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  1. Article ; Online: Being a Female Gastroenterologist in Turkey.

    Akhan Çetinkaya, Züleyha / Ersoy, Özdal / Tözün, Nurdan

    The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology

    2024  Volume 35, Issue 2, Page(s) 112–118

    Abstract: Background/aims: Our aim is to examine the representation of woman gastroenterologists in both work and social life in Turkey and to elucidate the difficulties they encounter during their career pathways or while actively practicing their profession.: ...

    Abstract Background/aims: Our aim is to examine the representation of woman gastroenterologists in both work and social life in Turkey and to elucidate the difficulties they encounter during their career pathways or while actively practicing their profession.
    Materials and methods: A self-structured survey consisting of 25 questions was sent via email to all 152 female gastroenterologists. Survey results were received from 140 participants.
    Results: Sixty percent of the woman gastroenterologists had marriage-career conflicts, and 74% of them stated that they could not manage work-life balance with their children. Among these woman gastroenterologists, 46.6% of them reported that they had faced carrier-related barriers and challenges while applying for an academic rise or expecting a promotion in their job, 58.5% were exposed to gender mobbing, and 35.6% were subjected to verbal or physical violence. On the other hand, woman gastroenterologists are found to be underrepresented in endoscopic interventions where only one-third of the participants perform invasive endoscopic procedures, and the percentage of those who perform advanced endoscopy such as endoscopic submucosal dissection and endoscopic mucosal resection remains even less as 8.9%. The number of women in leadership positions during their careers is found to be low, and only 2 women were selected as the president of the society since 1959, the establishment time of the Turkish Society of Gastroenterology.
    Conclusion: More effort is needed to keep a fair gender balance in Turkish gastroenterology society and to increase the women's representation in therapeutic endoscopy options and also in leadership positions.
    MeSH term(s) Female ; Humans ; Endoscopy, Gastrointestinal ; Gastroenterologists ; Gastroenterology ; Surveys and Questionnaires ; Turkey ; Physicians, Women
    Language English
    Publishing date 2024-03-07
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 1340275-4
    ISSN 2148-5607 ; 1300-4948
    ISSN (online) 2148-5607
    ISSN 1300-4948
    DOI 10.5152/tjg.2024.22612
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Very high alpha-fetoprotein in a young man due to concomitant presentation of hepatocellular carcinoma and Sertoli cell testis tumor.

    Ersoy, Ozdal

    World journal of gastroenterology

    2005  Volume 11, Issue 44, Page(s) 7051–7053

    Abstract: Studies reported that there is a close relationship between hepatocellular carcinoma (HCC) and testis carcinoma. Both tumors can be presented as synchronal tumors, or as testicular metastases of HCC or as hepatic metastases of testicular tumor( [7] ). ... ...

    Abstract Studies reported that there is a close relationship between hepatocellular carcinoma (HCC) and testis carcinoma. Both tumors can be presented as synchronal tumors, or as testicular metastases of HCC or as hepatic metastases of testicular tumor( [7] ). HCC is one of the most common malignancies worldwide and the incidence of HCC increases with age( [8] ). The relationship between hepatitis B incidence and HCC rates is also well recognized. Alpha fetoprotein (AFP) is produced by 70% of HCC. Though a level of AFP >400 ng/mL is diagnostic for HCC, in the presence of active hepatitis B infection, the cut-off level should be considered to be at least 1 000-4 000 ng/mL. Like HCC, germ cell tumors of the testis also release AFP; but it is shown that some of Sertoli cell tumors of testis can also release AFP( [10] ). Herein we have reported about the first case of HCC in the literature which is presented concomitantly with Sertoli-Leydig tumor of testis, leading to extremely high level of AFP in a 21-year-old man.
    MeSH term(s) Adult ; Biomarkers, Tumor/blood ; Carcinoma, Hepatocellular/blood ; Carcinoma, Hepatocellular/diagnosis ; Carcinoma, Hepatocellular/pathology ; Comorbidity ; Humans ; Liver Neoplasms/blood ; Liver Neoplasms/diagnosis ; Liver Neoplasms/pathology ; Male ; Neoplasms, Multiple Primary ; Sertoli Cell Tumor/blood ; Sertoli Cell Tumor/diagnosis ; Sertoli Cell Tumor/pathology ; Testicular Neoplasms/blood ; Testicular Neoplasms/diagnosis ; Testicular Neoplasms/pathology ; alpha-Fetoproteins/metabolism
    Chemical Substances Biomarkers, Tumor ; alpha-Fetoproteins
    Language English
    Publishing date 2005-07-20
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v11.i44.7051
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Validity and reliability of the measure yourself medical outcome profile 2 (MYMOP2) questionnaire among Turkish patients having anorectal disorders.

    Ersoy, Özdal / Temel, Yasemin Ecem / Alptekin, Hasan Kerem

    The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology

    2019  Volume 30, Issue 1, Page(s) 28–32

    Abstract: Background/aims: Measure Yourself Medical Outcome Profile 2 (MYMOP2) is a patient-generated outcome measure allowing patients to select the problems that are the most important to them and that they want to address, and it measures the effects of the ... ...

    Abstract Background/aims: Measure Yourself Medical Outcome Profile 2 (MYMOP2) is a patient-generated outcome measure allowing patients to select the problems that are the most important to them and that they want to address, and it measures the effects of the problem from a wide range of health care interventions. This study aimed to translate the questionnaire into Turkish language (Turkish MYMOP-TMYMOP) and add this clinically useful measure to Turkish medical practice by assessing its validity and reliability.
    Materials and methods: Fifty volunteers with anorectal disorders were prospectively included into the study. Each patient was enrolled into a pelvic floor training biofeedback program, specific to their anorectal symptomatology. The subjects were administered both the Nottingham Health Profile and the TMYMOP2 questionnaires before the treatment session (initial visit) and at the control follow-up visits (the first and second months, via e-mail or telephone calls).
    Results: The TMYMOP2 questionnaire was shown to be moderately valid (the Pearson correlation coefficient score between the total scores of the subgroups of the two questionnaires were 0.335 and 0.642, respectively, p<0.05) and highly reliable (the Cronbach's alfa coefficient score between the total scores of the subgroups of the two questionnaires were 0.77, 0.82, and 0.88 in the beginning and at the first and second month follow-up visits, respectively).
    Conclusion: The TMYMOP2 was shown to be a low-to-moderately valid and a highly reliable scale. Because it is brief and short to complete, it might be an important and free-to-use tool to measure the diseases, and it can enhance the patient-centered care within the Turkish health care context.
    MeSH term(s) Adult ; Biofeedback, Psychology/methods ; Female ; Humans ; Male ; Middle Aged ; Patient Outcome Assessment ; Pelvic Floor ; Prospective Studies ; Rectal Diseases/psychology ; Rectal Diseases/therapy ; Reproducibility of Results ; Statistics, Nonparametric ; Surveys and Questionnaires/standards ; Translations ; Treatment Outcome ; Turkey
    Language English
    Publishing date 2019-03-19
    Publishing country Turkey
    Document type Journal Article ; Validation Studies
    ZDB-ID 1340275-4
    ISSN 2148-5607 ; 1300-4948
    ISSN (online) 2148-5607
    ISSN 1300-4948
    DOI 10.5152/tjg.2018.17859
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Anxiety and Stress Levels Associated With COVID-19 Pandemic of University Students in Turkey: A Year After the Pandemic.

    Durbas, Atahan / Karaman, Hüseyin / Solman, Caǧla Hamide / Kaygisiz, Nisanur / Ersoy, Özdal

    Frontiers in psychiatry

    2021  Volume 12, Page(s) 731348

    Abstract: The outbreak of COVID-19 has been affecting the daily lives of almost everyone and puts huge psychological pressure on people worldwide, including Turkey. Anxiety and stress levels among university students were already a public health concern. Our study ...

    Abstract The outbreak of COVID-19 has been affecting the daily lives of almost everyone and puts huge psychological pressure on people worldwide, including Turkey. Anxiety and stress levels among university students were already a public health concern. Our study aims to demonstrate the anxiety and stress levels of university students in Turkey after the outbreak of COVID-19 according to the Coronavirus Anxiety Scale (CAS) and COVID Stress Scale (CSS). CAS is a brief mental health screener to identify probable cases of dysfunctional anxiety associated with the COVID-19 pandemic, and CSS was developed to understand and assess COVID-19-related distress. An online questionnaire was administered to active 1,265 university students in Turkey between February 27 and March 8, 2021,
    Language English
    Publishing date 2021-10-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2021.731348
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A Comparative Study Evaluating the Incidence of Colorectal Neoplasia(s) in Candidates for Bariatric Surgery by Screening Colonoscopy, 40-49 Versus 50-65 Years Old: a Preliminary Study.

    Toydemir, Toygar / Özgen, Görkem / Çalıkoğlu, İsmail / Ersoy, Özdal / Yerdel, Mehmet Ali

    Obesity surgery

    2019  Volume 29, Issue 8, Page(s) 2430–2435

    Abstract: Introduction: Obesity and metabolic syndrome (MetS) are associated with colorectal neoplasia (CRN) and carcinoma (CRC). Whether such subjects must undergo screening colonoscopy (SC) earlier, is unknown. Incidences of CRNs in 40-49- versus 50-65-year-old ...

    Abstract Introduction: Obesity and metabolic syndrome (MetS) are associated with colorectal neoplasia (CRN) and carcinoma (CRC). Whether such subjects must undergo screening colonoscopy (SC) earlier, is unknown. Incidences of CRNs in 40-49- versus 50-65-year-old bariatric patients were compared by SC. No prospective data on SC is available in morbidly obese/MetS.
    Material and methods: Surgical weight loss candidates over 39 years of age, asymptomatic, and average-risk for CRC offered SC. Those giving written informed consent were enrolled. Colonoscopies were done by the same surgeon. Smoking/drinking history, fasting blood glucose (FBG), insulin, C-peptide, triglyceride, high density lipoprotein, vitamin D, HbA1c, and insulin resistance parameters were recorded. CRN rate and the distribution of variables in patients 40-49 years of age were compared with 50-65. Student's t and Chi-square tests were used as appropriate. P < 0.05 was regarded as statistically significant.
    Results: Among 168 SCs, 47 had CRNs (27.9%). Including carcinoma, 15 had an advanced CRN (aCRN) (8.9% aCRN and 0.6% CRC). CRN rate was 35.6% in ≥ 50 years old whereas 22.1% in 40-49 (p = 0.053). aCRN rates (8.4% in 40-49 versus 9.6% in 50-65) were similar (p = 0.792). Metabolic parameters and smoking-drinking history were equally distributed between the groups except FBG and HbA1c as their mean levels were slightly higher in the 50-65 age group (p < 0.05).
    Conclusions: Presented results warrant routine SC in the 40-49-year-old morbidly obese and/or MetS patient population with average risk, and in aged > 50, it certainly must be enforced and included in the preoperative check-list if not done before.
    MeSH term(s) Adult ; Age Factors ; Aged ; Bariatric Surgery ; Colonoscopy ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/epidemiology ; Colorectal Neoplasms/etiology ; Early Detection of Cancer/methods ; Female ; Humans ; Incidence ; Male ; Mass Screening/methods ; Metabolic Syndrome/complications ; Metabolic Syndrome/epidemiology ; Middle Aged ; Multivariate Analysis ; Obesity, Morbid/complications ; Obesity, Morbid/epidemiology ; Obesity, Morbid/surgery ; Risk Factors ; Smoking/adverse effects ; Smoking/epidemiology ; Turkey/epidemiology
    Language English
    Publishing date 2019-03-15
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 1070827-3
    ISSN 1708-0428 ; 0960-8923
    ISSN (online) 1708-0428
    ISSN 0960-8923
    DOI 10.1007/s11695-019-03819-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: A rare cause of Fatty liver and elevated aminotransferase levels: chanarin-dorfman syndrome: a case report.

    Ersoy, Ozdal / Alkım, Canan / Onuk, Mehmet Derya / Demirsoy, Hüseyin / Argon, Dilek

    International journal of hepatology

    2011  Volume 2011, Page(s) 341372

    Abstract: Chanarin-Dorfman syndrome is a rare, inherited metabolic disorder of neutral lipid storage characterized by ichthyosis, lipid vacuoles in leukocytes, and involvement of several internal organs, mostly the liver. Since the initial case was reported by ... ...

    Abstract Chanarin-Dorfman syndrome is a rare, inherited metabolic disorder of neutral lipid storage characterized by ichthyosis, lipid vacuoles in leukocytes, and involvement of several internal organs, mostly the liver. Since the initial case was reported by Dorfman in 1974, nearly 50 cases have been reported, and the majority were from Middle East countries. Here, we report a 20-year-old patient with ichthyosis from Turkey, diagnosed as Chanarin-Dorfman syndrome presented with asypmtomatic elevated transaminases and hepatosteatosis, and also briefly review the updated clinical implications and management of this rarely seen syndrome. Prompt diagnosis of this syndrome avoids further unnecessary investigations in patients with ichthyosis.
    Language English
    Publishing date 2011-01-20
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2621468-4
    ISSN 2090-3456 ; 2090-3448
    ISSN (online) 2090-3456
    ISSN 2090-3448
    DOI 10.4061/2011/341372
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  7. Article: Eradication of Helicobacter pylori in follicular and nonfollicular gastritis.

    Mehmet, Sokmen / Ozdal, Ersoy / Kamil, Ozdil / Beşir, Kesici / Huseyin, Demirsoy / Nihat, Akbayir / Cigdem, Ersoy Yazici / Nusret, Erdogan

    Hepato-gastroenterology

    2009  Volume 56, Issue 91-92, Page(s) 930–934

    Abstract: Background/aims: Effective eradication therapy of Helicobacter pylori (Hp) in non-follicular type gastritis is commonly demonstrated by many studies. In contrast, some other studies show that the eradication of Hp is low in follicular type gastritis. ... ...

    Abstract Background/aims: Effective eradication therapy of Helicobacter pylori (Hp) in non-follicular type gastritis is commonly demonstrated by many studies. In contrast, some other studies show that the eradication of Hp is low in follicular type gastritis. However, the subject concerning the comparison of the results of triple-drug Hp eradication treatment between follicular and nonfollicular type gastritis is still unclear because of the paucity of studies. The aim of this study was to compare the results of Hp eradication therapy between follicular and non-follicular type gastritis.
    Methodology: Two age- and sex-matched groups, consisting of 21 patients with follicular type and 23 patients with nonfollicular type gastritis associated with Hp (histopathologically diagnosed after endoscopic procedure), were enrolled into our study. Triple-drug Hp eradication therapy [lansoprazole (L) 30 mg bid, amoxicillin (A) 1000 g bid and clarithromycin (C) 500 mg bid] was given to all patients in both groups for two weeks. Control for the eradication of Hp was performed by endoscopic biopsy (3 months after treatment) in the follicular group and by urea-breath test (1 month after treatment) in the nonfollicular group. Eradication of the follicles in follicular type gastritis was also observed in the control endoscopic biopsies. For the statistical analysis, SPSS 11 for Windows was used and paired-samples t-test was performed. p<0.05 was considered as significant.
    Results: In total, 66 patients were enrolled into the study. All were histopathologically diagnosed as having Hp-associated gastritis (31 follicular and 35 nonfollicular) and started on triple-drug Hp eradication therapy. Only 44 of these patients (21 follicular gastritis and 23 nonfollicular gastritis) completed 2 weeks of treatment. The other 22 patients were not able to complete the treatment because of not taking the drugs properly or of the side-effects of the drugs. Patient compliance ratio to the treatment was 67.7%. The ratios for Hp eradication in follicular and nonfollicular type gastritis were found to be 43% and 74% respectively. Lymphoid follicles in 43% of patients with follicular gastritis disappeared after the eradication therapy.
    Conclusions: Lymphoid follicles, which are thought to be the primary lesions of low-grade Mucosa associated lymphoid tissue (MALT) tumors, come out frequently in Hp-associated gastritis. Although the eradication of Hp is said to be difficult in the presence of lymphoid follicles, there is still limited knowledge about this situation. The ratio of effective eradication of Hp with LAC combination therapy in nonfollicular gastritis is nearly over 80%. However, in our study we observed an obvious lower Hp eradication ratio in follicular type gastritis than in nonfollicular gastritis. Thus, in order to achieve higher Hp eradication ratios in follicular gastritis, duration of the triple-drug treatment might be lengthened or bismuth salt preparations need to be added to triple combination therapies.
    MeSH term(s) 2-Pyridinylmethylsulfinylbenzimidazoles/administration & dosage ; Adult ; Amoxicillin/administration & dosage ; Anti-Bacterial Agents/administration & dosage ; Anti-Ulcer Agents/administration & dosage ; Clarithromycin/administration & dosage ; Drug Therapy, Combination ; Female ; Gastritis/drug therapy ; Gastritis/microbiology ; Gastritis/pathology ; Helicobacter Infections/drug therapy ; Helicobacter Infections/pathology ; Helicobacter pylori ; Humans ; Lansoprazole ; Male ; Middle Aged ; Prospective Studies ; Treatment Outcome ; Young Adult
    Chemical Substances 2-Pyridinylmethylsulfinylbenzimidazoles ; Anti-Bacterial Agents ; Anti-Ulcer Agents ; Lansoprazole (0K5C5T2QPG) ; Amoxicillin (804826J2HU) ; Clarithromycin (H1250JIK0A)
    Language English
    Publishing date 2009-05
    Publishing country Greece
    Document type Controlled Clinical Trial ; Journal Article
    ZDB-ID 801013-4
    ISSN 0172-6390
    ISSN 0172-6390
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Ki67 as a prognostic factor for long-term outcome following surgery in gastrointestinal stromal tumors.

    Turkel Kucukmetin, Nurten / Cicek, Bahattin / Saruc, Murat / Ersoy, Ozdal / Vardareli, Eser / Onder, Oguz / Gurluler, Ercument / Tiftikci, Arzu / Goksel, Suha / Tozun, Nurdan

    European journal of gastroenterology & hepatology

    2015  Volume 27, Issue 11, Page(s) 1276–1280

    Abstract: Objective: This study aimed to examine the value of Ki67 expression along with other potential prognostic factors for predicting overall survival and disease-free survival in patients with gastrointestinal stromal tumors who underwent curative resection. ...

    Abstract Objective: This study aimed to examine the value of Ki67 expression along with other potential prognostic factors for predicting overall survival and disease-free survival in patients with gastrointestinal stromal tumors who underwent curative resection.
    Patients and methods: Sixty-eight histologically confirmed and operated patients with gastrointestinal stromal tumors were included. Clinical and follow-up data were retrieved from medical records and patients were contacted at the end of the study. The effects of certain clinical and histopathological parameters on survival outcomes were examined.
    Results: Sixty-eight patients were followed for a mean duration of follow-up of 2923.3 patient-months. Twelve deaths (17.6%), seven metastasis (10.3%), and two local recurrences (2.9%) occurred. Overall survival was 102.5 months [95% confidence interval (CI), 88.3-116.8] and disease-free survival was 91.8 months (95% CI, 76.5-107.2). Multivariate analyses identified a high Ki67 index (≥ 10%) as an independent predictor of both poor overall survival (hazard ratio, 4.8; 95% CI 1.2-19.2; P=0.027) and poor disease-free survival (hazard ratio, 15.3; 95% CI, 4.7-50.2).
    Conclusion: A high Ki67 expression seems to be a useful prognostic factor that would aid in predicting disease course in gastrointestinal stromal tumors. These findings deserve further investigation in larger studies.
    MeSH term(s) Aged ; Disease-Free Survival ; Female ; Follow-Up Studies ; Gastrointestinal Neoplasms/chemistry ; Gastrointestinal Neoplasms/pathology ; Gastrointestinal Neoplasms/surgery ; Gastrointestinal Stromal Tumors/chemistry ; Gastrointestinal Stromal Tumors/secondary ; Gastrointestinal Stromal Tumors/surgery ; Humans ; Ki-67 Antigen/analysis ; Male ; Middle Aged ; Mitotic Index ; Neoplasm Recurrence, Local/chemistry ; Survival Rate ; Time Factors ; Treatment Outcome
    Chemical Substances Ki-67 Antigen
    Language English
    Publishing date 2015-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 1034239-4
    ISSN 1473-5687 ; 0954-691X
    ISSN (online) 1473-5687
    ISSN 0954-691X
    DOI 10.1097/MEG.0000000000000454
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  9. Article ; Online: Analyzing esophageal squamous cell papillomas for the presence of human papilloma virüs.

    Tiftikçi, Arzu / Kutsal, Eser / Altıok, Ender / İnce, Ümit / Çicek, Bahattin / Saruç, Murat / Türkel, Nurten / Ersoy, Özdal / Yenmiş, Güven / Tözün, Nurdan

    The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology

    2017  Volume 28, Issue 3, Page(s) 176–178

    Abstract: Background/aims: Human Papilloma Virus (HPV) infection can be a predisposing condition for the development of squamous cell papilloma (SCP) of the esophagus, which can progress to dysplasia and to carcinoma as a result of chronic infection. The aim of ... ...

    Abstract Background/aims: Human Papilloma Virus (HPV) infection can be a predisposing condition for the development of squamous cell papilloma (SCP) of the esophagus, which can progress to dysplasia and to carcinoma as a result of chronic infection. The aim of the present study was to search for the presence of HPV in the esophageal SCP, and to genotype the detected HPV.
    Materials and methods: Data from patients with definite diagnosis of SCP of the esophagus were identified from pathology records for two years period at different Hospitals. Slides from each patient were reviewed and samples with satisfactory papilloma tissues were submitted to molecular analysis. DNA has been isolated. DNA sequencing has been performed for genotyping HPV for all types.
    Results: Our study group consisted of 21 women and 17 men (a total of 38 patients), mean age was 41 years (range 17-67 years). Most of the papillomas were located at mid-esophagus (68%). Eight out of 38 patients (21%) had associated erosive esophagitis, and fourteen patients (36.8%) had Helicobacter Pylori (H. pylori). Of the 38 SCP analyzed, seven (19%) were positive for HPV DNA. Three of them were of genotype 6, whereas four were of genotype 16, 18, 31, 81 that are known as highly oncogenic. There were no correlations between the presence of HPV and the patient's age, the presence of reflux esophagitis or H. pylori, smoking habit and the location of the papillomas.
    Conclusion: The presence of high-risk type HPV in esophageal SCP may implicate a role of the virus in the pathogenesis of the esophageal tumor.
    Language English
    Publishing date 2017-05
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 1340275-4
    ISSN 2148-5607 ; 1300-4948
    ISSN (online) 2148-5607
    ISSN 1300-4948
    DOI 10.5152/tjg.2017.16636
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Distribution of gastric lymphoid follicles in Helicobacter pylori-associated gastritis.

    Sokmen, Mehmet / Sakiz, Damlanur / Akbayir, Nihat / Karaca, Cetin / Ersoy, Ozdal / Alkim, Canan / Demirsoy, Huseyin

    Hepato-gastroenterology

    2007  Volume 54, Issue 73, Page(s) 285–289

    Abstract: Background/aims: Lymphoid follicles and the satellite lesions (intestinal metaplasia, atrophy and dysplasia) are known as precursor lesions of mucosa associated lymphoid tissue lymphomas in gastritis. Little is known about their prevalence in different ... ...

    Abstract Background/aims: Lymphoid follicles and the satellite lesions (intestinal metaplasia, atrophy and dysplasia) are known as precursor lesions of mucosa associated lymphoid tissue lymphomas in gastritis. Little is known about their prevalence in different distributions and types of Helicobacter pylori-associated gastritis. The aim of the study was to estimate the topographic prevalence of these lesions in gastritis related with Helicobacter pylori and to associate them with the density of bacteria.
    Methodology: Histology for the type of gastritis and for lymphoid follicles and Helicobacter pylori density were studied in antrum and/or corpus biopsies taken from 107 consecutive patients with clinical diagnosis of peptic ulcer.
    Results: Lymphoid follicles, panmucosal and superficial gastritis were seen in 31 (31.9%), 84 (86.6%) and 13 (13.4%) out of 97 antrum biopsies, respectively. In the corresponding 28 corpus biopsies, these lesions were seen in 8 (28%), 15 (54%), 13 (46%), respectively. Lymphoid follicles were found more in panmucosal than superficial gastritis in the antrum, however in the same ratios in the corpus. In association with lymphoid follicles, Helicobacterpylori was positive in 7 (87%) of 8 corpus biopsies and in all (100%) of 31 antrum biopsies. No relation was observed between lymphoid follicles and Helicobacter pylori density.
    Conclusions: Examination of antrum biopsies rather than corpus biopsies would be sufficient to screen precarcinogenic lymphoid follicles in Helicobacterpylori associated gastritis.
    MeSH term(s) Adult ; Female ; Gastric Mucosa/metabolism ; Gastric Mucosa/microbiology ; Gastritis/metabolism ; Gastritis/microbiology ; Helicobacter Infections/metabolism ; Helicobacter pylori ; Humans ; Immunohistochemistry ; Lymphoid Tissue/metabolism ; Male ; Prospective Studies
    Language English
    Publishing date 2007-01
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 801013-4
    ISSN 0172-6390
    ISSN 0172-6390
    Database MEDical Literature Analysis and Retrieval System OnLINE

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