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Article ; Online: The development and application of the Malocclusion Impact Questionnaire (MIQ Chinese version)

XIN Weini / LI Chuang / XU Keying / XU Qingfeng

口腔疾病防治, Vol 30, Iss 11, Pp 805-

2022 Volume 810

Abstract: Objective To explore the feasibility of applying the Malocclusion Impact Questionnaire (MIQ) of Chinese version among Chinese teenagers, through the verification and evaluation of the Chinese version. Methods According to the standard procedures of the ... ...

Abstract	Objective To explore the feasibility of applying the Malocclusion Impact Questionnaire (MIQ) of Chinese version among Chinese teenagers, through the verification and evaluation of the Chinese version. Methods According to the standard procedures of the international quality of life assessment program, the MIQ was translated, back translated, adapted and updated culturally, and the Chinese version was established. The 161 teenagers with the first orthodontic treatment were included. This patient group was assessed for oral health-related quality of life by the Chinese version of the MIQ and Children's Perception Questionnaire (11-14 years old). The reliability and validity of the Chinese version of the MIQ were evaluated statistically by Spearman and factor analysis. Results A total of 161 valid questionnaires were collected. The internal consistency Cronbach's α of the Chinese scale was 0.887. The correlation coefficient between items and the scale ranged from 0.000 1 to 0.824. A significant positive correlation of the scores was noted between the translated scale and the Children's Perception Questionnaire (11-14 years old), and the correlation coefficient was 0.444 (P<0.001). Conclusion The reliability and validity of the Chinese version of the MIQ are reliable and can be applied for clinical orthodontic treatment.
Keywords	malocclusion ; psychometry ; quality of life ; factor analysis ; malocclusion impact questionnaire ; international quality of life assessment project ; teenager ; orthodontic treatment ; health-related quality of life ; Medicine ; R
Subject code	710
Language	Chinese
Publishing date	2022-11-01T00:00:00Z
Publisher	Editorial Department of Journal of Prevention and Treatment for Stomatological Diseases
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Accurate mandibular canal segmentation of dental CBCT using a two-stage 3D-UNet based segmentation framework.

Lin, Xi / Xin, Weini / Huang, Jingna / Jing, Yang / Liu, Pengfei / Han, Jingdan / Ji, Jie

BMC oral health

2023 Volume 23, Issue 1, Page(s) 551

Abstract: Objectives: The objective of this study is to develop a deep learning (DL) model for fast and accurate mandibular canal (MC) segmentation on cone beam computed tomography (CBCT).: Methods: A total of 220 CBCT scans from dentate subjects needing oral ... ...

Abstract	Objectives: The objective of this study is to develop a deep learning (DL) model for fast and accurate mandibular canal (MC) segmentation on cone beam computed tomography (CBCT). Methods: A total of 220 CBCT scans from dentate subjects needing oral surgery were used in this study. The segmentation ground truth is annotated and reviewed by two senior dentists. All patients were randomly splitted into a training dataset (n = 132), a validation dataset (n = 44) and a test dataset (n = 44). We proposed a two-stage 3D-UNet based segmentation framework for automated MC segmentation on CBCT. The Dice Similarity Coefficient (DSC) and 95% Hausdorff Distance (95% HD) were used as the evaluation metrics for the segmentation model. Results: The two-stage 3D-UNet model successfully segmented the MC on CBCT images. In the test dataset, the mean DSC was 0.875 ± 0.045 and the mean 95% HD was 0.442 ± 0.379. Conclusions: This automatic DL method might aid in the detection of MC and assist dental practitioners to set up treatment plans for oral surgery evolved MC.
MeSH term(s)	Humans ; Image Processing, Computer-Assisted/methods ; Mandibular Canal ; Dentists ; Spiral Cone-Beam Computed Tomography ; Professional Role ; Cone-Beam Computed Tomography/methods
Language	English
Publishing date	2023-08-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2091511-1
ISSN	1472-6831 ; 1472-6831
ISSN (online)	1472-6831
ISSN	1472-6831
DOI	10.1186/s12903-023-03279-2
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Article ; Online: Construction of Imidazole-Fused-Ring Systems by Iron-Catalyzed C(sp

Peng, Jiangling / Li, Shijia / Huang, Junwei / Meng, Qianli / Wang, Lixin / Xin, Wenlong / Li, Weini / Zhou, Wei / Zhang, Lanyue

The Journal of organic chemistry

2023 Volume 88, Issue 23, Page(s) 16581–16588

Abstract: An iron-catalyzed efficient C-H amination for the construction of imidazole-fused-ring systems was developed under aerobic conditions. Compared to previous studies, this work exhibited green features. The reaction was conducted in the green solvent ... ...

Abstract	An iron-catalyzed efficient C-H amination for the construction of imidazole-fused-ring systems was developed under aerobic conditions. Compared to previous studies, this work exhibited green features. The reaction was conducted in the green solvent anisole, with water as the only byproduct. Four C(sp
Language	English
Publishing date	2023-11-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	123490-0
ISSN	1520-6904 ; 0022-3263
ISSN (online)	1520-6904
ISSN	0022-3263
DOI	10.1021/acs.joc.3c02078
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Article ; Online: Sicca Symptoms, Oral Health Conditions, Salivary Flow and Oral

Xin, Weini / Leung, Katherine Chiu Man / Lo, Edward Chin Man / Mok, Mo Yin / Leung, Moon Ho

International journal of environmental research and public health

2020 Volume 17, Issue 10

Abstract: This study aimed to investigate the relationships among sicca symptoms, oral health conditions, salivary profiles and oral Candida in Sjögren's syndrome (SS) patients. Eighty-five SS patients (mean age = 50.5) and 40 healthy non-SS individuals (mean age = ...

Abstract	This study aimed to investigate the relationships among sicca symptoms, oral health conditions, salivary profiles and oral Candida in Sjögren's syndrome (SS) patients. Eighty-five SS patients (mean age = 50.5) and 40 healthy non-SS individuals (mean age = 51.4) were recruited. They self-completed the Sicca Symptoms Inventory (SSI). Decayed, missing and filled surface (DMFS) scores, salivary flow rates, pH and oral Candida colonization were determined. Mean SSI summary scores of SS patients and non-SS individuals were 11.1 and 5.4 respectively (
MeSH term(s)	Candida ; Case-Control Studies ; Female ; Health Status ; Humans ; Male ; Middle Aged ; Oral Health ; Sjogren's Syndrome/complications
Language	English
Publishing date	2020-05-21
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1660-4601
ISSN (online)	1660-4601
DOI	10.3390/ijerph17103625
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Article ; Online: A review on the treatment of multiple myeloma with small molecular agents in the past five years.

Zhang, Zhenzhen / Liu, Xin / Zhao, Liyun / Zhou, Yaru / Shi, Jianyou / Chen, Weini / Li, Jinqi

European journal of medicinal chemistry

2021 Volume 229, Page(s) 114053

Abstract: Multiple myeloma is currently incurable, and the incidence rate is increasing year by year worldwide. Although in recent years the combined treatment plan based on proteasome inhibitors and immunomodulatory drugs has greatly improved the treatment effect ...

Abstract	Multiple myeloma is currently incurable, and the incidence rate is increasing year by year worldwide. Although in recent years the combined treatment plan based on proteasome inhibitors and immunomodulatory drugs has greatly improved the treatment effect of multiple myeloma, most patients still relapse and become resistant to current treatments. To solve this problem, scientists are committed to developing drugs with higher specificity, such as iberdomide, which is highly specific to ikaros and aiolos. This review aims to focus on the small molecular agents that are being researched/clinically used for the treatment of multiple myeloma, including the target mechanism, structure-activity relationship and application prospects of small molecular agents.
MeSH term(s)	Animals ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Biomarkers, Tumor/chemistry ; Combined Modality Therapy ; Deubiquitinating Enzymes/chemistry ; Drug Development ; Drug Resistance ; Histone Deacetylases/chemistry ; Humans ; Ikaros Transcription Factor/chemistry ; Immunomodulating Agents/chemistry ; Immunomodulating Agents/pharmacology ; Models, Molecular ; Morpholines/chemistry ; Morpholines/pharmacology ; Multiple Myeloma/drug therapy ; Phthalimides/chemistry ; Phthalimides/pharmacology ; Piperidones/chemistry ; Piperidones/pharmacology ; Proteasome Inhibitors/chemistry ; Proteasome Inhibitors/pharmacology ; Treatment Outcome ; Ubiquitin-Protein Ligases/chemistry
Chemical Substances	Antineoplastic Agents ; Biomarkers, Tumor ; Immunomodulating Agents ; Morpholines ; Phthalimides ; Piperidones ; Proteasome Inhibitors ; Ikaros Transcription Factor (148971-36-2) ; iberdomide (8V66F27X44) ; Ubiquitin-Protein Ligases (EC 2.3.2.27) ; Deubiquitinating Enzymes (EC 3.4.19.12) ; Histone Deacetylases (EC 3.5.1.98)
Language	English
Publishing date	2021-12-17
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	188597-2
ISSN	1768-3254 ; 0009-4374 ; 0223-5234
ISSN (online)	1768-3254
ISSN	0009-4374 ; 0223-5234
DOI	10.1016/j.ejmech.2021.114053
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Article ; Online: Erratum to: A randomized, double-blind, placebo-controlled clinical trial of fluoride varnish in preventing dental caries of Sjögren's syndrome patients.

Xin, Weini / Leung, Katherine Chiu Man / Lo, Edward Chin Man / Mok, Mo Yin / Leung, Moon Ho

BMC oral health

2017 Volume 17, Issue 1, Page(s) 63

Language	English
Publishing date	2017-03-17
Publishing country	England
Document type	Published Erratum
ZDB-ID	2091511-1
ISSN	1472-6831 ; 1472-6831
ISSN (online)	1472-6831
ISSN	1472-6831
DOI	10.1186/s12903-017-0350-0
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Article ; Online: Sicca Symptoms, Oral Health Conditions, Salivary Flow and Oral Candida in Sjögren’s Syndrome Patients

Weini Xin / Katherine Chiu Man Leung / Edward Chin Man Lo / Mo Yin Mok / Moon Ho Leung

International Journal of Environmental Research and Public Health, Vol 17, Iss 3625, p

2020 Volume 3625

Abstract: This study aimed to investigate the relationships among sicca symptoms, oral health conditions, salivary profiles and oral Candida in Sjögren’s syndrome (SS) patients. Eighty-five SS patients (mean age = 50.5) and 40 healthy non-SS individuals (mean age = ...

Abstract	This study aimed to investigate the relationships among sicca symptoms, oral health conditions, salivary profiles and oral Candida in Sjögren’s syndrome (SS) patients. Eighty-five SS patients (mean age = 50.5) and 40 healthy non-SS individuals (mean age = 51.4) were recruited. They self-completed the Sicca Symptoms Inventory (SSI). Decayed, missing and filled surface (DMFS) scores, salivary flow rates, pH and oral Candida colonization were determined. Mean SSI summary scores of SS patients and non-SS individuals were 11.1 and 5.4 respectively ( p < 0.001). The most prevalent sicca symptoms in SS patients were eye irritation (93%), dry throat or nose (88%) and need of fluid for mouth wetting (88%). SS patients had significantly lower whole salivary flow rates than the non-SS individuals. Candida strains were isolated from over 60% of SS patients but not in non-SS patients. C. albicans was the predominant species. SSI summary score was negatively correlated to salivary flow rates while SSI summary and domain scores were positively correlated to the number of filled surfaces (FS) and DMFS scores and oral Candida counts. In conclusion, SS patients had more severe sicca symptoms than non-SS individuals. SSI scores were negatively correlated to the salivary flow rates but positively correlated to caries experience and oral Candida colonization.
Keywords	Sjögren’s syndrome ; Sicca Symptoms Inventory ; patient-reported outcomes ; oral Candida ; Medicine ; R
Subject code	610
Language	English
Publishing date	2020-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A randomized, double-blind, placebo-controlled clinical trial of fluoride varnish in preventing dental caries of Sjögren's syndrome patients.

Xin, Weini / Leung, Katherine Chiu Man / Lo, Edward Chin Man / Mok, Mo Yin / Leung, Moon Ho

BMC oral health

2016 Volume 16, Issue 1, Page(s) 102

Abstract: Background: Sjögren's syndrome (SS) patients are prone to caries development due to reduction of salivary flow. Topical fluoride is commonly prescribed for caries prevention.: Methods: In this 24-month randomized, double-blind, placebo-controlled ... ...

Abstract	Background: Sjögren's syndrome (SS) patients are prone to caries development due to reduction of salivary flow. Topical fluoride is commonly prescribed for caries prevention. Methods: In this 24-month randomized, double-blind, placebo-controlled clinical trial, SS patients were randomly assigned to receive either fluoride varnish or placebo gel quarterly. Development and arrest of caries at the coronal and root surfaces were recorded at 12-month and 24-month and compared to that of the baseline. Effect of fluoride varnish on oral Candida and lactobacilli colonization was explored by comparing baseline oral microbiological assessments to data obtained at 12-month and 24-month. Results: Seventy-eight SS patients (mean age = 50 years, 2 men) completed this trial. At 24-month, the mean new coronal enamel caries were 1.6 surfaces in both groups, and new dentin caries were 1.4 and 2.7 surfaces in the fluoride and placebo group respectively (p > 0.05). Mean arrested caries were 0.6 and 0.7 surfaces for fluoride and placebo groups respectively and that of root caries were 0.3 and 0.1 surfaces (p > 0.05). The mean oral Candida count was reduced by 30 % in the fluoride group but increased 61 % in the placebo group while no change in oral lactobacilli counts in both groups at 24 months (p > 0.05). SS patients receiving fluoride varnish were significantly less likely to develop dentin caries (p < 0.05). In contrast, those with high baseline DMFS scores (p = 0.05), harbored mixed Candida species (p < 0.05), or unstimulated whole saliva at low pH (p < 0.01) were significantly more likely to develop dentin caries. Conclusions: Results of this randomized clinical trial did not provide clear evidence to support or refute that quarterly applications of fluoride varnish can prevent development of dental caries in people with Sjögren's syndrome. Trial registration: This study was retrospectively registered at the ISRCTN registry ( ISRCTN85164658 ) on 9 Sept 2016 and was funded by the Research Grant Council of Hong Kong.
Language	English
Publishing date	2016-09-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2091511-1
ISSN	1472-6831 ; 1472-6831
ISSN (online)	1472-6831
ISSN	1472-6831
DOI	10.1186/s12903-016-0296-7
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Article ; Online: Relationship of clinical index between rheumatoid arthritis and chronic periodontitis

XIN Wei⁃ni / HOU Zhi⁃ duo / GONG Yao

口腔疾病防治, Vol 25, Iss 4, Pp 227-

2017 Volume 230

Abstract: Objective To explore the relationship betweenrheumatoid arthritis (RA) and chronic periodontitis (CP). Methods A total of 48 RA patients were recruited from the Rhematology Department of The First Affiliated Hospital of Shantou University Medical College ...

Abstract	Objective To explore the relationship betweenrheumatoid arthritis (RA) and chronic periodontitis (CP). Methods A total of 48 RA patients were recruited from the Rhematology Department of The First Affiliated Hospital of Shantou University Medical College (SUMC). RA patients were matched on age and gender with healthy controls, who were recruited from the Stomatology Department. Dental parameters including unstimulated salivary flow rate(UWS), stimulated salivary flow rate (SWS), bleeding on probe (BOP), periodontal probing pocket (PD), clinical attachment level (CAL) and decayed, missing and filling (DMF) were recorded in all cases. Erythrocyte sedimentation rate (ESR), C⁃reac⁃ tive protein (CRP) and Anticyclic citrullinated peptide antibody (Anti ⁃ CCP) were also recorded in RA patients. Results There were significant difference between RA group and health control group on salivary flow rate, BOP, PD, CAL and DMF (P < 0.001). Higher percentage of RA patients were diagnosed as periodontal disease than those in con⁃trol group (P < 0.001). There was relationship between CAL and Anti⁃CCP antibody (P < 0.001). Conclusion RA pa⁃ tients have higher risk of CP, and there might be relationship between RA and CP.
Keywords	Chronic periodontitis ; Rheumatoid arthritis ; Anticycliccitrullinated peptide antibody ; Salivary flow rate ; Clinical attachment level ; Medicine ; R
Subject code	610
Language	Chinese
Publishing date	2017-04-01T00:00:00Z
Publisher	Editorial Department of Journal of Prevention and Treatment for Stomatological Diseases
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Physicochemical properties, antioxidant activities and comprehensive phenolic profiles of tea-macerated Chardonnay wine and model wine.

Liang, Zijian / Zhang, Pangzhen / Ma, Wen / Zeng, Xin-An / Fang, Zhongxiang

Food chemistry

2023 Volume 436, Page(s) 137748

Abstract: A new type of flavored wine was produced by macerating either green tea or black tea ... into Chardonnay wine and model wine respectively, where the physicochemical properties (pH, titratable acidity ... activity (assessed by DPPH, FRAP and ABTS assays) were also observed in the tea macerated wines. A total ...

Abstract	A new type of flavored wine was produced by macerating either green tea or black tea into Chardonnay wine and model wine respectively, where the physicochemical properties (pH, titratable acidity, color) were modulated. Significant (p < 0.05) increases of total phenolic content and antioxidant activity (assessed by DPPH, FRAP and ABTS assays) were also observed in the tea macerated wines. A total of 160 phenolic and non-phenolic compounds were identified by HPLC-DAD-ESI-QTOF-MS/MS, where 55 phenolics were newly found in the tea macerated Chardonnay wine. The interaction between wine and tea phenolics led to additional 29 phenolic compounds and 4 non-phenolic compounds that were not found in either Chardonnay wine or tea. Catechin and epigallocatechin gallate were the most abundant phenolic compounds and contributed to the improved antioxidant activities. This study provided a promising prospect of tea as a novel additive in the production of flavored wine with enhanced functionalities.
MeSH term(s)	Antioxidants/chemistry ; Wine/analysis ; Tandem Mass Spectrometry ; Phenols/analysis ; Tea/chemistry
Chemical Substances	Antioxidants ; Phenols ; Tea
Language	English
Publishing date	2023-10-19
Publishing country	England
Document type	Journal Article
ZDB-ID	243123-3
ISSN	1873-7072 ; 0308-8146
ISSN (online)	1873-7072
ISSN	0308-8146
DOI	10.1016/j.foodchem.2023.137748
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