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  1. Article ; Online: Neutrophil-to-Lymphocyte Ratio and Risk of Nodal Metastasis in Early-Stage Lung Adenocarcinoma: A Brief Report From a Multicentric Analysis.

    Gallina, Filippo Tommaso / Chiappetta, Marco / Tajè, Riccardo / Forcella, Daniele / Sassorossi, Carolina / Congedo, Maria Teresa / Evangelista, Jessica / Sperduti, Isabella / Lococo, Filippo / Cappuzzo, Federico / Melis, Enrico / Margaritora, Stefano / Facciolo, Francesco

    Clinical lung cancer

    2024  

    Language English
    Publishing date 2024-03-15
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2145146-1
    ISSN 1938-0690 ; 1525-7304
    ISSN (online) 1938-0690
    ISSN 1525-7304
    DOI 10.1016/j.cllc.2024.03.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5893: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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    Zs.MO 440: Show issues

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  2. Article: A rare case of oral multisystem Langerhans cell histiocytosis.

    Facciolo, Maria-Teresa / Riva, Francesco / Gallenzi, Patrizia / Patini, Romeo / Gaglioti, Domenico

    Journal of clinical and experimental dentistry

    2017  Volume 9, Issue 6, Page(s) e820–e824

    Abstract: Langerhans cell histiocytosis (LCH) is a rare disorder characterized by high proliferation of Langerhans dendritic cells. LCH is a solitary or multifocal disease that primarily involves bone tissue and often affects children and young men. A 29 years-old ...

    Abstract Langerhans cell histiocytosis (LCH) is a rare disorder characterized by high proliferation of Langerhans dendritic cells. LCH is a solitary or multifocal disease that primarily involves bone tissue and often affects children and young men. A 29 years-old Caucasian man was referred to the Oral Surgery Unit of George Eastman Hospital - Umberto I teaching hospital, with third degree mobility of teeth belonging to second, third and fourth quadrant. Panoramic radiograph showed multiple radiolucent areas with well demarcated borders on the right and left site of the mandible and on the left site of the maxilla. Extractions of compromised teeth and biopsy of the osteolytic tissue were performed. The final diagnosis of multisystem Langerhans cell histiocytosis of the soft and hard tissues of the oral cavity was made. The patient was sent to the Hematology department of Umberto I Teaching Hospital of "Sapienza" - University of Rome for the proper treatment. The present case of rare multisystem LCH involving oral hard and soft tissues shows the strong importance of better investigate, with appropriate additional exams, initial shifty symptoms that could lead to a misdiagnosis.
    Language English
    Publishing date 2017-06-01
    Publishing country Spain
    Document type Case Reports
    ZDB-ID 2586647-3
    ISSN 1989-5488
    ISSN 1989-5488
    DOI 10.4317/jced.53774
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Ketogenic diet ameliorates autism spectrum disorders-like behaviors via reduced inflammatory factors and microbiota remodeling in BTBR T

    Olivito, Ilaria / Avolio, Ennio / Minervini, Damiana / Soda, Teresa / Rocca, Carmine / Angelone, Tommaso / Iaquinta, Francesco Salvatore / Bellizzi, Dina / De Rango, Francesco / Bruno, Rosalinda / De Bartolo, Loredana / Alò, Raffaella / Canonaco, Marcello / Facciolo, Rosa Maria

    Experimental neurology

    2023  Volume 366, Page(s) 114432

    Abstract: Autism Spectrum Disorder (ASD) is increasing, but its complete etiology is still lacking. Recently, application of ketogenic diet (KD) has shown to reduce abnormal behaviors while improving psychological/sociological status in neurodegenerative diseases. ...

    Abstract Autism Spectrum Disorder (ASD) is increasing, but its complete etiology is still lacking. Recently, application of ketogenic diet (KD) has shown to reduce abnormal behaviors while improving psychological/sociological status in neurodegenerative diseases. However, KD role on ASD and underlying mechanism remains unknown. In this work, KD administered to BTBR T
    MeSH term(s) Mice ; Animals ; Autism Spectrum Disorder/metabolism ; Mice, Inbred C57BL ; Diet, Ketogenic ; Brain/metabolism ; Microbiota ; Disease Models, Animal ; Mice, Inbred Strains
    Language English
    Publishing date 2023-05-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 207148-4
    ISSN 1090-2430 ; 0014-4886
    ISSN (online) 1090-2430
    ISSN 0014-4886
    DOI 10.1016/j.expneurol.2023.114432
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    Zs.A 184: Show issues Location:
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  4. Article ; Online: A risk stratification scheme for synchronous oligometastatic non-small cell lung cancer developed by a multicentre analysis.

    Spaggiari, Lorenzo / Bertolaccini, Luca / Facciolo, Francesco / Gallina, Filippo Tommaso / Rea, Federico / Schiavon, Marco / Margaritora, Stefano / Congedo, Maria Teresa / Lucchi, Marco / Ceccarelli, Ilaria / Alloisio, Marco / Bottoni, Edoardo / Negri, Giampiero / Carretta, Angelo / Cardillo, Giuseppe / Ricciardi, Sara / Ruffini, Enrico / Costardi, Lorena / Muriana, Giovanni /
    Viggiano, Domenico / Rusca, Michele / Ventura, Luigi / Marulli, Giuseppe / De Palma, Angela / Rosso, Lorenzo / Mendogni, Paolo / Crisci, Roberto / De Vico, Andrea / Maniscalco, Pio / Tamburini, Nicola / Puma, Francesco / Ceccarelli, Silvia / Voltolini, Luca / Bongiolatti, Stefano / Morelli, Angelo / Londero, Francesco

    Lung cancer (Amsterdam, Netherlands)

    2021  Volume 154, Page(s) 29–35

    Abstract: Backgrounds: Oligometastatic Non-Small Cell Lung Cancer (NSCLC) patients represent a category without a standard therapeutic approach. However, in selected oligometastatic NSCLC, radical surgery seems to offer a good prognosis. This retrospective study ... ...

    Abstract Backgrounds: Oligometastatic Non-Small Cell Lung Cancer (NSCLC) patients represent a category without a standard therapeutic approach. However, in selected oligometastatic NSCLC, radical surgery seems to offer a good prognosis. This retrospective study aimed to analyse the long-term outcomes of synchronous oligometastatic patients treated with curative intent and identify the factors associated with better results and the proposal of a risk stratification system for classifying the synchronous oligometastatic NSCLC.
    Methods: The medical records of patients from 18 centres with pathologically diagnosed synchronous oligometastatic NSCLC were retrospectively reviewed. The inclusion criteria were synchronous oligometastatic NSCLC, radical surgical treatment of the primary tumour with or without neoadjuvant/adjuvant therapy and radical treatment of all metastatic sites. The Kaplan - Meier method estimated survivals. A stratified backward stepwise Cox regression model was assessed for multivariable survival analyses.
    Results: 281 patients were included. The most common site of metastasis was the brain, in 50.89 % patients. Median overall survival was 40 months (95 % CI: 29-53). Age ≤65 years (HR = 1.02, 95 % CI: 1.00-1.05; p = 0.019), single metastasis (HR = 0.71, 95 % CI: 0.45-1.13; p = 0.15) and presence of contralateral lung metastases (HR = 0.30, 95 % CI: 0.15 - 0.62; p = 0.001) were associated with a good prognosis. The presence of pathological N2 metastases negatively affected survival (HR = 2.00, 95 % CI: 1.21-3.32; p = 0.0065). These prognostic factors were used to build a simple risk classification scheme.
    Conclusions: Treatment of selected synchronous oligometastatic NSCLC with curative purpose could be conducted safely and at acceptable 5-year survival levels, especially in younger patients with pN0 disease.
    MeSH term(s) Aged ; Carcinoma, Non-Small-Cell Lung/therapy ; Humans ; Kaplan-Meier Estimate ; Lung Neoplasms/diagnosis ; Lung Neoplasms/therapy ; Prognosis ; Retrospective Studies ; Risk Assessment ; Treatment Outcome
    Language English
    Publishing date 2021-02-12
    Publishing country Ireland
    Document type Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 632771-0
    ISSN 1872-8332 ; 0169-5002
    ISSN (online) 1872-8332
    ISSN 0169-5002
    DOI 10.1016/j.lungcan.2021.02.001
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    Zs.A 2135: Show issues Location:
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    Zs.MO 423: Show issues

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  5. Article ; Online: Epigenetic silencing of miR-145-5p contributes to brain metastasis.

    Donzelli, Sara / Mori, Federica / Bellissimo, Teresa / Sacconi, Andrea / Casini, Beatrice / Frixa, Tania / Roscilli, Giuseppe / Aurisicchio, Luigi / Facciolo, Francesco / Pompili, Alfredo / Carosi, Maria Antonia / Pescarmona, Edoardo / Segatto, Oreste / Pond, Greg / Muti, Paola / Telera, Stefano / Strano, Sabrina / Yarden, Yosef / Blandino, Giovanni

    Oncotarget

    2015  Volume 6, Issue 34, Page(s) 35183–35201

    Abstract: Brain metastasis is a major cause of morbidity and mortality of lung cancer patients. We assessed whether aberrant expression of specific microRNAs could contribute to brain metastasis. Comparison of primary lung tumors and their matched metastatic brain ...

    Abstract Brain metastasis is a major cause of morbidity and mortality of lung cancer patients. We assessed whether aberrant expression of specific microRNAs could contribute to brain metastasis. Comparison of primary lung tumors and their matched metastatic brain disseminations identified shared patterns of several microRNAs, including common down-regulation of miR-145-5p. Down-regulation was attributed to methylation of miR-145's promoter and affiliated elevation of several protein targets, such as EGFR, OCT-4, MUC-1, c-MYC and, interestingly, tumor protein D52 (TPD52). In line with these observations, restored expression of miR-145-5p and selective depletion of individual targets markedly reduced in vitro and in vivo cancer cell migration. In aggregate, our results attribute to miR-145-5p and its direct targets pivotal roles in malignancy progression and in metastasis.
    MeSH term(s) Animals ; Brain Neoplasms/genetics ; Brain Neoplasms/metabolism ; Brain Neoplasms/secondary ; Cell Line, Tumor ; Cell Movement/physiology ; CpG Islands ; DNA Methylation ; Down-Regulation ; Epigenesis, Genetic ; Gene Silencing ; Heterografts ; Humans ; Lung Neoplasms/genetics ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; Mice ; Mice, Nude ; MicroRNAs/biosynthesis ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Neoplasm Metastasis ; Signal Transduction
    Chemical Substances MIRN145 microRNA, human ; MicroRNAs
    Language English
    Publishing date 2015-11-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2560162-3
    ISSN 1949-2553 ; 1949-2553
    ISSN (online) 1949-2553
    ISSN 1949-2553
    DOI 10.18632/oncotarget.5930
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  6. Article: Feeding differences in pubertal and aged golden hamsters (Mesocricetus auratus) are related to specific cerebral expression pattern of histamine subtype 3 receptor.

    Madeo, Maria / Granata, Teresa / Facciolo, Rosa Maria / Tripepi, Sandro / Canonaco, Marcello

    Behavioral neuroscience

    2006  Volume 120, Issue 6, Page(s) 1235–1241

    Abstract: The hibernating golden hamster (Mesocricetus auratus) is becoming a useful rodent model to study the neurophysiological role of some neuromediators on vital behaviors such as sleep and thermoregulation. Recent works have shown that the histamine ... ...

    Abstract The hibernating golden hamster (Mesocricetus auratus) is becoming a useful rodent model to study the neurophysiological role of some neuromediators on vital behaviors such as sleep and thermoregulation. Recent works have shown that the histamine neuroreceptor subtypes (H-sub(1-3)R) are able to modulate such behaviors. Here, specific subtype(s) and cerebral nuclei that were actively operating on feeding behaviors in pubertal and adult hamsters were identified. Of the subtypes assessed, H-sub-3R antagonist (thioperamide) provoked significant (p < .001) changes in behavior (very low total food and water intake) in adults, whereas it did not significantly modify these behaviors in pubertals. The H-sub-3R antagonist's role seemed to be related to elevated amounts of stress-induced damaged neurons displaying, mainly, shrunken crenated cell membranes and altered synaptic processes in limbic areas such as amygdala, cortex, and hippocampus. At the transcription level, an evident expression pattern of H-sub-3R messenger RNA appeared in pubertals, especially in neurons of the cortex and hippocampus, whereas the same trend was featured in amygdalar areas of hibernating adult hamsters, suggesting early H-sub-3R regulatory activities, at least in limbic sites of this rodent model.
    MeSH term(s) Age Factors ; Aging/physiology ; Analysis of Variance ; Animals ; Animals, Newborn ; Behavior, Animal/drug effects ; Brain/metabolism ; Brain/ultrastructure ; Cricetinae ; Dose-Response Relationship, Drug ; Drinking/drug effects ; Eating/drug effects ; Feeding Behavior/drug effects ; Feeding Behavior/physiology ; Gene Expression Regulation, Developmental/drug effects ; Gene Expression Regulation, Developmental/physiology ; Histamine/pharmacokinetics ; Histamine H1 Antagonists/pharmacology ; In Situ Hybridization/methods ; Male ; Mesocricetus ; Microscopy, Electron, Transmission/methods ; Protein Binding/drug effects ; Receptors, Histamine H3/genetics ; Receptors, Histamine H3/metabolism ; Tritium/pharmacokinetics
    Chemical Substances Histamine H1 Antagonists ; Receptors, Histamine H3 ; Tritium (10028-17-8) ; Histamine (820484N8I3)
    Language English
    Publishing date 2006-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 230159-3
    ISSN 1939-0084 ; 0735-7044
    ISSN (online) 1939-0084
    ISSN 0735-7044
    DOI 10.1037/0735-7044.120.6.1235
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1837: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  7. Article: The histaminergic signaling system exerts a neuroprotective role against neurodegenerative-induced processes in the hamster.

    Canonaco, Marcello / Madeo, Maria / Alò, Raffaella / Giusi, Giuseppina / Granata, Teresa / Carelli, Antonio / Canonaco, Alessia / Facciolo, Rosa Maria

    The Journal of pharmacology and experimental therapeutics

    2005  Volume 315, Issue 1, Page(s) 188–195

    Abstract: The neurotoxic 3-nitropropionic acid (3-NP), a freckled milk vetch-derived inhibitor of mitochondrial enzymatic processes that is capable of mimicking the typical pathological features of neurodegenerative disorders, behaved in a differentiated manner in ...

    Abstract The neurotoxic 3-nitropropionic acid (3-NP), a freckled milk vetch-derived inhibitor of mitochondrial enzymatic processes that is capable of mimicking the typical pathological features of neurodegenerative disorders, behaved in a differentiated manner in a hibernating rodent (hamster) with respect to a nonhibernating rodent (rat). Treatment of the two rodents with both an acute and chronic 3-NP dose supplied deleterious neuronal effects due to distinct histamine receptor (H(n)R) transcriptional activities, especially in the case of the rat. In hamsters, these treatment modalities accounted for overall reduced global activity in a freely moving environment and overt motor symptoms such as hindlimb dystonia and clasping with respect to the greater abnormal motor behaviors in rats. This behavioral difference appeared to be strongly related to qualitative fewer neuronal alterations and, namely, lesser crenated cell membranes, swollen mitochondria, and darkened nuclei in hamster brain areas. Moreover, a mixed H(1,3)R mRNA expression pattern was reported for both rodents treated with a chronic 3-NP dose as demonstrated by predominantly low H1R mRNA levels (>50%) in rat striatum and cortex, whereas extremely high H3R levels (>80%) characterized the lateral and central amygdala nuclei plus the striatum of hamsters. Interestingly, the H3R antagonist (thioperamide) blocked 3-NP-dependent behaviors plus induced an up-regulation of H1R levels in mainly the above-reported hamster amygdalar nuclei. Overall, these results show, for the first time, that a major protective role against neurodegenerative events appears to be strongly related to the expression activity of H(1,3)R subtypes of amygdalar neurons in this hibernating model.
    MeSH term(s) Animals ; Cricetinae ; Mesocricetus ; Neurodegenerative Diseases/prevention & control ; Nitro Compounds/toxicity ; Propionates/toxicity ; RNA, Messenger/analysis ; Rats ; Rats, Wistar ; Receptors, Histamine H1/genetics ; Receptors, Histamine H1/physiology ; Receptors, Histamine H3/genetics ; Receptors, Histamine H3/physiology ; Signal Transduction/physiology
    Chemical Substances Nitro Compounds ; Propionates ; RNA, Messenger ; Receptors, Histamine H1 ; Receptors, Histamine H3 ; 3-nitropropionic acid (QY4L0FOX0D)
    Language English
    Publishing date 2005-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3106-9
    ISSN 1521-0103 ; 0022-3565
    ISSN (online) 1521-0103
    ISSN 0022-3565
    DOI 10.1124/jpet.105.088153
    Database MEDical Literature Analysis and Retrieval System OnLINE

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