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  1. Article ; Online: Enoxaparin is not an oral factor Xa inhibitor. Response to Sutton et al. real-world clinical outcomes among US veterans with oral factor Xa inhibitor-related major bleeding treated with andexanet alfa or 4-factor prothrombin complex concentrate.

    Buka, Richard J / Sutton, David J / Nicolson, Phillip Lr

    Journal of thrombosis and thrombolysis

    2024  Volume 57, Issue 4, Page(s) 739–741

    MeSH term(s) Humans ; Factor Xa Inhibitors/therapeutic use ; Enoxaparin/therapeutic use ; Veterans ; Factor Xa/pharmacology ; Hemorrhage/drug therapy ; Recombinant Proteins/therapeutic use ; Anticoagulants/therapeutic use ; Blood Coagulation Factors
    Chemical Substances Factor Xa Inhibitors ; prothrombin complex concentrates (37224-63-8) ; Enoxaparin ; PRT064445 ; Factor Xa (EC 3.4.21.6) ; Recombinant Proteins ; Anticoagulants ; Blood Coagulation Factors
    Language English
    Publishing date 2024-02-15
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1230645-9
    ISSN 1573-742X ; 0929-5305
    ISSN (online) 1573-742X
    ISSN 0929-5305
    DOI 10.1007/s11239-024-02948-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4352: Show issues Location:
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  2. Article ; Online: Alternative routes into clinical research: a guide for early career doctors.

    Nicolson, Phillip Lr / Belete, Martha / Hawes, Rebecca / Fowler, Nicole / Toh, Cheng Hock

    BMJ (Clinical research ed.)

    2024  Volume 385, Page(s) e076414

    MeSH term(s) Humans ; Physicians ; Career Choice ; Attitude of Health Personnel ; Surveys and Questionnaires
    Language English
    Publishing date 2024-04-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj-2023-076414
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: UK media reporting of NICE recommendation of crizanlizumab for patients with sickle cell disease.

    Buka, Richard J / Roy, Noémi / Nicolson, Phillip Lr

    EJHaem

    2022  Volume 4, Issue 1, Page(s) 13–17

    Abstract: Crizanlizumab was recommended for use in patients with sickle cell disease in the UK in October 2021 and received widespread media coverage. Accuracy of reporting is paramount in building trust with this group of patients who are often wary of the ... ...

    Abstract Crizanlizumab was recommended for use in patients with sickle cell disease in the UK in October 2021 and received widespread media coverage. Accuracy of reporting is paramount in building trust with this group of patients who are often wary of the medical profession. We carried out an analysis of internet-based news articles and applied a validated scoring system to assess quality. 21 articles from 19 media organisations were identified. 71% of articles stated unproven benefits of the drug and only 14% were of satisfactory quality. The former was largely due to quoting of two NHS England press releases. Overstating of drug efficacy may be detrimental to the need to address healthcare inequalities.
    Language English
    Publishing date 2022-12-25
    Publishing country United States
    Document type Journal Article
    ISSN 2688-6146
    ISSN (online) 2688-6146
    DOI 10.1002/jha2.623
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The negative impact of the COVID-19 pandemic on UK haematology registrars' well-being and training: Results of a UK nationwide survey.

    Altohami, Mohammed Oa / Langridge, Alexander / Shareef, Enas Mk / Nicolson, Phillip Lr

    EJHaem

    2021  Volume 2, Issue 4, Page(s) 785–788

    Abstract: The COVID-19 pandemic has disturbed medical training. Haematology registrars were surveyed using SurveyMonkey. Eighty-nine out of 269 (24.9%) responded. Reported stressors included concerns about transmitting the infection, disruption of leave, inferior ... ...

    Abstract The COVID-19 pandemic has disturbed medical training. Haematology registrars were surveyed using SurveyMonkey. Eighty-nine out of 269 (24.9%) responded. Reported stressors included concerns about transmitting the infection, disruption of leave, inferior patient outcomes, survivors' guilt and interruption of career progression. Only 31.2% felt ready to progress to the next training stage. Reported causes of lack of training were disruption of clinics and training days and utilisation of telephone consultations. Several stressors negatively impacted haematology registrars' well-being, training and progression. More emphasis on psychological support, outpatient clinic work and e-learning is needed.
    Language English
    Publishing date 2021-08-26
    Publishing country United States
    Document type Journal Article
    ISSN 2688-6146
    ISSN (online) 2688-6146
    DOI 10.1002/jha2.279
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Recent advances in understanding spleen tyrosine kinase (SYK) in human biology and disease, with a focus on fostamatinib.

    Cooper, Nichola / Ghanima, Waleed / Hill, Quentin A / Nicolson, Phillip Lr / Markovtsov, Vadim / Kessler, Craig

    Platelets

    2022  Volume 34, Issue 1, Page(s) 2131751

    Abstract: Spleen tyrosine kinase (SYK) is an important regulatory molecule of signal transduction pathways involved in the pathogenesis of autoimmune diseases such as immune thrombocytopenia (ITP), and the SYK-signaling pathway has emerged as a potential target ... ...

    Abstract Spleen tyrosine kinase (SYK) is an important regulatory molecule of signal transduction pathways involved in the pathogenesis of autoimmune diseases such as immune thrombocytopenia (ITP), and the SYK-signaling pathway has emerged as a potential target for the treatment of numerous diseases. The aim of this narrative review is to summarize the biological properties of SYK and its involvement in disease pathways, provide an update on SYK inhibitors in the treatment of ITP, and consider other potential applications. Fostamatinib, the only licensed SYK inhibitor to date, produces clinical response in ITP patients, including those who are refractory to other treatments. It appears to reduce the risk of thrombotic events and may therefore be a drug to consider for patients with an increased thrombotic risk. Encouraging results have also been obtained in the treatment of warm autoimmune hemolytic anemia. Several other SYK inhibitors have entered clinical trials for a range of indications, reflecting the ability of these drugs to affect multiple signaling pathways. SYK inhibitors have the potential to target several aspects of COVID-19 pathogenesis including thrombosis, without affecting normal hemostasis, and data from the first study of fostamatinib in COVID-19 are encouraging. It is hoped that ongoing trials in autoimmune indications other than ITP, as well as in hematological malignancies and other disorders, confirm the promise of SYK inhibitors.
    MeSH term(s) Humans ; Aminopyridines/pharmacology ; Aminopyridines/therapeutic use ; COVID-19 ; Oxazines/pharmacology ; Protein Kinase Inhibitors/pharmacology ; Purpura, Thrombocytopenic, Idiopathic/drug therapy ; Pyridines/pharmacology ; Syk Kinase
    Chemical Substances Aminopyridines ; fostamatinib (SQ8A3S5101) ; Oxazines ; Protein Kinase Inhibitors ; Pyridines ; Syk Kinase (EC 2.7.10.2) ; SYK protein, human (EC 2.7.10.2)
    Language English
    Publishing date 2022-11-04
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 1034283-7
    ISSN 1369-1635 ; 0953-7104
    ISSN (online) 1369-1635
    ISSN 0953-7104
    DOI 10.1080/09537104.2022.2131751
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2888: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  6. Article ; Online: A rationale for blocking thromboinflammation in COVID-19 with Btk inhibitors.

    Nicolson, Phillip Lr / Welsh, John D / Chauhan, Abhishek / Thomas, Mark R / Kahn, Mark L / Watson, Steve P

    Platelets

    2020  Volume 31, Issue 5, Page(s) 685–690

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; Protein Kinase Inhibitors ; Respiratory Distress Syndrome ; SARS-CoV-2
    Chemical Substances Protein Kinase Inhibitors
    Keywords covid19
    Language English
    Publishing date 2020-06-19
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1034283-7
    ISSN 1369-1635 ; 0953-7104
    ISSN (online) 1369-1635
    ISSN 0953-7104
    DOI 10.1080/09537104.2020.1775189
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2888: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: A rationale for blocking thromboinflammation in COVID-19 with Btk inhibitors

    Nicolson, Phillip Lr / Welsh, John D / Chauhan, Abhishek / Thomas, Mark R / Kahn, Mark L / Watson, Steve P

    Platelets

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32552307
    Database COVID19

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  8. Article ; Online: A HaemSTAR is born; a trainee-led, UK-wide research network in haematology.

    Nicolson, Phillip Lr / Desborough, Michael Jr / Hart, Daniel / Biss, Tina T / Lowe, Gillian C / Toh, Cheng-Hock

    Clinical medicine (London, England)

    2019  Volume 19, Issue 6, Page(s) 532–533

    MeSH term(s) Biomedical Research/education ; Biomedical Research/organization & administration ; Cooperative Behavior ; Hematology/education ; Hematology/organization & administration ; Hospitals ; Humans ; Information Dissemination ; United Kingdom
    Language English
    Publishing date 2019-11-22
    Publishing country England
    Document type Letter
    ZDB-ID 2048646-7
    ISSN 1473-4893 ; 1470-2118
    ISSN (online) 1473-4893
    ISSN 1470-2118
    DOI 10.7861/clinmed.2019-0313
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5439: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: A rationale for blocking thromboinflammation in COVID-19 with Btk inhibitors

    Nicolson, Phillip LR. / Welsh, John D. / Chauhan, Abhishek / Thomas, Mark R. / Kahn, Mark L. / Watson, Steve P.

    Platelets

    2020  Volume 31, Issue 5, Page(s) 685–690

    Keywords Hematology ; General Medicine ; covid19
    Language English
    Publisher Informa UK Limited
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 1034283-7
    ISSN 1369-1635 ; 0953-7104
    ISSN (online) 1369-1635
    ISSN 0953-7104
    DOI 10.1080/09537104.2020.1775189
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2888: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Anti-PF4 levels of patients with VITT do not reduce 4 months following AZD1222 vaccination

    Nicolson, Phillip LR / Montague, Samantha J / Smith, Christopher W / Lodwick, Clare S / Stoneley, Charlotte / Roberts, Matthew / Watson, Steve P / Lowe, Gillian C / Lester, William A

    medRxiv

    Abstract: Background: Anti-Platelet Factor 4 (PF4) IgG antibodies that activate platelets via FcγRIIa have been shown to be an important part of the pathophysiology of vaccine-induced immune thrombocytopenia and thrombosis (VITT). There is now extensive literature ...

    Abstract Background: Anti-Platelet Factor 4 (PF4) IgG antibodies that activate platelets via FcγRIIa have been shown to be an important part of the pathophysiology of vaccine-induced immune thrombocytopenia and thrombosis (VITT). There is now extensive literature on its presentation and initial management. There is no literature however on what happens to these patients following discharge. Methods: We collected clinical data and samples from seven patients presenting with VITT and followed them up for 82-145 days. We also collected clinical samples from them at last follow-up. Testing for anti-PF4/heparin antibodies was done using an anti-PF4/heparin enzymatic immunoassay. Flow Cytometry was used to look at FcγRIIa levels on patient platelets. Light Transmission Aggregometry with patient serum and healthy donor / patient platelets was used to analyse platelet responsiveness, in the presence and absence of PF4. Findings: All patients were discharged on direct oral anticoagulants. Two patients remain completely symptom free, three have ongoing headaches, two have residual neurological deficits. Two patients developed mild thrombocytopenia and worsening headache (but without cerebral venous sinus thrombosis) and were retreated, one of these with rituximab. All patients, except the one treated with rituximab, had similar anti-PF4 antibody titres at 80-120 days to their levels at diagnosis. Platelets from patients at follow-up had normal levels of FcγRIIa and had normal responses to thrombin and collagen-related-peptide. Patient serum from diagnosis strongly activated healthy donor platelets in the presence of PF4. Serum from follow-up was much weaker at stimulating platelets, even in the presence of PF4. Interpretation: This study shows that despite similar PF4 antibody titres at diagnosis and during follow-up, there are further differences in patient serum, that are not apparent from currently used testing, that result in lower levels of platelet activation during the follow-up period. Further understanding of these factors are important in order to assess duration of anticoagulation for these patients.
    Keywords covid19
    Language English
    Publishing date 2021-08-23
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2021.08.17.21262138
    Database COVID19

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