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Article ; Online: Ventricular arrhythmias in mitral valve prolapse syndrome and their relationship with electrocardiographic repolarization parameters.

Engin, Berat / Cevik, Erdem / Deniz, Rabia / Orta, Huseyin / Elitok, Ali

2023 Volume 10, Issue 2, Page(s) 205–211

Abstract: Objective: The aim of present study is to compare ventricular and supraventricular arrhythmia incidences in subjects with and without mitral valve prolapse (MVP) syndrome and to examine if an association exists between ventricular arrhythmias and ... ...

Abstract	Objective: The aim of present study is to compare ventricular and supraventricular arrhythmia incidences in subjects with and without mitral valve prolapse (MVP) syndrome and to examine if an association exists between ventricular arrhythmias and repolarization parameters in patients with MVP syndrome. Methods: This cross-sectional study involved 41 subjects with MVP Syndrome and 41 subjects with palpitation but without MVP (control group). All subjects were subjected to lead-electrocardiogram, transthoracic echocardiography, and 24-h Holter monitoring to identify repolarization abnormalities, structural abnormalities, and supraventricular and ventricular arrhythmias. The QRS width, QTC interval, and Tpeak-Tend intervals were measured for each participant. Results: The number of subjects who had premature ventricular contractions (PVCs), couplets, and non-sustained ventricular tachycardia (NSVTs) was significantly higher in the MVP group compared to the control group. Left ventricular end-systolic diameter (LVESD) and left ventricular end-diastolic diameter (LVEDD) and left atrial diameter were also significantly higher in the MVP group than the control group. QRS width and Tpeak-Tend interval were also significantly higher in subjects with MVP than the controls. Correlation analysis showed a positive correlation between the severity of mitral regurgitation (MR) and the number of PVCs and couplets, while there was a significant correlation between left atrium (LA) diameter and the number of the PVCs and NSVTs. Conclusion: Subjects with MVP experience ventricular arrhythmias more often including PVCs, couplets, and NSVTs compared to subjects without MVP. LVESD, LVEDD, LA diameter, QRS width, and Tpeak-Tend interval were increased in MVP subjects than those without MVP. There is an association between the severity of the MR and the frequency of the PVCs, couplets, or NSVTs.
Language	English
Publishing date	2023-04-19
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	3031921-3
ISSN	2536-4553 ; 2148-4902
ISSN (online)	2536-4553
ISSN	2148-4902
DOI	10.14744/nci.2021.12058
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Article ; Online: Author`s Reply.

Elitok, Ali / Emet, Samim

Anatolian journal of cardiology

2020 Volume 24, Issue 1, Page(s) 62–63

MeSH term(s)	Carotid Intima-Media Thickness ; Prognosis
Language	English
Publishing date	2020-07-06
Publishing country	Turkey
Document type	Letter ; Comment
ZDB-ID	2278670-3
ISSN	2149-2271 ; 2149-2263
ISSN (online)	2149-2271
ISSN	2149-2263
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Article ; Online: Serum spexin levels are not associated with size at birth but are associated with metabolic syndrome components in prepubertal children born at term.

Öztürk Önsal, Fatma Duygu / Elitok, Gizem Kara / Bülbül, Ali / Uçar, Ahmet

Journal of pediatric endocrinology & metabolism : JPEM

2022 Volume 35, Issue 5, Page(s) 649–655

Abstract: Background: Babies born small for gestational age (SGA) are at risk of obesity and metabolic syndrome (MetS). Spexin (SPX) is a novel peptide implicated in food intake and obesity. Spexin levels are lower in obese subjects. This study investigated the ... ...

Abstract	Background: Babies born small for gestational age (SGA) are at risk of obesity and metabolic syndrome (MetS). Spexin (SPX) is a novel peptide implicated in food intake and obesity. Spexin levels are lower in obese subjects. This study investigated the potential association of SPX and some obesity related peptides such as leptin and active ghrelin with size at birth and MetS components in prepubertal children born term and either SGA or appropriate for GA (AGA). Secondary aim was to identify whether any of the investigated peptides were associated with MetS components. Methods: We conducted a cross-sectional study of 37 consecutive (median age: 5.6 y) SGA- and 50 (median age: 5.9 y) AGA-born children. Clinical evaluations were performed using standard methods. Several biochemical variables (SPX, total leptin, and active ghrelin levels) were analyzed. Age-dependent cut-off values were used to define MetS components, including excess adiposity, hypertension, insulin resistance, and dyslipidemia. The associations between the assessed clinical and laboratory variables and MetS components were investigated. Results: Children born SGA had higher frequencies of MetS components than AGA-born peers (p < 0.01). None of the investigated peptides were different between children born SGA and AGA after correcting for body mass index (p > 0.05 for all). Serum SPX levels were lower in children with at least one metS component than those without MetS components (p = 0.018). Conclusions: Size at birth had no association with serum SPX. Serum SPX levels are decreased in prepubertal children with MetS components.
MeSH term(s)	Birth Weight ; Child, Preschool ; Cross-Sectional Studies ; Female ; Ghrelin ; Humans ; Infant, Newborn ; Infant, Small for Gestational Age/metabolism ; Insulin ; Leptin ; Metabolic Syndrome/etiology ; Obesity ; Peptide Hormones
Chemical Substances	Ghrelin ; Insulin ; Leptin ; Peptide Hormones ; SPX protein, human
Language	English
Publishing date	2022-03-28
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1231070-0
ISSN	2191-0251 ; 0334-018X
ISSN (online)	2191-0251
ISSN	0334-018X
DOI	10.1515/jpem-2021-0721
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Article: The Role of Aortic Stiffness Parameters in Evaluating Myocardial Ischemia.

Kumrular, Merve / Karaca Ozer, Pelin / Elitok, Ali

Cardiology research

2020 Volume 11, Issue 5, Page(s) 328–336

Abstract: Background: Arterial stiffness is a process resulting in deterioration of hemodynamic function of the aorta, a decrease in its compliance and elasticity, caused by the proportional change of components of the extracellular matrix. Although many ... ...

Abstract	Background: Arterial stiffness is a process resulting in deterioration of hemodynamic function of the aorta, a decrease in its compliance and elasticity, caused by the proportional change of components of the extracellular matrix. Although many researches have been done to determine the etiologies of myocardial ischemia in the absence of obstructive coronary artery disease, none of them has investigated the relation between the parameters of aortic stiffness and the myocardial ischemia documented by the exercise stress test. The present cross-sectional study aimed to investigate the difference of aortic stiffness parameters between the groups separated by exercise stress test result as positive and negative ischemic findings in the absence of obstructive coronary artery disease. Methods: The present study included 79 patients who were admitted to Istanbul Faculty of Medicine, Department of Cardiology with complaint of chest pain. Forty patients (21 women and 19 men) have ischemic findings on the exercise electrocardiography (ECG) test and 39 patients (20 women and 19 men) have normal exercise ECG results. The patients who have positive exercise ECG findings underwent coronary angiography and all the patients had non-obstructive coronary artery disease. Demographic features (age, sex and comorbidities) were statistically similar between the groups. Aortic stiffness measurements (pulse wave velocity, pulse pressure, aortic augmented pressure, augmentation index, systolic pressure-time index, diastolic pressure-time index and subendocardial viability ratio) were done with tonometric methods. Results: There was no significant difference between the two groups in terms of the aortic stiffness parameters. Systolic blood pressure (P = 0.33), diastolic blood pressure (P = 0.24), pulse pressure (P = 0.60), systolic pressure-time index (P = 0.10), diastolic pressure-time index (P = 0.91), subendocardial viability ratio (P = 0.19), aortic augmented pressure (P = 0.87), augmentation index (P = 0.58) and pulse wave velocity (P = 0.56) were detected between the two groups. Biochemical parameters were found similar between the two groups. Only low-density lipoprotein levels were slightly higher in patients with negative exercise stress test result (139 vs. 123 mg/dL, P = 0.02). Conclusion: There is no finding supporting that the aortic stiffness identifies the patients with non-obstructive coronary artery disease but with signs of myocardial ischemia and further investigation of other causes of myocardial ischemia is required.
Language	English
Publishing date	2020-08-01
Publishing country	Canada
Document type	Journal Article
ZDB-ID	2598593-0
ISSN	1923-2837 ; 1923-2829
ISSN (online)	1923-2837
ISSN	1923-2829
DOI	10.14740/cr1125
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Article ; Online: Left atrial appendage: The uncommon origin of focal atrial tachycardia in a pregnant woman.

Sonsöz, Mehmet Rasih / Bilge, Ahmet Kaya / Elitok, Ali

Anatolian journal of cardiology

2019 Volume 22, Issue 6, Page(s) 5013–5014

MeSH term(s)	Adult ; Atrial Appendage/diagnostic imaging ; Catheter Ablation ; Diagnosis, Differential ; Echocardiography ; Electrocardiography ; Female ; Humans ; Pregnancy ; Pregnancy Complications, Cardiovascular/diagnosis ; Pregnancy Complications, Cardiovascular/diagnostic imaging ; Pregnancy Complications, Cardiovascular/therapy ; Pregnancy Trimester, Third ; Prenatal Diagnosis ; Tachycardia, Supraventricular/diagnosis ; Tachycardia, Supraventricular/diagnostic imaging ; Tachycardia, Supraventricular/therapy
Language	English
Publishing date	2019-12-26
Publishing country	Turkey
Document type	Case Reports ; Journal Article
ZDB-ID	2278670-3
ISSN	2149-2271 ; 2149-2263
ISSN (online)	2149-2271
ISSN	2149-2263
DOI	10.14744/AnatolJCardiol.2019.17748
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Article: Association between Multiplate-measured aspirin resistance and vitamin D deficiency in stable coronary artery disease.

Surmen, Semih / Ozer, Pelin Karaca / Emet, Samim / Govdeli, Elif Ayduk / Elitok, Ali

Archives of medical sciences. Atherosclerotic diseases

2021 Volume 6, Page(s) e203–e208

Abstract: Introduction: Insufficient inhibition of platelets in patients with atherosclerosis despite antiplatelet therapy leads to important clinical consequences. The present study evaluated the role of vitamin D (VD) deficiency in aspirin resistance (AR) in ... ...

Abstract	Introduction: Insufficient inhibition of platelets in patients with atherosclerosis despite antiplatelet therapy leads to important clinical consequences. The present study evaluated the role of vitamin D (VD) deficiency in aspirin resistance (AR) in patients with stable coronary artery disease (CAD) treated with aspirin. Material and methods: This study included 70 patients with stable CAD who had been using 100 mg aspirin for at least seven days. Serum 25-hydroxyvitamin D [25-(OH)D] concentration was measured and patients with 25-(OH)D level < 20 ng/dl were defined as the VD deficient group. A Multiplate Platelet Function Analyzer (Multiplate) device was used to evaluate AR. Patients were defined as aspirin-sensitive (AS) when their AUC was ≤ 30 U, and aspirin resistant (AR) when their AUC was > 30 U. Results: AUC was > 30 U in 15 (21%) patients and these patients were considered AR. The mean 25-(OH)D level was 18.7 ±12.2 ng/ml in all patients. Forty-five (64%) patients were VD deficient. The rate of AR was higher in the VD deficient group than the sufficient group (29% vs. 8%, Conclusions: In the current study, an association was found between VD deficiency and AR in patients with stable CAD. VD supplementation may reduce platelet aggregation and overcome AR.
Language	English
Publishing date	2021-12-29
Publishing country	Poland
Document type	Journal Article
ISSN	2451-0629
ISSN	2451-0629
DOI	10.5114/amsad.2021.112242
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Article ; Online: Effect of bariatric surgery on flow-mediated dilation and carotid intima-media thickness in patients with morbid obesity: 1-year follow-up study.

Elitok, Ali / Emet, Samim / Bayramov, Farrukh / Karaayvaz, Ekrem / Türker, Fulya / Barbaros, Umut / Özcan, Mustafa

Anatolian journal of cardiology

2020 Volume 23, Issue 4, Page(s) 218–222

Abstract: Objective: Obesity is associated with increased cardiovascular (CV) mortality and morbidity. Bariatric surgery (BS) is currently an established therapeutic approach for severely obese patients. Carotid intima-media thickness (CIMT) and brachial artery ... ...

Abstract	Objective: Obesity is associated with increased cardiovascular (CV) mortality and morbidity. Bariatric surgery (BS) is currently an established therapeutic approach for severely obese patients. Carotid intima-media thickness (CIMT) and brachial artery flow-mediated dilation (FMD) provide important prognostic information beyond traditional CV risk factors. This study aimed to examine the effect of bariatric surgery-induced weight loss on CIMT and brachial artery FMD in morbidly obese patients. Methods: A total of 23 morbidly obese patients (40.4±5.6 years, 13 females) were examined before and after BS for 1 year with 3-month periods. CIMT, FMD, body composition, and metabolic parameters were determined. Results: All the patients exhibited significant weight loss following BS (p<0.001). Carotid intima-media thickness reduction was not significant from baseline to 6 months (p=0.069), but at 9 months (p=0.004), it became significant. Similarly, the difference between the preoperative and 6-month FMD assessments was not significant (p=0.057), but at 9 months (p<0.001), it became significant. Conclusion: Our study reveals that weight loss following BS causes improvements in CV risk factors, which is evident after 9 months of surgery.
MeSH term(s)	Adult ; Anastomosis, Roux-en-Y ; Bariatric Surgery ; Blood Chemical Analysis ; Brachial Artery/diagnostic imaging ; Brachial Artery/pathology ; Carotid Intima-Media Thickness ; Dilatation, Pathologic ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Obesity, Morbid/pathology ; Obesity, Morbid/physiopathology ; Obesity, Morbid/surgery ; Time Factors ; Ultrasonography ; Weight Loss/physiology
Language	English
Publishing date	2020-04-01
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	2278670-3
ISSN	2149-2271 ; 2149-2263
ISSN (online)	2149-2271
ISSN	2149-2263
DOI	10.14744/AnatolJCardiol.2019.85249
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Article ; Online: Vitamin D levels of 12-24-month-old healthy children in Turkey who received vitamin D supplementation until the age of one year.

Kara Elitok, Gizem / Bulbul, Lida / Bulbul, Ali / Cigerli, Sebnem / Uslu, Sinan

Archivos argentinos de pediatria

2020 Volume 118, Issue 2, Page(s) 95–101

Abstract: Introduction: The aim of this study was to evaluate vitamin D levels between 12-24 monthold healthy children supplemented with vitamin D (400 IU/day) during the first year.: Methods: Descriptive-sectional study conducted between June 2015, and May ... ...

Title translation	Concentración de vitamina D en niños sanos de 12 a 24 meses que recibieron suplementación con vitamina D hasta el año en Turquía.
Abstract	Introduction: The aim of this study was to evaluate vitamin D levels between 12-24 monthold healthy children supplemented with vitamin D (400 IU/day) during the first year. Methods: Descriptive-sectional study conducted between June 2015, and May 2016, in Istanbul (latitude 41ºN). Children aged 12-24 months followed up by the well-child clinic who had vitamin D supplementation in the first year were included in the study. The levels of calcium, phosphorus, alkaline phosphatase, parathyroid hormone and 25-hydroxyvitamin D [25(OH)D] were measured. Vitamin D status was defined as >20 ng/mL: sufficiency, 15-20 ng/mL: insufficiency and <15 ng/mL: deficiency. Results: The study was completed with 197 children. 26.9 % of children (n = 53) went on receiving supplementation after one year (mean dose 491 ± 267 IU/day). The mean 25(OH)D level was 38.0 ± 13.9 ng/mL. It was found that regular vitamin D intake under one year of age (p = 0.008) and continued support after one year of age (p = 0.042) increased level of 25(OH)D in children aged 12-24 months. Vitamin D deficiency was found in 4.1 % and vitamin D insufficiency in 7.1 %. Mother's education (p = 0.009) and use of formula (p = 0.012) were protective factors in relation to development of vitamin D deficiency or insufficiency. Conclusions: The level of 25(OH)D was sufficient in 88.8 % of children aged 12-24 months receiving 400 IU/day vitamin D supplementation in the first year. Vitamin D supplementation could not be required in healthy children aged 12- 24 months who received properly vitamin D supplementation in the first year.
MeSH term(s)	Biomarkers/blood ; Child, Preschool ; Dietary Supplements ; Drug Administration Schedule ; Female ; Follow-Up Studies ; Humans ; Infant ; Male ; Treatment Outcome ; Turkey ; Vitamin D/analogs & derivatives ; Vitamin D/blood ; Vitamin D/therapeutic use ; Vitamin D Deficiency/blood ; Vitamin D Deficiency/diagnosis ; Vitamin D Deficiency/prevention & control
Chemical Substances	Biomarkers ; Vitamin D (1406-16-2) ; 25-hydroxyvitamin D (A288AR3C9H)
Language	Spanish
Publishing date	2020-03-21
Publishing country	Argentina
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	424449-7
ISSN	1668-3501 ; 0325-0075 ; 0004-0487
ISSN (online)	1668-3501
ISSN	0325-0075 ; 0004-0487
DOI	10.5546/aap.2020.eng.95
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Article ; Online: Maternal Characteristics and Obstetric and Neonatal Outcomes of Singleton Pregnancies Among Adolescents.

Baş, Evrim Kiray / Bülbül, Ali / Uslu, Sinan / Baş, Vedat / Elitok, Gizem Kara / Zubarioğlu, Umut

Medical science monitor : international medical journal of experimental and clinical research

2020 Volume 26, Page(s) e919922

Abstract: BACKGROUND Adolescent pregnancy remains a global public health issue with serious implications on maternal and child health, particularly in developing countries The aim of this study was to investigate maternal characteristics and obstetric and neonatal ...

Abstract	BACKGROUND Adolescent pregnancy remains a global public health issue with serious implications on maternal and child health, particularly in developing countries The aim of this study was to investigate maternal characteristics and obstetric and neonatal outcomes of singleton pregnancies among adolescents. MATERIAL AND METHODS A total of 241 adolescent women who gave birth to singletons between January 2015 and December 2015 at our hospital were included in this descriptive cross-sectional study. Data on maternal sociodemographic and obstetric characteristics as well as neonatal outcome were recorded. RESULTS Primary school education (66.0%), lack of regular antenatal care (69.7%), religious (36.7%) and consanguineous (37.0) marriage, Southeastern Anatolia hometown (34.9%) and Eastern Anatolia hometown (21.2%) were noted in most of the adolescent pregnancies, while 95% were desired pregnancies within marriage. Pregnancy complications were noted in 19.5% (preeclampsia in 5.8%) and cesarean delivery was performed in 44.8% of adolescent pregnancies. Preterm delivery rate was 27.0% (20.3% were in >34 weeks). Overall, 13.3% of neonates were admitted to neonatal intensive care unit (NICU) in the postpartum period (prematurity in 28.1%), while 25.3% were re-admitted to NICU admission in the post-discharge 1-month (hyperbilirubinemia in 55.7%). Adolescent pregnancies were associated considerably high rates of fetal distress at birth (28.7%), preterm delivery (26.9%), and re-admission to NICU after hospital discharge (25.3%). CONCLUSIONS In conclusion, our findings indicate that along with considerably high rates of poor antenatal care, maternal anemia and cesarean delivery, adolescent pregnancies were also associated with high rates for fetal distress at birth, preterm delivery, and NICU re-admission within post-discharge 1-month.
MeSH term(s)	Adolescent ; Child ; Female ; Humans ; Infant, Newborn ; Intensive Care Units ; Maternal Health ; Obstetrics ; Pregnancy ; Pregnancy Outcome ; Pregnancy in Adolescence/physiology ; Young Adult
Language	English
Publishing date	2020-02-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	1439041-3
ISSN	1643-3750 ; 1234-1010
ISSN (online)	1643-3750
ISSN	1234-1010
DOI	10.12659/MSM.919922
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Article ; Online: Acute rheumatic fever: 10-year single-center experience: clinical and laboratory findings, with subclinical carditis and treatment complications.

Bulbul, Lida / Akyol, Mehmet Bedir / Civan, Hasret Ayyıldız / Elitok, Gizem Kara / Hatipoglu, Sami / Akkus, Canan Hasbal / Bulbul, Ali

Cardiology in the young

2021 Volume 31, Issue 9, Page(s) 1489–1494

Abstract: Background: Acute rheumatic fever in childhood continues to cause serious morbidity despite all developments. The objective of this study was to evaluate the clinical and laboratory characteristics of patients with acute rheumatic fever and to determine ...

Abstract	Background: Acute rheumatic fever in childhood continues to cause serious morbidity despite all developments. The objective of this study was to evaluate the clinical and laboratory characteristics of patients with acute rheumatic fever and to determine the frequency of subclinical carditis and the side effects of the drugs used in the treatment. Methods: The data of patients hospitalised between 2008 and 2018 with the diagnosis of acute rheumatic fever were included in the study. The relationship of gender and age with the frequency of major symptoms and the distribution of the drugs used in the treatment and their side effects were evaluated. Results: Medical records of 102 patients with complete data were reviewed. 56.9% of the patients were male and the mean age was 10.7 ± 1.9 years. The most common distribution of complaints found were arthritis (51%), arthralgia (25.5%) and fever (16.7%). 10.8% of all patients (n = 11) were diagnosed subclinical carditis via echocardiographic evaluation. The frequency of carditis was higher in female patients with a borderline statistical significance (p = 0.05). However, there was no statistically significant difference between gender and arthritis (p = 0.22) and carditis (p > 0.05). Anti-congestive therapy was required in 22% and inotropic treatment was needed in 6.1% cases. Toxic hepatitis developed in four cases during the acetylsalicylic acid treatment. Conclusions: In a 10-year period, detection of subclinical carditis in 10.8% cases supported that echocardiography should be performed as a standard method for the diagnosis of acute rheumatic fever. Patients should be followed closely in terms of hepatic toxicity due to acetylsalicylic acid used in the treatment.
MeSH term(s)	Child ; Echocardiography ; Female ; Humans ; Laboratories ; Male ; Myocarditis/chemically induced ; Myocarditis/diagnosis ; Myocarditis/epidemiology ; Rheumatic Fever ; Rheumatic Heart Disease/diagnosis ; Rheumatic Heart Disease/epidemiology
Language	English
Publishing date	2021-08-31
Publishing country	England
Document type	Journal Article
ZDB-ID	1078466-4
ISSN	1467-1107 ; 1047-9511
ISSN (online)	1467-1107
ISSN	1047-9511
DOI	10.1017/S1047951121003528
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