the potential role imprinting may have in the context of COVID-19 vaccines.
    MeSH term(s) Humans ; COVID-19 Vaccines ; COVID-19
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2023-04-19
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2023.04.012
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  3. Article ; Online: Long Live the Plasma Cell: The Basis of Sustained Humoral Immunity.

    Koutsakos, Marios / Ellebedy, Ali H

    Journal of immunology (Baltimore, Md. : 1950)

    2022  Volume 209, Issue 1, Page(s) 3–4

    MeSH term(s) Immunity, Cellular ; Immunity, Humoral ; Immunoglobulin G ; Plasma Cells
    Chemical Substances Immunoglobulin G
    Language English
    Publishing date 2022-06-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.2200121
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  4. Article ; Online: Special Issue-Immunity to Influenza Viruses.

    Koutsakos, Marios / Valkenburg, Sophie A

    Viruses

    2022  Volume 14, Issue 2

    Abstract: Influenza viruses remain a constant global threat with significant health and socioeconomic impact every year and have the potential to cause devastating pandemics [ ... ]. ...

    Abstract Influenza viruses remain a constant global threat with significant health and socioeconomic impact every year and have the potential to cause devastating pandemics [...].
    MeSH term(s) Animals ; Antibodies, Viral/immunology ; Birds ; Humans ; Immunity ; Influenza Vaccines/administration & dosage ; Influenza Vaccines/genetics ; Influenza Vaccines/immunology ; Influenza in Birds/genetics ; Influenza in Birds/immunology ; Influenza in Birds/prevention & control ; Influenza in Birds/virology ; Influenza, Human/genetics ; Influenza, Human/immunology ; Influenza, Human/prevention & control ; Influenza, Human/virology ; Orthomyxoviridae/genetics ; Orthomyxoviridae/physiology ; Vaccination
    Chemical Substances Antibodies, Viral ; Influenza Vaccines
    Language English
    Publishing date 2022-02-03
    Publishing country Switzerland
    Document type Editorial ; Introductory Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v14020319
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  5. Article: Special Issue—Immunity to Influenza Viruses

    Koutsakos, Marios / Valkenburg, Sophie A.

    Viruses. 2022 Feb. 03, v. 14, no. 2

    2022  

    Abstract: Influenza viruses remain a constant global threat with significant health and socioeconomic impact every year and have the potential to cause devastating pandemics [ ... ] ...

    Abstract Influenza viruses remain a constant global threat with significant health and socioeconomic impact every year and have the potential to cause devastating pandemics [...]
    Keywords Influenza A virus ; pandemic ; socioeconomic factors ; viruses
    Language English
    Dates of publication 2022-0203
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2516098-9
    ISSN 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v14020319
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: A race to determine what drives COVID-19 severity.

    Koutsakos, Marios / Kedzierska, Katherine

    Nature

    2020  Volume 583, Issue 7816, Page(s) 366–368

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-07-13
    Publishing country England
    Document type News ; Comment
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/d41586-020-01915-3
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  7. Article ; Online: Influenza B virus neuraminidase: a potential target for next-generation vaccines?

    Do, Thi Hoai Thu / Wheatley, Adam K / Kent, Stephen J / Koutsakos, Marios

    Expert review of vaccines

    2023  Volume 23, Issue 1, Page(s) 39–48

    Abstract: Introduction: Influenza B viruses (IBV) cause a significant health and economic burden annually. Due to lower antigenic drift rate, less extensive antigenic diversity, and lack of animal reservoirs, the development of highly effective universal vaccines ...

    Abstract Introduction: Influenza B viruses (IBV) cause a significant health and economic burden annually. Due to lower antigenic drift rate, less extensive antigenic diversity, and lack of animal reservoirs, the development of highly effective universal vaccines against IBV might be in reach. Current seasonal influenza vaccines are formulated to induce antibodies against the Hemagglutinin (HA) protein, but their effectiveness is reduced by mismatch between vaccine and circulating strains.
    Areas covered: Given antibodies against the Neuraminidase (NA) have been associated with protection during influenza infection, there is considerable interest in the development of NA-based influenza vaccines. This review summarizes insights into the role of NA-based immunity against IBV and highlights knowledge gaps that should be addressed to inform the design of next-generation influenza B vaccines. We discuss how antibodies recognize broadly cross-reactive epitopes on the NA and the lack of understanding of IBV NA antigenic evolution which would benefit vaccine development in the future.
    Expert opinion: Demonstrating NA antibodies as correlates of protection for IBV in humans would be paramount. Determining the extent of IBV NA antigenic evolution will be informative. Finally, it will be critical to determine optimal strategies for incorporating the appropriate NA antigens in existing clinically approved vaccine formulations.
    MeSH term(s) Animals ; Humans ; Influenza, Human ; Influenza B virus ; Influenza Vaccines ; Neuraminidase ; Antigens, Viral ; Antibodies, Viral ; Hemagglutinin Glycoproteins, Influenza Virus ; Orthomyxoviridae Infections/prevention & control
    Chemical Substances Influenza Vaccines ; Neuraminidase (EC 3.2.1.18) ; Antigens, Viral ; Antibodies, Viral ; Hemagglutinin Glycoproteins, Influenza Virus
    Language English
    Publishing date 2023-12-14
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2181284-6
    ISSN 1744-8395 ; 1476-0584
    ISSN (online) 1744-8395
    ISSN 1476-0584
    DOI 10.1080/14760584.2023.2290691
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    Zs.A 6077: Show issues Location:
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  8. Article ; Online: The rise and fall of bone marrow plasma cells after influenza vaccination.

    Koutsakos, Marios / Ellebedy, Ali H

    Immunology and cell biology

    2020  Volume 99, Issue 2, Page(s) 130–132

    Abstract: A recent report by Davis et al. shows that following vaccination, B-cell activation results in the emergence of a population of antibody-secreting cells (plasmablasts - PBs) in blood and a population of plasma cells (PCs) in the bone marrow, which likely ...

    Abstract A recent report by Davis et al. shows that following vaccination, B-cell activation results in the emergence of a population of antibody-secreting cells (plasmablasts - PBs) in blood and a population of plasma cells (PCs) in the bone marrow, which likely originate from the day 7 PBs. However, these newly arrived PCs do not become long-lived and their abundance decreases by 1 year post-vaccination.
    MeSH term(s) Bone Marrow ; Bone Marrow Cells ; Humans ; Influenza, Human/prevention & control ; Plasma Cells ; Vaccination
    Language English
    Publishing date 2020-11-09
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 284057-1
    ISSN 1440-1711 ; 0818-9641
    ISSN (online) 1440-1711
    ISSN 0818-9641
    DOI 10.1111/imcb.12417
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  9. Article ; Online: Influenza B virus neuraminidase

    Thi Hoai Thu Do / Adam K. Wheatley / Stephen J. Kent / Marios Koutsakos

    Expert Review of Vaccines, Vol 23, Iss 1, Pp 39-

    a potential target for next-generation vaccines?

    2024  Volume 48

    Abstract: ABSTRACTIntroduction Influenza B viruses (IBV) cause a significant health and economic burden annually. Due to lower antigenic drift rate, less extensive antigenic diversity, and lack of animal reservoirs, the development of highly effective universal ... ...

    Abstract ABSTRACTIntroduction Influenza B viruses (IBV) cause a significant health and economic burden annually. Due to lower antigenic drift rate, less extensive antigenic diversity, and lack of animal reservoirs, the development of highly effective universal vaccines against IBV might be in reach. Current seasonal influenza vaccines are formulated to induce antibodies against the Hemagglutinin (HA) protein, but their effectiveness is reduced by mismatch between vaccine and circulating strains.Areas covered Given antibodies against the Neuraminidase (NA) have been associated with protection during influenza infection, there is considerable interest in the development of NA-based influenza vaccines. This review summarizes insights into the role of NA-based immunity against IBV and highlights knowledge gaps that should be addressed to inform the design of next-generation influenza B vaccines. We discuss how antibodies recognize broadly cross-reactive epitopes on the NA and the lack of understanding of IBV NA antigenic evolution which would benefit vaccine development in the future.Expert opinion Demonstrating NA antibodies as correlates of protection for IBV in humans would be paramount. Determining the extent of IBV NA antigenic evolution will be informative. Finally, it will be critical to determine optimal strategies for incorporating the appropriate NA antigens in existing clinically approved vaccine formulations.
    Keywords Antibodies ; influenza B virus ; neuraminidase ; universal vaccines ; antigenic evolution ; Internal medicine ; RC31-1245
    Language English
    Publishing date 2024-12-01T00:00:00Z
    Publisher Taylor & Francis Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: The ABC of Major Histocompatibility Complexes and T Cell Receptors in Health and Disease.

    Kedzierska, Katherine / Koutsakos, Marios

    Viral immunology

    2020  Volume 33, Issue 3, Page(s) 160–178

    Abstract: A seminal discovery of major histocompatibility complex (MHC) restriction in T cell recognition by Peter Doherty and Rolf Zinkernagel has led to 45 years of exciting research on the mechanisms governing peptide MHC (pMHC) recognition by T cell receptors ( ...

    Abstract A seminal discovery of major histocompatibility complex (MHC) restriction in T cell recognition by Peter Doherty and Rolf Zinkernagel has led to 45 years of exciting research on the mechanisms governing peptide MHC (pMHC) recognition by T cell receptors (TCRs) and their importance in health and disease. T cells provide a significant level of protection against viral, bacterial, and parasitic infections, as well as tumors, hence, the generation of protective T cell responses is a primary goal for cell-mediated vaccines and immunotherapies. Understanding the mechanisms underlying generation of optimal high-avidity effector T cell responses, memory development, maintenance, and recall is of major importance for the rational design of preventative and therapeutic vaccines/immunotherapies. In this review, we summarize the lessons learned over the last four decades and outline our current understanding of the basis and consequences of pMHC/TCR interactions on T cell development and function, and TCR diversity and composition, driving better clinical outcomes and prevention of viral escape. We also discuss the current models of T cell memory formation and determinants of immunodominant T cell responses in animal models and humans. As TCR composition and diversity can affect both the protective capacity of T cells and protection against viral escape, defining the spectrum of TCR selection has implications for improving the functional efficacy of effector T cell responsiveness and memory formation.
    MeSH term(s) Allergy and Immunology/history ; Animals ; History, 20th Century ; History, 21st Century ; Humans ; Infections/immunology ; Infections/microbiology ; Infections/parasitology ; Infections/virology ; Major Histocompatibility Complex/genetics ; Major Histocompatibility Complex/immunology ; Peptides/immunology ; Protein Binding ; Receptors, Antigen, T-Cell/immunology ; T-Lymphocytes/immunology
    Chemical Substances Peptides ; Receptors, Antigen, T-Cell
    Language English
    Publishing date 2020-04-14
    Publishing country United States
    Document type Historical Article ; Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 639075-4
    ISSN 1557-8976 ; 0882-8245
    ISSN (online) 1557-8976
    ISSN 0882-8245
    DOI 10.1089/vim.2019.0184
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