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Article ; Online: Changes in pairwise correlations during running reshape global network state in the main olfactory bulb.

Chockanathan, Udaysankar / Crosier, Emily J W / Waddle, Spencer / Lyman, Edward / Gerkin, Richard C / Padmanabhan, Krishnan

Journal of neurophysiology

2021 Volume 125, Issue 5, Page(s) 1612–1623

Abstract: ... 3rd, 4th order) interactions governed population activity during locomotion. Taken together, we found ...

Abstract	Neural codes for sensory inputs have been hypothesized to reside in a broader space defined by ongoing patterns of spontaneous activity. To understand the structure of this spontaneous activity in the olfactory system, we performed high-density recordings of neural populations in the main olfactory bulb of awake mice. We observed changes in pairwise correlations of spontaneous activity between mitral and tufted (M/T) cells when animals were running, which resulted in an increase in the entropy of the population. Surprisingly, pairwise maximum entropy models that described the population activity using only assumptions about the firing rates and correlations of neurons were better at predicting the global structure of activity when animals were stationary as compared to when they were running, implying that higher order (3rd, 4th order) interactions governed population activity during locomotion. Taken together, we found that locomotion alters the functional interactions that shape spontaneous population activity at the earliest stages of olfactory processing, one synapse away from the sensory receptors in the nasal epithelium. These data suggest that the coding space available for sensory representations responds adaptively to the animal's behavioral state.
MeSH term(s)	Animals ; Behavior, Animal/physiology ; Electrophysiological Phenomena/physiology ; Female ; Male ; Mice ; Mice, Inbred C57BL ; Nerve Net/physiology ; Olfactory Bulb/physiology ; Olfactory Perception/physiology ; Running/physiology
Language	English
Publishing date	2021-03-03
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	80161-6
ISSN	1522-1598 ; 0022-3077
ISSN (online)	1522-1598
ISSN	0022-3077
DOI	10.1152/jn.00464.2020
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Article ; Online: SWDreader: a wavelet-based algorithm using spectral phase to characterize spike-wave morphological variation in genetic models of absence epilepsy.

Richard, C D / Tanenbaum, A / Audit, B / Arneodo, A / Khalil, A / Frankel, W N

Journal of neuroscience methods

2015 Volume 242, Page(s) 127–140

Abstract: ... between phase values at SWD fundamental frequency from the 2nd, 3rd, and 4th harmonics, then using ... SWD, and (3) regularities in the spectral power and phase profiles of SWCs can be used to detect ...

Abstract	Background: Spike-wave discharges (SWD) found in neuroelectrical recordings are pathognomonic to absence epilepsy. The characteristic spike-wave morphology of the spike-wave complex (SWC) constituents of SWDs can be mathematically described by a subset of possible spectral power and phase values. Morlet wavelet transform (MWT) generates time-frequency representations well-suited to identifying this SWC-associated subset. New method: MWT decompositions of SWDs reveal spectral power concentrated at harmonic frequencies. The phase relationships underlying SWC morphology were identified by calculating the differences between phase values at SWD fundamental frequency from the 2nd, 3rd, and 4th harmonics, then using the three phase differences as coordinates to generate a density distribution in a {360°×360°×360°} phase difference space. Strain-specific density distributions were generated from SWDs of mice carrying the Gria4, Gabrg2, or Scn8a mutations to determine whether SWC morphological variants reliably mapped to the same regions of the distribution, and if distribution values could be used to detect SWD. Comparison with existing methods: To the best of our knowledge, this algorithm is the first to employ spectral phase to quantify SWC morphology, making it possible to computationally distinguish SWC morphological subtypes and detect SWDs. Results/conclusions: Proof-of-concept testing of the SWDfinder algorithm shows: (1) a major pattern of variation in SWC morphology maps to one axis of the phase difference distribution, (2) variability between the strain-specific distributions reflects differences in the proportions of SWC subtypes generated during SWD, and (3) regularities in the spectral power and phase profiles of SWCs can be used to detect waveforms possessing SWC-like morphology.
MeSH term(s)	Algorithms ; Animals ; Brain/physiopathology ; Disease Models, Animal ; Electroencephalography/methods ; Epilepsy, Absence/diagnosis ; Epilepsy, Absence/genetics ; Epilepsy, Absence/physiopathology ; Mice, Inbred C3H ; Mice, Transgenic ; Mutation ; Seizures/diagnosis ; Seizures/genetics ; Seizures/physiopathology ; Wavelet Analysis
Language	English
Publishing date	2015-03-15
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	282721-9
ISSN	1872-678X ; 0165-0270
ISSN (online)	1872-678X
ISSN	0165-0270
DOI	10.1016/j.jneumeth.2014.12.016
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Article: Nivolumab-induced fulminant diabetic ketoacidosis followed by thyroiditis.

Tzoulis, Ploutarchos / Corbett, Richard W / Ponnampalam, Swarupini / Baker, Elly / Heaton, Daniel / Doulgeraki, Triada / Stebbing, Justin

Endocrinology, diabetes & metabolism case reports

2018 Volume 2018

Abstract: Five days following the 3rd cycle of nivolumab, a monoclonal antibody, which acts as immune ... and anti-GAD antibodies were 12 kIU/L (0-5 kU/L), while islet cell antibodies and serum C-peptide were ...

Abstract	Five days following the 3rd cycle of nivolumab, a monoclonal antibody, which acts as immune checkpoint inhibitor against the programmed cell death protein-1, for metastatic lung adenocarcinoma, a 56-year-old woman presented at the hospital critically ill. On admission, she had severe diabetic ketoacidosis (DKA), as evidenced by venous glucose of 47 mmol/L, blood ketones of 7.5 mmol/L, pH of 6.95 and bicarbonate of 6.6 mmol/L. She has had no personal or family history of diabetes mellitus (DM), while random venous glucose, measured 1 week prior to hospitalisation, was 6.1 mmol/L. On admission, her HbA1c was 8.2% and anti-GAD antibodies were 12 kIU/L (0-5 kU/L), while islet cell antibodies and serum C-peptide were undetectable. Nivolumab was recommenced without the development of other immune-mediated phenomena until 6 months later, when she developed hypothyroidism with TSH 18 U/L and low free T4. She remains insulin dependent and has required levothyroxine replacement, while she has maintained good radiological and clinical response to immunotherapy. This case is notable for the rapidity of onset and profound nature of DKA at presentation, which occurred two months following commencement of immunotherapy. Despite the association of nivolumab with immune-mediated endocrinopathies, only a very small number of patients developing type 1 DM has been reported to date. Patients should be closely monitored for hyperglycaemia and thyroid dysfunction prior to and periodically during immunotherapy. Learning points: Nivolumab can induce fulminant type 1 diabetes, resulting in DKA.Nivolumab is frequently associated with thyroid dysfunction, mostly hypothyroidism.Nivolumab-treated patients should be monitored regularly for hyperglycaemia and thyroid dysfunction.Clinicians should be aware and warn patients of potential signs and symptoms of severe hyperglycaemia.
Language	English
Publishing date	2018-03-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2785530-2
ISSN	2052-0573
ISSN	2052-0573
DOI	10.1530/EDM-18-0111
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Article ; Online: Social status and aggressive and disruptive behavior in girls: individual, group, and classroom influences.

Estell, David B / Farmer, Thomas W / Pearl, Ruth / Van Acker, Richard / Rodkin, Philip C

Journal of school psychology

2008 Volume 46, Issue 2, Page(s) 193–212

Abstract: ... affect the association between overt aggression and social status in a sample of 187 3rd grade girls ...

Abstract	Recent studies have found distinct subtypes of aggressive youth, marked by either high social status or social marginalization, and that various measures of status differentially associate with aggression. The majority of these studies, however, focused on boys, adolescents, and/or relational aggression in girls. The current research examined how the kind of status measured and the social ecology affect the association between overt aggression and social status in a sample of 187 3rd grade girls. Cluster analysis uncovered aggressive-popular, aggressive-unpopular, and prosocial-popular configurations. Although likeability was related solely to prosocial behavior, other measures of status co-occurred with both prosocial and aggressive behavior. Peer-group behavior complemented that of individuals, though peer-group and classroom acceptance of aggression were not related to cluster prevalence.
MeSH term(s)	Aggression/psychology ; Attention Deficit and Disruptive Behavior Disorders/epidemiology ; Attention Deficit and Disruptive Behavior Disorders/psychology ; Child ; Female ; Humans ; Peer Group ; Social Class ; Social Environment ; Social Perception
Language	English
Publishing date	2008-04
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2007811-0
ISSN	1873-3506 ; 0022-4405
ISSN (online)	1873-3506
ISSN	0022-4405
DOI	10.1016/j.jsp.2007.03.004
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Article: A novel alpha conotoxin (alpha-PIB) isolated from C. purpurascens is selective for skeletal muscle nicotinic acetylcholine receptors.

López-Vera, Estuardo / Jacobsen, Richard B / Ellison, Michael / Olivera, Baldomero M / Teichert, Russell W

Toxicon : official journal of the International Society on Toxinology

2007 Volume 49, Issue 8, Page(s) 1193–1199

Abstract: ... conotoxins, so named for the number of amino acids between 2nd/3rd and 3rd/4th cysteine residues ... of cysteine residues in the primary amino acid sequence: -CC-C-C-, where each dash represents a variable ... the alpha-conotoxins into distinct subfamilies. These subfamilies include the alpha 4/7-, alpha 4/3- and alpha 3/5 ...

Abstract	The alpha-conotoxin family is comprised of peptides that share the following arrangement of cysteine residues in the primary amino acid sequence: -CC-C-C-, where each dash represents a variable number of amino acids. The number of amino acids between cysteine residues has been used to group the alpha-conotoxins into distinct subfamilies. These subfamilies include the alpha 4/7-, alpha 4/3- and alpha 3/5-conotoxins, so named for the number of amino acids between 2nd/3rd and 3rd/4th cysteine residues, respectively. The alpha 3/5-conotoxins antagonize vertebrate-muscle nicotinic acetylcholine receptors (nAChRs), while the alpha 4/7- and alpha 4/3-conotoxins primarily inhibit vertebrate neuronal nAChRs. To date, these three subfamilies are the most extensively characterized of the alpha-conotoxin family. Here we report the purification and characterization of an unusual alpha 4/4-conotoxin, alpha-conotoxin PIB (alpha-PIB), from the venom of Conus purpurascens, with the following amino-acid sequence: ZSOGCCWNPACVKNRC (Z=pyroglutamate, O=hydroxyproline). This peptide demonstrates high affinity inhibition of vertebrate-muscle nAChRs, and paralytic effects when injected in vivo. Testing of alpha-PIB against other receptors indicated that the inhibitory effect is specific for skeletal muscle nAChRs. alpha-PIB shares the key biochemical and pharmacological characteristics of the alpha-conotoxin family.
MeSH term(s)	Amino Acid Sequence ; Animals ; Base Sequence ; Chromatography, High Pressure Liquid ; Conotoxins/genetics ; Conotoxins/toxicity ; Conus Snail/chemistry ; Electrophysiology ; Goldfish ; Mass Spectrometry ; Molecular Sequence Data ; Muscle, Skeletal/drug effects ; Muscle, Skeletal/metabolism ; Nicotinic Antagonists/metabolism ; Sequence Analysis, DNA
Chemical Substances	Conotoxins ; Nicotinic Antagonists
Language	English
Publishing date	2007-06-15
Publishing country	England
Document type	Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	204479-1
ISSN	1879-3150 ; 0041-0101
ISSN (online)	1879-3150
ISSN	0041-0101
DOI	10.1016/j.toxicon.2007.02.007
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Article ; Online: Remediating organizational functioning in children with ADHD: immediate and long-term effects from a randomized controlled trial.

Abikoff, Howard / Gallagher, Richard / Wells, Karen C / Murray, Desiree W / Huang, Lei / Lu, Feihan / Petkova, Eva

Journal of consulting and clinical psychology

2012 Volume 81, Issue 1, Page(s) 113–128

Abstract: ... organization, time management, and planning (OTMP) difficulties in 3rd- to 5th-grade children ... Sixty percent of OST and PATHKO participants versus 3% of controls no longer met OTMP inclusion criteria ...

Abstract	Objective: The study compared the efficacy of 2 behavioral interventions to ameliorate organization, time management, and planning (OTMP) difficulties in 3rd- to 5th-grade children with attention-deficit/hyperactivity disorder (ADHD). Method: In a dual-site randomized controlled trial, 158 children were assigned to organizational skills training (OST; N = 64); PATHKO, a performance-based intervention that precluded skills training (N = 61); or a wait-list control (WL, N = 33). Treatments were 20 individual clinic-based sessions over 10-12 weeks. OST involved skills building provided primarily to the child. PATHKO trained parents and teachers to reinforce children contingently for meeting end-point target goals. Primary outcomes were the Children's Organizational Skills Scales (COSS-Parent, COSS-Teacher). Other relevant functional outcomes were assessed. Percentage of participants no longer meeting inclusion criteria for OTMP impairments informed on clinical significance. Assessments occurred at post-treatment, 1-month post-treatment, and twice in the following school year. Results: OST was superior to WL on the COSS-P (Cohen's d = 2.77; p < .0001), COSS-T (d = 1.18; p < .0001), children's COSS self-ratings, academic performance and proficiency, homework, and family functioning. OST was significantly better than PATHKO only on the COSS-P (d = 0.63; p < .005). PATHKO was superior to WL on most outcomes but not on academic proficiency. Sixty percent of OST and PATHKO participants versus 3% of controls no longer met OTMP inclusion criteria. Significant maintenance effects were found for both treatments. Conclusions: Two distinct treatments targeting OTMP problems in children with ADHD generated robust, sustained functional improvements. The interventions show promise of clinical utility in children with ADHD and organizational deficits.
MeSH term(s)	Attention Deficit Disorder with Hyperactivity/psychology ; Attention Deficit Disorder with Hyperactivity/therapy ; Behavior Therapy/methods ; Child ; Educational Status ; Family ; Female ; Humans ; Male ; Parents ; Time ; Time Management ; Treatment Outcome
Language	English
Publishing date	2012-08-13
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural
ZDB-ID	121321-0
ISSN	1939-2117 ; 0022-006X
ISSN (online)	1939-2117
ISSN	0022-006X
DOI	10.1037/a0029648
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Article: Selected Contribution: Identification of differentially expressed genes between young and old rat soleus muscle during recovery from immobilization-induced atrophy.

Pattison, J Scott / Folk, Lillian C / Madsen, Richard W / Booth, Frank W

Journal of applied physiology (Bethesda, Md. : 1985)

2003 Volume 95, Issue 5, Page(s) 2171–2179

Abstract: ... but was elevated on the 3rd, 6th, and 10th days of recovery in old soleus muscles. The mRNAs identified ... levels of >24,000 transcripts were determined by using Affymetrix RGU34A-C high-density ... muscle of young (3- to 4-mo-old) but absent in old (30- to 31-mo-old) Fischer 344 x Brown Norway rats or ...

Abstract	After cessation of hindlimb immobilization, which resulted in a 27-37% loss in soleus mass, the atrophied soleus muscle of young but not old rats regrows to its mass before treatment. We hypothesized that during remobilization the mRNA levels of growth potentiating factor(s) would be present in the soleus muscle of young (3- to 4-mo-old) but absent in old (30- to 31-mo-old) Fischer 344 x Brown Norway rats or that mRNAs for growth inhibitory factor(s) would be absent in young but present in old. Gene expression levels of >24,000 transcripts were determined by using Affymetrix RGU34A-C high-density oligonucleotide microarrays in soleus muscles at 3, 6, 10, and 30 days of remobilization after cessation of a 10-day period of hindlimb immobilization. Each muscle sample was applied to an independent set of arrays. Recovery-related differences were determined by using a three-factor ANOVA with a false discovery rate-adjustment of P = 0.01, which yielded 64 significantly different probe sets. Elfin, amphiregulin, and clusterin mRNAs were selected for further confirmation by real-time PCR. Elfin mRNA levels were less in old than in young rats at 6, 10, and 30 days of remobilization. Amphiregulin expression exhibited a unique spike on the 10th day of successful regrowth in young rats but remained unchanged old. Clusterin mRNA was unchanged in young muscles but was elevated on the 3rd, 6th, and 10th days of recovery in old soleus muscles. The mRNAs identified as differentially expressed between young and old recovery may modulate muscle growth that could highlight new candidate mechanisms to explain the failure of old soleus muscle to recover lost muscle mass.
MeSH term(s)	Aging/physiology ; Amphiregulin ; Animals ; Clusterin ; EGF Family of Proteins ; Gene Expression/physiology ; Glycoproteins/genetics ; Hindlimb Suspension/adverse effects ; Hindlimb Suspension/physiology ; Homeodomain Proteins/genetics ; Intercellular Signaling Peptides and Proteins/genetics ; LIM Domain Proteins ; Male ; Molecular Chaperones/genetics ; Muscle, Skeletal/physiology ; Muscular Atrophy/genetics ; Muscular Atrophy/physiopathology ; Oligonucleotide Array Sequence Analysis ; RNA, Messenger/metabolism ; Rats ; Rats, Inbred BN ; Rats, Inbred F344 ; Recovery of Function/genetics
Chemical Substances	Amphiregulin ; Areg protein, rat ; Clusterin ; EGF Family of Proteins ; Glycoproteins ; Homeodomain Proteins ; Intercellular Signaling Peptides and Proteins ; LIM Domain Proteins ; Molecular Chaperones ; Pdlim1 protein, rat ; RNA, Messenger
Language	English
Publishing date	2003-11
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	219139-8
ISSN	1522-1601 ; 8750-7587 ; 0021-8987 ; 0161-7567
ISSN (online)	1522-1601
ISSN	8750-7587 ; 0021-8987 ; 0161-7567
DOI	10.1152/japplphysiol.00500.2003
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Article ; Online: Consensus on women's health aspects of polycystic ovary syndrome (PCOS): the Amsterdam ESHRE/ASRM-Sponsored 3rd PCOS Consensus Workshop Group.

Fauser, Bart C J M / Tarlatzis, Basil C / Rebar, Robert W / Legro, Richard S / Balen, Adam H / Lobo, Roger / Carmina, Enrico / Chang, Jeffrey / Yildiz, Bulent O / Laven, Joop S E / Boivin, Jacky / Petraglia, Felice / Wijeyeratne, C N / Norman, Robert J / Dunaif, Andrea / Franks, Stephen / Wild, Robert A / Dumesic, Daniel / Barnhart, Kurt

Fertility and sterility

2011 Volume 97, Issue 1, Page(s) 28–38.e25

Abstract: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in females, with a high prevalence. The etiology of this heterogeneous condition remains obscure, and its phenotype expression varies. Two widely cited previous ESHRE/ASRM sponsored ... ...

Abstract	Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in females, with a high prevalence. The etiology of this heterogeneous condition remains obscure, and its phenotype expression varies. Two widely cited previous ESHRE/ASRM sponsored PCOS consensus workshops focused on diagnosis (published in 2004) and infertility management (published in 2008), respectively. The present third PCOS consensus report summarizes current knowledge and identifies knowledge gaps regarding various women's health aspects of PCOS. Relevant topics addressed-all dealt with in a systematic fashion-include adolescence, hirsutism and acne, contraception, menstrual cycle abnormalities, quality of life, ethnicity, pregnancy complications, long-term metabolic and cardiovascular health, and finally cancer risk. Additional, comprehensive background information is provided separately in an extended online publication.
MeSH term(s)	Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/therapy ; Consensus ; Female ; Humans ; Infertility, Female/epidemiology ; Infertility, Female/etiology ; Infertility, Female/therapy ; Metabolic Diseases/epidemiology ; Metabolic Diseases/etiology ; Metabolic Diseases/therapy ; Neoplasms/epidemiology ; Neoplasms/etiology ; Neoplasms/therapy ; Polycystic Ovary Syndrome/complications ; Polycystic Ovary Syndrome/epidemiology ; Polycystic Ovary Syndrome/therapy ; Pregnancy ; Pregnancy Complications/epidemiology ; Pregnancy Complications/etiology ; Pregnancy Complications/therapy ; Risk Factors
Language	English
Publishing date	2011-12-06
Publishing country	United States
Document type	Consensus Development Conference ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80133-1
ISSN	1556-5653 ; 0015-0282
ISSN (online)	1556-5653
ISSN	0015-0282
DOI	10.1016/j.fertnstert.2011.09.024
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Article ; Conference proceedings: Consensus on women’s health aspects of polycystic ovary syndrome (PCOS): the Amsterdam ESHRE/ASRM-Sponsored 3rd PCOS Consensus Workshop Group

Fauser, Bart C.J.M / Tarlatzis, Basil C / Rebar, Robert W / Legro, Richard S / Balen, Adam H / Lobo, Roger / Carmina, Enrico / Chang, Jeffrey / Yildiz, Bulent O / Laven, Joop S.E / Boivin, Jacky / Petraglia, Felice / Wijeyeratne, C.N / Norman, Robert J / Dunaif, Andrea / Franks, Stephen / Wild, Robert A / Dumesic, Daniel / Barnhart, Kurt

Fertility and sterility. 2012 Jan., v. 97, no. 1

2012

Abstract	Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in females, with a high prevalence. The etiology of this heterogeneous condition remains obscure, and its phenotype expression varies. Two widely cited previous ESHRE/ASRM sponsored PCOS consensus workshops focused on diagnosis (published in 2004) and infertility management (published in 2008), respectively. The present third PCOS consensus report summarizes current knowledge and identifies knowledge gaps regarding various women’s health aspects of PCOS. Relevant topics addressed—all dealt with in a systematic fashion—include adolescence, hirsutism and acne, contraception, menstrual cycle abnormalities, quality of life, ethnicity, pregnancy complications, long-term metabolic and cardiovascular health, and finally cancer risk. Additional, comprehensive background information is provided separately in an extended online publication.
Keywords	acne ; adolescence ; animal ovaries ; contraception ; etiology ; females ; menstrual cycle ; nationalities and ethnic groups ; phenotype ; polycystic ovary syndrome ; pregnancy complications ; quality of life ; risk ; women
Language	English
Dates of publication	2012-01
Size	p. 28-38.e25.
Publishing place	Elsevier Inc.
Document type	Article ; Conference proceedings
ZDB-ID	80133-1
ISSN	1556-5653 ; 0015-0282
ISSN (online)	1556-5653
ISSN	0015-0282
DOI	10.1016/j.fertnstert.2011.09.024
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Article ; Online: The Effects of a DNA Virus Infection on the Reproductive Potential of Female Tsetse Flies, Glossina morsitans centralis and Glossina morsitans morsitans (Diptera

Sang Rosemary C / Jura Walter GZO / Otieno Leonard H / Mwangi Richard W

Memórias do Instituto Oswaldo Cruz., Vol 93, Iss 6, Pp 861-

Glossinidae)

1998 Volume 864

Abstract: ... the 3rd instar larval stage were studied and the data compared to those obtained from the control females ...

Abstract	Reproductive anomalies associated with the tsetse DNA virus infection in the female tsetse hosts, Glossina morsitans centralis Machado and Glossina morsitans morsitans Westwood, inoculated with the virus during the 3rd instar larval stage were studied and the data compared to those obtained from the control females injected with sterile physiological saline. Virus infected flies had significantly longer first and second pregnancy cycles (P<0.0001) and produced pupae that were of significantly less weight in milligrams (P<0.0001) compared to controls. Transmission of the virus to progeny was not absolute and only 21% of G. m. centralis and 48% of G. m. morsitans first progeny flies from infected females developed salivary gland hypertrophy as a result of transmission from mother to progeny. The virus infected females produced significantly fewere pupae compared to the controls during the experimental period (P<0.00001).
Keywords	DNA virus ; tsetse fly ; Glossina morsitans centralis ; Glossina morsitans morsitans ; reproductive potential ; pregnancy cycle ; pupal weights ; transovarial transmission ; Microbiology ; QR1-502 ; Science ; Q ; DOAJ:Microbiology ; DOAJ:Biology ; DOAJ:Biology and Life Sciences ; Arctic medicine. Tropical medicine ; RC955-962 ; Special situations and conditions ; RC952-1245 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Internal medicine ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Language	English
Publishing date	1998-01-01T00:00:00Z
Publisher	Instituto Oswaldo Cruz, Ministério da Saúde
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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