LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 190047

Search options

  1. Article ; Online: Y

    Li, Juan / Du, Yang / Jiang, Zhenqi / Tian, Yuchen / Qiu, Nianxiang / Wang, Yinjie / Lqbal, Muhammad Zubair / Hu, Menying / Zou, Ruifen / Luo, Lijia / Du, Shiyu / Tian, Jie / Wu, Aiguo

    Nanoscale

    2018  Volume 10, Issue 13, Page(s) 5845–5851

    Abstract: ... ligands for glioma imaging and therapy remains challenging. Neuropeptide Y (NPY) Y1 receptors (Y1Rs) are ...

    Abstract Due to the molecular and cellular heterogeneity of glioma, discovery of novel targeted sites and ligands for glioma imaging and therapy remains challenging. Neuropeptide Y (NPY) Y1 receptors (Y1Rs) are highly over expressed in various brain tumors including glioma, and can serve as potential targeting sites for glioma imaging and therapy. Here, we show by in vivo fluorescent imaging that a highly selective Y1R ligand, [Asn6, Pro34] NPY (AP-NPY), facilitated circumvention of the blood brain barrier (BBB) by nanomicelles specifically targeting glioma. Modification with AP-NPY stabilized doxorubicin-loaded nanomicelles in the normal physiological state and promoted drug release in the acidic tumor microenvironment. Furthermore, targeted delivery of AP-NPY nanomicelles improved the therapeutic efficacy of doxorubicin for glioma, producing a prolonged survival rate. These results suggest that Y1R is a novel targeted receptor, and its selective ligand AP-NPY improves BBB permeability and glioma targeting. Our study paves the way for developing a novel delivery system for diagnosis and treatment of glioma in which Y1Rs are over expressed.
    MeSH term(s) Animals ; Blood-Brain Barrier ; Brain Neoplasms/diagnostic imaging ; Brain Neoplasms/drug therapy ; Cell Line, Tumor ; Doxorubicin/administration & dosage ; Endothelial Cells ; Glioma/diagnostic imaging ; Glioma/drug therapy ; Humans ; Ligands ; Mice ; Mice, Nude ; Micelles ; Nanoparticles ; Neoplasms, Experimental/diagnostic imaging ; Neoplasms, Experimental/drug therapy ; Optical Imaging ; Protein Binding ; Receptors, Neuropeptide Y/metabolism
    Chemical Substances Ligands ; Micelles ; Receptors, Neuropeptide Y ; neuropeptide Y-Y1 receptor ; Doxorubicin (80168379AG)
    Language English
    Publishing date 2018-03-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2515664-0
    ISSN 2040-3372 ; 2040-3364
    ISSN (online) 2040-3372
    ISSN 2040-3364
    DOI 10.1039/c8nr00148k
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Carbon quantum dots modified and Y

    Gao, Jiamin / Xie, Huidong / Zuo, Feng / Liu, Hu / Zhao, Yajuan / Yang, Chang

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2024  Volume 30, Issue 20, Page(s) e202400170

    Abstract: ... density. Herein, carbon quantum dots modified and Y ...

    Abstract Supercapacitor is an important energy storage device widely used in the automobile industry, military production, and communication equipment because of its fast charge-discharge rate, and high power density. Herein, carbon quantum dots modified and Y
    Language English
    Publishing date 2024-02-15
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.202400170
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Structural and magnetic properties of Y

    Zhang, Yuanjing / Yang, Qinghui / Liu, Yingli / Hu, Aimin / Zhang, Ding / Li, Han / Yu, Jingyan / Huang, Jiantao / Lu, Yongcheng / Zhang, Lei / Xue, Qiang / Li, Yilei / Jin, Lichuan / Wen, Qiye / Zhang, Huaiwu

    Acta crystallographica Section B, Structural science, crystal engineering and materials

    2023  Volume 79, Issue Pt 2, Page(s) 157–163

    Abstract: ... applications. In this work, 200 nm Y ...

    Abstract Ultra-thin rare earth iron garnet (RIG) films with a narrow ferromagnetic resonance (FMR) line width and a low damping factor have attracted a great deal of attention for microwave and spintronic applications. In this work, 200 nm Y
    Language English
    Publishing date 2023-03-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2020841-8
    ISSN 2052-5206 ; 1600-5740 ; 1600-8650 ; 2052-5192
    ISSN (online) 2052-5206 ; 1600-5740 ; 1600-8650
    ISSN 2052-5192
    DOI 10.1107/S2052520623000483
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article: Fabrication and Luminescence Properties of Highly Transparent Green-Emitting Ho:Y

    Liu, Yan / Qin, Xianpeng / Gan, Lin / Zhou, Guohong / Hu, Song / Wang, Zhengjuan / Jiang, Juan / Zhang, Tianjin / Chen, Hetuo

    Materials (Basel, Switzerland)

    2024  Volume 17, Issue 2

    Abstract: Highly transparent Ho:Y ...

    Abstract Highly transparent Ho:Y
    Language English
    Publishing date 2024-01-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma17020402
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Synthesis of spherical CaO pellets incorporated with Mg, Y, and Ce inert carriers for CO

    Liu, Ding / Hu, Yingchao / Feng, Qiannian / Fu, Ruicheng

    Environmental science and pollution research international

    2024  Volume 31, Issue 14, Page(s) 21224–21234

    Abstract: Sintering and elutriation are two main problems of the calcium looping process for high-temperature ... ...

    Abstract Sintering and elutriation are two main problems of the calcium looping process for high-temperature CO
    MeSH term(s) Oxides ; Carbon Dioxide ; Calcium ; Calcium Compounds ; Temperature
    Chemical Substances Oxides ; Carbon Dioxide (142M471B3J) ; Calcium (SY7Q814VUP) ; Calcium Compounds
    Language English
    Publishing date 2024-02-22
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-024-32530-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 5915: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article ; Online: A D-Y Shaped Neuropeptide Y Mimetic Peptide-Dye Self-Assembly with Maximal Emission Beyond 1300 nm and Glioma Mitochondrial Activity Modulation.

    Li, Yanying / He, Xuelu / Wang, Pin / Yuan, Bo / Pan, Yuanbo / Hu, Xueyin / Lu, Liheng / Wu, Aiguo / Li, Juan

    Small (Weinheim an der Bergstrasse, Germany)

    2023  Volume 20, Issue 13, Page(s) e2308621

    Abstract: Neuropeptide Y (NPY), as one of the most abundant neuropeptides known, is widely distributed ...

    Abstract Neuropeptide Y (NPY), as one of the most abundant neuropeptides known, is widely distributed in the central and peripheral nervous system. However, most of the reported NPY-mimetic peptides are hard to cross the blood-brain barrier, target glioma mitochondria, and achieve self-assembly nanostructure in situ. Here, based on the α-helix structure of the novel chiral NPY-mimetic peptides
    MeSH term(s) Neuropeptide Y ; Receptors, Neuropeptide Y/metabolism ; Blood-Brain Barrier/metabolism
    Chemical Substances Neuropeptide Y ; Receptors, Neuropeptide Y
    Language English
    Publishing date 2023-12-18
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2168935-0
    ISSN 1613-6829 ; 1613-6810
    ISSN (online) 1613-6829
    ISSN 1613-6810
    DOI 10.1002/smll.202308621
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article: Investigation of inter-rater and test-retest reliability of Y balance test in college students with flexible flatfoot.

    Zheng, Yalin / Feng, Renzhi / Hu, Weiyin / Huang, Peng

    BMC sports science, medicine & rehabilitation

    2024  Volume 16, Issue 1, Page(s) 40

    Abstract: Background: The Lower Quarter Y Balance Test (YBT-LQ) has been widely used to assess dynamic ...

    Abstract Background: The Lower Quarter Y Balance Test (YBT-LQ) has been widely used to assess dynamic balance in various populations. Dynamic balance in flexible flatfoot populations is one of the risk factors for lower extremity injuries, especially in college populations in which more exercise is advocated. However, no study has demonstrated the reliability of the YBT-LQ in a college student flexible flatfoot population.
    Methods: A cross-sectional observational study. 30 college students with flexible flatfoot were recruited from Beijing Sports University. They have been thrice assessed for the maximal reach distance of YBT under the support of the lower limb on the flatfoot side. Test and retest were performed with an interval of 14 days. The outcome measures using the composite score and normalized maximal reach distances in three directions (anterior, posteromedial, and posterolateral). The relative reliability was reported as the Intraclass Correlation Coefficient (ICC). Minimal Detectable Change (MDC), Smallest worthwhile change (SWC), and Standard Error of Measurement (SEM) were used to report the absolute reliability.
    Results: For inter-rater reliability, the ICC values for all directions ranged from 0.84 to 0.92, SEM values ranged from 2.01 to 3.10%, SWC values ranged from 3.67 to 5.12%, and MDC95% values ranged from 5.58 to 8.60%. For test-retest reliability, the ICC values for all directions ranged from 0.81 to 0.92, SEM values ranged from 1.80 to 2.97%, SWC values ranged from 3.75 to 5.61%, and MDC95% values ranged from 4.98 to 8.24%.
    Conclusions: The YBT-LQ has "good" to "excellent" inter-rater and test-retest reliability. It appears to be a reliable assessment to use with college students with flexible flatfoot.
    Trial registration: This trial was prospectively registered at the Chinese Clinical Trial Registry with the ID number ChiCTR2300075906 on 19/09/2023.
    Language English
    Publishing date 2024-02-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2719537-5
    ISSN 2052-1847
    ISSN 2052-1847
    DOI 10.1186/s13102-024-00819-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article: Tuning the Surface Characteristics and Mechanical Properties of Y

    Liu, Hao / Chen, Ping-Hu / Chen, Yong / Wu, Wen-Xing / Li, Sheng / Qiu, Chang-Jun

    Materials (Basel, Switzerland)

    2022  Volume 15, Issue 15

    Abstract: ... micromelting, the crystal phase of Y ...

    Abstract The effects of laser parameters on the microstructure and properties of plasma-sprayed yttrium oxide coating on the graphite matrix were investigated. Tensile strength, porosity, roughness, and scratch meter tests were carried out to evaluate the critical load and mechanical properties of the coating after spraying and laser micro-melting. When the porosity and surface roughness of the coating are minimum, the critical load of the coating is 7.85 N higher than that of the spraying surface. After laser micromelting, the crystal phase of Y
    Language English
    Publishing date 2022-08-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma15155443
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: An Outbreak of Serogroup Y Meningococcal Meningitis in a Private Secondary Vocational School - Guangzhou City, Guangdong Province, China, 2023.

    Zeng, Xiang / He, Qing / Li, Yilan / Zhou, Yong / Shao, Xiaoping / Hu, Pei / Liang, Jian / Song, Yudan / Ma, Chao / Zhang, Lijie / Sun, Limei / Luo, Lei

    China CDC weekly

    2024  Volume 6, Issue 12, Page(s) 242–246

    Abstract: ... in reports of serogroups Y and W.: What is added by this report?: An outbreak of serogroup Y : What are ...

    Abstract What is already known about this topic?: The inclusion of meningococcal vaccines in the National Immunization Program (NIP) over several years has significantly reduced the incidence of meningococcal meningitis in China to historic lows. Worldwide, there has been a diversification of meningococcal serogroups, leading to a shift in dominant serogroups in China from serogroup A to serogroups C and B, accompanied by a rise in reports of serogroups Y and W.
    What is added by this report?: An outbreak of serogroup Y
    What are the implications for public health practice?: This outbreak underscores the critical need to enhance surveillance of meningococcal serogroups and population carrier, and advocate for vaccination with MenY-containing vaccines.
    Language English
    Publishing date 2024-04-17
    Publishing country China
    Document type Journal Article
    ISSN 2096-7071
    ISSN (online) 2096-7071
    DOI 10.46234/ccdcw2024.048
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Article ; Online: Neuron-derived neuropeptide Y fine-tunes the splenic immune responses.

    Yu, Jinsong / Xiao, Ke / Chen, Xiaohua / Deng, Lulu / Zhang, Lu / Li, Yue / Gao, Anran / Gao, Junjun / Wu, Chengchao / Yang, Xinmei / Zhou, Qiudi / Yang, Jian / Bao, Chenyu / Jiao, Jiaji / Cheng, Sheng / Guo, Zhiqing / Xu, Weize / Cao, Xiaojian / Guo, Zheng /
    Dai, Jinxia / Hu, Ji / Fu, Zhenfang / Cao, Gang

    Neuron

    2023  Volume 111, Issue 8, Page(s) 1346–1347

    Language English
    Publishing date 2023-04-20
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 808167-0
    ISSN 1097-4199 ; 0896-6273
    ISSN (online) 1097-4199
    ISSN 0896-6273
    DOI 10.1016/j.neuron.2023.03.032
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2496: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 92: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top