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  1. Article ; Online: Implications of the evolving knowledge of the genetic architecture of MASLD.

    Valenti, Luca V C / Moretti, Vittoria

    Nature reviews. Gastroenterology & hepatology

    2023  Volume 21, Issue 1, Page(s) 5–6

    Language English
    Publishing date 2023-11-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2493722-8
    ISSN 1759-5053 ; 1759-5045
    ISSN (online) 1759-5053
    ISSN 1759-5045
    DOI 10.1038/s41575-023-00866-0
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  2. Article ; Online: Uncovering the genetics of cirrhosis: New plots for the usual suspects.

    Valenti, Luca

    Liver international : official journal of the International Association for the Study of the Liver

    2020  Volume 40, Issue 2, Page(s) 281–282

    MeSH term(s) Fibrosis ; Humans ; Liver Cirrhosis
    Language English
    Publishing date 2020-02-10
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2102783-3
    ISSN 1478-3231 ; 1478-3223
    ISSN (online) 1478-3231
    ISSN 1478-3223
    DOI 10.1111/liv.14333
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  3. Article ; Online: Editorial: Unveiling new horizons for liver steatosis genetic variants beyond hepatocellular carcinoma diagnosis - exploring the potential of HSD17B13 inhibition.

    Valenti, Luca / Casirati, Elia

    Alimentary pharmacology & therapeutics

    2023  Volume 58, Issue 7, Page(s) 727–728

    MeSH term(s) Humans ; Carcinoma, Hepatocellular/diagnosis ; Carcinoma, Hepatocellular/genetics ; Liver Neoplasms/diagnosis ; Liver Neoplasms/genetics ; Fatty Liver
    Language English
    Publishing date 2023-08-24
    Publishing country England
    Document type Editorial
    ZDB-ID 639012-2
    ISSN 1365-2036 ; 0269-2813 ; 0953-0673
    ISSN (online) 1365-2036
    ISSN 0269-2813 ; 0953-0673
    DOI 10.1111/apt.17664
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  4. Article ; Online: Estrogen-ER-α axis induces PNPLA3 p.I148M protein variant to promote steatotic liver disease susceptibility in women.

    Cherubini, Alessandro / Casirati, Elia / Pelusi, Serena / Valenti, Luca

    Clinical and translational medicine

    2024  Volume 14, Issue 1, Page(s) e1524

    MeSH term(s) Humans ; Female ; Disease Susceptibility ; Fatty Liver/genetics ; Estrogens/genetics
    Chemical Substances Estrogens
    Language English
    Publishing date 2024-01-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2697013-2
    ISSN 2001-1326 ; 2001-1326
    ISSN (online) 2001-1326
    ISSN 2001-1326
    DOI 10.1002/ctm2.1524
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  5. Article ; Online: The contribution of genetics and epigenetics to MAFLD susceptibility.

    Moretti, Vittoria / Romeo, Stefano / Valenti, Luca

    Hepatology international

    2024  

    Abstract: Metabolic dysfunction-associated fatty liver disease (MAFLD) is the most common liver disease worldwide. The risk of developing MAFLD varies among individuals, due to a combination of environmental inherited and acquired genetic factors. Genome-wide ... ...

    Abstract Metabolic dysfunction-associated fatty liver disease (MAFLD) is the most common liver disease worldwide. The risk of developing MAFLD varies among individuals, due to a combination of environmental inherited and acquired genetic factors. Genome-wide association and next-generation sequencing studies are leading to the discovery of the common and rare genetic determinants of MAFLD. Thanks to the great advances in genomic technologies and bioinformatics analysis, genetic and epigenetic factors involved in the disease can be used to develop genetic risk scores specific for liver-related complications, which can improve risk stratification. Genetic and epigenetic factors lead to the identification of specific sub-phenotypes of MAFLD, and predict the individual response to a pharmacological therapy. Moreover, the variant transcripts and protein themselves represent new therapeutic targets. This review will discuss the current status of research into genetic as well as epigenetic modifiers of MAFLD development and progression.
    Language English
    Publishing date 2024-04-25
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2270316-0
    ISSN 1936-0541 ; 1936-0533
    ISSN (online) 1936-0541
    ISSN 1936-0533
    DOI 10.1007/s12072-024-10667-5
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  6. Article ; Online: Genetics: A new clinical tool for the hepatologist.

    Valenti, Luca / Ronzoni, Luisa

    Liver international : official journal of the International Association for the Study of the Liver

    2022  Volume 42, Issue 4, Page(s) 724–726

    MeSH term(s) Gastroenterologists ; Humans
    Language English
    Publishing date 2022-03-14
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2102783-3
    ISSN 1478-3231 ; 1478-3223
    ISSN (online) 1478-3231
    ISSN 1478-3223
    DOI 10.1111/liv.15205
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  7. Article ; Online: African genetic ancestry and protection against fatty liver disease.

    Romeo, Stefano / Valenti, Luca

    Liver international : official journal of the International Association for the Study of the Liver

    2022  Volume 42, Issue 10, Page(s) 2122–2123

    MeSH term(s) Blacks ; Genetic Predisposition to Disease ; Humans ; Liver Diseases ; Whites
    Language English
    Publishing date 2022-08-29
    Publishing country United States
    Document type Editorial
    ZDB-ID 2102783-3
    ISSN 1478-3231 ; 1478-3223
    ISSN (online) 1478-3231
    ISSN 1478-3223
    DOI 10.1111/liv.15364
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  8. Article ; Online: Usefulness of PNPLA3 variant for predicting hepatic events in steatotic liver disease: a matter of ethnicity or baseline risk?

    Vespasiani-Gentilucci, Umberto / Valenti, Luca / Romeo, Stefano

    Liver international : official journal of the International Association for the Study of the Liver

    2023  Volume 43, Issue 10, Page(s) 2052–2054

    MeSH term(s) Humans ; Ethnicity ; Fatty Liver/genetics
    Language English
    Publishing date 2023-09-09
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2102783-3
    ISSN 1478-3231 ; 1478-3223
    ISSN (online) 1478-3231
    ISSN 1478-3223
    DOI 10.1111/liv.15697
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  9. Article ; Online: Should Artificial Intelligence-based language models be allowed in developing scientific manuscripts? A debate between ChatGPT and the editors of Liver International.

    Aghemo, Alessio / Forner, Alejandro / Valenti, Luca

    Liver international : official journal of the International Association for the Study of the Liver

    2023  Volume 43, Issue 5, Page(s) 956–957

    MeSH term(s) Humans ; Artificial Intelligence ; Liver ; Language
    Language English
    Publishing date 2023-04-29
    Publishing country United States
    Document type Editorial
    ZDB-ID 2102783-3
    ISSN 1478-3231 ; 1478-3223
    ISSN (online) 1478-3231
    ISSN 1478-3223
    DOI 10.1111/liv.15580
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  10. Article ; Online: Fatty liver disease genetic risk variants and interference on sex hormones.

    Tavaglione, Federica / Jamialahmadi, Oveis / Valenti, Luca / Romeo, Stefano

    Liver international : official journal of the International Association for the Study of the Liver

    2023  Volume 43, Issue 5, Page(s) 958–961

    MeSH term(s) Humans ; Non-alcoholic Fatty Liver Disease ; Risk Factors ; Gonadal Steroid Hormones
    Chemical Substances Gonadal Steroid Hormones
    Language English
    Publishing date 2023-05-09
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2102783-3
    ISSN 1478-3231 ; 1478-3223
    ISSN (online) 1478-3231
    ISSN 1478-3223
    DOI 10.1111/liv.15562
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