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  1. Article ; Online: A reality check on the use of face masks during the COVID-19 outbreak in Hong Kong.

    Tam, Victor Cw / Tam, Shing Yau / Poon, Wai Kwong / Law, Helen Ka Wai / Lee, Shara Wy

    EClinicalMedicine

    2020  Volume 22, Page(s) 100356

    Keywords covid19
    Language English
    Publishing date 2020-04-24
    Publishing country England
    Document type Journal Article
    ISSN 2589-5370
    ISSN (online) 2589-5370
    DOI 10.1016/j.eclinm.2020.100356
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  2. Article ; Online: A reality check on the use of face masks during the COVID-19 outbreak in Hong Kong

    Victor CW Tam / Shing Yau Tam / Wai Kwong Poon / Helen Ka Wai Law / Shara WY Lee

    EClinicalMedicine, Vol 22, Iss , Pp - (2020)

    2020  

    Keywords Medicine (General) ; R5-920 ; covid19
    Language English
    Publishing date 2020-05-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: A reality check on the use of face masks during the COVID-19 outbreak in Hong Kong

    Tam, Victor CW / Tam, Shing Yau / Poon, Wai Kwong / Law, Helen Ka Wai / Lee, Shara WY

    EClinicalMedicine

    2020  Volume 22, Page(s) 100356

    Keywords covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ISSN 2589-5370
    DOI 10.1016/j.eclinm.2020.100356
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Exacerbated VEGF up-regulation accompanies diabetes-aggravated hemorrhage in mice after experimental cerebral ischemia and delayed reperfusion.

    Lai, Angela Ka Wai / Ng, Tsz Chung / Hung, Victor Ka Lok / Tam, Ka Cheung / Cheung, Chi Wai / Chung, Sookja Kim / Lo, Amy Cheuk Yin

    Neural regeneration research

    2021  Volume 17, Issue 7, Page(s) 1566–1575

    Abstract: Reperfusion therapy is the preferred treatment for ischemic stroke, but is hindered by its short treatment window, especially in patients with diabetes whose reperfusion after prolonged ischemia is often accompanied by exacerbated hemorrhage. The ... ...

    Abstract Reperfusion therapy is the preferred treatment for ischemic stroke, but is hindered by its short treatment window, especially in patients with diabetes whose reperfusion after prolonged ischemia is often accompanied by exacerbated hemorrhage. The mechanisms underlying exacerbated hemorrhage are not fully understood. This study aimed to identify this mechanism by inducing prolonged 2-hour transient intraluminal middle cerebral artery occlusion in diabetic Ins2
    Language English
    Publishing date 2021-12-16
    Publishing country India
    Document type Journal Article
    ZDB-ID 2388460-5
    ISSN 1876-7958 ; 1673-5374
    ISSN (online) 1876-7958
    ISSN 1673-5374
    DOI 10.4103/1673-5374.330612
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  5. Article: A reality check on the use of face masks during the COVID-19 outbreak in Hong Kong

    Victor, C W Tam / Shing, Yau Tam / Wai, Kwong Poon / Helen, K W Law / Shara, W Y Lee

    EClinicalMedicine

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #116279
    Database COVID19

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  6. Article ; Online: Pharmacokinetics and Pharmacodynamics of Clofazimine for Treatment of Cryptosporidiosis.

    Zhang, Cindy X / Love, Melissa S / McNamara, Case W / Chi, Victor / Woods, Ashley K / Joseph, Sean / Schaefer, Deborah A / Betzer, Dana P / Riggs, Michael W / Iroh Tam, Pui-Ying / Van Voorhis, Wesley C / Arnold, Samuel L M

    Antimicrobial agents and chemotherapy

    2021  Volume 66, Issue 1, Page(s) e0156021

    Abstract: Infection ... ...

    Abstract Infection with
    MeSH term(s) Adult ; Antiprotozoal Agents/pharmacology ; Antiprotozoal Agents/therapeutic use ; Child ; Clofazimine/pharmacology ; Clofazimine/therapeutic use ; Cryptosporidiosis/drug therapy ; Cryptosporidium ; Diarrhea/drug therapy ; Humans
    Chemical Substances Antiprotozoal Agents ; Clofazimine (D959AE5USF)
    Language English
    Publishing date 2021-11-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 217602-6
    ISSN 1098-6596 ; 0066-4804
    ISSN (online) 1098-6596
    ISSN 0066-4804
    DOI 10.1128/AAC.01560-21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 809: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Einzelsignatur: Show issues

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  7. Article ; Online: Anti-inflammatory mechanisms of the novel cytokine interleukin-38 in allergic asthma.

    Sun, Xiaoyu / Hou, Tianheng / Cheung, Edwin / Iu, Tiffany Nga-Teng / Tam, Victor Wai-Hou / Chu, Ida Miu-Ting / Tsang, Miranda Sin-Man / Chan, Paul Kay-Sheung / Lam, Christopher Wai-Kei / Wong, Chun-Kwok

    Cellular & molecular immunology

    2019  Volume 17, Issue 6, Page(s) 631–646

    Abstract: We elucidated the anti-inflammatory mechanisms of IL-38 in allergic asthma. Human bronchial epithelial cells and eosinophils were cocultured upon stimulation with the viral RLR ligand poly (I:C)/LyoVec or infection-related cytokine TNF-α to induce ... ...

    Abstract We elucidated the anti-inflammatory mechanisms of IL-38 in allergic asthma. Human bronchial epithelial cells and eosinophils were cocultured upon stimulation with the viral RLR ligand poly (I:C)/LyoVec or infection-related cytokine TNF-α to induce expression of cytokines/chemokines/adhesion molecules. House dust mite (HDM)-induced allergic asthma and humanized allergic asthma NOD/SCID murine models were established to assess anti-inflammatory mechanisms in vivo. IL-38 significantly inhibited induced proinflammatory IL-6, IL-1β, CCL5, and CXCL10 production, and antiviral interferon-β and intercellular adhesion molecule-1 expression in the coculture system. Mass cytometry and RNA-sequencing analysis revealed that IL-38 could antagonize the activation of the intracellular STAT1, STAT3, p38 MAPK, ERK1/2, and NF-κB pathways, and upregulate the expression of the host defense-related gene POU2AF1 and anti-allergic response gene RGS13. Intraperitoneal injection of IL-38 into HDM-induced allergic asthma mice could ameliorate airway hyperreactivity by decreasing the accumulation of eosinophils in the lungs and inhibiting the expression of the Th2-related cytokines IL-4, IL-5, and IL-13 in the bronchoalveolar lavage fluid (BALF) and lung homogenates. Histological examination indicated lung inflammation was alleviated by reductions in cell infiltration and goblet cell hyperplasia, together with reduced Th2, Th17, and innate lymphoid type 2 cell numbers but increased proportions of regulatory T cells in the lungs, spleen, and lymph nodes. IL-38 administration suppressed airway hyperreactivity and asthma-related IL-4 and IL-5 expression in humanized mice, together with significantly decreased CCR3
    MeSH term(s) Adult ; Animals ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Asthma/complications ; Asthma/drug therapy ; Asthma/genetics ; Asthma/immunology ; Bronchi/pathology ; Cells, Cultured ; Cytokines/pharmacology ; Cytokines/therapeutic use ; Down-Regulation/drug effects ; Eosinophils/drug effects ; Eosinophils/metabolism ; Epithelial Cells/drug effects ; Epithelial Cells/metabolism ; Gene Expression Regulation/drug effects ; Humans ; Hypersensitivity/complications ; Hypersensitivity/drug therapy ; Hypersensitivity/genetics ; Hypersensitivity/immunology ; Inflammation/complications ; Inflammation/immunology ; Inflammation/pathology ; Inflammation Mediators/metabolism ; Injections, Intraperitoneal ; Interleukins/pharmacology ; Interleukins/therapeutic use ; Ligands ; Male ; Mice ; Mice, Inbred BALB C ; Models, Biological ; Poly I-C/pharmacology ; Pyroglyphidae/drug effects ; Recombinant Proteins/pharmacology ; Recombinant Proteins/therapeutic use ; Signal Transduction/drug effects ; T-Lymphocytes, Regulatory/drug effects ; T-Lymphocytes, Regulatory/immunology ; Tumor Necrosis Factor-alpha/pharmacology
    Chemical Substances Anti-Inflammatory Agents ; Cytokines ; IL-38 protein, human ; Inflammation Mediators ; Interleukins ; Ligands ; Recombinant Proteins ; Tumor Necrosis Factor-alpha ; Poly I-C (O84C90HH2L)
    Language English
    Publishing date 2019-10-23
    Publishing country China
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2435097-7
    ISSN 2042-0226 ; 1672-7681
    ISSN (online) 2042-0226
    ISSN 1672-7681
    DOI 10.1038/s41423-019-0300-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6681: Show issues Location:
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  8. Article ; Online: Genetic variation of staphylococcal LukAB toxin determines receptor tropism.

    Perelman, Sofya S / James, David B A / Boguslawski, Kristina M / Nelson, Chase W / Ilmain, Juliana K / Zwack, Erin E / Prescott, Rachel A / Mohamed, Adil / Tam, Kayan / Chan, Rita / Narechania, Apurva / Pawline, Miranda B / Vozhilla, Nikollaq / Moustafa, Ahmed M / Kim, Sang Y / Dittmann, Meike / Ekiert, Damian C / Bhabha, Gira / Shopsin, Bo /
    Planet, Paul J / Koralov, Sergei B / Torres, Victor J

    Nature microbiology

    2021  Volume 6, Issue 6, Page(s) 731–745

    Abstract: Staphylococcus aureus has evolved into diverse lineages, known as clonal complexes (CCs), which exhibit differences in the coding sequences of core virulence factors. Whether these alterations affect functionality is poorly understood. Here, we studied ... ...

    Abstract Staphylococcus aureus has evolved into diverse lineages, known as clonal complexes (CCs), which exhibit differences in the coding sequences of core virulence factors. Whether these alterations affect functionality is poorly understood. Here, we studied the highly polymorphic pore-forming toxin LukAB. We discovered that the LukAB toxin variants produced by S. aureus CC30 and CC45 kill human phagocytes regardless of whether CD11b, the previously established LukAB receptor, is present, and instead target the human hydrogen voltage-gated channel 1 (HVCN1). Biochemical studies identified the domain within human HVCN1 that drives LukAB species specificity, enabling the generation of humanized HVCN1 mice with enhanced susceptibility to CC30 LukAB and to bloodstream infection caused by CC30 S. aureus strains. Together, this work advances our understanding of an important S. aureus toxin and underscores the importance of considering genetic variation in characterizing virulence factors and understanding the tug of war between pathogens and the host.
    MeSH term(s) Animals ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; CD11b Antigen/genetics ; CD11b Antigen/metabolism ; Genetic Variation ; Humans ; Ion Channels/genetics ; Ion Channels/metabolism ; Leukocidins/genetics ; Leukocidins/metabolism ; Mice, Inbred C57BL ; Phagocytes/metabolism ; Phagocytes/microbiology ; Staphylococcal Infections/genetics ; Staphylococcal Infections/metabolism ; Staphylococcal Infections/microbiology ; Staphylococcus aureus/genetics ; Staphylococcus aureus/metabolism ; Mice
    Chemical Substances Bacterial Proteins ; CD11b Antigen ; HVCN1 protein, human ; Ion Channels ; Leukocidins ; leukocidin AB, Staphylococcus aureus
    Language English
    Publishing date 2021-04-19
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 2058-5276
    ISSN (online) 2058-5276
    DOI 10.1038/s41564-021-00890-3
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  9. Article ; Online: Direct detection of Mycobacterium tuberculosis and drug resistance in respiratory specimen using Abbott Realtime MTB detection and RIF/INH resistance assay.

    Tam, Kingsley King-Gee / Leung, Kenneth Siu-Sing / To, Sabrina Wai-Chi / Siu, Gilman Kit-Hang / Lau, Terrence Chi-Kong / Shek, Victor Chi-Man / Tse, Cindy Wing-Sze / Wong, Samson Sai-Yin / Ho, Pak-Leung / Yam, Wing-Cheong

    Diagnostic microbiology and infectious disease

    2017  Volume 89, Issue 2, Page(s) 118–124

    Abstract: Abbott RealTime MTB (Abbott-RT) in conjunction with Abbott RealTime MTB RIF/INH Resistance (Abbott-RIF/INH) is a new, high-throughput automated nucleic acid amplification platform (Abbott-MDR) for detection of Mycobacterium tuberculosis complex (MTBC) ... ...

    Abstract Abbott RealTime MTB (Abbott-RT) in conjunction with Abbott RealTime MTB RIF/INH Resistance (Abbott-RIF/INH) is a new, high-throughput automated nucleic acid amplification platform (Abbott-MDR) for detection of Mycobacterium tuberculosis complex (MTBC) and the genotypic markers for rifampicin (RIF) and isoniazid (INH) resistance directly from respiratory specimens. This prospective study evaluated the diagnostic performance of this new platform for MTBC and multidrug-resistant tuberculosis (MDR-TB) using 610 sputum specimens in a tuberculosis high-burden setting. Using conventional culture results and clinical background as reference standards, Abbott-RT exhibited an overall sensitivity and specificity of 95.2% and 99.8%, respectively. Genotypic RIF/INH resistance of 178 "MTB detected" specimens was subsequently analyzed by Abbott-RIF/INH. Compared to phenotypic drug susceptibility test results, Abbott-RIF/INH detected resistance genotypic markers in 84.6% MDR-TB, 80% mono-RIF-resistant and 66.7% mono-INH-resistant specimens. Two of the RIF-resistant specimens carried a novel single, nonsense mutation at rpoB Q513 and in silico simulation demonstrated that the truncated RpoB protein failed to bind with other subunits for transcription. Overall, Abbott-MDR platform provided high throughput and reliable diagnosis of MDR-TB within a TB high-burden region.
    Language English
    Publishing date 2017-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604920-5
    ISSN 1879-0070 ; 0732-8893
    ISSN (online) 1879-0070
    ISSN 0732-8893
    DOI 10.1016/j.diagmicrobio.2017.06.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1845: Show issues Location:
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  10. Article ; Online: NEDD9 gene polymorphism influences the risk of Alzheimer disease and cognitive function in Chinese older persons.

    Fu, Yan / He, Fang / Tang, Nelson Leung Sang / Tam, Cindy Woon Chi / Lui, Victor Wing Cheong / Chiu, Helen Fung Kum / Lam, Linda Chiu Wa

    Alzheimer disease and associated disorders

    2012  Volume 26, Issue 1, Page(s) 88–90

    Abstract: Neural precursor cell expressed, developmentally down-regulated (NEDD9) gene was a new candidate risk gene for Alzheimer disease (AD). The CC genotype of a single nucleotide polymorphism rs760678 within this gene was associated with increasing risk of AD ...

    Abstract Neural precursor cell expressed, developmentally down-regulated (NEDD9) gene was a new candidate risk gene for Alzheimer disease (AD). The CC genotype of a single nucleotide polymorphism rs760678 within this gene was associated with increasing risk of AD in a large study with white population. Our study aimed to replicate the initial report in Chinese population and explore its effect on cognitive performance. A total of 262 patients with AD, 293 patients with mild cognitive impairment, and 434 cognitive intact controls were recruited in the study. The result showed that G allele had a greater risk of AD (χ for trend test=5.61, df 1, P=0.018). The effects were mainly observed among Apolipoprotein E (APOE) ε4 noncarriers (χ for trend test=4.30, df 1, P=0.038). After adjustment of sex, age, education year, and APOE ε4 status by logistic regression, significant association between NEDD9 GG genotype and AD remained [OR=2.04, 95% confidence interval (CI)=1.02-4.08, P=0.044]. The scores of Cantonese version of the Mini-mental State Examination and Alzheimer's Disease Assessment Subscale-Cognitive subscale were associated with N polymorphism after adjusting for sex, age, education year, and ApoE ε4 status (Linear regression model, P<0.05). Our study identified rs760678 within NEDD9 gene in association with the risk of AD and cognitive performance in Chinese older persons. The fact that different alleles accounted for the risk in different population might suggest that there were ethnic group specific haplotypes that were primarily responsible for the predisposition.
    MeSH term(s) Adaptor Proteins, Signal Transducing/genetics ; Aged ; Aged, 80 and over ; Aging/genetics ; Aging/psychology ; Alzheimer Disease/epidemiology ; Alzheimer Disease/genetics ; Apolipoprotein E4/genetics ; Asian Continental Ancestry Group/genetics ; China ; Cognition/physiology ; Cognitive Dysfunction/genetics ; Female ; Genetic Predisposition to Disease ; Genetic Testing ; Genotype ; Humans ; Male ; Middle Aged ; Neuropsychological Tests ; Phosphoproteins/genetics ; Polymorphism, Genetic ; Polymorphism, Single Nucleotide/genetics ; Risk
    Chemical Substances Adaptor Proteins, Signal Transducing ; Apolipoprotein E4 ; NEDD9 protein, human ; Phosphoproteins
    Language English
    Publishing date 2012-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1002700-2
    ISSN 1546-4156 ; 0893-0341
    ISSN (online) 1546-4156
    ISSN 0893-0341
    DOI 10.1097/WAD.0b013e3182135ef3
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    Zs.A 2569: Show issues Location:
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