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  1. Book ; Thesis: Eine durch Toll-like-Rezeptoren aktivierte, Interferon-abhängige angeborene Immunantwort tötet AML-Zellen

    Salhöfer, Friederike-Charlotte / Trilling, Mirko

    2022  

    Institution Universität Duisburg-Essen
    Author's details vorgelegt von Friederike-Charlotte Salhöfer. Gutacht/in: 1. Herr Univ.-Prof. Dr. rer. nat. M. Trilling, 2. Frau Priv.-Doz. Dr. med. A. H. Gäckler
    Language German
    Size 89 Seiten, Diagramme
    Publishing place Duisburg ; Essen
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität Duisburg-Essen, 2023
    HBZ-ID HT021729899
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2023 E 359 order for loan Magazin

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  2. Article ; Online: A rapid test recognizing mucosal SARS-CoV-2-specific antibodies distinguishes prodromal from convalescent COVID-19.

    Krempe, Friederike / Schöler, Lara / Katschinski, Benjamin / Herrmann, Anke / Anastasiou, Olympia E / Elsner, Carina / Ross, R Stefan / Scholz, Friedrich / Dittmer, Ulf / Miethe, Peter / Le-Trilling, Vu Thuy Khanh / Trilling, Mirko

    iScience

    2021  Volume 24, Issue 10, Page(s) 103194

    Abstract: The COVID-19 pandemic poses enormous challenges to global healthcare sectors. To prevent the overburden of medical systems, it is crucial to distinguish individuals approaching the most infectious early phase from those in the declining non-infectious ... ...

    Abstract The COVID-19 pandemic poses enormous challenges to global healthcare sectors. To prevent the overburden of medical systems, it is crucial to distinguish individuals approaching the most infectious early phase from those in the declining non-infectious phase. However, a large fraction of transmission events occur during pre- or asymptomatic phases. Especially in the absence of symptoms, it is difficult to distinguish prodromal from late phases of infection just by RT-PCR since both phases are characterized by low viral loads and corresponding high Ct values (>30). We evaluated a new rapid test detecting IgG antibodies recognizing SARS-CoV-2 nucleocapsid protein using two commercial antibody assays and an in-house neutralization test before determining suitability for testing clinical swab material. Our analyses revealed the combination of the well-known RT-PCR and the new rapid antibody test using one single clinical nasopharyngeal swab specimen as a fast, cost-effective, and reliable way to discriminate prodromal from subsiding phases of COVID-19.
    Language English
    Publishing date 2021-09-30
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2021.103194
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A rapid test recognizing mucosal SARS-CoV-2-specific antibodies distinguishes prodromal from convalescent COVID-19

    Friederike Krempe / Lara Schöler / Benjamin Katschinski / Anke Herrmann / Olympia E. Anastasiou / Carina Elsner / R. Stefan Ross / Friedrich Scholz / Ulf Dittmer / Peter Miethe / Vu Thuy Khanh Le-Trilling / Mirko Trilling

    iScience, Vol 24, Iss 10, Pp 103194- (2021)

    2021  

    Abstract: Summary: The COVID-19 pandemic poses enormous challenges to global healthcare sectors. To prevent the overburden of medical systems, it is crucial to distinguish individuals approaching the most infectious early phase from those in the declining non- ... ...

    Abstract Summary: The COVID-19 pandemic poses enormous challenges to global healthcare sectors. To prevent the overburden of medical systems, it is crucial to distinguish individuals approaching the most infectious early phase from those in the declining non-infectious phase. However, a large fraction of transmission events occur during pre- or asymptomatic phases. Especially in the absence of symptoms, it is difficult to distinguish prodromal from late phases of infection just by RT-PCR since both phases are characterized by low viral loads and corresponding high Ct values (>30).We evaluated a new rapid test detecting IgG antibodies recognizing SARS-CoV-2 nucleocapsid protein using two commercial antibody assays and an in-house neutralization test before determining suitability for testing clinical swab material. Our analyses revealed the combination of the well-known RT-PCR and the new rapid antibody test using one single clinical nasopharyngeal swab specimen as a fast, cost-effective, and reliable way to discriminate prodromal from subsiding phases of COVID-19.
    Keywords Immunology ; Virology ; Science ; Q
    Language English
    Publishing date 2021-10-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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