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Article ; Online: Tranexamic Acid Prevention of Hemorrhagic Complications Following Interpolated Flap Repair: A Single-Center, Retrospective, Cohort Study.

Freeman, S Caleb / Heath, Michael S / Neill, Brett / Morris, Caroline / Lucero, Olivia M / Yu, Wesley / Bar, Anna / Leitenberger, Justin J

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.

2023 Volume 49, Issue 12, Page(s) 1139–1142

Abstract: Background: Tranexamic acid (TXA) is increasingly being used to prevent hemorrhagic complications after dermatologic surgery. Interpolated flap repairs following Mohs micrographic surgery are at risk for increased bleeding events and unplanned health ... ...

Abstract	Background: Tranexamic acid (TXA) is increasingly being used to prevent hemorrhagic complications after dermatologic surgery. Interpolated flap repairs following Mohs micrographic surgery are at risk for increased bleeding events and unplanned health care utilization, particularly among patients on antithrombotic medication. Objective: To assess bleeding events after interpolated flap repair in patients receiving TXA compared with those who did not. Materials and methods: A retrospective review identified interpolated flap repairs in a 5-year period. Hemorrhagic complications were analyzed, defined as major bleeding events, which included all unplanned medical visits, and minor bleeding events, which included any unplanned patient phone calls or messages through electronic medical record. Results: One hundred fifteen patients had interpolated flap repair during the 5-year period, of which 21 (18.3%) received TXA postprocedure. Twenty-seven bleeding events were identified in the non-TXA group compared with 1 event in the TXA-treated group. Patients who received TXA were less likely to have had a bleeding event (28.7% vs 4.8%, p < .01). Conclusion: Patients undergoing interpolation flap repair were less likely to experience a bleeding event after subcutaneous injection of TXA.
MeSH term(s)	Humans ; Tranexamic Acid ; Retrospective Studies ; Antifibrinolytic Agents ; Cohort Studies ; Hemorrhage/chemically induced ; Hemorrhage/prevention & control
Chemical Substances	Tranexamic Acid (6T84R30KC1) ; Antifibrinolytic Agents
Language	English
Publishing date	2023-09-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	1227586-4
ISSN	1524-4725 ; 1076-0512
ISSN (online)	1524-4725
ISSN	1076-0512
DOI	10.1097/DSS.0000000000003931
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Zs.A 1212: Show issues

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Article ; Online: Quinacrine-Associated Punctate Palmar Keratoderma.

Haag, Carter / Lucero, Olivia M / Fett, Nicole M

Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases

2018 Volume 27, Issue 2, Page(s) e47–e49

MeSH term(s)	Humans ; Keratoderma, Palmoplantar/chemically induced ; Keratoderma, Palmoplantar/diagnosis ; Quinacrine/adverse effects
Chemical Substances	Quinacrine (H0C805XYDE)
Language	English
Publishing date	2018-06-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	1283266-2
ISSN	1536-7355 ; 1076-1608
ISSN (online)	1536-7355
ISSN	1076-1608
DOI	10.1097/RHU.0000000000000849
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Zs.A 4815: Show issues

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Article: Single-Cell Identification of Melanoma Biomarkers in Circulating Tumor Cells.

Fankhauser, Reilly / Chang, Matthew / Garrison, Zachary / Berryman, Rachel / Lucero, Olivia M / Fuiten, Allison / DePatie, Nicholas / Seifert, Hilary / Kulkarni, Rajan P

Cancers

2022 Volume 14, Issue 19

Abstract: The current standard for investigating tumors is surgical biopsy, which is costly, invasive, and difficult to perform serially. As an adjunct, circulating tumor cells (CTCs)-cells that have broken away from the primary tumor or metastatic sites-can be ... ...

Abstract	The current standard for investigating tumors is surgical biopsy, which is costly, invasive, and difficult to perform serially. As an adjunct, circulating tumor cells (CTCs)-cells that have broken away from the primary tumor or metastatic sites-can be obtained from a blood draw and offer the potential for obtaining serial genetic information and serving as biomarkers. Here, we detail the potential for melanoma CTCs to serve as biomarkers and discuss a clinically viable methodology for single-cell CTC isolation and analysis that overcomes previous limitations. We explore the use of melanoma CTC biomarkers by isolating and performing single-cell RNA sequencing on CTCs from melanoma patients. We then compared transcriptional profiles of single melanoma CTCs against A375 cells and peripheral blood mononuclear cells to identify unique genes differentially regulated in circulating melanoma tumor cells. The information that can be obtained via analysis of these CTCs has significant potential in disease tracking.
Language	English
Publishing date	2022-10-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers14194921
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Article ; Online: A case illustrating successful eradication of recurrent, aggressive basal cell carcinoma located in a scar with vismodegib.

Lucero, Olivia M / Fitzmaurice, Sarah / Thompson, Curtis / Leitenberge, Justin

Dermatology online journal

2018 Volume 24, Issue 2

Abstract: Vismodegib is a small molecule inhibitor of the Hedgehog signaling pathway that has shown efficacy in the control of locally advanced or metastatic basal cell carcinoma, although proof of its effectiveness in the elimination of aggressive tumors is ... ...

Abstract	Vismodegib is a small molecule inhibitor of the Hedgehog signaling pathway that has shown efficacy in the control of locally advanced or metastatic basal cell carcinoma, although proof of its effectiveness in the elimination of aggressive tumors is lacking. We report a case and provide complete histological evidence of a 69-year-old gentleman who presented with a recurrent, infiltrative, and sclerosing (morpheiform) basal cell carcinoma on his left upper lip that was entirely eradicated with a three-month course of vismodegib 150 mg daily. Complete histologic clearance of a tumor in a recurrent, infiltrative, and sclerosing basal cell carcinoma with vismodegib is uncommon.
MeSH term(s)	Aged ; Anilides/therapeutic use ; Antineoplastic Agents/therapeutic use ; Carcinoma, Basal Cell/drug therapy ; Carcinoma, Basal Cell/pathology ; Carcinoma, Basal Cell/surgery ; Cicatrix ; Combined Modality Therapy ; Humans ; Male ; Mohs Surgery ; Neoplasm Recurrence, Local/drug therapy ; Neoplasm Recurrence, Local/pathology ; Neoplasm Recurrence, Local/surgery ; Pyridines/therapeutic use ; Skin/pathology ; Skin Neoplasms/drug therapy ; Skin Neoplasms/pathology ; Skin Neoplasms/surgery
Chemical Substances	Anilides ; Antineoplastic Agents ; HhAntag691 ; Pyridines
Language	English
Publishing date	2018-02-15
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2026239-5
ISSN	1087-2108 ; 1087-2108
ISSN (online)	1087-2108
ISSN	1087-2108
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Article ; Online: Patient-Specific Targeting of the T-Cell Receptor Variable Region as a Therapeutic Strategy in Clonal T-Cell Diseases.

Lucero, Olivia M / Lee, Ji-Ann / Bowman, Jenna / Johnson, Kara / Sapparapu, Gopal / Thomas, John K / Fan, Guang / Chang, Bill H / Thiel-Klare, Karina / Eide, Christopher A / Okada, Craig / Palazzolo, Mike / Lind, Evan / Kosaka, Yoko / Druker, Brian J / Lydon, Nicholas / Bowers, Peter M

Clinical cancer research : an official journal of the American Association for Cancer Research

2023 Volume 29, Issue 20, Page(s) 4230–4241

Abstract: Purpose: Targeted therapeutics are a goal of medicine. Methods for targeting T-cell lymphoma lack specificity for the malignant cell, leading to elimination of healthy cells. The T-cell receptor (TCR) is designed for antigen recognition. T-cell ... ...

Abstract	Purpose: Targeted therapeutics are a goal of medicine. Methods for targeting T-cell lymphoma lack specificity for the malignant cell, leading to elimination of healthy cells. The T-cell receptor (TCR) is designed for antigen recognition. T-cell malignancies expand from a single clone that expresses one of 48 TCR variable beta (Vβ) genes, providing a distinct therapeutic target. We hypothesized that a mAb that is exclusive to a specific Vβ would eliminate the malignant clone while having minimal effects on healthy T cells. Experimental design: We identified a patient with large granular T-cell leukemia and sequenced his circulating T-cell population, 95% of which expressed Vβ13.3. We developed a panel of anti-Vβ13.3 antibodies to test for binding and elimination of the malignant T-cell clone. Results: Therapeutic antibody candidates bound the malignant clone with high affinity. Antibodies killed engineered cell lines expressing the patient TCR Vβ13.3 by antibody-dependent cellular cytotoxicity and TCR-mediated activation-induced cell death, and exhibited specific killing of patient malignant T cells in combination with exogenous natural killer cells. EL4 cells expressing the patient's TCR Vβ13.3 were also killed by antibody administration in an in vivo murine model. Conclusions: This approach serves as an outline for development of therapeutics that can treat clonal T-cell-based malignancies and potentially other T-cell-mediated diseases. See related commentary by Varma and Diefenbach, p. 4024.
MeSH term(s)	Humans ; Mice ; Animals ; Rituximab ; Receptors, Antigen, T-Cell/genetics ; T-Lymphocytes/immunology ; Receptors, Antigen, T-Cell, alpha-beta/genetics ; Receptors, Antigen, T-Cell, alpha-beta/immunology ; Lymphoma, T-Cell
Chemical Substances	Rituximab (4F4X42SYQ6) ; Receptors, Antigen, T-Cell ; Receptors, Antigen, T-Cell, alpha-beta
Language	English
Publishing date	2023-04-14
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	1225457-5
ISSN	1557-3265 ; 1078-0432
ISSN (online)	1557-3265
ISSN	1078-0432
DOI	10.1158/1078-0432.CCR-22-0906
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Zs.A 4223: Show issues

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Article ; Online: Phenotype switch in acute lymphoblastic leukaemia associated with 3 years of persistent CAR T cell directed-CD19 selective pressure.

Lucero, Olivia M / Parker, Kellee / Funk, Tracy / Dunlap, Jennifer / Press, Richard / Gardner, Rebecca A / Chang, Bill H

British journal of haematology

2019 Volume 186, Issue 2, Page(s) 333–336

MeSH term(s)	Antigens, CD19/metabolism ; Child, Preschool ; Humans ; Immunotherapy, Adoptive ; Male ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/metabolism ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/pathology ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/therapy
Chemical Substances	Antigens, CD19 ; CD19 molecule, human
Language	English
Publishing date	2019-02-27
Publishing country	England
Document type	Case Reports ; Letter
ZDB-ID	80077-6
ISSN	1365-2141 ; 0007-1048
ISSN (online)	1365-2141
ISSN	0007-1048
DOI	10.1111/bjh.15812
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Article ; Online: Sensitivity and Positive Predictive Value of Death Certificate Data Among Deaths Caused by Legionnaires' Disease in New York City, 2008-2013.

Tran, Olivia C / Lucero, David E / Balter, Sharon / Fitzhenry, Robert / Huynh, Mary / Varma, Jay K / Vora, Neil M

Public health reports (Washington, D.C. : 1974)

2018 Volume 133, Issue 5, Page(s) 578–583

Abstract: Objectives: Death certificates are an important source of information for understanding life expectancy and mortality trends; however, misclassification and incompleteness are common. Although deaths caused by Legionnaires' disease might be identified ... ...

Abstract	Objectives: Death certificates are an important source of information for understanding life expectancy and mortality trends; however, misclassification and incompleteness are common. Although deaths caused by Legionnaires' disease might be identified through routine surveillance, it is unclear whether Legionnaires' disease is accurately recorded on death certificates. We evaluated the sensitivity and positive predictive value of death certificates for identifying deaths from confirmed or suspected Legionnaires' disease among adults in New York City. Methods: We deterministically matched death certificate data from January 1, 2008, through December 31, 2013, on New York City residents aged ≥18 years to surveillance data on confirmed and suspected cases of Legionnaires' disease from January 1, 2008, through October 31, 2013. We estimated sensitivity and positive predictive value by using surveillance data as the reference standard. Results: Of 294 755 deaths, 27 (<0.01%) had an underlying cause of death of Legionnaires' disease and 33 (0.01%) had any mention of Legionnaires' disease on the death certificate. Of 1211 confirmed or suspected cases of Legionnaires' disease, 267 (22.0%) matched to a record in the death certificate data set. The sensitivity of death certificates that listed Legionnaires' disease as the underlying cause of death was 17.3% and of death certificates with any mention of Legionnaires' disease was 20.9%. The positive predictive value of death certificates that listed Legionnaires' disease as the underlying cause of death was 70.4% and of death certificates with any mention of Legionnaires' disease was 69.7%. Conclusions: Death certificates had limited ability to identify confirmed or suspected deaths with Legionnaires' disease. Provider trainings on the diagnosis of Legionnaires' disease, particularly hospital settings, and proper completion of death certificates might improve the sensitivity of death certificates for people who die of Legionnaires' disease.
MeSH term(s)	Adult ; Aged ; Death Certificates ; Disease Outbreaks ; Female ; Humans ; Legionnaires' Disease/epidemiology ; Male ; Middle Aged ; New York City/epidemiology ; Sensitivity and Specificity
Language	English
Publishing date	2018-07-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	120953-x
ISSN	1468-2877 ; 0033-3549
ISSN (online)	1468-2877
ISSN	0033-3549
DOI	10.1177/0033354918782494
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Zs.MO 479: Show issues

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Article: Keratinocyte carcinomas arising near arteriovenous fistulas: Case series and safety considerations for dermatologic surgery: A report of the International Transplant Skin Cancer Collaborative.

Lucero, Olivia M / Echaiz, Claudia Flores / Jafarian, Fatemeh / Fox, Matthew C / Vetto, John T / Mueller, Reid V / Teixeira, Pedro G / Zwald, Fiona O / Leitenberger, Justin J

JAAD case reports

2018 Volume 5, Issue 1, Page(s) 7–11

Language	English
Publishing date	2018-12-04
Publishing country	United States
Document type	Case Reports
ZDB-ID	2834220-3
ISSN	2352-5126
ISSN	2352-5126
DOI	10.1016/j.jdcr.2018.08.021
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Article ; Online: Identification, genetic testing, and management of hereditary melanoma.

Leachman, Sancy A / Lucero, Olivia M / Sampson, Jone E / Cassidy, Pamela / Bruno, William / Queirolo, Paola / Ghiorzo, Paola

Cancer metastasis reviews

2017 Volume 36, Issue 1, Page(s) 77–90

Abstract: Several distinct melanoma syndromes have been defined, and genetic tests are available for the associated causative genes. Guidelines for melanoma genetic testing have been published as an informal "rule of twos and threes," but these guidelines apply to ...

Abstract	Several distinct melanoma syndromes have been defined, and genetic tests are available for the associated causative genes. Guidelines for melanoma genetic testing have been published as an informal "rule of twos and threes," but these guidelines apply to CDKN2A testing and are not intended for the more recently described non-CDKN2A melanoma syndromes. In order to develop an approach for the full spectrum of hereditary melanoma patients, we have separated melanoma syndromes into two types: "melanoma dominant" and "melanoma subordinate." Syndromes in which melanoma is a predominant cancer type are considered melanoma dominant, although other cancers, such as mesothelioma or pancreatic cancers, may also be observed. These syndromes are associated with defects in CDKN2A, CDK4, BAP1, MITF, and POT1. Melanoma-subordinate syndromes have an increased but lower risk of melanoma than that of other cancer(s) seen in the syndrome, such as breast and ovarian cancer or Cowden syndrome. Many of these melanoma-subordinate syndromes are associated with well-established predisposition genes (e.g., BRCA1/2, PTEN). It is likely that these predisposition genes are responsible for the increased susceptibility to melanoma as well but with lower penetrance than that observed for the dominant cancer(s) in those syndromes. In this review, we describe our extension of the "rule of twos and threes" for melanoma genetic testing. This algorithm incorporates an understanding of the spectrum of cancers and genes seen in association with melanoma to create a more comprehensive and tailored approach to genetic testing.
MeSH term(s)	Algorithms ; Genetic Predisposition to Disease ; Genetic Testing ; Humans ; Melanoma/diagnosis ; Melanoma/genetics ; Melanoma/therapy
Language	English
Publishing date	2017
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604857-2
ISSN	1573-7233 ; 0167-7659
ISSN (online)	1573-7233
ISSN	0167-7659
DOI	10.1007/s10555-017-9661-5
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Zs.A 1812: Show issues

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Article ; Online: A re-evaluation of the "oncogenic" nature of Wnt/beta-catenin signaling in melanoma and other cancers.

Lucero, Olivia M / Dawson, David W / Moon, Randall T / Chien, Andy J

Current oncology reports

2010 Volume 12, Issue 5, Page(s) 314–318

Abstract: In cancer, Wnt/beta-catenin signaling is ubiquitously referred to as an "oncogenic" pathway that promotes tumor progression. This review examines how the regulation and downstream effects of Wnt/beta-catenin signaling in cancer varies depending on ... ...

Abstract	In cancer, Wnt/beta-catenin signaling is ubiquitously referred to as an "oncogenic" pathway that promotes tumor progression. This review examines how the regulation and downstream effects of Wnt/beta-catenin signaling in cancer varies depending on cellular context, with a focus on malignant melanoma. We emphasize that the cellular homeostasis of Wnt/beta-catenin signaling may represent a more appropriate concept than the simplified view of the Wnt/beta-catenin pathway as either oncogenic or tumor-suppressing. Ultimately, a more refined understanding of the contextual regulation of Wnt/beta-catenin signaling will be essential for addressing if and how therapeutic targeting of this pathway could be leveraged for patient benefit.
MeSH term(s)	Humans ; Melanoma/metabolism ; Melanoma/pathology ; Oncogenes/physiology ; Signal Transduction ; Wnt Proteins/metabolism ; beta Catenin/metabolism
Chemical Substances	Wnt Proteins ; beta Catenin
Language	English
Publishing date	2010-07-06
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2057359-5
ISSN	1534-6269 ; 1523-3790
ISSN (online)	1534-6269
ISSN	1523-3790
DOI	10.1007/s11912-010-0114-3
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